Review
Nutrition & Dietetics
Vincent Brandenburg, Markus Ketteler
Summary: This review examines the developments of vitamin D therapies in CKD patients and discusses the association between vitamin D deficiency and sHPT as well as its impact on important clinical outcomes in CKD patients. However, vitamin D therapy also comes with the risk of side effects, so it is necessary to address core issues regarding PTH target levels, optimal vitamin D levels, and the effectiveness of sHPT treatment in CKD patients.
Article
Pediatrics
Simei Wang, Quanmei Xu, Anqi Wang, Fang Yuan, Xiaona Luo, Yilin Wang, Miao Guo, Yuanfeng Zhang, Wenjing Zhang, Xiaobing Ji, Yun Ren, Yucai Chen
Summary: This study found a correlation between 25-hydroxyvitamin D deficiency and tic disorders (TD) in Chinese children, but no correlation between 25-hydroxyvitamin D deficiency and the severity of TD. Additionally, the deficiency of 25-hydroxyvitamin D was most pronounced in children over the age of 9.
FRONTIERS IN PEDIATRICS
(2022)
Article
Nutrition & Dietetics
Seunghye Lee, Hye Jin Chung, Sehyun Jung, Ha Nee Jang, Se-Ho Chang, Hyun-Jung Kim, Min-Chul Cho
Summary: Appropriate management of vitamin D deficiency and hyperparathyroidism is essential in preventing metabolic bone disorder and cardiovascular diseases in chronic kidney disease. The study found that the ratio of 24,25-dihydroxyvitamin D to 25-hydroxyvitamin D (VMR) can serve as a useful biomarker for evaluating metabolic bone disorder in CKD patients. The study concluded that 24,25-dihydroxyvitamin D and VMR have the potential to be reliable vitamin D biomarkers in CKD patients.
Article
Endocrinology & Metabolism
Michael Thompson, Dawn Aitken, Saliu Balogun, Flavia Cicuttini, Graeme Jones
Summary: The longitudinal increase in population 25(OH)D concentration is attributed to increased sun exposure and supplement use. Maintaining or achieving vitamin D sufficiency is associated with less bone mineral density loss over 10 years.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Shufei Zeng, Chang Chu, Cornelia Doebis, Volker von Baehr, Berthold Hocher
Summary: There is a strong positive linear correlation between free 25(OH)D (f25(OH)D) and total 25(OH)D, making them useful for assessing vitamin D levels. The recommended threshold level for f25(OH)D is 8.499 pg/mL, corresponding to a target concentration of at least 30 ng/mL for t25(OH)D. The upper limit for vitamin D is still unclear, with most experts favoring a upper limit of 100 ng/mL for t25(OH)D.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Juntao Xie, Qingui Chen, Dejian He
Summary: This study investigated the prevalence and predictors of abnormal blood 25-hydroxyvitamin D (25(OH)D) and its association with prognosis in critically ill patients. The findings suggest that deficient blood 25(OH)D is common in critically ill patients but is not an independent risk factor for hospital mortality, while elevated blood 25(OH)D is associated with worse prognosis.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Nathalie Gharibeh, Maryam Razaghi, Catherine A. Vanstone, ShuQin Wei, Dayre McNally, Frank Rauch, Glenville Jones, Martin Kaufmann, Hope A. Weiler
Summary: The study found that maternal gestational weight gain is related to neonatal bone mass, while maternal vitamin D status does not seem to have an impact.
Article
Nutrition & Dietetics
Guowei Li, Likang Li, Jonathan D. Adachi, Ruoting Wang, Zebing Ye, Xintong Liu, Lehana Thabane, Gregory Y. H. Lip
Summary: This study found a quasi J-shaped relationship between serum circulating 25-hydroxyvitamin D (25(OH)D) level and risk of recurrent stroke in patients with a stroke history. The lowest risk of recurrent stroke was observed at a 25(OH)D level of approximately 60 nmol/L, which was associated with a 48% reduction in risk compared to a level of 10 nmol/L.
Article
Immunology
Mariam El-Zein, Farzin Khosrow-Khavar, Ann N. Burchell, Pierre-Paul Tellier, Shaun Eintracht, Elizabeth McNamara, Francois Coutlee, Eduardo L. Franco
Summary: The study found that baseline serum 25-hydroxyvitamin D levels were not significantly associated with HPV prevalence and incidence, but showed a modest negative association with HPV clearance. Vitamin D levels <30 ng/mL were marginally associated with increased HPV clearance compared to levels >= 30 ng/mL.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Nutrition & Dietetics
RuTong Wang, Weijing Wang, Ping Hu, Ronghui Zhang, Xue Dong, Dongfeng Zhang
Summary: This study aimed to evaluate the association between dietary vitamin D intake and serum vitamin D concentrations with cognitive performance in older Americans. The results showed a positive association between dietary vitamin D intake, serum total 25-hydroxyvitamin D, and cognitive performance, with no significant gender differences in the associations. Further research is needed to clarify the effects of dietary vitamin D intake and specific serum D concentrations on cognitive performance.
Article
Nutrition & Dietetics
Ewelina A. Dziedzic, Jakub S. Gasior, Agnieszka Tuzimek, Marek Dabrowski, Waclaw Kochman
Summary: This study investigated the differences in monocyte-to-HDL ratio (MHR) and serum 25-hydroxyvitamin D (25(OH)D) concentration between male patients with different diagnoses of chronic coronary syndrome (CCS), and analyzed the correlation between 25(OH)D and MHR in this group. The results showed significant differences in 25(OH)D and MHR between acute coronary syndrome (ACS) patients and CCS patients, with the highest HDL and serum 25(OH)D concentrations observed in patients with CCS, and the highest value of MHR observed in patients with ST-elevation myocardial infarction (STEMI). There was also a significant correlation observed between 25(OH)D, HDL, and MHR.
Article
Endocrinology & Metabolism
Suyan Duan, Fang Lu, Buyun Wu, Chengning Zhang, Guangyan Nie, Lianqin Sun, Zhimin Huang, Honglei Guo, Bo Zhang, Changying Xing, Yanggang Yuan
Summary: This study found that decreased levels of 25-hydroxyvitamin D (25(OH)D) in patients with type 2 diabetes mellitus (T2DM) were associated with deteriorated renal function and increased risk of chronic kidney disease (CKD) progression.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
C. Min, D. M. Yoo, J. H. Wee, H. -J. Lee, H. G. Choi
Summary: The combination of high-intensity physical activity and high 25(OH)D levels is associated with low prevalence of osteoporosis/osteopenia, with high BMD positively correlated with this combination.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Fulvia Zappulo, Maria Cappuccilli, Alessandra Cingolani, Anna Scrivo, Anna Laura Croci Chiocchini, Miriam Di Nunzio, Chiara Donadei, Marianna Napoli, Francesco Tondolo, Giuseppe Cianciolo, Gaetano La Manna
Summary: Vitamin D plays a crucial role in bone metabolism, as well as having important extra-bone effects such as glucose homeostasis and cardiovascular protection. This narrative review provides an overview of the role of vitamin D in different settings, with a special focus on chronic kidney disease and kidney transplant.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Makoto Tsujita, Yohei Doi, Yoshitsugu Obi, Takayuki Hamano, Toshihide Tomosugi, Kenta Futamura, Manabu Okada, Takahisa Hiramitsu, Norihiko Goto, Yoshitaka Isaka, Asami Takeda, Shunji Narumi, Yoshihiko Watarai
Summary: The study found that cholecalciferol significantly reduced PTH levels and attenuated LS BMD loss after kidney transplantation, especially showing a more pronounced effect in patients with low bone mass.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)