Journal
CLINICAL NEPHROLOGY
Volume 78, Issue 4, Pages 328-331Publisher
DUSTRI-VERLAG DR KARL FEISTLE
DOI: 10.5414/CN107205
Keywords
hemolytic-uremic syndrome; Streptococcus pyogenes; Thomsen-Friedenreich antigen
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Funding
- Grants-in-Aid for Scientific Research [23591591] Funding Source: KAKEN
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Infection with Streptococcus pyogenes, a Group A beta-hemolytic streptococcus (GAS), is a rare cause of hemolytic-uremic syndrome (HUS). Invasive infections with Streptococcus pneumoniae that produce neuraminidase are a well-recognized cause of HUS without diarrhea. The Thomsen-Friedenreich antigen (T antigen) plays a role in the pathophysiology of pneumococcal HUS. We describe the case of a 3-year-old boy with GAS-associated HUS and show how T-antigen exposure was implicated in this case. He had no diarrhea and cultures for blood, urine, and stool were negative. The urinary pneumococcal antigen was negative; his direct Coombs test was positive. Glomerular capillary loops, tubular epithelium on his renal biopsy specimen, and red blood cells in his blood smear showed positive fluorescence with anti-T lectin. Although the pathogenesis of GAS-associated HUS is not well understood, T-antigen exposure may be implicated in some cases with GAS-associated HUS.
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