Article
Transplantation
Ahmed A. Awan, Carl P. Walther, Peter A. Richardson, Maulin Shah, Wolfgang C. Winkelmayer, Sankar D. Navaneethan
Summary: In patients with chronic kidney disease and anemia, absolute and functional iron deficiency anemia were associated with various clinical covariates. Functional IDA was linked to an increased risk of mortality and cardiovascular hospitalization, while absolute IDA was only associated with a higher risk of hospitalization.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Transplantation
Evgeny Shutov, Wladyslaw Sulowicz, Ciro Esposito, Avtandil Tataradze, Branislav Andric, Michael Reusch, Udaya Valluri, Nada Dimkovic
Summary: The study demonstrated that Roxadustat is more effective than placebo in treating anemia in patients with chronic kidney disease. The treatment group showed significantly higher Hb response rate and Hb change from baseline compared to the placebo group.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Medicine, General & Internal
Hammad Fadlalmola, Khaled Al-Sayaghi, Abdulqader Al-Hebshi, Maher Aljohani, Mohammed Albalawi, Ohoud Kashari, Alaa Alem, Mariam Alrasheedy, Saud Balelah, Faten Almuteri, Arwa Alyamani, Turki Alwasaidi
Summary: The higher the dose of daprodustat, the more significant impact on efficacy outcomes such as serum total iron-binding capacity (TIBC), hemoglobin, and ferritin. However, the safety profile of different doses of daprodustat still needs further investigation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pediatrics
Emre Leventoglu, Bahar Bueyuekkaragoez, Furkan cagri Kavas, Mert Can Hologlu, Akif Kavgaci, Kibriya Fidan, Aydin Dalgic, Sevcan A. Bakkaloglu, Fatma Sedef Tunaoglu, Oguz Soeylemezoglu
Summary: Cardiovascular diseases are the main causes of morbidity in children with chronic kidney disease (CKD). This study evaluates the use of electrocardiography (ECG) in detecting dangerous changes in CKD and kidney replacement therapies and compares its value in predicting cardiovascular outcomes with echocardiography. The findings suggest that ECG can be used to detect cardiovascular problems, especially in hemodialysis (HD) patients. ECG abnormalities suggestive of left ventricular hypertrophy (LVH) should prompt referrals for echocardiographic assessment.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Physiology
Jia-Lin Li, Zhen Cai, Jing Zhao, Xiang-Gang Zhu, Qian Li, Yan-Shuang Li, Meng-Chao Liu, Fang-Qiang Cui, Wen-Jing Zhao, Wen-Quan Niu
Summary: This study aimed to examine the association between three anemia-related biomarkers and the adequacy of peritoneal dialysis (PD) in patients with chronic kidney disease (CKD). The results suggest that the deterioration of anemia-related biomarkers may contribute to the development of inadequate PD.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Urology & Nephrology
Steven Fishbane, Carol A. Pollock, Mohamed El-Shahawy, Elizabeth T. Escudero, Anjay Rastogi, Bui Pham Van, Lars Frison, Mark Houser, Maksym Pola, Dustin J. Little, Nicolas Guzman, Pablo E. Pergola
Summary: Roxadustat effectively increases hemoglobin in patients with dialysis-dependent CKD, and its adverse event profile is comparable to that of epoetin alfa.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Robert Provenzano, Steven Fishbane, Lynda Szczech, Robert Leong, Khalil G. Saikali, Ming Zhong, Tyson T. Lee, Mark T. Houser, Lars Frison, John Houghton, Dustin J. Little, Kin-Hung Peony Yu, Thomas B. Neff
Summary: The study showed that roxadustat was at least as effective as epoetin alfa in patients new to dialysis, with a lower risk of major adverse cardiovascular events and MACE+ in the roxadustat group compared to the epoetin alfa group.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Ahmed Abu-Zaid, Duha Magzoub, Mohammad Abdulrahman Aldehami, Abdulrahman Adel Behiry, Akshaya Srikanth Bhagavathula, Raouf Hajji
Summary: Iron treatment is associated with a significant decrease in FGF23 levels in CKD patients, with oral iron therapy being more effective than intravenous iron therapy.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Review
Nutrition & Dietetics
Aleksandra Beata Juszczak, Maciej Kupczak, Tomasz Konecki
Summary: This narrative review summarizes 98 studies of chronic kidney disease (CKD) and the effects of vitamin supplementation on patients on dialysis. The findings suggest potential effectiveness of certain vitamins, such as B, D, or C, but recommendations for vitamins A and K are still unclear due to potential toxicity. Further research is needed to evaluate the effectiveness and risks of vitamin supplementation for CKD patients.
Article
Endocrinology & Metabolism
Joao Victor Salgado, Miguel Angelo Goes, Natalino Salgado Filho
Summary: The global nephrology community acknowledges the increasing burden of kidney disease and emphasizes on early diagnosis, understanding of disease progression, and development of new therapeutic interventions. FGF21 is considered a key regulator of lipid, glucose, and energy metabolism, as well as stress responses. While promising results have been shown with FGF21 analogs in metabolic disease, its exact role in kidney function remains poorly understood.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2021)
Letter
Medicine, General & Internal
H. Franklin Bunn
Summary: The trials show convincing evidence that vadadustat is effective in treating anemia in patients with chronic kidney disease, compared to darbepoetin alfa which has prolonged life span in circulation.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Urology & Nephrology
Sishir Gang, Prakash Khetan, Deepak Varade, Venkata Ramakrishna Chinta, Siddharth Mavani, Umesh Gupta, S. Venkata Krishna Reddy, Sunil Rajanna, Tarun Jeloka, Vivek Ruhela, Kevinkumar Kansagra, Pooja Kanani, Jayesh Bhatt, Kuldipsinh Zala
Summary: This study demonstrates that desidustat is noninferior to epoetin in the treatment of anemia in CKD patients on dialysis and is well-tolerated.
AMERICAN JOURNAL OF NEPHROLOGY
(2022)
Review
Nutrition & Dietetics
Carlo Garofalo, Chiara Ruotolo, Claudia Annoiato, Maria Elena Liberti, Roberto Minutolo, Luca De Nicola, Giuseppe Conte, Silvio Borrelli
Summary: A systematic review and meta-analysis revealed that approximately 1.5% of patients undergoing maintenance dialysis experience recovery of kidney function unrelated to acute kidney injury. The prevalence of recovery is higher in the United States compared to other countries.
Review
Urology & Nephrology
Qiaoqiao Zhou, Mian Mao, Jing Li, Furong Deng
Summary: This meta-analysis evaluates the efficacy and safety of roxadustat for anemia in dialysis-dependent chronic kidney disease patients. The results show that roxadustat significantly increases hemoglobin levels and improves iron utilization. It also decreases low-density lipoprotein-cholesterol and total cholesterol. There were no significant differences in treatment-emergent adverse events, treatment-emergent serious adverse events, and major adverse cardiovascular events between roxadustat and erythropoiesis-stimulating agents.
Article
Medicine, Research & Experimental
Jonathan Barratt, Frank Dellanna, Jose Portoles, Gabriel Choukroun, Luca De Nicola, James Young, Nada Dimkovic, Michael Reusch
Summary: This study aimed to investigate the safety of roxadustat compared with erythropoiesis-stimulating agents (ESA) in non-dialysis-dependent (NDD) or incident dialysis-dependent (ID-DD) chronic kidney disease (CKD) patients with anemia. The results showed that roxadustat was comparable to ESA in terms of major adverse cardiovascular events (MACE), all-cause mortality, and treatment-emergent adverse events (TEAEs). There was no evidence of increased risk of cardiovascular events or mortality with roxadustat.
ADVANCES IN THERAPY
(2023)