Article
Virology
Ray T. Y. So, Daniel K. W. Chu, Kenrie P. Y. Hui, Chris K. P. Mok, Marcus H. H. Shum, Sumana Sanyal, John M. Nicholls, John C. W. Ho, Man-chun Cheung, Ka-chun Ng, Hin-Wo Yeung, Michael C. W. Chan, Leo L. M. Poon, Jincun Zhao, Tommy T. Y. Lam, Malik Peiris
Summary: This study identified an amino acid substitution (nsp6 L232F) in clade B MERS-CoV that is more common in human infections and confers higher replication ability in the human respiratory tract. This mutation is associated with the transmission of the virus from camels to humans, highlighting the importance of MERS-CoV as a zoonotic threat and the need for continued surveillance in camels and humans.
JOURNAL OF VIROLOGY
(2023)
Article
Virology
Dae-Gyun Ahn, Gun Young Yoon, Sunhee Lee, Keun Bon Ku, Chonsaeng Kim, Kyun-Do Kim, Young-Chan Kwon, Geon-Woo Kim, Bum-Tae Kim, Seong-Jun Kim
Summary: Recent outbreaks of zoonotic coronaviruses, such as MERS-CoV and SARS-CoV-2, have caused significant casualties and economic shock. A novel compound, KCB261770, has been identified to effectively inhibit MERS-CoV frameshifting, showing potential as a drug candidate for interfering with pan-coronavirus frameshifting.
Article
Multidisciplinary Sciences
Salmaan Sharif, Aamer Ikram, Adnan Khurshid, Muhammad Salman, Nayab Mehmood, Yasir Arshad, Jamal Ahmed, Rana Muhammad Safdar, Lubna Rehman, Ghulam Mujtaba, Jaffar Hussain, Johar Ali, Mehar Angez, Muhammad Masroor Alam, Ribqa Akthar, Muhammad Wasif Malik, Mirza Zeeshan Iqbal Baig, Muhammad Suleman Rana, Muhammad Usman, Muhammad Qaisar Ali, Abdul Ahad, Nazish Badar, Massab Umair, Sana Tamim, Asiya Ashraf, Faheem Tahir, Nida Ali
Summary: The study found 27% of wastewater samples tested positive for SARs-CoV-2, indicating the potential for monitoring viral spread through wastewater surveillance. Additionally, the detection of virus sequence data in wastewater highlights the importance of surveillance for early warning signs.
Article
Multidisciplinary Sciences
J. Gutierrez-Alvarez, J. M. Honrubia, A. Sanz-Bravo, E. Gonzalez-Miranda, R. Fernandez-Delgado, M. T. Rejas, S. Zuniga, I Sola, L. Enjuanes
Summary: Deletion of the envelope (E) gene from the Middle East respiratory syndrome coronavirus (MERS-CoV) generates a replication-competent propagation-defective RNA replicon. Further combination with accessory open reading frames (ORFs) can enhance the attenuation of the replicon, resulting in highly safe and promising vaccine candidates.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Microbiology
Javier Gutierrez-Alvarez, Jose M. Honrubia, Raul Fernandez-Delgado, Li Wang, Carlos Castano-Rodriguez, Sonia Zuniga, Isabel Sola, Luis Enjuanes
Summary: There is a potential vaccine candidate for MERS-CoV developed by generating mutants with partial deletions in the E protein, which has been shown to be attenuated and provide complete protection against virulent MERS-CoV. This approach highlights the importance of identifying and targeting virulence factors to design efficient vaccines.
Review
Biochemistry & Molecular Biology
Mujeeb Khan, Syed F. Adil, Hamad Z. Alkhathlan, Muhammad N. Tahir, Sadia Saif, Merajuddin Khan, Shams T. Khan
Summary: The article summarizes the three deadly pandemics associated with novel coronaviruses that humans have witnessed in the twenty-first century: SARS, MERS, and COVID-19. Specifically, it describes the epidemiological characteristics of COVID-19, such as transmission, death rate, and discusses various treatment strategies and different approaches to vaccine development.
Review
Biochemistry & Molecular Biology
Ridhima Kaul, Pradipta Paul, Sanjay Kumar, Dietrich Buesselberg, Vivek Dhar Dwivedi, Ali Chaari
Summary: This review summarizes the activities and structure-activity relationships of flavonoids in combating SARS-CoV-2 from in vitro studies to clinical research. The study found that flavonoids such as quercetin and myricetin derivatives, baicalein, baicalin, EGCG, and tannic acid show promising activities against SARS-CoV-2.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Microbiology
Hanan Al-Khalaifah, Mohammad Alotaibi, Afaf Al-Nasser
Summary: This article examines the origin of coronaviruses and the risk of transmission between humans and animals, with a focus on avian coronaviruses and their possible relation to SARS-CoV-2.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Shan Lu, Zhiheng Xing, Shiyu Zhao, Xianglu Meng, Juhong Yang, Wenlong Ding, Jigang Wang, Chencui Huang, Jingxu Xu, Baocheng Chang, Jun Shen
Summary: The study found that COVID-19 patients with diabetes had more serious lung inflammatory exudation than those without diabetes, and blood glucose level was positively correlated with pulmonary inflammatory exudation in COVID-19 patients.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2021)
Review
Immunology
Eijaz Ahmed Bhat, Johra Khan, Nasreena Sajjad, Ahmad Ali, Fahad M. Aldakeel, Ayesha Mateen, Mohammed S. Alqahtani, Rabbani Syed
Summary: This article provides an overview of the epidemiology, genome structure, and treatment and prevention of COVID-19, focusing on the structure of its viral proteins and pathogenic mechanisms.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Clayton J. Otter, Alejandra Fausto, Li Hui Tan, Alisha S. Khosla, Noam A. Cohen, Susan R. Weiss
Summary: This study compares the replication and cytotoxicity of several coronaviruses in human nasal epithelial cells. The results show that different viruses have different replication abilities and cytotoxic effects, and the status of nasal epithelial cells (such as asthma inflammation) also affects the availability of viral receptors and replication.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Review
Immunology
Zhenyu Zhao, Kefeng Lu, Binli Mao, Shi Liu, Mirko Trilling, Ailong Huang, Mengji Lu, Yong Lin
Summary: SARS-CoV-2 is the third highly pathogenic emerging human coronavirus, causing the COVID-19 pandemic globally. Studies show that coronavirus infections may be related to autophagy, which could even promote viral infection and replication. It remains unclear how coronavirus infections induce autophagy and whether the autophagic machinery is essential for viral propagation.
EMERGING MICROBES & INFECTIONS
(2021)
Article
Chemistry, Analytical
Nosaibah Samman, Kheireddine El-Boubbou, Khawlah Al-Muhalhil, Rizwan Ali, Ahmed Alaskar, Naif Khalaf Alharbi, Atef Nehdi
Summary: COVID-19 pandemic has had a devastating impact on healthcare systems, economies, and education worldwide, causing millions of deaths. Despite the urgent need, there is currently no specific and effective treatment available, and the existing PCR-based tests have limitations. In this study, a novel nano-biosensor diagnostic assay called MICaFVi is introduced, which combines magnetic immuno-capture with flow virometry for sensitive detection of viral particles and pseudoviruses.
Article
Pharmacology & Pharmacy
Mahmoud Kandeel, Mizuki Yamamoto, Byoung Kwon Park, Abdulla Al-Taher, Aya Watanabe, Jin Gohda, Yasushi Kawaguchi, Kentaro Oh-hashi, Hyung-Joo Kwon, Jun-ichiro Inoue
Summary: A highly potent set of peptides was designed to prevent MERS-CoV fusion through competition with HR2 at its HR1 binding site. These peptides demonstrated strong inhibition of MERS-CoV cell-cell fusion and plaque formation, with no cytotoxic effects at high concentrations, suggesting their potential as promising antiviral agents.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biology
Rui P. Silva, Yimin Huang, Annalee W. Nguyen, Ching-Lin Hsieh, Oladimeji S. Olaluwoye, Tamer S. Kaoud, Rebecca E. Wilen, Ahlam N. Qerqez, Jun-Gyu Park, Ahmed M. Khalil, Laura R. Azouz, Kevin C. Le, Amanda L. Bohanon, Andrea M. DiVenere, Yutong Liu, Alison G. Lee, Dzifa A. Amengor, Sophie R. Shoemaker, Shawn M. Costello, Eduardo A. Padlan, Susan Marqusee, Luis Martinez-Sobrido, Kevin N. Dalby, Sheena D'Arcy, Jason S. McLellan, Jennifer A. Maynard, Leslie Goo
Summary: Understanding the protective potential of conserved epitopes in SARS-CoV-2 and other coronaviruses is crucial for addressing the current pandemic and future outbreaks. Researchers have identified a highly conserved epitope in the S2 domain of beta-coronaviruses, specifically in the hinge region. An antibody called RAY53 targets this epitope and has been found to mediate immune responses against SARS-CoV-2 spike protein. However, mutations in the hinge region and other spike protein changes may impact antibody binding and evade existing serum antibodies. This study provides valuable insights into the targeting of S2 core epitopes and the limitations of this approach.
Article
Pediatrics
Alicia M. Alcamo, Michael S. Wolf, Lauren J. Alessi, Hey J. Chong, Michael Green, John V. Williams, Dennis W. Simon
Review
Virology
Bethany K. Sederdahl, John Williams
Article
Multidisciplinary Sciences
Timothy P. Sheahan, Amy C. Sims, Sarah R. Leist, Alexandra Schafer, John Won, Ariane J. Brown, Stephanie A. Montgomery, Alison Hogg, Darius Babusis, Michael O. Clarke, Jamie E. Spahn, Laura Bauer, Scott Sellers, Danielle Porter, Joy Y. Feng, Tomas Cihlar, Robert Jordan, Mark R. Denison, Ralph S. Baric
NATURE COMMUNICATIONS
(2020)
Article
Multidisciplinary Sciences
Thomas Klink, Danielle A. Rankin, Bhinnata Piya, Andrew J. Spieker, Samir Faouri, Asem Shehabi, John V. Williams, Najwa Khuri-Bulos, Natasha B. Halasa
Article
Cell Biology
Timothy P. Sheahan, Amy C. Sims, Shuntai Zhou, Rachel L. Graham, Andrea J. Pruijssers, Maria L. Agostini, Sarah R. Leist, Alexandra Schafer, Kenneth H. Dinnon, Laura J. Stevens, James D. Chappell, Xiaotao Lu, Tia M. Hughes, Amelia S. George, Collin S. Hill, Stephanie A. Montgomery, Ariane J. Brown, Gregory R. Bluemling, Michael G. Natchus, Manohar Saindane, Alexander A. Kolykhalov, George Painter, Jennifer Harcourt, Azaibi Tamin, Natalie J. Thornburg, Ronald Swanstrom, Mark R. Denison, Ralph S. Baric
SCIENCE TRANSLATIONAL MEDICINE
(2020)
Article
Medicine, General & Internal
L. A. Jackson, E. J. Anderson, N. G. Rouphael, P. C. Roberts, M. Makhene, R. N. Coler, M. P. McCullough, J. D. Chappell, M. R. Denison, L. J. Stevens, A. J. Pruijssers, A. McDermott, B. Flach, N. A. Doria-Rose, K. S. Corbett, K. M. Morabito, S. O'Dell, S. D. Schmidt, P. A. Swanson, M. Padilla, J. R. Mascola, K. M. Neuzil, H. Bennett, W. Sun, E. Peters, M. Makowski, J. Albert, K. Cross, W. Buchanan, R. Pikaart-Tautges, J. E. Ledgerwood, B. S. Graham, J. H. Beigel
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Article
Pediatrics
Brian Rha, Aaron T. Curns, Joana Y. Lively, Angela P. Campbell, Janet A. Englund, Julie A. Boom, Parvin H. Azimi, Geoffrey A. Weinberg, Mary A. Staat, Rangaraj Selvarangan, Natasha B. Halasa, Monica M. McNeal, Eileen J. Klein, Christopher J. Harrison, John V. Williams, Peter G. Szilagyi, Monica N. Singer, Leila C. Sahni, Daniella Figueroa-Downing, Darius McDaniel, Mila M. Prill, Brett L. Whitaker, Laura S. Stewart, Jennifer E. Schuster, Barbara A. Pahud, Gina Weddle, Vasanthi Avadhanula, Flor M. Munoz, Pedro A. Piedra, Daniel C. Payne, Gayle Langley, Susan I. Gerber
Article
Virology
Meredith C. Rogers, Margot Miranda-Katz, Yu Zhang, Tim D. Oury, Melissa B. Uccellini, Adolfo Garcia-Sastre, John Williams
Article
Cell Biology
Andrea J. Pruijssers, Amelia S. George, Alexandra Schafer, Sarah R. Leist, Lisa E. Gralinksi, Kenneth H. Dinnon, Boyd L. Yount, Maria L. Agostini, Laura J. Stevens, James D. Chappell, Xiaotao Lu, Tia M. Hughes, Kendra Gully, David R. Martinez, Ariane J. Brown, Rachel L. Graham, Jason K. Perry, Venice Du Pont, Jared Pitts, Bin Ma, Darius Babusis, Eisuke Murakami, Joy Y. Feng, John P. Bilello, Danielle P. Porter, Tomas Cihlar, Ralph S. Baric, Mark R. Denison, Timothy P. Sheahan
Article
Virology
Jens H. Kuhn, Scott Adkins, Daniela Alioto, Sergey V. Alkhovsky, Gaya K. Amarasinghe, Simon J. Anthony, Tatjana Avsic-Zupanc, Maria A. Ayllon, Justin Bahl, Anne Balkema-Buschmann, Matthew J. Ballinger, Tomas Bartonicka, Christopher Basler, Sina Bavari, Martin Beer, Dennis A. Bente, Eric Bergeron, Brian H. Bird, Carol Blair, Kim R. Blasdell, Steven B. Bradfute, Rachel Breyta, Thomas Briese, Paul A. Brown, Ursula J. Buchholz, Michael J. Buchmeier, Alexander Bukreyev, Felicity Burt, Nihal Buzkan, Charles H. Calisher, Mengji Cao, Inmaculada Casas, John Chamberlain, Kartik Chandran, Remi N. Charrel, Biao Chen, Michela Chiumenti, Il-Ryong Choi, J. Christopher S. Clegg, Ian Crozier, John V. da Graca, Elena Dal Bo, Alberto M. R. Davila, Juan Carlos de la Torre, Xavier de Lamballerie, Rik L. de Swart, Patrick L. Di Bello, Nicholas Di Paola, Francesco Di Serio, Ralf G. Dietzgen, Michele Digiaro, Valerian V. Dolja, Olga Dolnik, Michael A. Drebot, Jan Felix Drexler, Ralf Duerrwald, Lucie Dufkova, William G. Dundon, W. Paul Duprex, John M. Dye, Andrew J. Easton, Hideki Ebihara, Toufic Elbeaino, Koray Ergunay, Jorlan Fernandes, Anthony R. Fooks, Pierre B. H. Formenty, Leonie F. Forth, Ron A. M. Fouchier, Juliana Freitas-Astua, Selma Gago-Zachert, George Fu Gao, Maria Laura Garcia, Adolfo Garcia-Sastre, Aura R. Garrison, Aiah Gbakima, Tracey Goldstein, Jean-Paul J. Gonzalez, Anthony Griffiths, Martin H. Groschup, Stephan Guenther, Alexandro Guterres, Roy A. Hall, John Hammond, Mohamed Hassan, Jussi Hepojoki, Satu Hepojoki, Udo Hetzel, Roger Hewson, Bernd Hoffmann, Seiji Hongo, Dirk Hoeper, Masayuki Horie, Holly R. Hughes, Timothy H. Hyndman, Amara Jambai, Rodrigo Jardim, Daohong Jiang, Qi Jin, Gilda B. Jonson, Sandra Junglen, Serpil Karadag, Karen E. Keller, Boris Klempa, Jonas Klingstrom, Gary Kobinger, Hideki Kondo, Eugene V. Koonin, Mart Krupovic, Gael Kurath, Ivan V. Kuzmin, Lies Laenen, Robert A. Lamb, Amy J. Lambert, Stanley L. Langevin, Benhur Lee, Elba R. S. Lemos, Eric M. Leroy, Dexin Li, Jianrong Li, Mifang Liang, Wenwen Liu, Yan Liu, Igor S. Lukashevich, Piet Maes, William Marciel de Souza, Marco Marklewitz, Sergio H. Marshall, Giovanni P. Martelli, Robert R. Martin, Shin-Yi L. Marzano, Sebastien Massart, John W. McCauley, Nicole Mielke-Ehret, Angelantonio Minafra, Maria Minutolo, Ali Mirazimi, Hans-Peter Muehlbach, Elke Muhlberger, Rayapati Naidu, Tomohide Natsuaki, Beatriz Navarro, Jose A. Navarro, Sergey V. Netesov, Gabriele Neumann, Norbert Nowotny, Marcio R. T. Nunes, Are Nylund, Arnfinn L. Okland, Renata C. Oliveira, Gustavo Palacios, Vicente Pallas, Bernadett Palyi, Anna Papa, Colin R. Parrish, Alex Pauvolid-Correa, Janusz T. Paweska, Susan Payne, Daniel R. Perez, Florian Pfaff, Sheli R. Radoshitzky, Aziz-ul Rahman, Pedro L. Ramos-Gonzalez, Renato O. Resende, Carina A. Reyes, Bertus K. Rima, Victor Romanowski, Gabriel Robles Luna, Paul Rota, Dennis Rubbenstroth, Jonathan A. Runstadler, Daniel Ruzek, Sead Sabanadzovic, Jiri Salat, Amadou Alpha Sall, Maria S. Salvato, Kamil Sarpkaya, Takahide Sasaya, Martin Schwemmle, Muhammad Z. Shabbir, Xiaohong Shi, Zhengli Shi, Yukio Shirako, Peter Simmonds, Jana Sirmarova, Manuela Sironi, Sophie Smither, Teemu Smura, Jin-Won Song, Kirsten M. Spann, Jessica R. Spengler, Mark D. Stenglein, David M. Stone, Petra Strakova, Ayato Takada, Robert B. Tesh, Natalie J. Thornburg, Keizo Tomonaga, Noel Tordo, Jonathan S. Towner, Massimo Turina, Ioannis Tzanetakis, Rainer G. Ulrich, Anna Maria Vaira, Bernadette van den Hoogen, Arvind Varsani, Nikos Vasilakis, Martin Verbeek, Victoria Wahl, Peter J. Walker, Hui Wang, Jianwei Wang, Xifeng Wang, Lin-Fa Wang, Taiyun Wei, Heather Wells, Anna E. Whitfield, John V. Williams, Yuri I. Wolf, Zhiqiang Wu, Xin Yang, Xinglou Yang, Xuejie Yu, Natalya Yutin, F. Murilo Zerbini, Tong Zhang, Yong-Zhen Zhang, Guohui Zhou, Xueping Zhou
ARCHIVES OF VIROLOGY
(2020)
Article
Medicine, General & Internal
E. J. Anderson, N. G. Rouphael, A. T. Widge, L. A. Jackson, P. C. Roberts, M. Makhene, J. D. Chappell, M. R. Denison, L. J. Stevens, A. J. Pruijssers, A. B. McDermott, B. Flach, B. C. Lin, N. A. Doria-Rose, S. O'Dell, S. D. Schmidt, K. S. Corbett, P. A. Swanson, M. Padilla, K. M. Neuzil, H. Bennett, B. Leav, M. Makowski, J. Albert, K. Cross, V. V. Edara, K. Floyd, M. S. Suthar, D. R. Martinez, R. Baric, W. Buchanan, C. J. Luke, V. K. Phadke, C. A. Rostad, J. E. Ledgerwood, B. S. Graham, J. H. Beigel
NEW ENGLAND JOURNAL OF MEDICINE
(2020)
Letter
Medicine, General & Internal
Alicia T. Widge, Nadine G. Rouphael, Lisa A. Jackson, Evan J. Anderson, Paul C. Roberts, Mamodikoe Makhene, James D. Chappell, Mark R. Denison, Laura J. Stevens, Andrea J. Pruijssers, Adrian B. McDermott, Britta Flach, Bob C. Lin, Nicole A. Doria-Rose, Sijy O'Dell, Stephen D. Schmidt, Kathleen M. Neuzil, Hamilton Bennett, Brett Leav, Mat Makowski, Jim Albert, Kaitlyn Cross, Venkata-Viswanadh Edara, Katharine Floyd, Mehul S. Suthar, Wendy Buchanan, Catherine J. Luke, Julie E. Ledgerwood, John R. Mascola, Barney S. Graham, John H. Beigel
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Microbiology
Jennifer Gribble, Laura J. Stevens, Maria L. Agostini, Jordan Anderson-Daniels, James D. Chappell, Xiaotao Lu, Andrea J. Pruijssers, Andrew L. Routh, Mark R. Denison
Summary: Recombination is essential for coronavirus diversity and the emergence of new strains. The mechanisms of CoV recombination are not well understood, but studies have shown extensive and diverse recombination products in CoVs during replication. The nsp14-ExoN protein is crucial for native recombination in CoVs, highlighting its potential as a target for inhibitors to control SARS-CoV-2 and future emerging zoonotic CoVs.
Article
Microbiology
Krista G. Freeman, Katherine S. Wetzel, Yu Zhang, Kira M. Zack, Deborah Jacobs-Sera, Sara M. Walters, Dominique J. Barbeau, Anita K. McElroy, John V. Williams, Graham F. Hatfull
Summary: Researchers explored the potential of using mycobacteriophages as a vaccine platform, citing advantages such as a large variety of characterized phages and the ability to display multiple antigen copies on a single particle. They found that mycobacteriophage Bxb1 and its recombinants displaying SARS-CoV-2 antigens exhibit strong immunogenicity.
Article
Infectious Diseases
Kathleen Chiotos, Molly Hayes, David W. Kimberlin, Sarah B. Jones, Scott H. James, Swetha G. Pinninti, April Yarbrough, Mark J. Abzug, Christine E. MacBrayne, Vijaya L. Soma, Daniel E. Dulek, Surabhi B. Vora, Alpana Waghmare, Joshua Wolf, Rosemary Olivero, Steven Grapentine, Rachel L. Wattier, Laura Bio, Shane J. Cross, Nicholas O. Dillman, Kevin J. Downes, Kathryn Timberlake, Jennifer Young, Rachel C. Orscheln, Pranita D. Tamma, Hayden T. Schwenk, Philip Zachariah, Margaret Aldrich, David L. Goldman, Helen E. Groves, Gabriella S. Lamb, Alison C. Tribble, Adam L. Hersh, Emily A. Thorell, Mark R. Denison, Adam J. Ratner, Jason G. Newland, Mari M. Nakamura
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2020)