Article
Infectious Diseases
Rongrong Li, Huaming Xu, Hao Tang, Jilu Shen, Yuanhong Xu
Summary: This study investigated the resistance and virulence characteristics of ESBLs-producing Escherichia coli in bloodstream infections. The results showed that the most common resistance gene was blaCTX-M, the most common multi-locus sequence typing was ST131, and there was a correlation between the classification of E. coli and specific virulence factors. Most resistance genes could be transferred between bacteria through plasmids. Therefore, it is necessary to strengthen the monitoring of ESBLs-producing isolates in the medical environment.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Multidisciplinary Sciences
Yanjun Zhang, Hairu Wang, Yanfang Li, Yabin Hou, Chonghua Hao
Summary: This study investigated the drug susceptibility and genetic relationship of clinical Escherichia coli isolates from patients with BSIs in Shanxi, China. The results revealed a high prevalence of MDR in E. coli strains isolated from BSIs and a serious spread of ESBL genes in Shanxi. Phylogenetic analysis indicated genetic diversity among E. coli BSIs isolates.
Article
Microbiology
Wen-Chi Chen, Chih-Hsin Hung, Yao-Shen Chen, Jin-Shiung Cheng, Susan Shin-Jung Lee, Fan-Chen Tseng, Ming-Fang Cheng, Jiun-Ling Wang
Summary: This study found a higher frequency of ST 131 strains and longer hospital stay in patients with cirrhosis in the ESBLEC group compared to the NESBLEC group in bloodstream infections. The 30-day re-admission/mortality rates were similar between the two groups, but ST 131 strains were associated with 30-day re-admission.
Article
Microbiology
Gabhan Chalmers, Julie Cobean, Ryan P. Snyder, John R. Barta, Patrick Boerlin
Summary: ESC-resistant Escherichia coli were isolated from broiler chickens raised with and without therapeutic antimicrobials in Canada over a two-year period. The resistant isolates showed similarities in characteristics and plasmid types regardless of antimicrobial use. Despite the cessation of cephalosporin use in poultry production in Canada, the prevalence of ESC-resistant E. coli remained high, indicating a need for further research on transmission and persistence.
VETERINARY MICROBIOLOGY
(2021)
Article
Medicine, General & Internal
Monica Romero Nieto, Sara Maestre Verdu, Vicente Gil, Carlos Perez Barba, Jose Antonio Quesada Rico, Reyes Pascual Perez
Summary: This study identified male sex, smoking, hypertension, urinary incontinence, and recurrent urinary tract infections as independent factors associated with the presence of ESBL-producing E. coli in patients with acute community-acquired pyelonephritis. The multivariate logistic models could correctly classify individuals with ESBL-producing E. coli infection in 80.2% of cases.
JOURNAL OF CLINICAL MEDICINE
(2021)
Correction
Multidisciplinary Sciences
Swaine L. Chen, Ying Ding, Anucha Apisarnthanarak, Shirin Kalimuddin, Sophia Archuleta, Sharifah Faridah Syed Omar, Partha Pratim De, Tse Hsien Koh, Kean Lee Chew, Nadia Atiya, Nuntra Suwantarat, Rukumani Devi Velayuthan, Joshua Guo Xian Wong, David C. Lye
Summary: The paper has been amended and the revised version can be accessed through a link at the top of the paper.
SCIENTIFIC REPORTS
(2021)
Editorial Material
Microbiology
Johann D. D. Pitout
Summary: Escherichia coli is a major cause of bloodstream infections worldwide. A longitudinal study in a Madrid hospital found that certain E. coli B2 phylogroups dominated the community E. coli population and were often introduced into hospital settings. Longitudinal surveys from England and Canada also showed that certain ST131 subclades were responsible for increased resistance to fluoroquinolones and cephalosporins in E. coli during the mid- to late 2000s.
Article
Immunology
John Cao, Yanina Dubrovskaya, Justin Siegfried, Arnold Decano, Dana Mazo, Sarah Hochman, Ioannis M. Zacharioudakis, Jonathan So, Sadie Solomon, John Papadopoulos, Kassandra Marsh
Summary: This retrospective study compared the treatment strategies for TZP-NS/CRO-S E coli or K pneumoniae infections in noncritically ill adults. The results showed no significant difference in clinical outcomes between patients who received carbapenem and those who received carbapenem-sparing agents.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Babafela Awosile, Jessica Eisnor, Matthew E. Saab, Luke Heider, J. T. McClure
Summary: This study aimed to determine the occurrence of antimicrobial resistance to the extended-spectrum cephalosporins in Escherichia coli isolates from retail meat products in the Maritime Provinces of Canada. It was found that selective culture significantly improved the recovery of ESC-resistant E. coli isolates from retail meat samples. The study demonstrated the presence of ESBL-and AmpC-resistance genes in retail meat products in the Maritime Provinces of Canada.
CANADIAN JOURNAL OF MICROBIOLOGY
(2021)
Article
Microbiology
Bejan Mahmud, Meghan A. Wallace, Kimberly A. Reske, Kelly Alvarado, Carol E. Muenks, David A. Rasmussen, Carey-Ann D. Burnham, Cristina Lanzas, Erik R. Dubberke, Gautam Dantas
Summary: ESBL-producing Escherichia coli is becoming increasingly prevalent, driven by the spread of ESBL-encoding plasmids. This study provides an in-depth genomic investigation of clinical ESBL-like E. coli isolates, revealing a comprehensive map of plasmid sharing across different boundaries. Through sequence-based network analysis, specific plasmid lineages responsible for disseminating major ESBLs have been identified. This work highlights the importance of plasmid-mediated spread in the dissemination of ESBLs and provides valuable insight into the factors underlying the increased prevalence of these genes in clinical settings.
Article
Public, Environmental & Occupational Health
Melissa C. MacKinnon, Scott A. McEwen, David L. Pearl, Outi Lyytikainen, Gunnar Jacobsson, Peter Collignon, Daniel B. Gregson, Louis Valiquette, Kevin B. Laupland
Summary: The study found that the incidence rates of E. coli bloodstream infections and third-generation cephalosporin resistance have significantly increased. Factors such as region, sex, and age play important roles in analyzing these rates.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Microbiology
Gilles Vossius, Cecile Meex, Filip Moerman, Marie Thys, Marie Ernst, Marie-Eve Bourgeois, Lea Wagner, Thibaut Delahaye, Gilles Darcis
Summary: The study aimed to assess the impact of third-generation cephalosporins (3GCs) vs. alternative antibiotics on clinical outcomes in bloodstream infections (BSIs) due to AmpC-inducible Enterobacterales (AmpC-E). The findings suggest that 3GC definitive therapy may not result in poorer clinical outcomes for the treatment of BSIs caused by AmpC-E.
Article
Public, Environmental & Occupational Health
Wan-Ling Chen, Ming-Fang Cheng, Fan-Chen Tseng, Pin-Chien Wu, I-Fei Huang, Yun-Wen Chen, Yee-Hsuan Chiou, Yao-Shen Chen, Susan Shin-Jung Lee, Wan-Yu Hung, Jiun-Ling Wang, Chih-Hsin Hung
Summary: In this study, the distribution and resistance mechanisms of ESBL-producing E. coli strains were investigated in 120 children. The analysis revealed that these strains were mainly found in densely populated urban areas, with ST131 being the most challenging group. Therefore, the importance of enhancing environmental surveillance and sanitary procedures is emphasized.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Microbiology
William C. Shropshire, Benjamin Strope, Selvalakshmi Selvaraj Anand, Jordan Bremer, Patrick McDaneld, Micah M. Bhatti, Anthony R. Flores, Awdhesh Kalia, Samuel A. Shelburne
Summary: Using whole-genome sequencing, this study characterized the molecular epidemiology of extended-spectrum cephalosporin-resistant Escherichia coli (ESC-R-Ec) infections at a cancer center in Houston. The study identified a temporal dynamic of ESC-R-Ec infections, with peaks occurring in the last 6 months of the year, and a stable proportion of STc131 strains throughout the study period. The study also revealed the presence of genetically diverse ESC-R-Ec clonal complexes during infection peaks.
Article
Microbiology
Katharina Meissner, Carola Sauter-Louis, Stefan E. Heiden, Katharina Schaufler, Herbert Tomaso, Franz J. Conraths, Timo Homeier-Bachmann
Summary: Antimicrobial resistance is a growing global problem in the treatment of bacterial infections in animals and humans. This study found that ESBL-positive E. coli, especially of the CTX-M type, were present in both conventional and organic pig farms. The percentage of ESBL-positive pens was higher on conventional farms and varied greatly on organic farms. The farms of origin appeared to have a major influence on the occurrence of ESBL-producing E. coli in the fattening farms.
Editorial Material
Immunology
Jesus Rodriguez-Bano, Belen Gutierrez-Gutierrez
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
German Penalva, Juan Carlos Crespo-Rivas, Ana Belen Guisado-Gil, Angel Rodriguez-Villodres, Maria Eugenia Pachon-Ibanez, Barbara Cachero-Alba, Blas Rivas-Romero, Josefa Gil-Moreno, Maria Isabel Galva-Borras, Mercedes Garcia-Moreno, Maria Dolores Salamanca-Bautista, Manuel Bautista Martinez-Rascon, Maria Rosa Cantudo-Cuenca, Ruth Concepcion Ninahuaman-Poma, Maria de los Angeles Enrique-Miron, Aurora Perez-Barroso, Inmaculada Marin-Ariza, Miguel Gonzalez-Florido, Maria del Rosario Mora-Santiago, Susana Belda-Rustarazo, Jose Antonio Exposito-Tirado, Clara Maria Rosso-Fernandez, Maria Victoria Gil-Navarro, Jose Antonio Lepe-Jimenez, Jose Miguel Cisneros
Summary: Antimicrobial stewardship programs in nursing homes can improve antibiotic prescribing patterns, reduce antimicrobial use, and decrease the prevalence of multidrug-resistant organisms. The study found that educational programs were effective in achieving these outcomes, even during the COVID-19 pandemic.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Francesc Escrihuela-Vidal, Achim J. Kaasch, Maja Von Cube, Siegbert Rieg, Winfried V. Kern, Harald Seifert, Kyoung-Ho Song, Chun-Hsing Liao, Robert Tilley, Hannah Gott, Matt Scarborough, Claire Gordon, Martin J. Llewelyn, Richard Kuehl, Laura Morata, Alex Soriano, Jonathan Edgeworth, Enrique Ruiz De Gopegui, Emmanuel Nsutebu, Jose Miguel Cisneros, Vance G. Fowler, Guy Thwaites, Joaquin Lopez-Contreras, Gavin Barlow, Hugo Guillermo Ternavasio-De La Vega, Jesus Rodriguez-Bano, Luis Eduardo Lopez-Cortes
Summary: This study analysed the adherence and impact of quality-of-care indicators (QCIs) in the management of Staphylococcus aureus bloodstream infection. The results showed that adherence to QCIs was associated with reduced 90-day mortality.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Review
Oncology
Elena Carrara, Elisa Razzaboni, Anna Maria Azzini, Maria Elena De Rui, Mariana Nunes Pinho Guedes, Anna Gorska, Maddalena Giannella, Linda Bussini, Michele Bartoletti, Federica Arbizzani, Zaira R. Palacios-Baena, Giulia Caponcello, Natalia Maldonado, Jesus Rodriguez-Bano, Carlo Visco, Mauro Krampera, Evelina Tacconelli
Summary: The main aim of this systematic review is to quantify the risk and identify predictors of clinical progression of SARS-CoV-2 in hematological patients compared to different control populations. The study found that hematological patients had a higher risk of COVID-19-related mortality, hospitalization, intensive-care admission, and mechanical ventilation compared to controls. Older age, male sex, and hypertension were significantly related to worse clinical outcomes in hematological patients with COVID-19.
HEMATOLOGICAL ONCOLOGY
(2023)
Letter
Infectious Diseases
Sonsoles Salto-Alejandre, Marta Carretero-Ledesma, Pedro Camacho-Martinez, Judith Berastegui-Cabrera, Carmen Infante, Regino Rodriguez-Alvarez, Jorge Alba, Patricia Perez-Palacios, Emilio Garcia-Diaz, Cristina Roca, Julia Praena, Maria Jose Blanco-Vidal, Sonia Santibanez, Rocio Valverde-Ortiz, Javier Nieto-Arana, Concepcion Garcia-Garcia, David Gutierrez-Campos, Natalia Maldonado, Gabriel Bernal, Miguel Angel Gomez-Bravo, Jose Manuel Sobrino, Manuela Aguilar-Guisado, Rocio Alvarez-Marin, Josune Goikoetxea-Aguirre, Jose Antonio Oteo, Zaira R. Palacios-Baena, Alvaro Pascual, Jose Antonio Lepe, Jesus Rodriguez-Bano, Jose Miguel Cisneros, Jeronimo Pachon, Javier Sanchez-Cespedes, Elisa Cordero
JOURNAL OF INFECTION
(2023)
Article
Immunology
Joachim Doua, Jeroen Geurtsen, Jesus Rodriguez-Bano, Oliver A. Cornely, Oscar Go, Aina Gomila-Grange, Andrew Kirby, Peter Hermans, Andrea Gori, Valentina Zuccaro, Stefan Gravenstein, Marc Bonten, Jan Poolman, Michal Sarnecki
Summary: This multinational study describes the clinical profile of patients with invasive Escherichia coli disease (IED) in tertiary care hospitals. Most patients with IED were adults aged >= 60 years, and the urinary tract was the most common source of infection. Systemic inflammatory response syndrome (SIRS) was identified in 77.4% of patients, and the case-fatality rate was 20.0%. A proposed clinical case definition showed a 96.1% agreement with physician's diagnoses.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Nerea Castillo-Fernandez, Pedro Maria Martinez Perez-Crespo, Elena Salamanca-Rivera, Laura Herrera-Hidalgo, Aristides de Alarcon, Maria Dolores Navarro-Amuedo, Teresa Marrodan Ciordia, Maria Teresa Perez-Rodriguez, Juan Sevilla-Blanco, Alfredo Jover-Saenz, Jonathan Fernandez-Suarez, Carlos Arminanzas-Castillo, Jose Maria Reguera-Iglesias, Clara Natera Kindelan, Lucia Boix-Palop, Eva Leon Jimenez, Fatima Galan-Sanchez, Alfonso del Arco Jimenez, Alberto Bahamonde-Carrasco, David Vinuesa Garcia, Alejandro Smithson Amat, Jordi Cuquet Pedragosa, Isabel Maria Reche Molina, Ines Perez Camacho, Esperanza Merino de Lucas, Belen Gutierrez-Gutierrez, Jesus Rodriguez Bano, Luis Eduardo Lopez Cortes
Summary: A post-hoc analysis of two Spanish cohorts showed that sequential OPAT is as safe and effective as conventional hospitalization for treating patients with S. aureus bacteremia.
Article
Medicine, General & Internal
Adi Turjeman, Elodie von Dach, Jose Molina, Erica Franceschini, Fidi Koppel, Dana Yelin, Yael Dishon-Benattar, Cristina Mussini, Jesus Rodriguez-Bano, Jose Miguel Cisneros, Angela Huttner, Mical Paul, Leonard Leibovici, Dafna Yahav
Summary: This study aims to compare the effect of short and long-term treatment in Gram-negative bacteremia on all-cause mortality in pre-specified subgroups. The results show that in patients with stable hemodynamics and normal temperature for 48 hours prior to discontinuation, seven days of antibiotic therapy for enterobacterales bacteremia result in similar outcomes as 14 days.
Article
Surgery
Elena Perez-Nadales, Mario Fernandez-Ruiz, Alejandra M. Natera, Belen Gutierrez-Gutierrez, Alessandra Mularoni, Giovanna Russelli, Ligia Camera Pierrotti, Maristela Pinheiro Freire, Marco Falcone, Giusy Tiseo, Mario Tumbarello, Francesca Raffaelli, Edson Abdala, Marta Bodro, Elena Gervasi, Maria Carmen Farinas, Elena M. Seminari, Juan Jose Caston, Juan Antonio Marin-Sanz, Victor Galvez-Soto, Meenakshi M. Rana, Belen Loeches, Pilar Martin-Davila, Alvaro Pascual, Jesus Rodriguez-Bano, Jose Maria Aguado, Luis Martinez-Martinez, Julian Torre-Cisneros, REIPI INCREMENT-SOT Study Grp
Summary: This study compared the efficacy of ceftazidime-avibactam (CAZ-AVI) and the best available therapy (BAT) in treating solid organ transplant recipients with bloodstream infection caused by carbapenemase-producing Klebsiella pneumoniae. The results showed that patients treated with CAZ-AVI had higher clinical success rates at 14-day and 30-day and lower 30-day mortality compared to those receiving BAT.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Microbiology
S. Diaz-Diaz, E. Recacha, Marina R. Pulido, Maria Romero-Munoz, B. de Gregorio-Iaria, F. Docobo-Perez, A. Pascual, J. M. Rodriguez-Martinez
Summary: The suppression of the SOS response and Dam methylation system enhances the in vitro activity of quinolones. Dual targeting of the recA (SOS response) and Dam methylation system genes increases the sensitivity of Escherichia coli to quinolones, even in a resistant strain model. This genetic and microbiological approach demonstrates the potential for preventing the evolution of resistance by suppressing both systems in quinolone-resistant strains.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Maddalena Giannella, Manuel Huth, Elda Righi, Jan Hasenauer, Lorenzo Marconi, Angelina Konnova, Akshita Gupta, An Hotterbeekx, Matilda Berkell, Zaira R. Palacios-Baena, Maria Cristina Morelli, Mariarosa Tame, Marco Busutti, Luciano Potena, Elena Salvaterra, Giuseppe Feltrin, Gino Gerosa, Lucrezia Furian, Patrizia Burra, Salvatore Piano, Umberto Cillo, Mara Cananzi, Monica Loy, Gianluigi Zaza, Francesco Onorati, Amedeo Carraro, Fiorella Gastaldon, Maurizio Nordio, Samir Kumar-Singh, Jesus Rodriguez Bano, Tiziana Lazzarotto, Pierluigi Viale, Evelina Tacconelli
Summary: This study aimed to assess the predictors of negative antibody response in solid organ transplant recipients after the first booster of SARS-CoV-2 vaccination. Machine learning models and clinical data were used to identify age, type of transplant, time between transplant and vaccination, immunosuppressive drugs, type of vaccine, and graft function as significant predictors of negative antibody response. This study is of significant importance for improving vaccination strategies in solid organ transplant recipients.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Health Care Sciences & Services
Nithya Babu Rajendran, Fabiana Arieti, Carla Alejandra Mena-Benitez, Liliana Galia, Maela Tebon, Julio Alvarez, Beryl Primrose Gladstone, Lucie Collineau, Giulia De Angelis, Raquel Duro, William Gaze, Siri Goepel, Souha S. Kanj, Annemarie Kaesbohrer, Direk Limmathurotsakul, Estibaliz Lopez de Abechuco, Elena Mazzolini, Nico T. Mutters, Maria Diletta Pezzani, Elisabeth Presterl, Hanna Renk, Jesus Rodriguez-Bano, Oana Sandulescu, Federico Scali, Robert Skov, Thirumalaisamy P. Velavan, Cuong Vuong, Evelina Tacconelli
Summary: Strategic and standardised approaches are crucial for analyzing and reporting surveillance data on antimicrobial resistance (AMR) and informing antibiotic policies. This paper describes a multidisciplinary initiative involving experts from the human, animal, and environmental sectors to develop proposals for structuring and reporting full-scale AMR and antimicrobial consumption/antimicrobial residue surveillance data. The recommendations from this study can support national and regional plans to reduce resistance rates and promote a One Health approach to antimicrobial policy.
LANCET REGIONAL HEALTH-EUROPE
(2023)
Article
Infectious Diseases
Beatriz Fernandez-Rubio, Laura Herrera-Hidalgo, Luis E. Lopez-Cortes, Rafael Luque-Marquez, Aristides De Alarcon, Sonia Luque-Pardos, Aurora Fernandez-Polo, Jose Maria Gutierrez-Urbon, Jesus Rodriguez-Bano, Maria Victoria Gil-Navarro, Alicia Gutierrez-Valencia
Summary: This study evaluated the physical and chemical stability of temocillin at different temperatures and stored in different containers at the recommended dose for OPAT. It was found that temocillin is stable under OPAT conditions and can be an appropriate treatment option for patients. A novel LC-MS/MS method was also developed for the quantification of temocillin.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Manuel Poyato-Borrego, Maria Leon-Lopez, Jenifer Martin-Gonzalez, Jose M. Cisneros-Herreros, Daniel Cabanillas-Balsera, Juan J. Segura-Egea
Summary: This study analyzed the prevalence of apical periodontitis and the frequency of root canal treatment in patients with SARS-CoV-2 infection, correlating them with the severity of the disease. The results showed that the oral health status of COVID-19 patients correlated with the severity of the SARS-CoV-2 virus infection.
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
(2023)