Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 18, Issue 8, Pages E299-E304Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1469-0691.2012.03847.x
Keywords
Antiretroviral therapy; chronic HIV infection; recent HIV infection; resistance epidemiology; transmitted resistance
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Funding
- DynaNets project
- Future and Emerging Technologies (FET)-Open [233847]
- Collaborative HIV and Anti-HIV Drug Resistance Network (CHAIN) project
- Seventh Framework Programme (FP7) [223131]
- NIH [R01 NS06389701A2]
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Clin Microbiol Infect Abstract Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naive HIV-1-infected patients, with a genotypic resistance test (GRT) performed =6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR.
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