Article
Pharmacology & Pharmacy
M. O. I. Albureikan, L. M. A. Alotaibi
Summary: This study aimed to compare the antibacterial activity of chloroxylenol and thymol on microorganisms isolated from long fingernails. The results showed that pathogenic bacteria may be harbored under long nails, emphasizing the importance of good nail hygiene to prevent disease spread.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2023)
Article
Microbiology
Rio Nakamura, Merime Oota, Shuhei Matsumoto, Takafumi Sato, Yoshinori Yamano
Summary: Cefiderocol is a novel antibiotic that shows potent activity against difficult-to-treat Gram-negative bacteria, including strains resistant to carbapenems. In in vitro and animal studies, Cefiderocol demonstrated strong antimicrobial activity against Stenotrophomonas maltophilia, even against strains resistant to trimethoprim-sulfamethoxazole. These results suggest that Cefiderocol could be a promising treatment option for infections caused by S. maltophilia, especially those resistant to traditional antibiotics.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Vemula Prasastha Ram, Jyothsna Yasur, Padikkamannil Abishad, Chatragadda Ramesh, Diksha Purushottam Gourkhede, Pokkittath Radhakrishnan Arya, Varsha Unni, Jess Vergis, Satya Veer Singh Malik, Megha Kaore, Nitin Vasantrao Kurkure, Byrappa Kullaiah, Sukhadeo Baliram Barbuddhe, Deepak Bhiwa Rawool
Summary: By fabricating and conjugating nanosilver-thymol using eco-friendly processes, the bio-efficacy and environmental safety of both phytochemicals and nanoparticles can be increased. AgT showed strong antibacterial activity against multi-drug resistant enteroaggregative Escherichia coli (MDR-EAEC) strains, with improved safety compared to thymol.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Microbiology
Krisztina M. Papp-Wallace, Adam B. Shapiro, Scott A. Becka, Elise T. Zeiser, John J. LiPuma, Douglas J. Lane, Rekha G. Panchal, John P. Mueller, John P. O'Donnell, Alita A. Miller
Summary: Burkholderia genus, including pathogens causing Melioidosis and Glanders, are hard to treat, but the combination of sulbactam-durlobactam (SUL-DUR) shows potential for treating these infections by inhibiting bacterial growth and reducing beta-lactamase activity.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Agricultural Engineering
Fernanda Tomiotto-Pellissier, Bruna Taciane da Silva Bortoleti, Virginia Marcia Concato, Ana Flavia Marques Ganaza, Ana Carolina Quasne, Beatriz Ricci, Pedro Vinicius Dolce E Carvalho, Gustavo Henrique Della Colleta, Danielle Lazarin-Bidoia, Taylon Felipe Silva, Manoela Daiele Goncalves, Renata Katsuko Takayama Kobayashi, Gerson Nakazato, Idessania Nazareth Costa, Ivete Conchon-Costa, Milena Menegazzo Miranda-Sapla, Wander Rogerio Pavanelli
Summary: This study investigated the leishmanicidal and immunomodulatory effects of oregano essential oil (OEO) on experimental Leishmania amazonensis-model through in silico, in vitro, and in vivo approaches. The results demonstrated that OEO containing carvacrol, thymol, gamma-terpinene, p-cymene, and beta-caryophyllene as the main components showed potential as an oral and topical drug development for the treatment of L. amazonensis. OEO exhibited leishmanicidal activity by inducing a combination of autophagic, apoptotic, and necrotic events, and had immunomodulatory effects without triggering a pro-inflammatory response.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Veterinary Sciences
Robin C. Anderson, Gizem Levent, Branko T. Petrujkic, Roger B. Harvey, Michael E. Hume, Haiqi He, Kenneth J. Genovese, Ross C. Beier, Toni L. Poole, Tawni L. Crippen, David J. Nisbet
Summary: Research indicates that residual fat in the distal gut of food-producing animals may limit the effectiveness of free or conjugated thymol. Therefore, further studies are needed to overcome these obstacles and enhance the bactericidal activity of free and conjugated thymol in the lower gastrointestinal tract.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Pharmacology & Pharmacy
You Zhi Nicholas Cheang, Heng Rong Donald Ting, Hui Qi Vanessa Koh, Sylvie Alonso
Summary: Research indicates that metformin has a poor anti-DENV activity in vitro in one cell line, associated with AMPK activation. However, it shows pro-DENV activity in another cell line, suggesting AMPK-independent effects. Another compound, 991, a direct AMPK activator, demonstrated reduced viral titers against all four serotypes across both cell lines.
ANTIVIRAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
J. Burns, C. P. McCoy, N. J. Irwin
Summary: This study evaluated the antibacterial activity of a suite of weak organic acids against common nosocomial uropathogens and found that these weak organic acids, when used individually or in combination, displayed bactericidal activities against bacteria in both planktonic and biofilm modes of growth. The synergistic multi-mechanistic combinations identified in this study are anticipated to play an important role in the treatment and prevention of catheter-associated UTIs.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Agronomy
Cesar Chacon, Emanuel Bojorquez-Quintal, Goretty Caamal-Chan, Victor M. Ruiz-Valdiviezo, Joaquin A. Montes-Molina, Eduardo R. Garrido-Ramirez, Luis M. Rojas-Abarca, Nancy Ruiz-Lau
Summary: The study revealed a fungistatic effect of the essential oil of P. auritum on Fusarium spp., which may be attributed to the presence of eugenol and thymol/p-cimen-8-ol in the oil. The antifungal activity was evaluated through direct contact and poisoned food tests, with the oil showing inhibition over 40% on Fusarium spp. at certain concentrations. Additionally, DART-MS chemical analysis identified key metabolites with high relative intensity in the oil.
Article
Infectious Diseases
Lubna Razaq, Fakhur Uddin, Shahzad Ali, Shah Muhammad Abbasi, Muhammad Sohail, Nabila E. Yousif, Hala M. Abo-Dief, Zeinhom M. El-Bahy
Summary: Antibiotic resistance in uropathogens has become a major issue in the treatment of urinary tract infections. New formulations such as MEV and CZA have shown significant activity against drug-resistant pathogens.
Article
Medicine, Research & Experimental
Katherine Miranda-Cadena, Cristina Marcos-Arias, Estibaliz Mateo, Jose Manuel Aguirre-Urizar, Guillermo Quindos, Elena Eraso
Summary: The study evaluated the effects of three phytocompounds on Candida planktonic and sessile cells, with cinnamaldehyde being the most active in inhibiting biofilm adhesion, while carvacrol and thymol significantly reduced both mature biofilm biomass and metabolic activity. These results highlight the potential of cinnamaldehyde, carvacrol, and thymol as promising alternatives for candidiasis treatment and emphasize the need for further research on their safety, toxicity, pharmacodynamics, and pharmacokinetics.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Tingting Guo, Mengying Li, Xiaoli Sun, Yuhang Wang, Liying Yang, Hongmei Jiao, Guocai Li
Summary: The combination of capsaicin and colistin showed synergistic effects against colistin-resistant Acinetobacter baumannii, reducing the reliance on high doses of colistin and potentially lowering its dose-dependent side effects. This novel therapeutic approach may offer a new treatment option for controlling Acinetobacter baumannii infections.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Parasitology
Chuanchuan Liu, Haining Fan, Lu Guan, Ri-li Ge, Lan Ma
Summary: Crocin demonstrated parasiticidal activity against E. multilocularis both in vitro and in vivo. It showed lower toxicity to mammalian cells compared to metacestodes. Administration of crocin significantly reduced metacestode weight and caused structural disruption in the parasite.
PARASITES & VECTORS
(2021)
Article
Parasitology
Chuanchuan Liu, Haining Fan, Jie Ma, Lan Ma, Ri-li Ge
Summary: The study demonstrated that thiacloprid has promising parasiticidal activity against E. multilocularis both in vitro and in vivo, showing effectiveness against metacestodes and germinal cells. Additionally, thiacloprid also promoted collagen deposition in the host lesion microenvironment, suggesting its potential value in the treatment of AE.
PARASITES & VECTORS
(2021)
Article
Microbiology
Francoise Roquet-Baneres, Mattheo Alcaraz, Claire Hamela, Jan Abendroth, Thomas E. Edwards, Laurent Kremer
Summary: Researchers have discovered that a compound called NITD-916 displays potent antimicrobial activity against M. fortuitum both in vitro and in vivo. This compound inhibits the growth of M. fortuitum by targeting InhA(MFO) and shows promising effectiveness against drug resistance. This study suggests that NITD-916 could be a potential drug for the treatment of M. fortuitum pulmonary diseases.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
