Journal
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
Volume 10, Issue 3, Pages 177-180Publisher
CIG MEDIA GROUP, LP
DOI: 10.3816/CLML.2010.n.027
Keywords
Fludarabine; Heavy chain; Light chain; Mass spectrometry; Senile amyloidosis; Transthyretin
Categories
Funding
- Celgene Corporation
- Genzyme Corporation
- Millennium Pharmaceuticals, Inc.
Ask authors/readers for more resources
Primary (AL) amyloidosis is the most prevalent type of systemic amyloidosis, and management of this disease has evolved through the years from supportive care to aggressive treatments that include immunomodulatory agents and high-dose chemotherapy with hematopoietic stem cell transplantation. However, other types of amyloidosis are increasingly recognized, such as familial amyloidosis and senile cardiac amyloidosis, and management of these conditions is different from that of AL amyloidosis. Congo red staining with exhibition of an apple-green birefringence is diagnostic of amyloid. Immunohistochemistry can detect amyloid deposits but has limitations, and newer molecular techniques such as mass spectrometry show promise in determining types of amyloidosis. Physicians need to be aware of clinical scenarios that can mimic AL amyloidosis to avoid misdiagnosis and harm to the patient.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available