Article
Materials Science, Biomaterials
Zhiqiang Zhang, Anning Li, Xingqi Min, Qunqun Zhang, Jun Yang, Guo Chen, Meijuan Zou, Wei Sun, Gang Cheng
Summary: Researchers prepared a biomimetic and thermosensitive hydrogel encapsulating reactive oxygen species (ROS)-sensitive tegafur (TF)-protoporphyrin IX (PpIX) heterodimers (TTP) to synergize chemotherapy and photodynamic therapy for breast cancer treatment. This innovative approach overcame major obstacles in breast cancer treatment and opened up new paths for treatment.
BIOMATERIALS SCIENCE
(2021)
Review
Cell Biology
Alireza Mafi, Malihe Rezaee, Neda Hedayati, Sara Diana Hogan, Russel J. Reiter, Mohammad-Hossein Aarabi, Zatollah Asemi
Summary: Combined chemotherapy is an effective treatment for cancer patients, as it combines multiple therapeutic agents to target different aspects of cancer. 5-FU is a widely used chemotherapy agent, while melatonin has shown anti-cancer properties. This review aims to evaluate the role of melatonin as a complementary agent with 5-FU-based chemotherapy and identify their common signaling pathways.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Medicine, Research & Experimental
Xuelei Wang, Apeng Wang, Wenkai Feng, Dan Wang, Xiaoru Guo, Xiaowei Wang, Qingfang Miao, Mingliang Liu, Guimin Xia
Summary: A novel liposomal formulation of the chemotherapeutic drug 5-fluorouracil (5-FU) was designed and evaluated. The liposomal formulation showed improved cellular uptake, induction of cell apoptosis, and inhibition of cell migration compared to free 5-FU. Furthermore, the liposomal formulation exhibited a slow drug release profile, long plasma half-life, and high tumor accumulation. The formulation also demonstrated negligible systemic toxicity in animal studies.
MOLECULAR PHARMACEUTICS
(2022)
Review
Pharmacology & Pharmacy
Jingyi Hu, Anqi Li, Yueyang Guo, Ting Ma, Siqi Feng
Summary: This review summarizes the main tumor metabolic alterations linked with 5-FU resistance and proposes potential chemotherapy combinations from the perspective of intervening tumor metabolism to overcome 5-FU resistance.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Po-Huang Chen, Yi-Ying Wu, Cho-Hao Lee, Chi-Hsiang Chung, Yu-Guang Chen, Tzu-Chuan Huang, Ren-Hua Yeh, Ping-Ying Chang, Ming-Shen Dai, Shiue-Wei Lai, Ching-Liang Ho, Jia-Hong Chen, Yeu-Chin Chen, Je-Ming Hu, Sung-Sen Yang, Wu-Chien Chien
Summary: The population-based cohort study conducted in Taiwan showed that uracil and tegafur (UFT) had similar efficacy to fluorouracil (5-FU) in treating Stage II and III colon cancer patients, with lower incidence of adverse events.
Review
Oncology
Hossein Moutabian, Mehrsa Majdaeen, Ruhollah Ghahramani-Asl, Masoumeh Yadollahi, Esmaeil Gharepapagh, Gholamreza Ataei, Zahra Falahatpour, Hamed Bagheri, Bagher Farhood
Summary: This study aimed to review the potential therapeutic effects of resveratrol in combination with 5-fluorouracil (5-FU) against colorectal cancer. The results demonstrated that co-administration of resveratrol could sensitize the colorectal cancer cells to 5-FU treatment via various mechanisms.
CANCER CELL INTERNATIONAL
(2022)
Article
Oncology
G. Carlsson, A. Koumarianou, T. K. Guren, J. Haux, P. Katsaounis, N. Kentepozidis, P. Pfeiffer, M. Braendengen, D. Mavroudis, H. Taffin, L. Skintemo, R. Tell, C. Papadimitriou
Summary: Arfolitixorin, a new form of folate, has shown promise in improving the treatment outcomes of colorectal cancer. This study demonstrated that Arfolitixorin, when combined with 5-FU, is well-tolerated and can achieve partial response. Additionally, there were no significant pharmacokinetic differences observed. These findings suggest that Arfolitixorin could be a potential treatment option for patients with colorectal cancer.
Article
Biology
Dulla Naveen Kumar, Aiswarya Chaudhuri, Deepa Dehari, Anusmita Shekher, Subash C. Gupta, Shreyasi Majumdar, Sairam Krishnamurthy, Sanjay Singh, Dinesh Kumar, Ashish Kumar Agrawal
Summary: In this study, folic acid functionalized bovine milk-derived exosomes were used as a carrier for oral delivery of paclitaxel (PAC) in combination with 5-fluorouracil (5-FU). The folic acid functionalized exosomes showed enhanced efficacy against breast cancer, with improved drug delivery and increased cellular uptake.
Article
Biochemistry & Molecular Biology
Kwan-Ling Yip, Tsen-Ni Tsai, I-Ping Yang, Zhi-Feng Miao, Yen-Cheng Chen, Ching-Chun Li, Wei-Chih Su, Tsung-Kun Chang, Ching-Wen Huang, Hsiang-Lin Tsai, Yung-Sung Yeh, Jaw-Yuan Wang
Summary: Metformin enhances the chemosensitivity of colorectal cancer cells to 5-fluorouracil and oxaliplatin by inducing cell cycle arrest and apoptosis through modulation of mitochondria-related proteins.
Article
Medicine, General & Internal
Y. Doki, J. A. Ajani, K. Kato, J. Xu, L. Wyrwicz, S. Motoyama, T. Ogata, H. Kawakami, C. -H. Hsu, A. Adenis, F. El Hajbi, M. Di Bartolomeo, M. I. Braghiroli, E. Holtved, S. A. Ostoich, H. R. Kim, M. Ueno, W. Mansoor, W. -C. Yang, T. Liu, J. Bridgewater, T. Makino, I. Xynos, X. Liu, M. Lei, K. Kondo, A. Patel, J. Gricar, I. Chau, Y. Kitagawa
Summary: In patients with advanced esophageal squamous-cell carcinoma, both first-line treatment with nivolumab plus chemotherapy and first-line treatment with nivolumab plus ipilimumab resulted in significantly longer overall survival than chemotherapy alone, with no new safety signals identified.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Polymer Science
Xiukun Xue, Yanjuan Wu, Xiao Xu, Ben Xu, Zhaowei Chen, Tianduo Li
Summary: Polymeric prodrugs have been extensively studied for cancer therapy, with a new pH and reduction dual-sensitive dextran-di-drugs conjugate showing promising potential for effective combination chemotherapy. The conjugate demonstrated efficient cellular uptake, drug release behavior, and remarkable reversal of resistance in cisplatin-resistant lung carcinoma cells.
Article
Immunology
Stphannie Jamyla de Araujo Barbosa, Maisie Mitchele Barbosa Oliveira, Susana Barbosa Ribeiro, Caroline Addison Carvalho Xavier de Medeiros, Maria Laura de Souza Lima, Gerlane Coelho Bernardo Guerra, Raimundo Fernandes de Araujo Junior, Francisco Caninde de Sousa Junior, Agnes Andrade Martins, Daniel Felipe Fernandes Paiva, Raphael Victor Silva Andrade, Conceicao S. Martins Reboucas, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitao, Aurigena Antunes de Araujo
Summary: This study evaluated the effect of oral administration of Lacticaseibacillus casei on 5-FU-induced intestinal mucositis. The results showed that L. casei protected the intestines from 5-FU-induced inflammation, oxidative stress, and improved intestinal barrier function.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Wing-Lok Chan, Cheuk-Wai Choi, Ian Yu-Hong Wong, Terence Hon-Ting Tsang, Adrian Tin-Chung Lam, Rosa Pui-Ying Tse, K. K. Chan, Claudia Wong, Betty Tze-Ting Law, Emina Edith Cheung, Siu-Yin Chan, Ka-On Lam, Dora Kwong, Simon Law
Summary: This study reviewed the long-term clinical outcomes and safety data of induction chemotherapy followed by surgery or definitive chemoradiotherapy in patients with locally advanced unresectable esophageal cancer. The results showed that patients who received subsequent surgery had significantly longer median overall survival compared to those who had definitive chemoradiotherapy or no definitive treatment. Induction chemotherapy followed by conversion surgery offered a chance of cure with long-term survival benefit and manageable toxicities in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Food Science & Technology
Yan Zhu, Ruixue Zhang, Ying Wei, Muyi Cai, Yongqing Ma, Ruizeng Gu, Haixin Zhang, Xingchang Pan
Summary: The study demonstrated that RP and CP reduced uric acid levels in hyperuricemia mice by inhibiting the activities of XOD and ADA, regulating various protein levels, and protecting renal function. The combination of RP and CP showed better efficacy in preventing hyperuricemia and protecting kidney function.
Article
Pharmacology & Pharmacy
Guolian Ren, Yujie Li, Canqi Ping, Danyu Duan, Ning Li, Jiaqi Tang, Rongrong Wang, Wenju Guo, Xiaomin Niu, Qiuyue Ji, Guoshun Zhang, Ruili Wang, Shuqiu Zhang
Summary: This study developed co-assembled nanoparticles (DSD/HP NPs) using mono sulfide-modified docetaxel (DTX) prodrugs (DSD) and hematoporphyrin (HP) to enhance the synergistic anti-tumor effect of chemotherapy and photodynamic therapy. The DSD/HP NPs exhibited distinct characteristics, good stability, slow release of DTX and HP, and significant inhibition of tumor growth. In vivo studies showed prolonged drug circulation time, increased drug distribution in the tumor site, and reduced exposure to normal tissues. This promising co-assembled nano-drug delivery system has the potential to improve therapeutic efficiency and achieve better anti-tumor effects.
