Role of autotaxin and lysophosphatidate in cancer progression and resistance to chemotherapy and radiotherapy

Autotaxin Inhibition: Challenges and Progress Toward Novel Anti-Cancer Agents

(2012) Abby Parrill et al.   Anti-Cancer Agents in Medicinal Chemistry

Chemical Evolution of Autotaxin Inhibitors

(2012) Harald M. H. G. Albers et al.   CHEMICAL REVIEWS

Requirement of Osteopontin in the migration and protection against Taxol-induced apoptosis via the ATX-LPA axis in SGC7901 cells

(2011) Rihua Zhang et al.   BMC CELL BIOLOGY

Benzyl and Naphthalene Methylphosphonic Acid Inhibitors of Autotaxin with Anti-invasive and Anti-metastatic Activity

(2011) Renuka Gupte et al.   ChemMedChem

Non-Edg family LPA receptors: the cutting edge of LPA research

(2011) K. Yanagida et al.   JOURNAL OF BIOCHEMISTRY

Binding of Autotaxin to Integrins Localizes Lysophosphatidic Acid Production to Platelets and Mammalian Cells

(2011) Zachary Fulkerson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into autotaxin: how to produce and present a lipid mediator

(2011) Wouter H. Moolenaar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis of substrate discrimination and integrin binding by autotaxin

(2011) Jens Hausmann et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models

(2011) V Härmä et al.   ONCOGENE

Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance

(2010) Nasser Samadi et al.   BIOCHIMIE

A novel, orally active LPA1 receptor antagonist inhibits lung fibrosis in the mouse bleomycin model

(2010) JS Swaney et al.   BRITISH JOURNAL OF PHARMACOLOGY

Autotaxin delays apoptosis induced by carboplatin in ovarian cancer cells

(2010) Susanne Vidot et al.   CELLULAR SIGNALLING

Autotaxin inhibitors: a perspective on initial medicinal chemistry efforts

(2010) Abby L Parrill et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Group VIA phospholipase A2 in both host and tumor cells is involved in ovarian cancer development

(2010) Hui Li et al.   FASEB JOURNAL

Estradiol Induces Export of Sphingosine 1-Phosphate from Breast Cancer Cells via ABCC1 and ABCG2

(2010) Kazuaki Takabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autotaxin Signaling via Lysophosphatidic Acid Receptors Contributes to Vascular Endothelial Growth Factor-Induced Endothelial Cell Migration

(2010) M. M. Ptaszynska et al.   MOLECULAR CANCER RESEARCH

Boronic acid-based inhibitor of autotaxin reveals rapid turnover of LPA in the circulation

(2010) H. M. H. G. Albers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acidin vivo

(2009) Jose L. Tomsig et al.   BIOCHEMICAL JOURNAL

Phosphatidate degradation: Phosphatidate phosphatases (lipins) and lipid phosphate phosphatases

(2009) David N. Brindley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Expression of Autotaxin and Lysophosphatidic Acid Receptors Increases Mammary Tumorigenesis, Invasion, and Metastases

(2009) Shuying Liu et al.   CANCER CELL

Dual Activity Lysophosphatidic Acid Receptor Pan-Antagonist/Autotaxin Inhibitor Reduces Breast Cancer Cell Migration In vitro and Causes Tumor Regression In vivo

(2009) Honglu Zhang et al.   CANCER RESEARCH

Restoring Endocrine Response in Breast Cancer Cells by Inhibition of the Sphingosine Kinase-1 Signaling Pathway

(2009) Olga Sukocheva et al.   ENDOCRINOLOGY

Domain Interplay Mediated by an Essential Disulfide Linkage Is Critical for the Activity and Secretion of the Metastasis-promoting Enzyme Autotaxin

(2009) Silvia Jansen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Ligand Selectivity of the GPR92/LPA5Lysophosphatidate Receptor Indicates Role in Human Platelet Activation

(2009) Jesica R. Williams et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysophosphatidic Acid 2 Receptor-mediated Supramolecular Complex Formation Regulates Its Antiapoptotic Effect

(2009) Shuyu E et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomics screen in transformed stem cells reveals RNASEH2A, PPAP2C, and ADARB1 as putative anticancer drug targets

(2009) J. M. Flanagan et al.   MOLECULAR CANCER THERAPEUTICS

Design of isoform-selective phospholipase D inhibitors that modulate cancer cell invasiveness

(2009) Sarah A Scott et al.   Nature Chemical Biology

An integrin αvβ3–c-Src oncogenic unit promotes anchorage-independence and tumor progression

(2009) Jay S Desgrosellier et al.   NATURE MEDICINE

Role of sphingolipids in the cytoplasmic signaling of estrogens

(2009) O. Sukocheva et al.   STEROIDS

Doxorubicin induces ceramide and diacylglycerol accumulation in rat hepatocytes through independent routes

(2009) Rosa Martínez et al.   TOXICOLOGY LETTERS

Identification of the orphan GPCR, P2Y10 receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor

(2008) Masanori Murakami et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Autotaxin (ATX): A multi-functional and multi-modular protein possessing enzymatic lysoPLD activity and matricellular properties

(2008) L YUELLING   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Cross-talk between LPA1 and Epidermal Growth Factor Receptors Mediates Up-regulation of Sphingosine Kinase 1 to Promote Gastric Cancer Cell Motility and Invasion

(2008) D. Shida et al.   CANCER RESEARCH

Targeting SphK1 as a New Strategy against Cancer

(2008) Dai Shida et al.   CURRENT DRUG TARGETS

Lysophosphatidic acid signaling through LPA receptor subtype 1 induces colony scattering of gastrointestinal cancer cells

(2008) Kum-Joo Shin et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Lipid phosphate phosphatases and signaling

(2008) David N. Brindley et al.   JOURNAL OF LIPID RESEARCH

S32826, A Nanomolar Inhibitor of Autotaxin: Discovery, Synthesis and Applications as a Pharmacological Tool

(2008) G. Ferry et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Role of LPA4/p2y9/GPR23 in Negative Regulation of Cell Motility

(2008) Zendra Lee et al.   MOLECULAR BIOLOGY OF THE CELL

Positive Feedback between Vascular Endothelial Growth Factor-A and Autotaxin in Ovarian Cancer Cells

(2008) M. M. Ptaszynska et al.   MOLECULAR CANCER RESEARCH

Identification of small-molecule inhibitors of autotaxin that inhibit melanoma cell migration and invasion

(2008) Lauren P. Saunders et al.   MOLECULAR CANCER THERAPEUTICS

G protein–coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth

(2008) Sandra M Pasternack et al.   NATURE GENETICS

In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation

(2008) P Taghavi et al.   ONCOGENE

Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis

(2008) N Samadi et al.   ONCOGENE

Estrogen and progesterone interactive effects in postconfluent MCF-7 cell culture

(2008) O.A. Sukocheva et al.   STEROIDS