Article
Radiology, Nuclear Medicine & Medical Imaging
Timothy L. Kline, Marie E. Edwards, Jeffrey Fetzer, Adriana V. Gregory, Deema Anaam, Andrew J. Metzger, Bradley J. Erickson
Summary: This study developed and validated a fully automated approach for semantic segmentation of renal cysts in MR images of patients with ADPKD. The automated method performed at the level of interobserver variability and showed comparable consistency with manual segmentation in terms of cyst volume.
ABDOMINAL RADIOLOGY
(2021)
Article
Urology & Nephrology
Youngwoo Kim, Cheng Tao, Hyungchan Kim, Geum-Yoon Oh, Jeongbeom Ko, Kyongtae T. Bae
Summary: A fully automated segmentation method was developed to measure TKV in ADPKD patients. This method accurately segments the kidney regions while excluding exophytic cysts and has a similar accuracy to that of manual methods.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Ahsan Alam, Emilie Cornec-Le Gall, Ronald D. Perrone
Summary: This article describes autosomal dominant polycystic kidney disease, its signs and symptoms, diagnosis, and treatment options.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sadjad Riyahi, Hreedi Dev, Jon D. Blumenfeld, Hanna Rennert, Xiaorui Yin, Hanieh Attari, Irina Barash, Ines Chicos, Warren Bobb, Stephanie Donahue, Martin R. Prince
Summary: This study investigated the utility of MRI features in predicting disease progression in ADPKD. It was found that combining multiple MRI features, such as hemorrhagic renal cysts and liver and spleen volumes, enhanced sensitivity for predicting eGFR decline in ADPKD compared to the standard model including only ht-TKV.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Biochemistry & Molecular Biology
Zhiwei Qiu, Jinzhao He, Guangying Shao, Jiaqi Hu, Xiaowei Li, Hong Zhou, Min Li, Baoxue Yang
Summary: This study identified obacunone as a potential therapeutic drug for ADPKD, as it inhibited cyst formation and expansion and regulated lipid peroxidation and cell proliferation pathways.
Review
Nutrition & Dietetics
Lauren Pickel, Ioan-Andrei Iliuta, James Scholey, York Pei, Hoon-Ki Sung
Summary: Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive growth of renal cysts and loss of functional nephrons. Evidence suggests that dietary interventions such as caloric restriction, intermittent fasting, and ketogenic diets have the potential to slow disease progression and confer metabolic benefits.
ADVANCES IN NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Claudio Ponticelli, Gabriella Moroni, Francesco Reggiani
Summary: Autosomal-Dominant Polycystic Kidney Disease (ADPKD) is a genetic disorder caused by mutations in PKD1 or PKD2 genes. The involvement of autophagy in ADPKD remains a subject of investigation, with potential implications on cyst formation and fibrosis. Autophagy inducers have shown promising results in preclinical studies and may provide a potential avenue for future investigations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Guangying Shao, Shuai Zhu, Baoxue Yang
Summary: ADPKD is a common hereditary kidney disease characterized by progressively enlarged cysts that destroy renal function, potentially leading to ESRD. Herbal medicines have shown potential in inhibiting cyst development and ADPKD progression, providing new insights for clinical therapeutic strategies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Urology & Nephrology
Tatsuya Suwabe, Yoshifumi Ubara, Yuki Oba, Hiroki Mizuno, Daisuke Ikuma, Masayuki Yamanouchi, Akinari Sekine, Kiho Tanaka, Eiko Hasegawa, Junichi Hoshino, Naoki Sawa
Summary: This study investigated the frequency, causative factors, and effects of acute renal cyst bleeding on the enlargement of polycystic kidneys in ADPKD patients on dialysis. The results showed that the total volume of acute renal cyst bleeding was significantly associated with total kidney volume and was greater in younger patients. These findings suggest that renal cyst bleeding and renal artery blood flow may synergistically accelerate the enlargement of polycystic kidneys in ADPKD patients on dialysis.
JOURNAL OF NEPHROLOGY
(2023)
Article
Biology
Maria Rombolotti, Fabio Sangalli, Domenico Cerullo, Andrea Remuzzi, Ettore Lanzarone
Summary: This study proposes a method for kidney and cyst segmentation in micro-CT images of mice with Autosomal Dominant Polycystic Kidney Disease and normal mice using fully convolutional networks. Different network architectures are compared and evaluated based on Intersection over Union and Dice coefficients. The results show that the U-Net with a batch normalization layer after each pair of 3 x 3 convolutions, and the U-Net with convolutional layers replaced by inception blocks perform the best.
COMPUTERS IN BIOLOGY AND MEDICINE
(2022)
Article
Medicine, General & Internal
Jin Liu, Xiaorui Yin, Hreedi Dev, Xianfu Luo, Jon D. D. Blumenfeld, Hanna Rennert, Martin R. R. Prince
Summary: This study investigates the association between autosomal dominant polycystic kidney disease (ADPKD) and pleural effusion. Pleural effusions were observed in 21% of ADPKD subjects compared to 8% in controls. In a subpopulation controlling for renal function, 25% of ADPKD subjects had pleural effusions compared to 5% of controls.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Jessica T. T. Camargo, Camilo A. Gonzalez, Lina Herrera, Nancy Yomayusa-Gonzalez, Milciades Ibanez, Ana M. M. Valbuena-Garcia, Lizbeth Acuna-Merchan
Summary: This study investigated the prevalence, geographical location, and ethnic groups of ADPKD patients undergoing dialysis or kidney transplant in Colombia between 2015 and 2019. The prevalence of ADPKD was lower compared to Europe and the US, and further genetic prevalence studies may be needed in some states with higher prevalence.
Article
Medicine, General & Internal
Alexander R. Chang, Bryn S. Moore, Jonathan Z. Luo, Gino Sartori, Brian Fang, Steven Jacobs, Yoosif Abdalla, Mohammed Taher, David J. Carey, William J. Triffo, Gurmukteshwar Singh, Tooraj Mirshahi
Summary: This study reveals substantial genetic and phenotypic variability in autosomal dominant polycystic kidney disease (ADPKD) among patients within a regional health system in the US. In addition to PKD1 and PKD2, LOF variants in IFT140, GANAB, and HNF1B were associated with ADPKD diagnosis. Patients with a family history of ADPKD had a higher yield for genetic determinants of the disease.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Multidisciplinary Sciences
Katharina Hopp, Victoria A. Catenacci, Nidhi Dwivedi, Timothy L. Kline, Wei Wang, Zhiying You, Dustin T. Nguyen, Kristen Bing, Bhavya Poudyal, Ginger C. Johnson, Matthew R. Jackman, Marsha Miller, Cortney N. Steele, Natalie J. Serkova, Paul S. MacLean, Raphael A. Nemenoff, Berenice Gitomer, Michel Chonchol, Kristen L. Nowak
Summary: This study demonstrates that both daily caloric restriction (DCR) and intermittent fasting (IMF) can lead to significant weight loss and slow cyst growth in ADPKD patients. DCR has better efficacy in weight loss compared to IMF, and patients showed higher adherence and tolerability to DCR.
Article
Biochemistry & Molecular Biology
Johannes Leierer, Paul Perco, Benedikt Hofer, Susanne Eder, Alexander Dzien, Julia Kerschbaum, Michael Rudnicki, Gert Mayer
Summary: Changes in protein concentrations in the body fluids of ADPKD patients mainly involve dysregulation of various molecular processes, including markers such as EGF, APLN, VEGFA, and AGT. These markers are significantly correlated with renal function and disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)