Article
Medicine, General & Internal
Naya Huang, Huiyan Li, Li Fan, Qian Zhou, Dongying Fu, Lin Guo, Chunyan Yi, Xueqing Yu, Haiping Mao
Summary: This study found that patients with high phosphorus and low albumin were at greater risk of all-cause mortality compared to those with low phosphorus and high albumin, while patients with low levels of both parameters had a higher risk of both all-cause and cardiovascular mortality. This suggests that low albumin may be a useful marker for identifying higher-risk subgroups of patients undergoing CAPD, regardless of their serum phosphorus levels.
FRONTIERS IN MEDICINE
(2021)
Article
Nutrition & Dietetics
Kuan-Ju Lai, Yao-Peng Hsieh, Ping-Fang Chiu, Pei-Ru Lin
Summary: This study investigated the association between albumin and globulin levels and mortality in patients on peritoneal dialysis. It found that patients with low albumin and high globulin had the highest risk of all-cause and cardiovascular mortality, indicating the importance of nutritional and inflammatory status in predicting mortality in these patients.
Article
Medicine, General & Internal
Naya Huang, Yuanying Liu, Zhen Ai, Qian Zhou, Haiping Mao, Xiao Yang, Yuanwen Xu, Xueqing Yu, Wei Chen
Summary: The clinical importance of hypokalemia is likely underestimated in Chinese dialysis patients, and the role of serum albumin in its clinical effect is not fully understood. This study found a U-shaped association between serum potassium and mortality in a Chinese dialysis patient cohort, with the lowest risk at a potassium concentration of 4.0 mmol/L. Serum albumin was found to mediate the association between potassium and mortality.
CHINESE MEDICAL JOURNAL
(2023)
Article
Transplantation
Marcelo Barreto Lopes, Angelo Karaboyas, Junhui Zhao, David W. Johnson, Talerngsak Kanjanabuch, Martin Wilkie, Kosaku Nitta, Hideki Kawanishi, Jeffrey Perl, Ronald L. Pisoni
Summary: This study investigates the association between serum phosphorus levels and adverse outcomes in peritoneal dialysis (PD) patients. It finds that higher serum phosphorus levels are associated with increased morbidity and mortality, highlighting the need for improved treatment strategies in this population. The study suggests that serial serum phosphorus measurements should be considered when assessing patients' risks of adverse outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Luis Perez, Zhiying You, Isaac Teitelbaum, Emily S. Andrews, Rachael Reddin, Lorena Ramirez-Renteria, Gabriela Wilson, Jessica Kendrick
Summary: This study found that the use of sucroferric oxyhydroxide improved phosphorus control and phosphorus-attuned albumin in PD patients while reducing medication burden. However, there were no significant improvements in self-reported appetite and dietary intake.
Article
Transplantation
Junichi Hoshino, Masanori Abe, Takayuki Hamano, Takeshi Hasegawa, Atsushi Wada, Shigeru Nakai, Norio Hanafusa, Ikuto Masakane, Kosaku Nitta
Summary: The GA/A1c ratio is significantly associated with 3-year mortality, especially infectious and cardiovascular mortality, in dialysis patients with diabetes. This ratio may be a promising new clinical indicator of survival in these patients, independent of their current glycemic control and nutritional markers.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Health Care Sciences & Services
Cheng-Yin Chung, Ping-Hsun Wu, Yi-Wen Chiu, Shang-Jyh Hwang, Ming-Yen Lin
Summary: This study found that receiving at least one year of nephrology care before dialysis initiation was associated with a 22% lower post-dialysis mortality hazard. Intermittent care showed some survival benefits, with slightly lower hazards ratio compared to care over one to two years and care over two years.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ji Eun Kim, Sehoon Park, Myeong-Seok Kim, Sung Jin Kang, Jang Wook Lee, Kwang Soo Kim, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Minsu Park, Hajeong Lee
Summary: This study aimed to explore the association between statin initiation after starting dialysis and all-cause mortality in statin-naive ESKD patients. The results showed that statin initiation was associated with a lower risk of all-cause mortality. However, there was no significant association with major adverse cardiovascular events. Further prospective studies are needed to validate these findings.
Article
Urology & Nephrology
Li Jin, Xiaopei Wang, Ying Ma, Jie Zheng, Wanhong Lu, Liyi Xie, Jing Lv
Summary: Based on the results of this study, the improvement of serum albumin level after 1 year of peritoneal dialysis can predict the mortality rate among peritoneal dialysis patients.
Article
Transplantation
Alex Y. Pai, John Sy, Joseph Kim, Carola-Ellen Kleine, Jessica Edward, Jui-Ting Hsiung, Csaba P. Kovesdy, Kamyar Kalantar-Zadeh, Elani Streja
Summary: This study examined the association between serum globulin levels and mortality in hemodialysis patients. The results showed that higher globulin levels were associated with an increased risk of death, while lower albumin: globulin ratios and serum protein levels were also associated with a higher mortality risk.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Transplantation
Hyung Woo Kim, Ga Young Heo, Hyo Jeong Kim, Shin-Wook Kang, Jung Tak Park, Eun Lee
Summary: Insomnia may increase the risk of cardio-cerebrovascular disease and all-cause mortality in end-stage kidney disease patients who initiate maintenance dialysis, especially in younger and male patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cardiac & Cardiovascular Systems
Hongyu Li, Yating Wang, Yiping Xu, Kefei Wu, Xiaohui Lu, Yagui Qiu, Xiao Yang, Qinghua Liu, Haiping Mao
Summary: This study found that lower serum chloride levels were associated with increased all-cause and cardiovascular disease mortality in continuous ambulatory peritoneal dialysis (CAPD) patients, especially in patients over the age of 50 or with a history of diabetes.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Article
Medicine, General & Internal
Panai Song, Dong Yang, Jine Li, Ning Zhuo, Xiao Fu, Lei Zhang, Hongqing Zhang, Hong Liu, Lin Sun, Yinghong Liu
Summary: This study found that age, cardiovascular disease, and time-averaged albumin were independent risk factors for all-cause mortality in PD patients. Time-averaged albumin and serum albumin reach rate can better predict the prognosis of PD patients.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jihong Deng, Xingming Tang, Ruiying Tang, Jiexin Chen, Huankai Guo, Qian Zhou, Xiaojiang Zhan, Haibo Long, Fenfen Peng, Xiaoyang Wang, Yueqiang Wen, Xiaoran Feng, Ning Su, Na Tian, Xianfeng Wu, Qingdong Xu
Summary: This study aimed to evaluate the association between atherogenic index (AI) and mortality risk in patients undergoing peritoneal dialysis (PD). The results showed that AI was independently associated with all-cause and cardiovascular disease (CVD) mortality in PD patients.
Article
Urology & Nephrology
Xiaoling Zhou, Yidan Guo, Yang Luo
Summary: The study found an association between serum intact parathyroid hormone levels and mortality in hemodialysis patients, showing a U-shaped curve of this relationship. The optimal range of serum iPTH levels conferring the lowest risk of all-cause and cardiovascular mortality may range from 150 pg/mL to 450 pg/mL in this group of incident HD patients.
Article
Cardiac & Cardiovascular Systems
Lingyao Zeng, Sylvain Moser, Nazanin Mirza-Schreiber, Claudia Lamina, Stefan Coassin, Christopher P. Nelson, Tarmo Annilo, Oscar Franzen, Marcus E. Kleber, Salome Mack, Till F. M. Andlauer, Beibei Jiang, Barbara Stiller, Ling Li, Christina Willenborg, Matthias Munz, Thorsten Kessler, Adnan Kastrati, Karl-Ludwig Laugwitz, Jeanette Erdmann, Susanne Moebus, Markus M. Noethen, Annette Peters, Konstantin Strauch, Martina Mueller-Nurasyid, Christian Gieger, Thomas Meitinger, Elisabeth Steinhagen-Thiessen, Winfried Maerz, Andres Metspalu, Johan L. M. Bjoerkegren, Nilesh J. Samani, Florian Kronenberg, Bertram Mueller-Myhsok, Heribert Schunkert
Summary: This study attempts to identify non-additive genetic effects associated with CAD, specifically epistatic interactions. A SNP pair located in cis at the LPA locus was found to be jointly associated with risk for CAD, peripheral arterial disease, aortic stenosis, hepatic lipoprotein(a) levels, and Lp(a) serum levels, while individual SNPs displayed no association. Further exploration revealed a strong dependency on a rare variant influencing risk through additive genetic as well as epistatic effects.
CARDIOVASCULAR RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Valentin Blanchard, Kevin Chemello, Tim Hollstein, Clement Chong-Hong-Fong, Friederike Schumann, Thomas Grenkowitz, Brice Nativel, Stefan Coassin, Mikael Croyal, Ursula Kassner, Claudia Lamina, Elisabeth Steinhagen-Thiessen, Gilles Lambert
Summary: The size of apo(a) is an independent determinant of the response to PCSK9i, and each additional kringle domain is associated with a 3% additional reduction in Lp(a). This partly explains the variable efficacy of PCSK9i and allows for the identification of patients who will benefit most from these therapies in terms of Lp(a) lowering.
CARDIOVASCULAR RESEARCH
(2022)
Article
Medicine, General & Internal
Silvia Di Maio, Claudia Lamina, Stefan Coassin, Lukas Forer, Reinhard Wuerzner, Sebastian Schoenherr, Florian Kronenberg
Summary: The study found that SARS-CoV-2 infections enforce the association between high Lp(a) and IHD, but the risk for thromboembolic events is not influenced by Lp(a.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Johannes P. Schwaiger, Barbara Kollerits, Inga Steinbrenner, Hansi Weissensteiner, Sebastian Schoenherr, Lukas Forer, Fruzsina Kotsis, Claudia Lamina, Markus P. Schneider, Ulla T. Schultheiss, Christoph Wanner, Anna Koettgen, Kai-Uwe Eckardt, Florian Kronenberg
Summary: This study investigated the association between apoA-IV and all-cause mortality and cardiovascular outcomes in patients with CKD. The results showed that higher levels of apoA-IV were associated with lower inflammation levels and reduced risk of all-cause mortality, cardiovascular events, and heart failure.
JOURNAL OF INTERNAL MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Florian Kronenberg
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Lukas Lunger, Andreas Melmer, Wolfgang Sturm, Claudia Lamina, Alexander Tschoner, Julia Engl, Armin Honlinger, Clemens Engler, Peter Willeit, Stefan Kiechl, Johann Willeit, Dietmar Ofner, Heinz Wykypiel, Markus Laimer, Herbert Tilg, Christoph Ebenbichler
Summary: The study demonstrates that weight loss induced by bariatric surgery can halt the natural progression of carotid intima media thickness (C-IMT) over a 10-year observation period, compared to a population-based control cohort.
WIENER KLINISCHE WOCHENSCHRIFT
(2023)
Article
Medical Laboratory Technology
L. Renee Ruhaak, Fred P. H. T. M. Romijn, Ilijana Begcevic Brkovic, Zsusanna Kuklenyik, Julia Dittrich, Uta Ceglarek, Andrew N. Hoofnagle, Harald Althaus, Eduardo Angles-Cano, Stefan Coassin, Vincent Delatour, Liesbet Deprez, Ioannis Dikaios, Gerhard M. Kostner, Florian Kronenberg, Alicia Lyle, Urban Prinzing, Hubert W. Vesper, Christa M. Cobbaert, Int Federation Clinical Chem Lab Med Working Grp Apolipoproteins Mass Spect
Summary: In order to ensure the accuracy and reliability of medical results from in vitro diagnostic and in-house tests, a higher order reference measurement system traceable to endorsed reference measurement procedures and reference materials is needed. A candidate reference measurement procedure for serum apolipoprotein(a) [apo(a)] based on mass spectrometry was developed and provisionally validated. The method demonstrated accurate quantitation of serum apo(a) and fulfilled predefined analytical performance specifications.
CLINICAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Patrick B. Mark, Juan J. Carrero, Kunihiro Matsushita, Yingying Sang, Shoshana H. Ballew, Morgan E. Grams, Josef Coresh, Aditya Surapaneni, Nigel J. Brunskill, John Chalmers, Lili Chan, Alex R. Chang, Rajkumar Chinnadurai, Gabriel Chodick, Massimo Cirillo, Dick de Zeeuw, Marie Evans, Amit X. Garg, Orlando M. Gutierrez, Hiddo J. L. Heerspink, Gunnar H. Heine, William G. Herrington, Junichi Ishigami, Florian Kronenberg, Jun Young Lee, Adeera Levin, Rupert W. Major, Angharad Marks, Girish N. Nadkarni, David M. J. Naimark, Christoph Nowak, Mahboob Rahman, Charumathi Sabanayagam, Mark Sarnak, Simon Sawhney, Markus P. Schneider, Varda Shalev, Jung-Im Shin, Moneeza K. Siddiqui, Nikita Stempniewicz, Keiichi Sumida, Jose M. Valdivielso, Jan van den Brand, Angela Yee-Moon Wang, David C. Wheeler, Lihua Zhang, Frank L. J. Visseren, Benedicte Stengel
Summary: This study investigated the association between cardiovascular disease (CVD) and future risk of kidney failure with replacement therapy (KFRT). It found that both prevalent and incident CVD were strongly associated with KFRT risk, with incident HF showing the strongest association.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Florian Kronenberg, Samia Mora, Erik S. G. Stroes, Brian A. Ference, Benoit J. Arsenault, Lars Berglund, Marc R. Dweck, Marlys L. Koschinsky, Gilles Lambert, Francois Mach, Catherine J. McNeal, Patrick M. Moriarty, Pradeep Natarajan, Borge G. Nordestgaard, Klaus G. Parhofer, Salim S. Virani, Arnold von Eckardstein, Gerald F. Watts, Jane K. Stock, Kausik K. Ray, Lale S. Tokgozoglu, Alberico L. Catapano
Summary: In 2022, the European Atherosclerosis Society (EAS) released a new consensus statement on the relationship between lipoprotein(a) [Lp(a)] and atherosclerotic cardiovascular disease (ASCVD) and aortic stenosis. This statement highlights the importance of understanding Lp(a) concentration and its impact on lifetime risk for ASCVD. It also provides practical advice on using Lp(a) concentration to manage risk factors, despite the lack of currently available targeted therapies to lower Lp(a).
Article
Biochemistry & Molecular Biology
Sebastian Schoenherr, Hansi Weissensteiner, Florian Kronenberg, Lukas Forer
Summary: This paper presents a major upgrade to the Haplogrep software, including added features such as haplogroup summary statistics and variant annotations from various genome databases, improved algorithms for large-scale data, and a new web framework. These improvements allow researchers to classify and investigate thousands of samples more conveniently.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Medicine, General & Internal
Ferdinand J. Donhauser, Martina E. Zimmermann, Anna B. Steinkirchner, Simon Wiegrebe, Alexander Dietl, Caroline Brandl, Ralph Burkhardt, Andre Gessner, Frank Schweda, Tobias Bergler, Elke Schaeffner, Carsten A. Boeger, Florian Kronenberg, Andreas Luchner, Klaus J. Stark, Iris M. Heid
Summary: Cardiovascular risk factors are common in old-aged individuals, but there is limited population-based data on their control in this population. The AugUR cohort study analyzed the cardiovascular risk factor control in the 70+-year-old population of/near Regensburg. The study found that a significant proportion of participants had high LDL-cholesterol, HbA1c, or blood pressure levels beyond recommended levels, and these factors were associated with impaired kidney function.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Marlys L. Koschinsky, Erik S. G. Stroes, Florian Kronenberg
Summary: This review focuses on the causal association between Lipoprotein(a) (Lp(a)) and cardiovascular outcomes, the mechanisms by which elevated Lp(a) contributes to cardiovascular diseases, the metabolic insights on the production and clearance of Lp(a), and the current and future therapeutic approaches to lower Lp(a) concentrations.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lea Azour, Yunan Hu, Jane P. Ko, Baiyu Chen, Florian Knoll, Jeffrey B. Alpert, Geraldine Brusca-Augello, Derek M. Mason, Maj L. Wickstrom, Young Joon (Fred) Kwon, James Babb, Zhengrong Liang, William H. Moore
Summary: This study examined the deep learning denoised (DLD) computed tomography (CT) chest images at varying low doses using quantitative and qualitative perceptual image analysis. The results showed that DLD improved image quality quantitatively, but at doses of 10 mAs and below, the image quality was inferior to standard-dose images.
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY
(2023)
Article
Biochemistry & Molecular Biology
Adriana Koller, Claudia Lamina, Caroline Brandl, Martina E. Zimmermann, Klaus J. Stark, Hansi Weissensteiner, Reinhard Wuerzner, Iris M. Heid, Florian Kronenberg, Jay Stewart
Summary: This study suggests that mtDNA copy number in blood may serve as a more accessible biomarker for age-related macular degeneration (AMD) than mtDNA copy number in the retina, providing new insights into the relationship between mtDNA-CN and AMD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Adriana Koller, Caroline Brandl, Claudia Lamina, Martina E. Zimmermann, Monika Summerer, Klaus J. Stark, Reinhard Wuerzner, Iris M. Heid, Florian Kronenberg
Summary: The study found an association between RTL and AMD restricted to women, which may be related to altered reactive oxygen species levels and higher telomerase activity in women. The results provide a clue to the gender-differential pathway for oxidative stress and AMD.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)