Review
Urology & Nephrology
Estelle Tran, Oliver Karadjian, Christopher T. T. Chan, Emilie Trinh
Summary: Home hemodialysis (HHD) offers benefits for patients with end-stage kidney disease, but its low prevalence and high discontinuation rates pose challenges. This review aims to understand technique survival in HHD patients, identify clinical factors contributing to attrition, and explore strategies to prevent discontinuation. With increasing efforts to promote home modalities, it is important to target high-risk patients, improve training practices, and identify modifiable practices to enhance technique survival.
Article
Urology & Nephrology
Osama El Shamy, Graham Abra, Christopher Chan
Summary: The article discusses the complexity and multifactorial nature of writing a home hemodialysis prescription, emphasizing the importance of considering patient values, preferences, and lifestyle. It also introduces different home HD modalities and machines, along with their attributes and limitations, to guide providers in delivering a patient-centered home HD approach.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Greg Knoll, Patricia Campbell, Michael Chasse, Dean Fergusson, Tim Ramsay, Priscilla Karnabi, Jeffrey Perl, Andrew A. House, Joseph Kim, Olwyn Johnston, Rahul Mainra, Isabelle Houde, Dana Baran, Darin J. Treleaven, Lynne Senecal, Lee Anne Tibbles, Marie-Josee Hebert, Christine White, Martin Karpinski, John S. Gill
Summary: This study investigated the use of immunosuppressants in patients with kidney transplant failure and found that prolonged use of immunosuppressants for more than 2 years was not associated with an increased risk of death or hospitalized infection. However, continued use of immunosuppressants did not prevent rejection of the failed allograft or an increase in anti-HLA antibodies.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
David J. Semple, Matthew Sypek, Shahid Ullah, Christopher Davies, Stephen McDonald
Summary: A study on patients returning to in-center hemodialysis (ICHD) after home hemodialysis (HHD) treatment failure revealed a significant increase in mortality. This risk was observed in both the early (0-30 days and 30-90 days) and late (>90 days) periods after HHD treatment failure. Further investigation into specific causes of treatment failure and death may identify high-risk patients.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Transplantation
Isabelle Ethier, Yeoungjee Cho, Carmel Hawley, Elaine M. Pascoe, Matthew A. Roberts, David Semple, Annie-Claire Nadeau-Fredette, Germaine Wong, Wai H. Lim, Matthew P. Sypek, Andrea K. Viecelli, Scott Campbell, Carolyn van Eps, Nicole M. Isbel, David W. Johnson
Summary: The study compared the survival outcomes of HHD patients and kidney transplant recipients, finding that living donor and standard criteria donor recipients had reduced risks of mortality compared to HHD patients, while the risk of mortality was comparable between expanded criteria donor recipients and HHD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Su-Ju Lin, Shu-Chen Chang, Chun-Wu Tung, Yung-Chien Hsu, Ya-Hsueh Shih, Yi-Ling Wu, Tse-Chih Chou, Chun-Liang Lin
Summary: The study investigated the association between the optimal timing for cannulation after arteriovenous graft (AVG) creation and AVG survival in hemodialysis patients. Results showed that having the first cannulation between 31 and 90 days after AVG construction led to significantly superior functional cumulative survival. It is recommended to avoid waiting for more than 3 months for the best long-term survival.
Article
Multidisciplinary Sciences
Do Hyoung Kim, AJin Cho, Hayne Cho Park, Bo Yeon Kim, Miri Lee, Gui Ok Kim, Jinseog Kim, Young-Ki Lee
Summary: This study evaluated the impact of regular laboratory testing on mortality in Korean patients undergoing maintenance hemodialysis. The results showed that regular laboratory testing was associated with a decreased mortality risk and improved survival among patients receiving hemodialysis.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Lazar A. Chisavu, Adrian Apostol, Gheorghe N. Pop, Viviana Ivan, Oana Schiller, Flaviu Bob, Luciana Marc, Adelina Mihaescu, Florica Gadalean, Iulia Grosu, Bogdan Timar, Adalbert Schiller
Summary: Left ventricular abnormalities are common in patients with chronic kidney disease, increasing the risk of mortality. Patients undergoing long-term hemodialysis experience progression of cardiovascular diseases, with heart failure with decreased left ventricular ejection fraction (<50%) associated with higher mortality risk. Regular monitoring of LV function is crucial for patient management and risk assessment.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Chunxia Li, Dafu Zhang, Xiaolin Pang, Hongjiang Pu, Ming Lei, Bingbing Fan, Jiali Lv, Dingyun You, Zhenhui Li, Tao Zhang
Summary: In addition to CEA, dynamic monitoring of CA19-9 and CA125 is recommended to monitor the prognosis of CRC patients. Different trajectory groups based on preoperative levels and longitudinal trajectories have significant impact on overall survival and recurrence-free survival of patients.
Article
Orthopedics
Fahd F. Mahmood, Martin Beck, Arthur de Gast, Philipp Rehbein, Gary J. French, Roland Becker, Martin Dominkus, Naeder Helmy, Lutz Hollmann, Joe Baines
Summary: This study utilized a Vitamin E-infused highly cross-linked polyethylene acetabular cup and showed improvements in patient symptoms in the medium to long-term follow-up, with a cup survival rate of 98.9%. A lucent line was observed in one case, but no evidence of acetabular osteolysis was found throughout the follow-up period.
JOURNAL OF ARTHROPLASTY
(2021)
Article
Immunology
Rene Clavero, Alfredo Parra-Lucares, Gabriel Mendez-Valdes, Eduardo Villa, Karin Bravo, Evelyn Mondaca, Josseline Aranda, Rose Brignardello, Cynthia Gajardo, Angelica Ordenes, Evelyn Colombo, Jessica Tapia, Andoni Etcheverry, Jose Zuniga, Luis Toro
Summary: The CoronaVac vaccine produces a lower humoral response compared to the BNT162b2 vaccine in end-stage renal disease (ESRD) patients on hemodialysis.
Article
Clinical Neurology
Anouk van Westrhenen, Richard H. C. P. Lazeron, Johannes van Dijk, Frans S. S. D. Leijten, Roland Thijs
Summary: This study aimed to evaluate the performance of the wearable seizure detection device NightWatch in detecting nocturnal seizures in children with epilepsy in a home setting, and to assess its impact on caregiver burden. The results showed that NightWatch demonstrated high sensitivity in detecting nocturnal seizures and significantly reduced caregiver stress.
Article
Medicine, General & Internal
Nina Sophia Decker, Theron Johnson, Johannes A. Vey, Charlotte Le Cornet, Sabine Behrens, Nadia Obi, Rudolf Kaaks, Jenny Chang-Claude, Renee Turzanski Fortner
Summary: Recent studies have shown associations between a range of circulating oxysterols and mortality following a breast cancer diagnosis, particularly with cardiovascular disease death. However, these associations were not statistically significant after adjusting for multiple comparisons.
Article
Urology & Nephrology
Yaya Yang, Haixia Zhang, Xiaolei Lan, Xianhui Qin, Yan Huang, Jieyu Wang, Pei Luo, Zhen Wen, Yumin Li, Yaozhong Kong, Qijun Wan, Qi Wang, Sheng Huang, Yan Liu, Aiqun Liu, Fanna Liu, Shenglin Yang, Yongxin Lu, Yanhong Zhao, Junzhi Chen, Zihan Lei, Yanhuan He, Zizhen Lin, Youbao Li, Min Liang
Summary: This multicenter prospective cohort study found that low BMI and high WHR were individually and jointly associated with higher mortality risk in maintenance hemodialysis patients.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Health Care Sciences & Services
Mary M. Scott, Haris Imsirovic, Michael Pugliese, Sarina R. Isenberg, Tim Ramsay, Amy T. Hsu, David Ponka, Henry Siu, Douglas G. Manuel, Peter Tanuseputro
Summary: This study identifies primary care physicians who deliver home visits at patients' end of life in Ontario, Canada, describes the characteristics of these physicians, and explores the associations with home visit delivery. The findings show that older age, international training, previous home visit experience, specific remuneration models, and practice locations in small rural or remote areas and large metropolitan areas are associated with increased likelihood of delivering end-of-life home visits.
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT
(2023)
Article
Urology & Nephrology
Silvia J. Leon, Reid Whitlock, Claudio Rigatto, Paul Komenda, Clara Bohm, Ewa Sucha, Sarah E. Bota, Meltem Tuna, David Collister, Manish Sood, Navdeep Tangri
Summary: Discontinuation of RAAS inhibitors is associated with adverse clinical outcomes in patients with CKD, including high mortality, increased risk of cardiovascular events, and initiation of dialysis.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Urology & Nephrology
Thomas W. Ferguson, Gerard D. Harper, John E. Milad, Paul V. J. Komenda
Summary: The development of new personal hemodialysis systems has made dialysis smaller and simpler while maintaining the same effectiveness as conventional systems. Increasing the use of lower-intensity assistance and full self-care dialysis may bring economic benefits to public health payers. The study found that the annual costs of using the SC+ hemodialysis system for self-care dialysis were relatively low in the United Kingdom.
HEMODIALYSIS INTERNATIONAL
(2022)
Article
Pediatrics
Geoff D. C. Ball, Andrea Eaton, Sarah Rathwell, Chenhui Peng, Katerina Maximova, Ane Kokkvoll, Emily Zehnder, Josephine Ho, Arnaldo Perez
Summary: This study found that few children were re-referred for pediatric obesity management, but for those who were re-referred, being re-referred once only increased the likelihood of treatment initiation.
JOURNAL OF PEDIATRICS
(2022)
Article
Public, Environmental & Occupational Health
Katerina Maximova, Mohammad K. A. Khan, Julia Dabravolskaj, Laena Maunula, Arto Ohinmaa, Paul J. Veugelers
Summary: The closure of schools due to the COVID-19 pandemic has raised concerns about the lifestyle behaviors, mental health, and wellbeing of children from socioeconomically disadvantaged backgrounds. A survey conducted among students in socioeconomically disadvantaged communities in northern Canada revealed that most students experienced a decrease in physical activity and delayed sleep/wake-up times during the lockdown. However, there were modest improvements in mental health and wellbeing. It was also found that screen time and snacking increased. Positive attitudes were strongly associated with maintaining healthy lifestyle behaviors and positive mental health during the lockdown.
Review
Pharmacology & Pharmacy
Silvia J. Leon, Aaron Trachtenberg, Derek Briscoe, Maira Ahmed, Ingrid Hougen, Nicole Askin, Reid Whitlock, Thomas Ferguson, Navdeep Tangri, Claudio Rigatto, Paul Komenda
Summary: Studies have found that prescribed opioids may increase the risk of motor vehicle collisions. There is evidence of a dose-response relationship, but due to study heterogeneity, a quantitative meta-analysis was not feasible.
JOURNAL OF PHARMACY TECHNOLOGY
(2022)
Article
Urology & Nephrology
Hongru Ren, Silvia J. Leon, Reid Whitlock, Claudio Rigatto, Paul Komenda, Clara Bohm, David Collister, Navdeep Tangri
Summary: This study examined the prescription patterns of SPS/CPS and their impact on RAASi treatment in patients with CKD after an episode of hyperkalemia. The results showed a low frequency of SPS/CPS prescription after hyperkalemia, with RAASi discontinuation or down-titration being the most common approach. New options for managing hyperkalemia in this population are needed.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Urology & Nephrology
Thomas Ferguson, Pietro Ravani, Manish M. Sood, Alix Clarke, Paul Komenda, Claudio Rigatto, Navdeep Tangri
Summary: This study developed a random forest model to predict the progression of CKD using demographic and laboratory data. Internal and external validation showed that the model accurately predicted eGFR decline or kidney failure.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Public, Environmental & Occupational Health
Siyuan Liu, Lalani L. Munasinghe, Katerina Maximova, Jennifer P. Taylor, Arto Ohinmaa, Paul J. Veugelers
Summary: The study aims to estimate the economic burden of excessive free sugar consumption in Canada. Based on data from a health survey in 2015 and risk estimates, the researchers found that complying with free sugar recommendations could have avoided billions of dollars in healthcare and indirect costs.
CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE
(2022)
Article
Environmental Sciences
Elham Khodayari Moez, Katerina Maximova, Shannon Sim, Ambikaipakan Senthilselvan, Roman Pabayo
Summary: Capturing socioeconomic inequalities related to chronic disease is challenging, but a comprehensive individual-level SES index showed a negative association with smoking intensity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Nutrition & Dietetics
Julia Dabravolskaj, Paul J. Veugelers, Angelica Amores, Scott T. Leatherdale, Karen A. Patte, Katerina Maximova
Summary: This study examined the associations between lifestyle behaviors and depression and anxiety in Canadian high school students. The results showed that adherence to recommendations for various aspects of lifestyle, such as diet, physical activity, screen time, sleep, and substance use, was associated with lower scores of depressive and anxiety symptoms. Adhering to more recommendations was linked to lower symptom scores.
INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY
(2023)
Article
Public, Environmental & Occupational Health
Katerina Maximova, Enrique Loyola Elizondo, Holly Rippin, Joao Breda, Francesco P. Cappuccio, Morteza Hajihosseini, Kremlin Wickramasinghe, Irina Novik, Vital Pisaryk, Lela Sturua, Ainura Akmatova, Galina Obreja, Saodat Azimzoda Mustafo, Banu Ekinci, Toker Erguder, Shukhrat Shukurov, Gahraman Hagverdiyev, Diana Andreasyan, Carina Ferreira-Borges, Nino Berdzuli, Stephen Whiting, Natalia Fedkina, Ivo Rakovac
Summary: This study aimed to assess educational inequalities in high blood pressure (HBP) awareness, treatment and control, physician's advice on salt reduction, and salt knowledge, perceptions and consumption behaviors in Eastern Europe and Central Asia to inform strategies for improving blood pressure control and reducing salt intake. The results showed significant differences in HBP awareness, treatment and control, as well as salt knowledge and perceptions, based on education level. Participants with lower education had less coverage of physician's advice on salt reduction, especially those with untreated HBP or unaware of their HBP. There was an education gradient in salt knowledge and perceptions, but not in salt consumption behaviors. It is urgently needed to enhance public and patient knowledge and awareness of HBP and its risk factors, particularly targeting socio-economically disadvantaged groups, to alleviate the growing burden of HBP in low- and middle-income countries.
PUBLIC HEALTH NUTRITION
(2023)
Article
Nutrition & Dietetics
Melissa A. Fernandez, Katerina Maximova, Jayne A. Fulkerson, Kim D. Raine
Summary: This study investigated the impact of cooking skills and cooking with processed foods on health and diet outcomes. The findings suggest that individuals with poor cooking skills are less likely to have adequate fruit and vegetable intake and are more likely to have obesity. It also indicates that in addition to improving cooking skills, reducing the use of processed foods is important for promoting better health and diet outcomes.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2023)
Article
Public, Environmental & Occupational Health
Katerina Maximova, Xiuyun Wu, Mohammed K. A. Khan, Julia Dabravolskaj, Shannon Sim, Boshra Mandour, Roman Pabayo, Paul J. Veugelers
Summary: This study compares the pre-pandemic and post-lockdown inequalities in lifestyle behaviors and mental health among children. The findings show that the inequalities in lifestyle behaviors have increased during the pandemic, while the inequalities in mental health have small and non-significant changes. The study suggests that school health programs can help alleviate the negative impact of the pandemic on children's lifestyle behaviors and mental health.
SSM-POPULATION HEALTH
(2023)
Article
Urology & Nephrology
Reid H. Whitlock, Mohammad Nour-Mohammadi, Sarah Curtis, Paul Komenda, Clara Bohm, David Collister, Navdeep Tangri, Claudio Rigatto
Summary: This study used administrative health databases to identify patients at high risk of Fabry disease and found that 1364 high-risk patients had not been tested. Administrative health databases can assist in identifying high-risk populations and further design screening programs for Fabry disease.
CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE
(2023)
Review
Urology & Nephrology
Ali Taha, Yasmin Iman, Jay Hingwala, Nicole Askin, Priyanka Mysore, Claudio Rigatto, Clara Bohm, Paul Komenda, Navdeep Tangri, David Collister
Summary: This article conducted a systematic review on patient navigator programs in kidney disease and found that navigators can improve some health outcomes for patients with chronic kidney disease, but there is heterogeneity in their structure and function.