Article
Nutrition & Dietetics
Hidehiko Nakano, Hideki Hashimoto, Masaki Mochizuki, Hiromu Naraba, Yuji Takahashi, Tomohiro Sonoo, Kensuke Nakamura
Summary: The risk of acute functional decline increases with age, with factors such as age, serum albumin levels, and pre-admission care needs identified as risk factors for functional deterioration in infected patients.
Article
Environmental Sciences
Hans-Georg Olbrich, Martin Roosli, Eva Herrmann, Christian Maschke, Kerstin Schadow, Torsten Haehnel, Hans-Jorgen Rupprecht, Martin Kaltenbach
Summary: This study found associations between aircraft noise and recurrence risk as well as all-cause mortality in patients with acute coronary heart disease, with more pronounced effects compared to previous population-based cohort studies. In contrast, associations with road traffic and railway noise were weaker and not significant, suggesting that acute coronary heart disease patients are particularly vulnerable to the effects of transportation noise.
ENVIRONMENTAL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Raul Sanchez-Gimenez, Oscar M. Peiro, Gil Bonet, Anna Carrasquer, George A. Fragkiadakis, Monica Bullo, Christopher Papandreou, Alfredo Bardaji
Summary: This study aimed to examine the relationship between tricarboxylic acid (TCA) cycle metabolites and the risk of cardiovascular events and mortality after acute coronary syndrome (ACS), and to evaluate the mediating role of renal function in these associations. The results showed positive associations between certain metabolites and the risk of major adverse cardiovascular events (MACE) and all-cause mortality. However, these associations became non-significant after adjusting for estimated glomerular filtration rate (eGFR), indicating the strong mediating effect of eGFR.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Medicine, General & Internal
Angelo Silverio, Francesco Paolo Cancro, Luca Esposito, Michele Bellino, Debora D'Elia, Monica Verdoia, Maria Giovanna Vassallo, Michele Ciccarelli, Carmine Vecchione, Gennaro Galasso, Giuseppe De Luca
Summary: The control of cardiovascular risk factors, promotion of a healthy lifestyle, and antithrombotic therapy are important for secondary prevention after acute coronary syndrome (ACS). Identification of novel risk factors and targets is essential to optimize preventive strategies for patients who have recurrent ischemic events despite optimal control of traditional risk factors and pharmacological therapy.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Hematology
Niema Kazem, Felix Hofer, Lorenz Koller, Andreas Hammer, Christian Hengstenberg, Alexander Niessner, Patrick Sulzgruber
Summary: In patients aged 65 and older, lymphocyte fraction, neutrophil fraction, and neutrophil-to-lymphocyte ratio were strongly and independently associated with mortality, indicating their potential as prognostic markers. Conversely, no significant effects were observed in patients under 65 years old. These findings suggest age-specific cellular immunity markers can aid in identifying high-risk individuals and informing proper secondary prevention strategies after ACS.
THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Medicine, General & Internal
Rainer U. Pliquett, Andrea Tannapfel, Sait S. Daneschnejad
Summary: In a patient with pyelonephritis of his failed renal allograft, rapid progression of coronary artery disease was observed within 3 weeks when infection was uncontrolled. Surgical interventions for both pyelonephritis and coronary artery disease were performed with successful outcomes.
Article
Cardiac & Cardiovascular Systems
Roland Klingenberg, Soheila Aghlmandi, Lorenz Raeber, Alexander Akhmedov, Baris Gencer, David Carballo, David Nanchen, Heiner C. Bucher, Nicolas Rodondi, Francois Mach, Stephan Windecker, Ulf Landmesser, Arnold von Eckardstein, Christian W. Hamm, Thomas F. Luescher, Christian M. Matter
Summary: This study found that the novel biomarker CCN1 can predict adverse outcomes in patients with acute coronary syndromes, adding incremental value to the GRACE risk score, suggesting distinct underlying molecular mechanisms.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Kaivan Vaidya, Bradley Tucker, Rahul Kurup, Chinmay Khandkar, Elvis Pandzic, Jennifer Barraclough, Joshua Machet, Ashish Misra, Mary Kavurma, Gonzalo Martinez, Kerry-Anne Rye, Blake J. Cochran, Sanjay Patel
Summary: The study found that colchicine suppresses NET formation in patients with ACS post-PCI by restoring cytoskeletal dynamics. These findings warrant further investigation in randomized trials powered for clinical end points.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Matilda Hurskainen, Juho Tynkkynen, Markku Eskola, Terho Lehtimaki, Jussi Hernesniemi
Summary: This study aimed to investigate the risk factors for ischemic stroke (IS) after acute coronary syndromes (ACS). Based on a retrospective registry study of 8049 ACS patients, it was found that previous stroke, atrial fibrillation or flutter, and heart failure indicated by the Killip classification were the most significant risk factors for both early-onset and late-onset IS. Left ventricular ejection fraction and coronary artery disease severity were important risk factors for early-onset IS, while age and peripheral artery disease were important risk factors for late-onset IS. The CHA(2)DS(2)-VASc score and its components were strong predictors for both early-onset and late-onset IS.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Medicine, General & Internal
Victoria A. Brazhnik, Larisa O. Minushkina, Olga I. Boeva, Niyaz R. Khasanov, Elena D. Kosmacheva, Marina A. Chichkova, Dmitry A. Zateyshchikov
Summary: The study demonstrates the importance of the de-escalation strategy of antiplatelet therapy in life expectancy after ACS and PCI. Factors such as age, antithrombotic therapy options, history of chronic heart failure, and uric acid levels were found to be important predictors of death. The de-escalation group showed lower all-cause death rate, without significant differences in bleeding or nonfatal recurrent coronary events compared to other therapy options.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Kathy Ming Feng, Wu-Chien Chien, Yi-Hao Chen, Chien-An Sun, Chi-Hsiang Chung, Jiann-Torng Chen, Ching-Long Chen
Summary: This study found that uveitis could be a predictor of ACS in patients with AS. Both anterior uveitis and posterior segment involvement were associated with an increased risk of ACS in AS patients. Age, diabetes mellitus, hypertension, hyperlipidemia, chronic obstructive pulmonary disease, asthma, and systemic steroids were significant risk factors for ACS. The all-cause mortality was higher in the uveitis group compared to the non-uveitis group.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Eleana Bolla, Nikolaos Tentolouris, Petros P. Sfikakis, Maria G. Tektonidou
Summary: This study aimed to evaluate the prevalence of Metabolic Syndrome (MetS) in antiphospholipid syndrome (APS) patients and its associations with cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. The results showed that MetS was present in approximately one-fourth of APS patients and was associated with arterial thrombosis, cardiovascular risk biomarkers, physical activity, and subclinical atherosclerosis. This suggests that MetS plays an important role in cardiovascular risk stratification and management in APS.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Raul Sanchez-Gimenez, Oscar M. Peiro, Gil Bonet, Anna Carrasquer, Georgios A. Fragkiadakis, Monica Bullo, Christopher Papandreou, Alfredo Bardaji
Summary: This study found that renal function may be a key mediator in the association between plasma TMAO and cardiovascular events after ACS. Additionally, dimethylglycine may play a role in the pathogenesis of MACE, which may be at least partially mediated by renal function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Emil Hagstrom, P. Gabriel Steg, Michael Szarek, Deepak L. Bhatt, Vera A. Bittner, Nicolas Danchin, Rafael Diaz, Shaun G. Goodman, Robert A. Harrington, J. Wouter Jukema, Evangelos Liberopoulos, Nikolaus Marx, Jennifer McGinniss, Garen Manvelian, Robert Pordy, Michel Scemama, Harvey D. White, Andreas M. Zeiher, Gregory G. Schwartz
Summary: This study investigated the predictive role of apolipoprotein B (apoB) levels in residual risk after acute coronary syndrome and found that apoB provides additional predictive information. The study also found that lowering apoB levels with the medication alirocumab can reduce cardiovascular events. Therefore, controlling apoB levels is important for reducing the risk after acute coronary syndrome.
Article
Immunology
Xiaoxuan Ma, Meiming Su, Qingze He, Zhidan Zhang, Fanshun Zhang, Zhenghong Liu, Lu Sun, Jianping Weng, Suowen Xu
Summary: By analyzing human plaque tissue data and conducting experiments on mice, this study identifies PHACTR1 as being associated with endothelial dysfunction, which it regulates through inflammation response and NO production, and finds that its expression can be reduced by certain drugs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yan Liang, Jun Zhu, Lisheng Liu, Sonia S. Anand, Stuart J. Connolly, Jackie Bosch, Tomasz J. Guzik, Martin O'Donnell, Gilles R. Dagenais, Keith Aa Fox, Olga Shestakovska, Scott D. Berkowitz, Eva Muehlhofer, Lars Keller, Salim Yusuf, John W. Eikelboom
Summary: In patients with stable coronary artery disease or peripheral artery disease, the combination of rivaroxaban (2.5 mg twice daily) and aspirin compared with aspirin alone appears to produce consistent benefits in women and men, independent of baseline cardiovascular risk. There was no significant interaction between randomized treatment and baseline cardiovascular risk for major adverse cardiovascular events or major bleeding.
CARDIOVASCULAR RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Jan Steffel, John W. Eikelboom, Sonia S. Anand, Olga Shestakovska, Salim Yusuf, Keith A. A. Fox
Article
Cardiac & Cardiovascular Systems
John Hung, Andreas Roos, Erik Kadesjo, David A. McAllister, Dorien M. Kimenai, Anoop S. Shah, Atul Anand, Fiona E. Strachan, Keith A. A. Fox, Nicholas L. Mills, Andrew R. Chapman, Martin J. Holzmann
Summary: The GRACE 2.0 score showed good discrimination for predicting all-cause death at 1 year in patients with type 1 myocardial infarction, but only moderate discrimination for those with type 2 myocardial infarction.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Guillaume Marquis-Gravel, Megan L. Neely, Marco Valgimigli, Francesco Costa, David Van Klaveren, Rituparna Altner, Deepak L. Bhatt, Paul W. Armstrong, Keith A. A. Fox, Harvey D. White, E. Magnus Ohman, Matthew T. Roe
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2020)
Article
Cardiac & Cardiovascular Systems
Zak Loring, Suchit Mehrotra, Jonathan P. Piccini, John Camm, David Carlson, Gregg C. Fonarow, Keith A. A. Fox, Eric D. Peterson, Karen Pieper, Ajay K. Kakkar
Article
Cardiac & Cardiovascular Systems
Francois Schiele, Suleman Aktaa, Xavier Rossello, Ingo Ahrens, Marc J. Claeys, Jean-Philippe Collet, Keith A. A. Fox, Chris P. Gale, Kurt Huber, Zaza Iakobishvili, Alan Keys, Ekaterini Lambrinou, Sergio Leonardi, Maddalena Lettino, Frederick A. Masoudi, Susanna Price, Tom Quinn, Eva Swahn, Holger Thiele, Adam Timmis, Marco Tubaro, Christiaan J. M. Vrints, David Walker, Hector Bueno, Sigrun Halvorsen, Tomas Jernberg, Jarle Jortveit, Mai Blondal, Borja Ibanez, Christian Hassager
Summary: Updated quality indicators for the management of acute myocardial infarction were developed based on contemporary knowledge and accumulated experience, aiming to evaluate and improve the quality of care for myocardial infarction.
EUROPEAN HEART JOURNAL-ACUTE CARDIOVASCULAR CARE
(2021)
Article
Hematology
Jean-Pierre Bassand, Saverio Virdone, Marc Badoz, Freek W. A. Verheugt, A. John Camm, Frank Cools, Keith A. A. Fox, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Werner Hacke, Gloria Kayani, Frank Misselwitz, Karen S. Pieper, Alexander G. G. Turpie, Martin van Eickels, Ajay K. Kakkar
Summary: In patients with atrial fibrillation, NOACs show lower risks of bleeding and all-cause mortality compared to VKAs, with major bleeding associated with the highest risk of death. Minor bleeding and CRNM bleeding are also linked to a higher risk of death compared to no bleeding. A significant percentage of deaths within 30 days after a major bleed are due to intracranial/intraspinal hemorrhage.
Article
Cardiac & Cardiovascular Systems
Matthew A. Cavender, Michelle L. O'Donoghue, Antonio Abbate, Philip Aylward, Keith Aa Fox, Ruchira X. Glaser, Jeong-Gun Park, Jose Lopez-Sendon, Ph Gabriele Steg, Marc S. Sabatine, David A. Morrow
Summary: Losmapimod attenuated inflammatory response in patients with STEMI but not in those with NSTEMI. Differences in outcomes between the two patient groups suggest a potential need for separate strategies in managing inflammation in MI, with a stronger focus on heart failure.
AMERICAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Pishoy Gouda, Chinthanie Ramasundarahettige, Sonia Anand, Eva Muhlhoffer, Scott Berkowitz, Keith Aa Fox, John Eikelboom, Robert Welsh
Summary: This study assessed clinical factors predicting the presence of PAD in patients with CAD, revealing that routinely available clinical information has limited utility in identifying patients with CAD and concomitant PAD.
Article
Cardiac & Cardiovascular Systems
Sonia S. Anand, Will Hiatt, Leanne Dyal, Rupert Bauersachs, Scott D. Berkowitz, Kelley R. H. Branch, Sebastian Debus, Keith A. A. Fox, Yan Liang, Eva Muehlhofer, Mark Nehler, Lloyd P. Haskell, Manesh Patel, Michael Szarek, Salim Yusuf, John Eikelboom, Marc P. Bonaca
Summary: Among peripheral artery disease (PAD) patients, low-dose rivaroxaban plus aspirin is superior to aspirin alone in reducing cardiovascular and limb events, including acute limb ischemia and major vascular amputation. Despite an increased risk of major bleeding, there is no significant increase in severe bleeding with the combination therapy.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Keith A. A. Fox, Saverio Virdone, Karen S. Pieper, Jean-Pierre Bassand, A. John Camm, David A. Fitzmaurice, Samuel Z. Goldhaber, Shinya Goto, Sylvia Haas, Gloria Kayani, Ali Oto, Frank Misselwitz, Jonathan P. Piccini, Frederik Dalgaard, Alexander G. G. Turpie, Freek W. A. Verheugt, Ajay K. Kakkar
Summary: This study confirms the effectiveness of the GARFIELD-AF integrated risk tool in predicting mortality, stroke, and bleeding in patients with atrial fibrillation, and compares it with the traditional predictors CHA(2)DS(2)-VASc and HAS-BLED.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2022)
Article
Medicine, General & Internal
Keith A. A. Fox, Saverio Virdone, Jean-Pierre Bassand, A. John Camm, Shinya Goto, Samuel Z. Goldhaber, Sylvia Haas, Gloria Kayani, Yukihiro Koretsune, Frank Misselwitz, Seil Oh, Jonathan P. Piccini, Alex Parkhomenko, Jitendra Pal Singh Sawhney, Janina Stepinska, Alexander G. G. Turpie, Freek W. A. Verheugt, Ajay K. Kakkar
Summary: The variability in outcomes for patients with newly diagnosed AF across countries cannot be explained by baseline characteristics and antithrombotic treatments. Mortality rates are correlated with Healthcare Access and Quality indices.
Letter
Cardiac & Cardiovascular Systems
Nana Pogosova, Jacqueline Bosch, Deepak L. Bhatt, Keith A. A. Fox, Stuart J. Connolly, Marco Alings, Peter Verhamme, Eva Muehlhofer, Olga Shestakovska, Salim Yusuf, John W. Eikelboom
Article
Cardiac & Cardiovascular Systems
Josephine Harrington, Anthony P. Carnicelli, Kaiyuan Hua, Lars Wallentin, Manesh R. Patel, Stefan H. Hohnloser, Robert P. Giugliano, Keith A. A. Fox, Ziad Hijazi, Renato D. Lopes, Sean D. Pokorney, Hwanhee Hong, Christopher B. Granger
Summary: Through meta-analysis of multiple research databases, it was found that standard-dose DOACs are safer and more effective than warfarin in patients with kidney dysfunction. While lower-dose DOACs do not significantly lower the incidence of bleeding or intracranial hemorrhage compared to standard-dose DOACs, they are associated with a higher incidence of stroke and systemic embolism as well as death. Therefore, these findings support the use of standard-dose DOACs over warfarin in patients with kidney dysfunction.
Editorial Material
Cardiac & Cardiovascular Systems
Florian A. Wenzl, Keith A. A. Fox, Thomas F. Luescher
EUROPEAN HEART JOURNAL
(2023)