Article
Transplantation
Luke Pickup, Charalampos Loutradis, Jonathan P. Law, Julia J. Arnold, Indranil Dasgupta, Pantelis Sarafidis, Jonathan N. Townend, Paul Cockwell, Charles J. Ferro
Summary: This study evaluated the incidence of acute kidney injury using pre-admission and admission creatinine levels and found that even minor increases in creatinine levels were associated with increased mortality. This can help clinicians identify patients at higher risk for adverse outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Kavish R. Patidar, Mobasshir A. Naved, Ananth Grama, Mohammad Adibuzzaman, Arzina Aziz Ali, James E. Slaven, Archita P. Desai, Marwan S. Ghabril, Lauren Nephew, Naga Chalasani, Eric S. Orman
Summary: This study investigated hospitalized patients with cirrhosis and acute kidney injury in the US and found that acute kidney disease developed in 1 in 3 patients, which was associated with worse survival and chronic kidney disease.
JOURNAL OF HEPATOLOGY
(2022)
Article
Transplantation
Rouvick M. Gama, Katherine Clark, Mahua Bhaduri, Amanda Clery, Kelly Wright, Priscilla Smith, Hayley Martin, Royce P. Vincent, Satish Jayawardene, Kate Bramham
Summary: The study found that approximately 1 in 40 pregnancies are affected by Pr-AKI, with common causes being infection, preeclampsia, and hemorrhage. While most women experienced recovery of renal function, about 10% did not recover. The research suggests the need for better understanding of the long-term impacts of Pr-AKI on pregnancy and renal outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Pediatrics
Satoshi Kimura, Kazuyoshi Shimizu, Tatsuo Iwasaki, Tomoyuki Kanazawa, Takashi Morimatsu, Takeru Hatano, Hiroshi Morimatsu
Summary: This study aimed to determine the incidence of unrecognized cardiac surgery-associated acute kidney injury (CSA-AKI) in pediatric cardiac patients and assess its association with clinical outcomes. The results show that unrecognized CSA-AKI is not rare and is associated with prolonged mechanical ventilation, high postoperative BNP level, and prolonged length of stay in hospital.
PEDIATRIC NEPHROLOGY
(2023)
Article
Urology & Nephrology
Cen Hong, Qiang Zhu, Yiling Li, Shanhong Tang, Su Lin, Yida Yang, Shanshan Yuan, Lichun Shao, Yunhai Wu, Bang Liu, Bimin Li, Fanping Meng, Yu Chen, Min Hong, Xingshun Qi
Summary: This retrospective multicenter study found that serum cystatin C (CysC) can accurately assess acute kidney injury (AKI), and AKI re-defined by CysC can better predict the in-hospital mortality of cirrhotic patients with acute gastrointestinal bleeding.
Review
Medicine, General & Internal
Yu-Long Yao, Yuan Gao
Summary: Evaluation of kidney function recovery is crucial for patients with acute kidney injury (AKI) as it impacts their quality of life. The standards for evaluating kidney function include conventional indices, biomarkers, and imaging methods of kidney function.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Pediatrics
W. Alton Russell, David Scheinker, Scott M. Sutherland
Summary: The method of baseline determination influences both the incidence of AKI and its association with clinical outcomes, highlighting the need for standardized criteria. Imputing baseline for all patients, even when preadmission creatinine is available, may identify a more clinically relevant subset of the disease.
PEDIATRIC NEPHROLOGY
(2021)
Article
Clinical Neurology
Kanta Tanaka, Masatoshi Koga, Mayumi Fukuda-Doi, Adnan Qureshi, Haruko Yamamoto, Kaori Miwa, Masafumi Ihara, Kazunori Toyoda
Summary: This study used group-based trajectory modeling to analyze blood pressure changes in patients with acute intracerebral hemorrhage receiving antihypertensive treatment, and found that different blood pressure trajectories were associated with different outcomes. Specifically, the high-to-low SBP group showed increased risks of death or disability and acute kidney injury.
Article
Pediatrics
Gopal Agrawal, Sanjay Wazir, Sidharth Kumar Sethi, Abhishek Tibrewal, Rohan Dhir, Naveen Bajaj, Naveen Parkash Gupta, Shishir Mirgunde, Jagdish Sahoo, Binesh Balachandran, Kamran Afzal, Anubha Shrivastava, Jyoti Bagla, Sushma Krishnegowda, Ananth Konapur, Kritika Soni, Vamsi Krishna Kolukula, Rupali Jangid, Timothy Bunchman, Rupesh Raina
Summary: This study aims to create the first prospective neonatal all-cause AKI data repository in India, describe the incidence of neonatal AKI in NICUs, determine risk factors and short-term/long-term outcomes. This will contribute to therapeutic advancements, understanding of epidemiological trends, risk factors and outcomes, and identification of disparities in management nationwide.
FRONTIERS IN PEDIATRICS
(2021)
Article
Urology & Nephrology
George Vasquez-Rios, Wonsuk Oh, Samuel Lee, Pavan Bhatraju, Sherry G. Mansour, Dennis G. Moledina, Faris F. Gulamali, Edward D. Siew, Amit X. Garg, Pinaki Sarder, Vernon M. Chinchilli, James S. Kaufman, Chi-yuan Hsu, Kathleen D. Liu, Paul L. Kimmel, Alan S. Go, Mark M. Wurfel, Jonathan Himmelfarb, Chirag R. Parikh, Steven G. Coca, Girish N. Nadkarni
Summary: This study identified four subphenotypes of acute kidney injury (AKI) with different clinical features and biomarker profiles, which were associated with longitudinal clinical outcomes.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Infectious Diseases
Silvijus Abramavicius, Vaidotas Galaune, Agile Tunaityte, Astra Vitkauskiene, Gintautas Gumbrevicius, Aurelija Radzeviciene, Romaldas Maciulaitis
Summary: The study found that current eGFR estimators for patients with acute kidney injury (AKI) pose risks of inaccuracy in renal function assessment and drug dosing, with the exception of the Cockcroft-Gault estimator, which is more appropriate.
Article
Medicine, General & Internal
Jiaye Liu, Tingyan Wang, Qingxian Cai, Deliang Huang, Liqin Sun, Qing He, Fu-Sheng Wang, Jun Chen
Summary: COVID-19 patients are at risk of acute kidney injury and continuous decline in estimated glomerular filtration rate during hospitalization, which can be early predicted by baseline factors. Some individuals still had renal dysfunction when finally discharged from hospital.
FRONTIERS IN MEDICINE
(2021)
Article
Critical Care Medicine
George Kuo, Jia-Jin Chen, Chieh-Li Yen, Pei -Chun Fan, Cheng-Chia Lee, Chih-Hsiang Chang
Summary: This study investigated the association between small increase in creatinine and subsequent severe AKI in ICU patients. The results showed that small creatinine elevation within the first 48 hours of ICU admission was strongly associated with AKI, kidney replacement therapy, and death. This association was more prominent in patients with normal baseline creatinine.
JOURNAL OF CRITICAL CARE
(2022)
Article
Critical Care Medicine
Yuxian Kuai, Min Li, Jiao Chen, Zhen Jiang, Zhenjiang Bai, Hui Huang, Lin Wei, Ning Liu, Xiaozhong Li, Guoping Lu, Yanhong Li
Summary: The incidence and staging of AKI vary depending on the definition and baseline SCr estimation method used. The modified KDIGO definition based on the Schwartz method may be the preferable approach for diagnosing pediatric AKI, showing high relevance to PICU mortality and providing promise for improving clinicians' ability to diagnose AKI in critically ill children.
Article
Anesthesiology
Moataz Maher Emara, Doaa Galal Diab, Amr Mohamed Yassen, Maha A. Abo-Zeid
Summary: This study aimed to investigate the role of mannitol as an oxygen-free radical scavenger in the prevention of early AKI after LDLT. The results showed that mannitol did not significantly reduce the incidence of early AKI or improve kidney function recovery.
BMC ANESTHESIOLOGY
(2022)
Editorial Material
Emergency Medicine
Martin Than, Sandra Richardson, John Pickering
EMERGENCY MEDICINE JOURNAL
(2022)
Article
Transplantation
Daniel Christiadi, Charles Simpson, Kate O'brien, Kylie Taylor, Grant Luxton, Monica Rossleigh, Jonathan Erlich, Zoltan H. Endre
Summary: Plasma cystatin C after oral protein loading can effectively assess kidney functional reserve in patients with Stage 3 and 4 chronic kidney disease. It can predict disease progression and prognosis.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Medicine, General & Internal
Cho-Han Chiang, Cho-Hung Chiang, John W. Pickering, Kiril M. Stoyanov, Derek P. Chew, Johannes T. Neumann, Francisco Ojeda, Nils A. Sorensen, Ke-Ying Su, Peter Kavsak, Andrew Worster, Kenji Inoue, Tonje R. Johannessen, Dan Atar, Michael Amann, Willibald Hochholzer, Arash Mokhtari, Ulf Ekelund, Raphael Twerenbold, Christian Mueller, Philipp Bahrmann, Nicolas Buttinger, Maureen Dooley, Onlak Ruangsomboon, Richard M. Nowak, Christopher R. DeFilippi, William F. Peacock, Tomas G. Neilan, Michael A. Liu, Wan-Ting Hsu, Gin Hoong Lee, Pui-Un Tang, Kevin Sheng-Kai Ma, Dirk Westermann, Stefan Blankenberg, Evangelos Giannitsis, Martin P. Than, Chien-Chang Lee
Summary: The diagnostic accuracy of the ESC 0/1-hour and 0/2-hour algorithms is higher in ruling out index AMI compared to the 0/3-hour algorithm, with higher sensitivities and negative predictive values.
ANNALS OF INTERNAL MEDICINE
(2022)
Article
Emergency Medicine
Annabel Vincent, Scott Pearson, John W. Pickering, James Weaver, Leanne Toney, Laura Hamill, Michael Hurrell, Martin Than
Summary: This retrospective study examined data from a 10-year period and found that modern MSCT has a sensitivity of 99.6% for aneurysmal SAH and 99.0% for all SAH within 48 hours of headache onset. The sensitivity for aneurysmal SAH was 100% within 24 hours of headache onset.
EMERGENCY MEDICINE JOURNAL
(2022)
Article
Clinical Neurology
Xin Huang, Yihan Li, Christopher Fowler, James D. Doecke, Yen Ying Lim, Candace Drysdale, Vicky Zhang, Keunha Park, Brett Trounson, Kelly Pertile, Rebecca Rumble, John W. Pickering, Robert A. Rissman, Floyd Sarsoza, Sara Abdel-Latif, Yong Lin, Vincent Dore, Victor Villemagne, Christopher C. Rowe, Jurgen Fripp, Ralph Martins, James S. Wiley, Paul Maruff, Jacobo E. Mintzer, Colin L. Masters, Ben J. Gu
Summary: This study examined leukocyte antigens in sporadic Alzheimer's disease (AD) and identified differentially expressed markers. A proposed panel of four leukocyte markers showed high predictive accuracy for PET A beta status. These findings were validated in independent cohorts, demonstrating the utility of leukocyte-based biomarkers for AD screening and diagnosis.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Hamish Jamieson, Prasad S. Nishtala, Hans Ulrich Bergler, Susan K. Weaver, John W. Pickering, Nagham J. Ailabouni, Rebecca Abey-Nesbit, Carolyn Gullery, Joanne Deely, Susan B. Gee, Sarah N. Hilmer, Dee Mangin
Summary: Polypharmacy is linked to poor outcomes in older adults. Targeted deprescribing of anticholinergic and sedative medications may be beneficial for frail older adults. However, our pharmacist-led deprescribing intervention did not reduce the anticholinergic/sedative load among frail older participants within 6 months.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Multidisciplinary Sciences
John W. Pickering, Richard Scrase, Richard Troughton, Hamish A. Jamieson
Summary: This study aimed to evaluate the value of adding blood biomarkers to needs assessments in predicting one-year survival rate in older adults. The research found that adding Brain Naturetic Peptide (BNP) improved the accuracy of the risk prediction model, particularly in patients without a diagnosis of congestive heart failure.
Article
Transplantation
Michael G. Collins, Magid A. Fahim, Elaine M. Pascoe, Carmel M. Hawley, David W. Johnson, Julie Varghese, Laura E. Hickey, Philip A. Clayton, John S. Gill, Kathryn B. Dansie, Rachael C. McConnochie, Liza A. Vergara, Charani Kiriwandeniya, Donna Reidlinger, Peter F. Mount, Laurence Weinberg, Colin J. McArthur, P. Toby Coates, Zoltan H. Endre, David Goodman, Kirsten Howard, Martin Howell, Jagadish S. Jamboti, John Kanellis, Jerome M. Laurence, Wai H. Lim, Steven J. McTaggart, Philip J. O'Connell, Helen L. Pilmore, Germaine Wong, Steven J. Chadban
Summary: This study investigates delayed graft function (DGF) and aims to determine whether using a low-chloride crystalloid solution (Plasma-Lyte 148) can reduce the risk of DGF. The study finds that the trial participants and nonparticipants have similar baseline characteristics, and the trial results are broadly applicable to deceased donor kidney transplantation practice worldwide.
TRANSPLANTATION DIRECT
(2022)
Article
Multidisciplinary Sciences
Ariel Graykowski, Ryan A. Lambert, Franck Marchis, Dorian Cazeneuve, Paul A. Dalba, Thomas M. Esposito, Daniel O'Conner Peluso, Lauren A. Sgro, Guillaume Blaclard, Antonin Borot, Arnaud Malvache, Laurent Marfisi, Tyler M. Powell, Patrice Huet, Matthieu Limagne, Bruno Payet, Colin Clarke, Susan Murabana, Daniel Chu Owen, Ronald Wasilwa, Keiichi Fukui, Tateki Goto, Bruno Guillet, Patrick Huth, Satoshi Ishiyama, Ryuichi Kukita, Mike Mitchell, Michael Primm, Justus Randolph, Darren A. Rivett, Matthew Ryno, Masao Shimizu, Jean-Pierre Toullec, Stefan Will, Wai-Chun Yue, Michael Camilleri, Kathy Graykowski, Ron Janetzke, Des Janke, Scott Kardel, Margaret Loose, John W. Pickering, Barton A. Smith, Ian M. Transom
Summary: On September 26, 2022, the DART spacecraft successfully collided with the satellite Dimorphos, which orbits the asteroid 65803 Didymos. This test aimed to determine the changes in Dimorphos' orbit and evaluate the effectiveness of deflecting potentially hazardous asteroids. Optical observations revealed that Dimorphos experienced a maximum brightening of 2.29 +/- 0.14 magnitudes upon impact, and it took approximately 23.7 +/- 0.7 days for Didymos to return to its pre-impact brightness. The study also estimated the minimum mass of ejecta to be 0.3-0.5% of Dimorphos' mass and observed a reddening effect in the ejecta upon impact.
Article
Geriatrics & Gerontology
Rebecca Abey-Nesbit, Hamish A. Jamieson, Hans Ulrich Bergler, Ngaire Kerse, John W. Pickering, Ruth Teh
Summary: This study found that cognitive impairment is the most common health issue for community-dwelling older adults in New Zealand. Cardiovascular disease has the highest mortality risk for all ethnic groups, and in the non-Maori/non-Pacific group, the risk of mortality with cognitive impairment is as high as the risk of cardiovascular disease. Additionally, there is an inverse relationship between age and cancer mortality risk. Important differences between ethnic groups are also reported.
Editorial Material
Emergency Medicine
John W. Pickering, Laura Joyce, Martin Than
CANADIAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Primary Health Care
Rory Miller, Garry Nixon, Tim Stokes, Michelle Smith, John W. Pickering, Talis Liepins, Martin Than
Summary: This study aimed to estimate the costs associated with assessing patients with low-risk chest pain using the rural accelerated chest pain pathway (RACPP) in rural general practice compared with transporting such patients to a distant emergency department (ED). The results showed that using the RACPP in general practice resulted in a median cost saving of NZ$1184 compared with transferring the same patient to ED.
JOURNAL OF PRIMARY HEALTH CARE
(2023)
Proceedings Paper
Computer Science, Artificial Intelligence
Andre M. Carrington, Paul W. Fieguth, Franz Mayr, Nick D. James, Andreas Holzinger, John W. Pickering, Richard Aviv
Summary: This paper presents a novel contribution to the state-of-art by defining a binary chance baseline to identify areas and points in a ROC plot that are more useful than chance. Examples of classifying benchmark data are provided.
MACHINE LEARNING AND KNOWLEDGE EXTRACTION, CD-MAKE 2022
(2022)
Proceedings Paper
Astronomy & Astrophysics
R. A. Lambert, F. Marchis, J. Asencio, G. Blaclard, L. A. Sgro, J. D. Giorgini, P. Plavchan, T. White, A. Verveen, T. Goto, P. Kuossari, N. Sethu, M. A. Loose, S. Will, K. Sibbernsen, J. W. Pickering, J. Randolph, K. Fukui, P. Huet, B. Guillet, O. Clerget, S. Stahl, N. Yoblonsky, M. Lauvernier, T. Matsumura, M. Yamato, J-M Laugier, O. Brodt-Vilain, A. Espudo, R. Kukita, S. Iida, S. Kardel, D. Green, P. Tikkanen, A. Douvas, M. Billiani, G. Knight, M. Ryno, G. Simard, R. Knight, M. Primm, B. Wildhagen, J. Poncet, T. Frachon, M. Shimizu, A. Jackson, B. Parker, G. Redfern, P. Nikiforov, E. Friday, K. Lincoln, J. Sweitzer, R. Mitsuoka, K. Cabral, A. Katterfeld, M. Fairfax
Summary: This article presents a coordinated campaign of observations using the network of Unistellar digital telescopes and citizen astronomers to monitor the brightness of the James Webb Space Telescope (JWST) as it undergoes various phases of deployment. The collected observations allowed for the detection of specific phases and variations in the lightcurve, demonstrating the power of a global array of small telescopes for conducting long-term scientific campaigns.
GROUND-BASED AND AIRBORNE TELESCOPES IX
(2022)
Article
Medical Informatics
Dimitrios Doudesis, Kuan Ken Lee, Jason Yang, Ryan Wereski, Anoop S. Shah, Athanasios Tsanas, Atul Anand, John W. Pickering, Martin P. Than, Nicholas L. Mills
Summary: A machine learning algorithm that accurately predicts the likelihood of myocardial infarction can be applied in routine clinical practice, improving the diagnosis and risk assessment for patients suspected of acute coronary syndrome.
LANCET DIGITAL HEALTH
(2022)