Article
Materials Science, Multidisciplinary
Yang Wan, Wenqiang Fang, Rika Wright Carlsen, Haneesh Kesari
Summary: Rotational head motions play a crucial role in traumatic brain injury, and there is a need for methods to quickly predict brain tissue strains and strain rates to estimate injury risk and guide protective equipment design. Idealized continuum mechanics based head models provide a simpler and faster approach to estimate brain strains and strain rates. In this study, a new head model accounting for finite rotations is proposed, which shows comparable strain predictions to a more detailed finite element head model. This model can serve as a basis for introducing finite rotations into more sophisticated head models in the future.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2023)
Review
Critical Care Medicine
David Hacker, Christopher A. Jones, Eyrsa Yasin, Sophie Preece, Holly Davies, Andrew Hawkins, Antonio Belli, Emily Paton
Summary: Cognitive outcomes were compared between mild traumatic brain injury (mTBI) with positive brain imaging (complicated mTBI) and mTBI with normal imaging (uncomplicated mTBI) as well as moderate to severe TBI. The findings showed that complicated mTBI had poorer cognitive outcomes than uncomplicated mTBI, but the deficits were not as severe as in moderate-severe TBI. The deficits in complicated mTBI were present in processing speed, memory, executive function, and language beyond 3 months post-injury.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Isabel Rosalie Arianne Retel Helmrich, David van Klaveren, Nada Andelic, Hester Lingsma, Andrew Maas, David Menon, Suzanne Polinder, Cecilie Roe, Ewout W. Steyerberg, Ernest Van Veen, Lindsay Wilson
Summary: This study aimed to examine the relationship between disability and health-related quality of life (HRQoL) following traumatic brain injury (TBI), while considering variation in personal, injury-related, and environmental factors.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pediatrics
Xenophon Sinopidis, Panagiotis Kallianezos, Constantinos Petropoulos, Despoina Gkentzi, Eirini Kostopoulou, Sotirios Fouzas, Theodore Dassios, Aggeliki Vervenioti, Ageliki Karatza, Stylianos Roupakias, Antonios Panagidis, Evangelos Blevrakis, Eleni Jelastopulu
Summary: This study aims to evaluate the stress of children with mild head injuries and their parents' relevant perception during the early post-traumatic period. Results showed that 33.7% of children and 19.0% of parents were diagnosed with stress after one week, and 9.9% of children and 3.9% of parents after one month. It indicates that mild head injuries can have an impact on the emotional well-being of children and should not be overlooked.
Article
Critical Care Medicine
Rune Hatlestad Karlsen, Simen Berg Saksvik, Jonas Stenberg, Astri Johansen Lundervold, Alexander Olsen, Ida Rautio, Line Folvik, Asta Kristine Haberg, Anne Vik, Justin E. Karr, Grant L. Iverson, Toril Skandsen
Summary: This study examined the subacute cognitive effects of mild traumatic brain injury (MTBI) using neuropsychological tests and found associations between injury severity and cognitive function. Different types of tests showed varying levels of cognitive impairment, with MTBI patients generally experiencing good neuropsychological outcomes 2 weeks after injury. No specific tests were found to be more sensitive to subtle cognitive deficits in this study.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Medicine, General & Internal
Francesco Corallo, Viviana Lo Buono, Rocco Salvatore Calabro, Maria Cristina De Cola
Summary: The study suggests that patients with traumatic brain injury may experience significant improvement in cognitive function after cranioplasty, particularly four years post-surgery. This highlights the importance of cranioplasty in the complex management of TBI patients, demonstrating the potential long-term cognitive benefits following the surgical procedure.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
William Torregrossa, Michele Torrisi, Rosaria De Luca, Carmela Casella, Carmela Rifici, Mirjam Bonanno, Rocco Salvatore Calabro
Summary: Traumatic brain injury is damage to the brain occurring after birth, resulting in deterioration of cognitive, behavioural, and emotional functions. Neuropsychological evaluation can assist clinicians in assessing the patient's condition, reaching differential diagnoses, and developing intervention strategies. However, it is difficult to determine the most suitable assessment tool for different brain injury conditions considering the various rating scales available.
Article
Clinical Neurology
Martina Stippler, Stacey Keith, Emmalin B. Nelton, Charles S. Parsons, Jennifer Singleton, Leslie A. Bilello, Carrie D. Tibbles, Roger B. Davis, Jonathan A. Edlow, Carlo L. Rosen
Summary: The study showed that using a head CT scan triage algorithm can significantly reduce the number of routine follow-up head CT scans in complicated mild traumatic brain injury patients, while ensuring no missed injuries or delayed surgeries. Adoption of the protocol was high among all services managing TBI patients.
Article
Behavioral Sciences
Claire Kostelnik, Irwin Lucki, Kwang H. Choi, Caroline A. Browne
Summary: This review outlines the increased risk of PTSD following mTBI in military populations and emphasizes the importance of establishing translationally relevant animal models. It also evaluates the translational relevance of fear conditioning paradigms and addresses the lack of research on fear memory enhancement over time post mTBI. Additionally, potential neurobiological substrates implicated in altered fear memory post mTBI are discussed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Critical Care Medicine
Kelly M. M. Naugle, Tyler Nguyen, Jared A. A. Smith, Jonathan Saxe, Fletcher A. A. White
Summary: Recent research examined race differences in pain-related outcomes following mild traumatic brain injury (TBI). The study found that African Americans with mild TBI reported more severe headache pain, worse pain modulation, higher pain sensitivity, and greater pain catastrophizing compared to Caucasians with mild TBI. These race differences were not observed in the healthy TBI-free control group. The results suggest that psychological and pain modulatory profiles following mild TBI could contribute to intense and persistent headaches among African Americans.
JOURNAL OF NEUROTRAUMA
(2023)
Article
Clinical Neurology
Yegeta Wondafrash Habte, Hengameh B. Pajer, Temesgen Beyene Abicho, Yohannes Feleke, Yacob Alemu Bizuneh, Belinda Shao, Heather S. Spader
Summary: This study validated the applicability of the Canadian CT Head Rule and the New Orleans Criteria in an Ethiopian population, demonstrating their high sensitivity in ruling out clinically important brain injury and potentially reducing the need for CT scans in low-resource settings.
WORLD NEUROSURGERY
(2023)
Article
Neurosciences
Ming-Xiong Huang, Charles W. Huang, Deborah L. Harrington, Ashley Robb-Swan, Annemarie Angeles-Quinto, Sharon Nichols, Jeffrey W. Huang, Lu Le, Carl Rimmele, Scott Matthews, Angela Drake, Tao Song, Zhengwei Ji, Chung-Kuan Cheng, Qian Shen, Ericka Foote, Imanuel Lerman, Kate A. Yurgil, Hayden B. Hansen, Robert K. Naviaux, Robert Dynes, Dewleen G. Baker, Roland R. Lee
Summary: Combat-related mild traumatic brain injury is a major cause of disabilities in Veterans and military personnel. A novel deep-learning neural network method, 3D-MEGNET, was developed and applied to resting-state magnetoencephalography data, showing excellent diagnostic accuracy in distinguishing cmTBI individuals from healthy controls. The all-frequency model outperformed individual band models, indicating the importance of optimal combinations of regions and frequencies in neuroimaging for behavioral relevance.
HUMAN BRAIN MAPPING
(2021)
Article
Neurosciences
Ashley L. Ware, Keith Owen Yeates, Bryce Geeraert, Xiangyu Long, Miriam H. Beauchamp, William Craig, Quynh Doan, Stephen B. Freedman, Bradley G. Goodyear, Roger Zemek, Catherine Lebel
Summary: Sophisticated network-based approaches such as structural connectomics may help detect a biomarker of mild traumatic brain injury (mTBI) in children. This study compared the structural connectome of children with mTBI or mild orthopedic injury (OI) to that of typically developing (TD) children, finding that both mTBI and OI groups demonstrated reduced global and regional network efficiency and segregation compared to TD children. This suggests a general effect of childhood injury on brain structure that could reflect pre- and postinjury factors.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Zachary M. Weil, Kate Karelina, Bailey Whitehead, Ruth Velazquez-Cruz, Robin Oliverio, Mark Pinti, Divine C. Nwafor, Samuel Nicholson, Julie A. Fitzgerald, John Hollander, Candice M. Brown, Ning Zhang, A. Courtney DeVries
Summary: Recent studies have shown that traumatic brain injury (TBI) can worsen outcomes after stroke by affecting neuroimmune and neurometabolic functions. In a mouse model, TBI led to larger stroke infarcts, more severe functional deficits, and increased neuroinflammation. Treatment with the insulin sensitizing drug pioglitazone was able to prevent the exacerbation of ischemic outcomes caused by TBI, suggesting that metabolic dysfunction plays a role in these processes.
EXPERIMENTAL NEUROLOGY
(2021)
Editorial Material
Substance Abuse
Hillary Samples
Article
Substance Abuse
Stephen Crystal, Molly Nowels, Hillary Samples, Mark Olfson, Arthur Robin Williams, Peter Treitler
Summary: This study found that repeat overdose is common among patients with medically-treated opioid overdose. The risk factors for repeat overdose vary depending on the type of opioid involved, which has implications for intervention strategies. Medication for opioid use disorder (MOUD) following an index overdose involving heroin/synthetic opioids is associated with a significant reduction in the risk of repeat overdose.
DRUG AND ALCOHOL DEPENDENCE
(2022)
Editorial Material
Pediatrics
Greta Bushnell, Hillary Samples, Tobias Gerhard, Diane P. Calello, Mark Olfson
Article
Medicine, General & Internal
Thuy Nguyen, Engy Ziedan, Kosali Simon, Jennifer Miles, Stephen Crystal, Hillary Samples, Sumedha Gupta
Summary: This study found that the COVID-19 pandemic resulted in a decrease in filled buprenorphine prescriptions for members of racial and ethnic minority groups, but not for White individuals. These findings suggest that members of racial and ethnic minority groups experienced greater loss in access to buprenorphine during the pandemic across different payer types.
Article
Medicine, General & Internal
Pia M. Mauro, Sarah Gutkind, Erin M. Annunziato, Hillary Samples
Summary: In this cross-sectional study, low utilization of MOUD was found among people who may have needed treatment for OUD, especially adolescents and older adults. The high prevalence of contacts with the health care and legal systems suggests significant gaps in care delivery or linkage.
Editorial Material
Psychiatry
Arthur Robin Williams, Christine M. Mauro, Tianshu Feng, Amanda Wilson, Angelo Cruz, Mark Olfson, Stephen Crystal, Hillary Samples, Lisa Chiodo
AMERICAN JOURNAL OF PSYCHIATRY
(2023)
Editorial Material
Rehabilitation
Donna K. Broshek, Jamie E. Pardini, Stanley A. Herring
Article
Substance Abuse
Leah K. Hamilton, Katherine Wheeler-Martin, Corey S. Davis, Silvia S. Martins, Hillary Samples, Magdalena Cerda
Summary: This study classified and evaluated the laws and provisions addressing the opioid epidemic based on expert consensus. The results showed that Good Samaritan laws, naloxone access laws, and pain management clinic laws were considered the most helpful provisions, while drug-induced homicide laws were rated the most harmful. These ratings provide a foundation for evaluating the overdose policy environment in each state.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2022)
Article
Health Care Sciences & Services
Peter Treitler, Hillary Samples, Richard Hermida, Stephen Crystal
Summary: The implementation of New Jersey's opioid prescribing limit policy led to an increase in new opioid prescriptions and initial prescriptions with supply on day 90. While the policy did decrease the percentage of new prescriptions with > 5 days' supply, it did not result in an overall decline in new opioid prescriptions or in the rate of transitions to long-term use.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Behavioral Sciences
Racheal M. Smetana, Prem P. Batchala, Bern G. Lee, Tamer Albataineh, Donna K. Broshek, Nathan B. Fountain, Salma Abbas, Mark Quigg
Summary: This study evaluated the pathophysiology behind verbal learning/memory deficits in patients with mesial temporal lobe epilepsy (MTLE) using 18-fluorodeoxyglucose positron emission tomography (FDG-PET). The results showed that verbal memory deficits were associated with hypometabolism in limbic structures, perisylvian cortex, and contralateral limbic and nonlimbic structures. This study has important implications for epilepsy surgery protocols that use neuropsychological data and FDG-PET to assess surgical risks.
EPILEPSY & BEHAVIOR
(2023)
Article
Medicine, General & Internal
Peter Treitler, Molly Nowels, Hillary Samples, Stephen Crystal
Summary: This study assessed the impact of New Jersey Medicaid initiatives on buprenorphine prescribing trends and found an upward trend in the number of prescriptions and recipients following the implementation of the initiatives. However, no change was observed in the retention rate of buprenorphine treatment episodes lasting 180 days or more, indicating a challenge in maintaining long-term treatment.
Article
Substance Abuse
Emilie Bruzelius, Magdalena Cerda, Corey S. Davis, Victoria Jent, Katherine Wheeler-Martin, Christine M. Mauro, Stephen Crystal, Katherine M. Keyes, Hillary Samples, Deborah S. Hasin, Silvia S. Martins
Summary: The distribution and access to naloxone are associated with a decrease, rather than an increase, in lifetime heroin and injection drug use among adolescents. This suggests that naloxone access does not promote high-risk substance use behaviors among teenagers.
INTERNATIONAL JOURNAL OF DRUG POLICY
(2023)
Article
Public, Environmental & Occupational Health
Hillary Samples, Molly A. Nowels, Arthur R. Williams, Mark Olfson, Stephen Crystal
Summary: This study found that receiving medication-assisted treatment (such as buprenorphine treatment) after a nonfatal opioid overdose significantly reduced the risk of fatal opioid overdose. However, less than 1 in 20 individuals received such treatment, highlighting the need to strengthen care connections after critical opioid-related events, particularly for vulnerable groups.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE
(2023)
Article
Substance Abuse
Jennifer Miles, Peter Treitler, Richard Hermida, Amesika N. Nyaku, Kosali Simon, Sumedha Gupta, Stephen Crystal, Hillary Samples
Summary: The study revealed racial disparities in timely access to medication for opioid use disorder among Medicare disability beneficiaries, highlighting the need to improve healthcare services for underserved minority groups and increase the accessibility of office-based buprenorphine prescribing.
DRUG AND ALCOHOL DEPENDENCE
(2023)
Article
Health Care Sciences & Services
Jennifer Miles, Peter Treitler, James Lloyd, Hillary Samples, Anais Mahone, Richard Hermida, Sumedha Gupta, Alexandra Duncan, Vanessa Baaklini, Kosali I. Simon, Stephen Crystal
Summary: This study analyzed Medicare Part D claims from 2015-19 to identify racial and ethnic disparities in buprenorphine receipt among Medicare disability beneficiaries with opioid use disorder or overdose. The findings showed persistent high disparities, especially for Black beneficiaries, suggesting the need for targeted interventions and policies.