Review
Infectious Diseases
Giovanni Autore, Luca Bernardi, Filippo Ghidini, Claudio La Scola, Alberto Berardi, Giacomo Biasucci, Federico Marchetti, Andrea Pasini, Maria Elena Capra, Claudia Castellini, Vera Cioni, Sante Cantatore, Andrea Cella, Francesca Cusenza, Alessandro De Fanti, Elisa Della Casa Muttini, Margherita Di Costanzo, Alessandra Dozza, Claudia Gatti, Cristina Malaventura, Luca Pierantoni, Giovanni Parente, Gabriella Pelusi, Serafina Perrone, Laura Serra, Francesco Torcetta, Enrico Valletta, Gianluca Vergine, Francesco Antodaro, Andrea Bergomi, Jennifer Chiarlolanza, Laura Leoni, Franco Mazzini, Roberto Sacchetti, Agnese Suppiej, Lorenzo Iughetti, Andrea Pession, Mario Lima, Susanna Esposito
Summary: Low-dose continuous antibiotic prophylaxis (CAP) is commonly used to prevent urinary tract infections (UTIs) in children, but its efficacy is controversial. This systematic review found that CAP has a limited role in preventing UTI recurrences and complications in children, while also posing a risk of emerging antimicrobial resistances.
Article
Pharmacology & Pharmacy
Jumpei Saito, Sayaka Miyamoto, Mayumi Yamada, Akimasa Yamatani, Fabrice Ruiz, Thibault Vallet
Summary: This study investigated the acceptability of cefaclor for pediatric UTI prevention and found that most patients exhibited good adherence to this medication. However, requirements for greater dosing frequency or poor acceptability in certain patients could potentially impact adherence to the treatment.
Review
Pharmacology & Pharmacy
George G. Zhanel, Christina Deng, Sheryl Zelenitsky, Courtney K. Lawrence, Heather J. Adam, Alyssa Golden, Liam Berry, Frank Schweizer, Michael A. Zhanel, Neal Irfan, Denice Bay, Philippe Lagace-Wiens, Andrew Walkty, Lionel Mandell, Joseph P. Lynch, James A. Karlowsky
Summary: Lefamulin is a novel oral and intravenous pleuromutilin developed for community-acquired bacterial pneumonia, with a unique mechanism of action and broad-spectrum antibacterial activity. It has been approved by FDA, EMA, and Health Canada for the treatment of CABP.
Article
Multidisciplinary Sciences
Richard Childers, Ben Liotta, Jesse Brennan, Phoebe Wang, Jacob Kattoula, Thien Tran, Henry Montilla-Guedez, Edward M. Castillo, Gary Vilke
Summary: This study observed the association between urine testing and inappropriate antibiotic use as well as delayed discharge in discharged ED patients at risk of urinary tract infection (UTI) misdiagnosis. The results showed that urine testing was linked to inappropriate antibiotic use and longer length of stay. Performing urine testing on patients without specific UTI symptoms may cause more harm than benefit.
Article
Infectious Diseases
Nicolas Eduard Frei, Sarah Draeger, Maja Weisser, Michael Osthoff
Summary: This study assessed the duration of antibiotic treatment for diverticulitis, complicated urinary tract infection (UTI), and endocarditis, and found that prolonged courses of antibiotic treatment were common and adherence to treatment guidelines was poor.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Kelly C. Gamble, Dusten T. Rose, Julia Sapozhnikov
Summary: The study aimed to evaluate the clinical outcomes of oral step-down antibiotics compared with continued intravenous therapy in non-bacteremic urinary tract infections. The results showed no significant difference between the two treatment groups in terms of clinical failure, readmission rate, and other outcomes. However, the switch group was associated with reduced hospital length of stay and antibiotic costs.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Article
Infectious Diseases
Brian N. Malley, Jonathan Yabes, Elizabeth H. Gimbel, Chung-Chou H. Chang, Donald A. Yealy, Michael Fine, Derek M. Angus, David T. F. Huang
Summary: The Procalcitonin Antibiotic Consensus Trial (ProACT) found that providing a procalcitonin antibiotic prescribing guideline to hospital-based clinicians did not reduce antibiotic use. The study aimed to determine the threshold adherence rate for reducing antibiotic use and to explore opportunities to increase adherence.
BMC INFECTIOUS DISEASES
(2023)
Article
Orthopedics
Helene Bocle, Jean-Philippe Lavigne, Nicolas Cellier, Julien Crouzet, Pascal Kouyoumdjian, Albert Sotto, Paul Loubet
Summary: The study compared the effect of early and late intravenous-to-oral antibiotic switch on treatment failure in Staphylococcus aureus prosthetic bone and joint infection, with results showing that early oral switch can reduce the treatment failure rate. Infections with methicillin-resistant S. aureus, obesity, and non-conventional empiric antibiotic therapy were significantly associated with treatment failure.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Infectious Diseases
Gregor John, Eric Mugnier, Etienne Pittet, Dominique Marianne Staehli, Olivier Clerc, Alain Foguena Kenfak, Andreas Konasch, Reto Lienhard, Daniel Genne
Summary: Urinary culture sensitivity decreases rapidly after administering empirical antibiotics, highlighting the impact of antibiotic treatment on urine culture results.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Review
Infectious Diseases
Susanna Esposito, Giacomo Biasucci, Andrea Pasini, Barbara Predieri, Gianluca Vergine, Antonella Crisafi, Cristina Malaventura, Luca Casadio, Marcello Sella, Luca Pierantoni, Claudia Gatti, Letizia Paglialonga, Chiara Sodini, Claudio La Scola, Luca Bernardi, Giovanni Autore, Giulia Dal Canto, Alberto Argentiero, Sante Cantatore, Martina Ceccoli, Alessandro De Fanti, Agnese Suppiej, Marcello Lanari, Nicola Principi, Andrea Pession, Lorenzo Iughetti
Summary: Febrile urinary tract infection (UTI) is a common and serious bacterial illness in children. Early effective antibiotic treatment is essential, but antibiotic resistance is increasing, making it more difficult to choose the best therapy. Efforts to reduce and rationalize antibiotic consumption, as well as antibiotic stewardship, are important in limiting the emergence of resistance.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Oncology
Shigeo Ishikawa, Iku Yamamori, Satoshi Takamori, Kenichiro Kitabatake, Kaoru Edamatsu, Ayako Sugano, Hiroyuki Oizumi, Hirohisa Kato, Jun Suzuki, Kaito Sato, Kazuyuki Yusa, Mitsuaki Sadahiro, Mitsuyoshi Iino
Summary: In lung cancer surgery patients, factors such as older age, postoperative complications, increased intraoperative bleeding, more invasive operative approaches (such as open surgery), and lack of perioperative oral care intervention were significantly associated with prolonged postoperative hospital stay. Additionally, older age and longer operative time were identified as significant independent risk factors for postoperative respiratory infections.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Geriatrics & Gerontology
Bethany M. Gilbert, Louise O'Keefe, Natalie Baker
Summary: There is growing evidence supporting the use of antibiotic stewardship programs (ASP) in various healthcare settings due to their association with improved patient outcomes, reduced resistance, and better healthcare costs. However, research on this evidence in long-term care facilities is limited. This study evaluated the ASP for urinary tract infection (UTI) management in a long-term care facility. It found improvements in appropriate diagnosis and antibiotic prescribing for UTI, but could not draw conclusions on the impact on patient outcomes. The ASP was considered beneficial in the facility, highlighting the need for sustained commitment from facility leadership and healthcare providers. Nurse practitioners have the necessary skills to support facilities in educating and implementing systematic programs for judicious antibiotic prescribing.
Article
Urology & Nephrology
Jennifer T. Anger, Brooke R. Bixler, Rebecca S. Holmes, Una J. Lee, Yahir Santiago-Lastra, Shelley S. Selph
Summary: The purpose of this study is to update the 2019 guideline on recurrent uncomplicated urinary tract infections in women by the American Urological Association. The study utilized a systematic review and literature review to gather new evidence and make revisions to the guideline. The updates primarily focused on recent publications related to antibiotic prophylaxis, non-antibiotic prophylaxis, and estrogen therapy.
JOURNAL OF UROLOGY
(2022)
Article
Immunology
Tariq Azamgarhi, Ashik Shah, Simon Warren
Summary: The study demonstrated that implementing the findings of the OVIVA trial into clinical practice, with follow-up by an established OPAT service for patients on oral antibiotics, is safe and effective. Two-thirds of patients were switched to suitable oral antibiotic regimens, leading to reductions in hospital length of stay and antibiotic costs.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Amber M. M. Goedken, Kendra Y. Y. Foster, Erika J. J. Ernst
Summary: Females and males with recurrent urinary tract infections may receive prescription prophylaxis to reduce the infection frequency. Little is known about how prescription prophylaxis differs between patients meeting and exceeding the minimum threshold for recurrent urinary tract infections. This study aimed to estimate the association between infection frequency and receipt of prescription prophylaxis and describe the type of prescription prophylaxis initiated. The findings suggest that the odds of receiving prophylaxis were greater in patients with three or more infections compared to those with only two infections, and the type of prophylaxis used differed between the two groups.
Article
Immunology
Maia Simon, Ouarda Pereira, Marlies E. J. L. Hulscher, Jeroen Schouten, Nathalie Thilly, Celine Pulcini
Summary: The study aimed to provide a set of quantity metrics and proxy indicators for estimating the volume and appropriateness of antibiotic use in nursing homes. The research found significant variability in antibiotic use volume between nursing homes, with low performance scores for proxy indicators but good clinimetric properties for some indicators.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Dominique Lescure, Anja Haenen, Sabine de Greeff, Andreas Voss, Anita Huis, Marlies Hulscher
Summary: Hand hygiene compliance of nursing staff in LTCFs is influenced by both setting-specific and setting-transcending determinants. Nurses must balance hygienic practices, acute care needs, and creating a homelike environment for residents, which affects compliance. Interventions should be selected based on theoretical foundations and tailored to address these determinants.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Article
Immunology
Colette Smit, Anders Boyd, Bart J. A. Rijnders, Thijs J. W. van de Laar, Eliane M. Leyten, Wouter F. Bierman, Kees Brinkman, Mark A. A. Claassen, Jan den Hollander, Anne Boerekamps, Astrid M. Newsum, Janke Schinkel, Maria Prins, Joop E. Arends, Eline L. M. Op de Coul, Marc van der Valk, Peter Reiss
Summary: The incidence of HCV infections in individuals with HIV in the Netherlands has decreased since 2015, with a significant rate of reinfection observed mainly in men who have sex with men, highlighting the need for additional preventive measures.
Article
Infectious Diseases
M. C. Kallen, M. E. J. L. Hulscher, B. Elzer, S. E. Geerlings, P. D. van der Linden, S. Teerenstra, S. Natsch, B. C. Opmeer, J. M. Prins
Summary: The study compared three methods of measuring and providing feedback on hospital antibiotic use in developing AMS interventions, finding that feedback on quality was more commonly used to identify improvement targets and was preferred over feedback on quantity; consistent use of implementation tool may increase effectiveness of AMS intervention.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Oncology
Ramon P. van der Zee, Carel J. M. van Noesel, Ivonne Martin, Timo J. ter Braak, Danielle A. M. Heideman, Henry J. C. de Vries, Jan M. Prins, Renske D. M. Steenbergen
Summary: DNA methylation markers show high accuracy for detecting AIN3+ in both HIV-positive and HIV-negative risk groups, supporting the broad application of methylation analysis in anal cancer prevention programs.
MOLECULAR ONCOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Marieke J. Spijk-de Jonge, Julia M. Weijers, Steven Teerenstra, Glyn Elwyn, Mart A. F. J. van de Laar, Piet L. C. M. van Riel, Anita M. P. Huis, Marlies E. J. L. Hulscher
Summary: This study evaluated the effectiveness of an intervention to improve disease activity-based management of rheumatoid arthritis (RA). The intervention, called DAS-pass strategy, aimed to increase patients' knowledge about disease activity and empower them to participate in treatment decisions. Although the intervention did not significantly affect patient empowerment, attitudes towards medication, or disease activity, it did lead to a significant improvement in knowledge about disease activity among the intervention group compared to the control group, particularly for patients with low baseline knowledge.
PATIENT EDUCATION AND COUNSELING
(2022)
Review
Infectious Diseases
Ali Auzin, Menoeska Spits, Evelina Tacconelli, Jose Rodriguez-Bano, Marlies Hulscher, Eddy Adang, Andreas Voss, Heiman Wertheim
Summary: This scoping review identifies the thresholds used for changing empirical antibiotic therapies (EATs) and the criteria they are based on. The study finds that the thresholds are limited and often based on expert opinion estimates, resulting in a broad range. Standardization is needed to support guideline development and treatment decisions.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Multidisciplinary Sciences
R. I. Helou, C. M. Waltmans-den Breejen, J. A. Severin, M. E. J. L. Hulscher, A. Verbon
Summary: This study evaluated a COVID-19 app designed for healthcare workers and its user experience. The results showed that the app was widely used in hospitals and had high user satisfaction. The study suggests that an app with local hospital policies is valuable during a pandemic.
Article
Infectious Diseases
Caroline Emilie, Phebe de Nocker, Nadia Saidani, Mark Gilchrist, R. Andrew Seaton, Sanjay Patel, Guillaume Beraud, Diamantis Kofteridis, Jeroen Schouten, Nathalie Thilly, Marvin Berrevoets, Marlies Hulscher, Franky Buyle, Celine Pulcini
Summary: Delivery of parenteral antimicrobials in non-inpatient settings (DPANS) varies among European countries, with the availability and organization of DPANS being highly heterogeneous. Most countries provide DPANS through specialized outpatient parenteral antimicrobial therapy (OPAT) services or infusion services, but only a few have formal OPAT team structures with specifically trained staff. Some countries rely on ad hoc arrangements for DPANS. The majority of countries cover the costs of DPANS for patients managed by specialized OPAT/infusion services.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Review
Infectious Diseases
Robin M. E. Janssen, Anke J. M. Oerlemans, Johannes G. Van der Hoeven, Jaap Ten Oever, Jeroen A. Schouten, Marlies E. J. L. Hulscher
Summary: This review examines the behavioral determinants that contribute to the prolongation of antibiotic therapy in daily hospital practice. The findings reveal that these determinants are largely related to individual healthcare professionals' knowledge, skills, and cognition, as well as their interactions. Additionally, certain determinants are identified that explain the variation in duration for different pathogens, diseases, and patient, professional, or hospital department characteristics.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Review
Infectious Diseases
Samuel Afari-Asiedu, Martha Ali Abdulai, Alma Tostmann, Ellen Boamah-Kaali, Kwaku Poku Asante, Heiman F. L. Wertheim, Marlies Hulscher
Summary: This review examines the effectiveness of interventions aimed at improving antibiotic dispensing practices at the community level in low- and middle-income countries. The results indicate that educational meetings, distribution of educational materials, and educational outreach meetings are effective strategies for improving antibiotic dispensing.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Public, Environmental & Occupational Health
Anja Haenen, Sabine de Greeff, Andreas Voss, Janine Liefers, Marlies Hulscher, Anita Huis
Summary: Hand hygiene compliance is low in long-term care facilities and is influenced by multiple factors, which vary among different cadres of staff. Strategies to improve hand hygiene should consider these determinants and their variations across different staff positions.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2022)
Article
Immunology
Anne C. de Munter, Jeannine L. A. Hautvast, Wilhelmina L. M. Ruijs, D. Henri Spaan, Marlies E. J. L. Hulscher, Robert A. C. Ruiter
Review
Psychology, Biological
Daphne Bussink-Voorend, Jeannine L. A. Hautvast, Lisa Vandeberg, Olga Visser, Marlies E. J. L. Hulscher
Summary: This systematic review examines the concept of vaccine hesitancy and finds that the term is used inconsistently. It suggests defining vaccine hesitancy as a psychological state of indecisiveness that people may experience when making a vaccination decision.
NATURE HUMAN BEHAVIOUR
(2022)
Article
Infectious Diseases
Hester H. Stoorvogel, Marlies E. J. L. Hulscher, Heiman F. L. Wertheim, Ed P. F. Yzerman, Maarten Scholing, Jeroen A. Schouten, Jaap ten Oever
Summary: This study assessed the organization of outpatient parenteral antimicrobial therapy (OPAT) in Dutch acute care hospitals and identified barriers and potential improvements. The presence of an OPAT program was associated with well-organized OPAT care. Implementing a team-based OPAT program could contribute to improvements. The observed variations provide leads for further research, guidelines, and practical implementation programs.