Article
Multidisciplinary Sciences
Ashleigh S. Paparella, Briana L. Aboulache, Rajesh K. Harijan, Kathryn S. Potts, Peter C. Tyler, Vern L. Schramm
Summary: Clostridium difficile produces toxins TcdA and TcdB causing diarrhea by affecting host cell functions using UDP-glucose, leading to disease onset. Researchers identified potential therapeutic approach using transition state analogue iminosugars.
NATURE COMMUNICATIONS
(2021)
Review
Infectious Diseases
Helen S. Lee, Kamryn Plechot, Shruti Gohil, Jennifer Le
Summary: Clostridium difficile infection (CDI) is a significant healthcare-associated infection with varying diagnostic methods. Overdiagnosis from highly sensitive tests may lead to unnecessary treatment and adverse outcomes. It is important to optimize the sensitivity and specificity of laboratory tests to differentiate clinical CDI from colonization.
INFECTIOUS DISEASES AND THERAPY
(2021)
Article
Biotechnology & Applied Microbiology
Meng Wang, Zifeng Deng, Yanmei Li, Yi Ma, Jufang Wang
Summary: A novel lytic protein Cw1-CWB2 with high binding specificity and strong lytic activity has been designed in this study for combating C. difficile.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Medicine, General & Internal
Ibrahim A. Al-Zahrani
Summary: Clostridioides difficile (C. difficile) infection is a global threat to many healthcare settings. Excessive use of antimicrobials, lack of optimal antibiotic policies, and suboptimal infection control practices have fueled the development of this health issue. Prudent use of antimicrobials and simple infection control measures can significantly reduce infection rates.
SAUDI MEDICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Anna Esser, Guenter Mayer
Summary: The glmS ribozymes of C. difficile and L. monocytogenes were validated and characterized, showing unique properties such as discrimination between co-factors and activity at low temperatures, while relying on glucosamine-6-phosphate and divalent cations for cleavage reactions.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Genetics & Heredity
Bilal Ahmed Abbasi, Aishwarya Dharan, Astha Mishra, Devansh Saraf, Irsad Ahamad, Prashanth Suravajhala, Jayaraman Valadi
Summary: In this study, the genomes of six strains of Clostridium difficile were annotated and characterized using in silico approaches. The functional properties of proteins involved in the pathophysiology of the disease were identified, providing valuable information for understanding the biological nature of the strains and developing pharmaceutical targets.
FRONTIERS IN GENETICS
(2022)
Article
Immunology
Malin Inghammar, Henrik Svanstrom, Marianne Voldstedlund, Mads Melbye, Anders Hviid, Kare Molbak, Bjorn Pasternak
Summary: In a nationwide study among adults in Denmark, it was found that the use of PPIs is associated with a moderately increased risk of community-associated Clostridium difficile infection. The elevated risk remained up to 1 year after the end of PPI treatment.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Surgery
Young Il Kim, Chang Sik Yu, Yang Soo Kim, Chan Wook Kim, Jong Lyul Lee, Yong Sik Yoon, In Ja Park, Seok-Byung Lim, Jin Cheon Kim
Summary: Adjuvant chemotherapy and colorectal anastomosis leakage increase the risk of Clostridium difficile infection, and patients with Clostridium difficile infection also have a higher risk of anastomosis leakage after rectal surgery.
Editorial Material
Medicine, General & Internal
Leslie L. Chang, Jessica Allegretti, Andrew M. Skinner, Erik R. Dubberke
Summary: This article presents a case study of a patient who was recently treated for C. difficile infection and now requires intravenous antibiotics. It includes two essays, one advocating for the use of oral vancomycin for prophylaxis against C. difficile, and the other arguing against it.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Microbiology
Mahmoud Fayez, Waleed R. El-Ghareeb, Ahmed Elmoslemany, Saleem J. Alsunaini, Mohamed Alkafafy, Othman M. Alzahrani, Samy F. Mahmoud, Ibrahim Elsohaby
Summary: The study investigated the presence of Clostridium perfringens and Clostridioides difficile in camel minced meat samples collected from small butcher shops and supermarkets in Al-Ahsa Governorate, Saudi Arabia. It was found that most isolates exhibited resistance to at least one antimicrobial, with some showing multidrug resistance. This highlights the importance of enforcing food safety standards and conducting regular inspections in abattoirs, small butcher shops, and supermarkets.
Article
Biotechnology & Applied Microbiology
Jianfeng Wang, Chu Yang, Chao Zhang, Xiaoyan Mao, An Lizhe
Summary: In this study, the genome of Clostridium difficile was studied using metagenomic technology, revealing its gene sequence information and potential toxicological genes. Through gene function analysis and pathogenicity analysis, the metabolism activity, catalytic activity, carbohydrate-active enzyme genes and other aspects of the bacterium were understood, and an assessment was made on its virulence genes.
Review
Multidisciplinary Sciences
Tebelay Dilnessa, Alem Getaneh, Workagegnehu Hailu, Feleke Moges, Baye Gelaw
Summary: A high prevalence of C. difficile was observed among hospitalized patients, emphasizing the need for attention and prevention. The resistance of C. difficile to metronidazole and vancomycin was lower compared to other antibiotics.
Article
Engineering, Environmental
Derongs Lorine, Druilhe Celine, Le Marechal Caroline, Barbut Frederic, Heurtevent Lorette, Buffet Julie, Martin Laure, Ziebal Christine, Poezevara Typhaine, Rouxel Sandra, Houard Emmanuelle, Syed Zaidi Rabab, Couturier Jeanne, Pourcher Anne-Marie
Summary: This study found that anaerobic digestion effectively removed E. coli, enterococci, C. perfringens, and C. difficile, but the chemical parameters did not reach concentrations capable of inactivating these bacteria. Increasing hydraulic retention time only reduced the concentration of E. coli in the digestate, while increasing organic loading rate reduced the removal of enterococci and C. difficile.
Article
Immunology
Giovanny Herrera, Laura Vega, Anny Camargo, Manuel Alfonso Patarroyo, Juan David Ramirez, Marina Munoz
Summary: This study found that the coexistence of Clostridium perfringens and Clostridium difficile can lead to minor differences in the composition and diversity of gut bacterial communities, particularly in patients with hospital-acquired diarrhea. These alterations suggest a need for a comprehensive understanding of gut microbiota.
COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
(2023)
Article
Multidisciplinary Sciences
Srijita Basak, Debashrito Deb, Utkarsh Narsaria, Tamalika Kar, Filippo Castiglione, Indraneel Sanyal, Pratap D. Bade, Anurag P. Srivastava
Summary: Clostridium difficile infection is a major health-associated infection with high incidence and mortality rates. A chimeric vaccine candidate was designed using immunoinformatics, which showed stability and reliability in silico and molecular dynamics simulations. Docking studies demonstrated stable interactions with immune receptors, and in silico modeling indicated competent expression in E. coli system for potential immune response.
SCIENTIFIC REPORTS
(2021)