Article
Medicine, General & Internal
Sylvain Goutelle, Anne Conrad, Cecile Pouderoux, Evelyne Braun, Frederic Laurent, Marie-Claude Gagnieu, Sabine Cohen, Jerome Guitton, Florent Valour, Tristan Ferry
Summary: Suppressive parenteral antibiotic therapy with beta-lactams may be necessary for Gram-negative bone and joint infections. Subcutaneous administration in outpatient settings, guided by therapeutic drug monitoring and PK/PD principles, can effectively control infections without promoting resistance, supporting further clinical evaluations.
FRONTIERS IN MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Hui-Yin Yow, Kayatri Govindaraju, Audrey Huili Lim, Nusaibah Abdul Rahim
Summary: In the era of Bad Bugs, No Drugs, optimizing antibiotic therapy against multi-drug resistant (MDR) pathogens is crucial. Mathematical modelling has played an important role in personalized antibiotic treatment.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Infectious Diseases
Christopher Robson, Bryan Tan, Rhonda Stuart, Stephen Nicholls, Benjamin A. Rogers, Indy Sandaradura
Summary: This review aims to investigate the factors influencing beta-lactam pharmacokinetics (PK) and pharmacodynamics (PD) variability in infective endocarditis (IE) and to determine optimal PK/PD target parameters for therapy. The findings suggest that time-dependent killing is important for beta-lactams in IE, but there is currently no consensus on the optimal drug exposure for treatment.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Review
Pharmacology & Pharmacy
Kun Mi, Kaixiang Zhou, Lei Sun, Yixuan Hou, Wenjin Ma, Xiangyue Xu, Meixia Huo, Zhenli Liu, Lingli Huang
Summary: Antimicrobial resistance is a significant public health issue. The semi-mechanistic PK/PD model is a mathematical tool that captures the relationship between dose, exposure, and response in terms of the mechanism, allowing for the optimization of dosage regimens and the suppression of resistance development.
Article
Infectious Diseases
Romain Guilhaumou, Constance Chevrier, Jean Loup Setti, Elisabeth Jouve, Amelie Marsot, Nathan Julian, Olivier Blin, Pierre Simeone, David Lagier, Djamel Mokart, Nicolas Bruder, Marc Garnier, Lionel Velly
Summary: This study aimed to describe the pharmacokinetic/pharmacodynamic target attainment of continuously infused beta-lactam antibiotics in ICU patients and evaluate the impact of dosage adjustment. The results showed that the empirical dosages of beta-lactam antibiotics were often lower than recommended. Indexed creatinine clearance was associated with dosage underdosing or overdosing. Adjusting the dosage improved target attainment. This study provides important insights into optimizing beta-lactam therapy for ICU patients.
Article
Pharmacology & Pharmacy
Teresa Garcia-Martinez, Maria Dolores Belles-Medall, Maria Garcia-Cremades, Raul Ferrando-Piqueres, Victor Mangas-Sanjuan, Matilde Merino-Sanjuan
Summary: This study aimed to develop a population pharmacokinetic/pharmacodynamic model of daptomycin and establish optimal dose recommendations in patients with normal and impaired renal function. The results indicate that bactericidal effects for Gram+ strains can be achieved with specific daily doses based on body weight and renal function. By evaluating the impact of different dosing regimens on treatment outcomes, the study provides insights for optimizing the use of daptomycin.
Article
Pharmacology & Pharmacy
Frederico S. Martins, Peijuan Zhu, M. Tobias Heinrichs, Sherwin K. B. Sy
Summary: This study evaluated paediatric dosing regimens for meropenem plus fosfomycin against multidrug-resistant bacteria, using PBPK models and PD analyses to identify effective dosing regimens for Klebsiella pneumoniae and Pseudomonas aeruginosa.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Infectious Diseases
Saeed Alqahtani, Asma Alfarhan, Abdullah Alsultan, Emad Alsarhani, Abdulaziz Alsubaie, Yousif Asiri
Summary: Micafungin is commonly used for invasive candidiasis in critically ill patients and those with cancer, as well as for empirical antifungal therapy in patients with neutropenic fever. This study found that cancer patients had significantly higher micafungin clearance compared to non-cancer patients, and that factors such as transaminases and body weight influenced micafungin clearance. The probability of target attainment increased with higher doses and decreased with higher MICs in both groups, with non-cancer patients achieving higher pharmacokinetic/pharmacodynamic targets in simulations.
Article
Medicine, General & Internal
Maria Ghita, Charlotte Billiet, Dana Copot, Dirk Verellen, Clara Mihaela Ionescu
Summary: The study utilized a PKPD model to accurately predict lung growth curves in non-small cell lung cancer patients, demonstrating the potential value of mathematical modeling in anticancer research.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Anne Quynh-Nhu Nguyen, Andre Y. Denault, Yves Theoret, France Varin
Summary: This study investigated the PK/PD relationship of inhaled milrinone in patients with pulmonary hypertension undergoing cardiac surgery, using the mAP/mPAP ratio as a PD marker. The results showed that peak concentrations of milrinone were reached at the end of inhalation, and the magnitude of the peak response of the mAP/mPAP ratio was associated with difficult separation from bypass.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Alexandre Le Marouille, Emma Petit, Coureche Kaderbhai, Isabelle Desmoulins, Audrey Hennequin, Didier Mayeur, Jean-David Fumet, Sylvain Ladoire, Zoe Tharin, Siavoshe Ayati, Silvia Ilie, Bernard Royer, Antonin Schmitt
Summary: A study investigated the kinetics of circulating neutrophils in patients treated with palbociclib. A popPK model and a PK/PD model were constructed, showing a correlation between higher estimated C-ressSS and increased risk of developing neutropenia.
Article
Immunology
Timothy J. Carrothers, H. Maxime Lagraauw, Lars Lindbom, Todd A. Riccobene
Summary: A population pharmacokinetic model of dalbavancin was developed using data from 1124 pediatric patients. Simulations showed that single-dose regimens of dalbavancin had adequate pharmacokinetic/pharmacodynamic target attainment in pediatric patients.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Junzhen Wu, Xinyi Yang, Jufang Wu, Jingjing Wang, Hailan Wu, Yu Wang, Hong Yuan, Huahui Yang, Hailin Wang, Jing Zhang
Summary: This study aimed to assess whether dose adjustment is necessary for contezolid in patients with moderate hepatic impairment for more rational use of the drug. The results showed that moderate hepatic impairment did not significantly affect the pharmacokinetic parameters of contezolid, indicating that dose adjustment is not required.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Infectious Diseases
Maria Kipourou, Olga Begou, Katerina Manika, Georgios Ismailos, Paschalina Kontou, Georgia Pitsiou, Helen Gika, Ioannis Kioumis
Summary: This study evaluated the pharmacokinetic profile of tigecycline in plasma and its penetration to sputum in moderately ill patients with an infectious acute exacerbation of chronic obstructive pulmonary disease (COPD). The results showed that tigecycline has sufficient lung penetration in pulmonary infections of moderate severity and has clinical effectiveness against commonly causative bacteria in COPD exacerbations.
Article
Pharmacology & Pharmacy
Yuancheng Chen, Xiaojie Wu, Chengyuan Tsai, Liwen Chang, Jicheng Yu, Guoying Cao, Beining Guo, Yaoguo Shi, Demei Zhu, Fupin Hu, Jinyi Yuan, Yang Liu, Xu Zhao, Yingyuan Zhang, Jufang Wu, Jing Zhang
Summary: Integrative PK/PD analysis supports the reliable clinical and microbiological efficacy of nemonoxacin 500 mg q24 h in treating community-acquired pneumonia caused by S. pneumoniae, S. aureus, and K. pneumoniae, regardless of patient sex, mild renal impairment, empty stomach or not. However, nemonoxacin 750 mg q24 h would provide better efficacy than 500 mg q24 h for CAP caused by H. parainfluenzae in terms of CFR.
FRONTIERS IN PHARMACOLOGY
(2023)