Review
Chemistry, Physical
Xing Huang, Qing-Kun Shen, Hong-Yan Guo, Zhe-Shan Quan, Xiaoting Li
Summary: "Research Progress on Pharmacological Effects and Structural Modification of Fusidic Acid" reviews the latest research progress on the pharmacological effects and structural modification of fusidic acid, including its wide range of activities such as anti-inflammatory, antimalarial, antiparasitic and antiviral activities, with strong efficacy in the field of antibacterial. Future research will focus on improving efficacy, exploring new pharmacological activities and structural modifications of fusidic acid. Hopefully, this review provides useful information for the drug discovery of fusidic acid derivatives.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Medicinal
Junjun Long, Tianhao Ying, Lei Zhang, Tao Yu, Jinhui Wu, Yasen Liu, Xiaoli Li, Guoliang You, Leiming Zhang, Yi Bi
Summary: In this study, a new series of fusidic acid derivatives were designed and synthesized, and compound 30 was identified as a potent STING inhibitor with the ability to suppress LPS-induced inflammatory responses. In vivo experiments confirmed the anti-inflammatory effect of compound 30 and its potential for treating sepsis. This study lays the groundwork for the future development of anti-inflammatory agents for sepsis treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Polymer Science
Mervt M. Almostafa, Heba S. Elsewedy, Tamer M. Shehata, Wafaa E. Soliman
Summary: This study developed and evaluated a novel fusidic acid nanoemulgel (FA-NEG) for topical skin application. The FA-NEG displayed good characteristics for topical application and showed improved antibacterial activity compared to other formulations. The potential antibacterial effect of myrrh essential oil was also indicated.
Article
Microbiology
Charles Omollo, Vinayak Singh, Elizabeth Kigondu, Antonina Wasuna, Pooja Agarwal, Atica Moosa, Thomas R. Ioerger, Valerie Mizrahi, Kelly Chibale, Digby F. Warner
Summary: The study aimed to identify synergistic anti-TB drug combinations capable of restoring therapeutic efficacy against drug-resistant mutants of Mycobacterium tuberculosis. The results showed that certain drug combinations exhibited potentiating effects against M. tuberculosis, and some combinations could partially restore sensitivity against resistant mutants.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Infectious Diseases
Shuying Chen, Lulin Rao, Chunchan Lin
Summary: This study reports the prevalence of fusidic acid resistance among clinical isolates of Staphylococcus epidermidis from a tertiary hospital in Wenzhou, China. The study found a high prevalence of fusidic acid resistance in methicillin-resistant Staphylococcus epidermidis (MRSE) isolates and a high positive rate of the fusB gene. The study also showed that the fusidic acid-resistant S. epidermidis isolates had high rates of resistance to other non-β-lactam antimicrobials.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Public, Environmental & Occupational Health
Bahareh Hajikhani, Mehdi Goudarzi, Sareh Kakavandi, Sana Amini, Samira Zamani, Alex van Belkum, Hossein Goudarzi, Masoud Dadashi
Summary: The global prevalence of FRSA, FRMRSA, and FRMSSA was found to be 0.5%, 2.6%, and 6.7% respectively, indicating an increasing incidence of fusidic acid resistance. Prudent prescription of fusidic acid and development of monitoring strategies are needed to tackle this issue.
ANTIMICROBIAL RESISTANCE AND INFECTION CONTROL
(2021)
Review
Multidisciplinary Sciences
Stefan Monecke, Elke Mueller, Sascha D. Braun, Marc Armengol-Porta, Michele Bes, Samar Boswihi, Maged El-Ashker, Ines Engelmann, Darius Gawlik, Mayada Gwida, Helmut Hotzel, Rania Nassar, Annett Reissig, Antje Ruppelt-Lorz, Abiola Senok, Ali M. Somily, Edet E. Udo, Ralf Ehricht
Summary: In this study, a previously unknown MRSA lineage CC1153 from the Middle East, including strains from humans and livestock, was characterized. The CC1153 lineage carries specific genes and has been observed in multiple countries in the Middle East. The presence of fusidic acid-resistant MRSA poses a public health threat due to resistance to multiple antibiotics commonly used in both hospital and community settings.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Wende Zheng, Borong Tu, Zhen Zhang, Jinxuan Li, Zhenping Yan, Kaize Su, Duanyu Deng, Ying Sun, Xu Wang, Bingjie Zhang, Kun Zhang, Wing-Leung Wong, Panpan Wu, Weiqian David Hong, Song Ang
Summary: The study aimed to explore the structure-activity relationships of FA derivatives as antibacterial agents to develop novel ones possessing a broad antimicrobial spectrum. A pharmacophore model was established and common structural characteristics were determined. Seven new FA derivatives were designed and evaluated for their activity using the pharmacophore model and molecular docking studies. The FA-7 derivative displayed the best antibacterial property and further 3D-QSAR studies were conducted on all derivatives.
FRONTIERS IN CHEMISTRY
(2023)
Article
Chemistry, Analytical
Mohamed Ibrahim, Nasser Ali Alhabib, Doaa Alshora, Mounir M. Salem Bekhit, Ehab Taha, Wael A. Mahdi, Abdulelah M. Harthi
Summary: A simple, sensitive, and robust UPLC assay was developed for the determination of fusidic acid. The effect of formic acid concentration and column temperature on retention time, peak area, and peak height was investigated. The optimized condition was found to be a mobile phase consisting of 72% acetonitrile and 28% water containing 0.1% formic acid, with a column temperature of 40?.
Letter
Medicine, General & Internal
Jemma Alarcon, Moon Kim, Dawn Terashita, Kusha Davar, Jacob M. Garrigues, Jack P. Guccione, Mark G. Evans, Peera Hemarajata, Noah Wald-Dickler, Paul Holtom, Rodrigo Garcia Tome, Lovelyn Anyanwu, Naman K. Shah, Matthew Miller, Todd Smith, Audrey Matheny, Whitni Davidson, Christina L. Hutson, Jonathan Lucas, Odey C. Ukpo, Nicole M. Green, Sharon E. Balter
Summary: A case of mpox-related death in the United States is reported, where the patient had a compromised immune system, and evaluation indicated widespread viral infection.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Cell Biology
Irene Tracey
Summary: Neuroimaging-based pain biomarkers show promise in providing objective brain-related information about acute and chronic pain states, but there are challenges to be addressed in the future.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Michael Weber, Henrik von der Emde, Marcel Leutenegger, Philip Gunkel, Sivakumar Sambandan, Taukeer A. Khan, Jan Keller-Findeisen, Volker C. Cordes, Stefan W. Hell
Summary: This study demonstrates all-optical, room temperature localization of fluorophores with sub-angstrom precision. By utilizing the concept of MINSTED nanoscopy, the researchers successfully localized individual fluorophores bound to DNA strands by increasing the power of a STED donut beam and using on/off switching. This research opens up new areas of application in studying macromolecular complexes in cells.
NATURE BIOTECHNOLOGY
(2023)
Article
Polymer Science
Mohammad F. Bostanudin, Aisha Salam, Kawthar Kayed, Nasrullah Jan
Summary: The study investigates the fabrication of nanomaterials made of amphiphilically-altered polysaccharides and their potential in enhancing drug transport across the skin. Alkylated chitosan nanomaterials were constructed and compared with neat chitosan nanomaterials in terms of drug release and diffusion. The results demonstrate that alkylated chitosan nanomaterials exhibit slower drug release but faster penetration across the skin, and have better antimicrobial activity.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Oncology
Jacqueline M. Mix, Mona Saraiya, Trevor D. Thompson, Troy D. Querec, April Greek, Thomas C. Tucker, Edward S. Peters, Charles F. Lynch, Brenda Y. Hernandez, Glenn Copeland, Marc T. Goodman, Elizabeth R. Unger
Summary: The study compared HPV prevalence among high-grade cervical precancers and invasive cervical cancers before and after HPV vaccine availability. No significant reduction in vaccine-type prevalence was observed between the two studies, likely due to low HPV vaccination coverage among women in the postvaccine study. Monitoring HPV-type prevalence through population-based strategies remains important for evaluating the impact of the HPV vaccine.
Article
Environmental Sciences
Emily K. Burchfield, Katherine S. Nelson
Summary: The study revealed that human activities have reinforced the geographical distribution of agricultural yields in the United States, but these gains have not directly translated into net income for farmers. Differences in yield gains were observed among operators, input expenditures and yields, as well as major regions. Increased input expenditures may lead to marginal decreases in yields, raising important questions about the interaction between yields and farmer livelihoods.
ENVIRONMENTAL RESEARCH LETTERS
(2021)