Journal
CLINICAL INFECTIOUS DISEASES
Volume 53, Issue 9, Pages 915-926Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/cid/cir508
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Funding
- Office of the Director, National Institutes of Health (NIH)
- Fogarty International Center
- Office of AIDS Research
- National Cancer Center
- National Eye Institute, National Heart, Blood, and Lung Institute
- National Institute of Dental and Craniofacial Research
- National Institute on Drug Abuse
- National Institute of Mental Health
- National Institute of Allergy and Infectious Diseases
- NIH Office of Women's Health and Research [R24 TW007988, RO1NS55627]
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Central nervous system (CNS) tuberculosis (TB) is a devastating infection with high rates of morbidity and mortality worldwide and may manifest as meningitis, tuberculoma, abscess, or other forms of disease. Immunosuppression, due to either human immunodeficiency virus infection or solid organ transplantation, increases susceptibility for acquiring or reactivating TB and complicates the management of underlying immunosuppression and CNS TB infection. This article reviews how immunosuppression alters the clinical presentation, diagnosis, treatment, and outcome of TB infections of the CNS.
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