Article
Microbiology
Timothy J. Straub, Wen-Chi Chou, Abigail L. Manson, Henry L. Schreiber, Bruce J. Walker, Christopher A. Desjardins, Sinead B. Chapman, Kerrie L. Kaspar, Orsalem J. Kahsai, Elizabeth Traylor, Karen W. Dodson, Meredith A. J. Hullar, Scott J. Hultgren, Christina Khoo, Ashlee M. Earl
Summary: While cranberry juice consumption had minimal impact on the overall gut microbiome, a significant difference was found in the abundance of an unnamed Flavonifractor species between study arms. Further research is needed to assess the role of cranberry consumption and this species in the context of health and wellbeing in cases of recurrent UTIs.
Article
Microbiology
Amber M. M. Goedken, Kendra Y. Y. Foster, Erika J. J. Ernst
Summary: Females and males with recurrent urinary tract infections may receive prescription prophylaxis to reduce the infection frequency. Little is known about how prescription prophylaxis differs between patients meeting and exceeding the minimum threshold for recurrent urinary tract infections. This study aimed to estimate the association between infection frequency and receipt of prescription prophylaxis and describe the type of prescription prophylaxis initiated. The findings suggest that the odds of receiving prophylaxis were greater in patients with three or more infections compared to those with only two infections, and the type of prophylaxis used differed between the two groups.
Review
Urology & Nephrology
Michael Kwok, Stephen McGeorge, Johanna Mayer-Coverdale, Bianca Graves, David L. Paterson, Patrick N. A. Harris, Rachel Esler, Caroline Dowling, Sumudu Britton, Matthew J. Roberts
Summary: This study compares recurrent urinary tract infection guidelines from major urological and non-urological organizations internationally. The results show that there is consistency in the definition and evaluation of rUTIs, as well as antibiotic prophylaxis strategies. However, there are variations in symptomatic treatment and antibiotic-sparing preventative strategies.
Article
Medicine, General & Internal
Marloes Franssen, Johanna Cook, Jared Robinson, Nicola Williams, Margaret Glogowska, Yaling Yang, Julie Allen, Christopher C. Butler, Nick Thomas, Alastair Hay, Michael Moore, Gail Hayward
Summary: Recurrent urinary tract infections (RUTIs) have a significant negative impact on quality of life and healthcare costs, with daily prophylactic antibiotics being the only proven treatment. D-mannose, believed to inhibit bacterial adherence to uroepithelial cells, is being used by some women to prevent RUTIs. The MERIT study will evaluate the clinical and cost-effectiveness of D-mannose in reducing infection frequency and symptom burden for women with RUTI in UK primary care.
Article
Urology & Nephrology
Monique H. Vaughan, Jialiang Mao, Lisa A. Karstens, Li Ma, Cindy L. Amundsen, Kenneth E. Schmader, Nazema Y. Siddiqui
Summary: The study found associations between anaerobic bacteria in the urinary microbiome and postmenopausal recurrent UTI, suggesting a need for further investigation.
JOURNAL OF UROLOGY
(2021)
Article
Public, Environmental & Occupational Health
Hala Alghoraibi, Aisha Asidan, Raneem Aljawaied, Raghad Almukhayzim, Aljoharah Alsaydan, Elaf Alamer, Waleed Baharoon, Emad Masuadi, Abeer Al Shukairi, Laila Layqah, Salim Baharoon
Summary: This study retrospectively analyzed the prescription pattern of continuous antibiotic prophylaxis for recurrent urinary tract infections (UTIs) in adult patients from January 2016 to December 2018. The results showed that although continuous prophylactic antibiotics were effective in reducing the recurrence rate, emergency room visits, and hospital admissions due to UTIs, they were only used in 55% of patients with recurrent infections. Trimethoprim/sulfamethoxazole was the most frequently prescribed prophylactic antibiotic.
JOURNAL OF EPIDEMIOLOGY AND GLOBAL HEALTH
(2023)
Review
Immunology
Philipp Jent, Julia Berger, Annette Kuhn, Barbara W. Trautner, Andrew Atkinson, Jonas Marschall
Summary: Recurrent urinary tract infections are common, and antibiotic prophylaxis significantly reduces the risk of developing UTIs. Different antibiotics appear to have similar efficacy, and intermittent application is equally effective as continuous application.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Oghenekome A. Gbinigie, Elizabeth A. Spencer, Carl J. Heneghan, Joseph J. Lee, Christopher C. Butler
Summary: The current evidence on the use of cranberry extract in the management of acute, uncomplicated UTIs is inconclusive, with more rigorous trials needed to assess its effectiveness.
Article
Chemistry, Analytical
Hilary Urena-Saborio, Anu Prathap M. Udayan, Emilia Alfaro-Viquez, Sergio Madrigal-Carballo, Jess D. Reed, Sundaram Gunasekaran
Summary: Consumption of cranberries can prevent urinary tract infections by the interaction of proanthocyanidins with virulence factors on UTI-causing bacteria. Functionalized biosensors using cranberry PAC were shown to effectively detect and diagnose UTIs associated with ExPEC, exhibiting high sensitivity, selectivity, reproducibility, and stability.
Article
Medicine, General & Internal
Silje Rebekka Heltveit-Olsen, Par-Daniel Sundvall, Ronny Gunnarsson, Egill Snaebjornsson Arnljots, Anna Kowalczyk, Maciek Godycki-Cwirko, Tamara N. Platteel, Hilde A. M. Koning, Wim G. Groen, Christina Ahren, Nils Grude, Theo J. M. Verheij, Cees M. P. M. Hertogh, Morten Lindbaek, Sigurd Hoye
Summary: This study aims to assess whether Methenamine hippurate can reduce the incidence of UTIs in older women with recurrent UTIs through a randomized, controlled, triple-blind phase IV clinical trial. The results will be disseminated in peer-reviewed journals and scientific conferences after obtaining ethical approvals in all participating countries.
Article
Immunology
Bradley J. Langford, Kevin A. Brown, Christina Diong, Alex Marchand-Austin, Kwaku Adomako, Arezou Saedi, Kevin L. Schwartz, Jennie Johnstone, Derek R. MacFadden, Larissa M. Matukas, Samir N. Patel, Gary Garber, Nick Daneman
Summary: The study on antibiotic prophylaxis in older adults with UTI found that although it can reduce hospitalization or ED visits for some patients, it also increases the risk of antibiotic resistance and Clostridioides difficile infections, as well as general medication adverse events.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Biology
Amr S. Abu Lila, Azza A. H. Rajab, Marwa H. Abdallah, Syed Mohd Danish Rizvi, Afrasim Moin, El-Sayed Khafagy, Shams Tabrez, Wael A. H. Hegazy
Summary: Urinary tract infections are a common health care facility-associated infection, and bacteria can survive hostile environments by forming biofilms which provide protection and increase gene transfer. Understanding the role of biofilm formation in recurrent UTIs and finding strategies to eradicate biofilms are crucial for preventing this growing public health concern.
Article
Urology & Nephrology
Sebastian Nestler, Britta Gruene, Lydia Schilchegger, Adriana Suna, Anita Perez, Andreas Neisius
Summary: The study compared the efficacy of StroVac and Nitrofurantoin in preventing urinary tract infections in women with recurrent UTIs over a two-year follow-up. StroVac was found to be more effective with lower side effects compared to Nitrofurantoin, making it a viable non-antibiotic prophylaxis option for patients with rUTI.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Article
Infectious Diseases
Concetta Caglioti, Rossana Iannitti, Giada Ceccarelli, Laura Selan, Marco Artini, Rosanna Papa, Antonio Malvasi, Rosaria Gentile, Diletta Del Bianco, Florinda Apone, Paola Angelini, Federico Palazzetti, Bernard Fioretti
Summary: Urinary tract infections primarily affect women and are commonly treated with antibiotics. However, antibiotic resistance can limit the effectiveness of this approach. Proanthocyanidins found in cranberry extracts have shown promise as a treatment for UTIs due to their ability to inhibit bacterial adhesion, reducing virulence. This study demonstrated via microscopy and scattering measurements that a mixture of cranberry and chondroitin sulfate can form a crosslinked structure with barrier properties. The best mixture was identified through experimentation and confirmed to have barrier properties using transepithelial electrical resistance chambers. Additionally, the mixture showed variable inhibitory effects on biofilm formation by antibiotic-resistant Escherichia coli strains, suggesting potential benefits for UTIs with antibiotic resistance profiles.
Article
Infectious Diseases
Thijs ten Doesschate, Kelly Hendriks, Cornelis Henri van Werkhoven, Evelien C. van der Hout, Tamara N. Platteel, Irene A. M. Groenewegen, Anouk E. Muller, Andy I. M. Hoepelman, Marc J. M. Bonten, Suzanne E. Geerlings
Summary: This study compares the effectiveness and safety of daily prophylaxis with 50 mg or 100 mg nitrofurantoin for recurrent urinary tract infection. The results show that there is no significant difference in the risk of UTI or pyelonephritis between the two dosages, but there is a higher risk of cough, dyspnea, and nausea with the 100 mg dosage.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
