Article
Microbiology
Dennis Maletich Junqueira, Caroline Tochetto, Tavis K. Anderson, Danielle Gava, Vanessa Haach, Mauricio E. Cantao, Amy L. Vincent Baker, Rejane Schaefer
Summary: This study analyzed a large number of H1N1pdm09 gene sequences from humans and swine globally between 2009 and 2022, and found that there was rapid transmission of the virus from humans to swine in Brazil during 2009-2011, but most of the infections in swine were self-limited with limited onward transmission. After 2012, there was a reduction in human-to-swine H1N1pdm09 transmissions in Brazil. The study highlights the dynamic interplay between human-to-swine transmission, antigenic drift, and the establishment of swine-to-swine transmission in shaping the evolution and persistence of H1N1pdm09 in swine populations.
FRONTIERS IN MICROBIOLOGY
(2023)
Review
Virology
Gloria Perez-Rubio, Marco Antonio Ponce-Gallegos, Bruno Andre Dominguez-Mazzocco, Jaime Ponce-Gallegos, Roman Alejandro Garcia-Ramirez, Ramces Falfan-Valencia
Summary: Research has shown that genetic susceptibility to Influenza A virus infection is influenced by multiple pathways, including innate immune response, complement activation, and variants in inflammatory response genes. Specific gene polymorphisms such as SNPs play key roles in host immune responses, affecting viral replication and host response, representing important factors in genetic susceptibility to IAV infection.
Article
Immunology
Veronica A. Ferrando, Marcel E. Friedrich, Shrey Gandhi, Alexander Mellmann, Doerthe Masemann, Anmari Christersson, Darisuren Anhlan, Linda Brunotte, Monika Stoll, Timm Harder, Martin Beer, Yvonne Boergeling, Stephan Ludwig
Summary: Influenza A viruses, including the H1N1pdm09 virus, cause recurrent epidemics and occasional pandemics in humans. The reassortment of these viruses in swine and their ability to replicate in human lung tissue suggest a possible zoonotic potential. Reassortment frequently occurs in the PB1, PA, and NA segments, resulting in the generation of reassortants that can reach high titers in swine lung cells.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Immunology
Jiapei Yu, Hui Li, Ju Jia, Zhisheng Huang, Shuai Liu, Ying Zheng, Shengrui Mu, Xiaoyan Deng, Xiaohui Zou, Yeming Wang, Xiao Shang, Dan Cui, Lixue Huang, Xiaoxuan Feng, William J. Liu, Bin Cao
Summary: Despite the use of vaccines and anti-viral drugs, influenza A virus still poses a significant epidemic risk to global public health. Through single-cell transcriptome analyses, we have identified the high heterogeneity of susceptibility to viral infection and biological responses in different subsets of CD4(+) T and CD8(+) T cells. Effector memory CD8(+) T cells (CD8(+) T-EM) were found to be the most susceptible subset to pandemic influenza A virus infection among primary human T cells. Non-productive infection was established in CD8(+) T-EM and naive CD8(+) T cells, indicating the mechanisms of intracellular antiviral activities in human T cells.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Virology
Nutan Mytle, Sonja Leyrer, Jon R. Inglefield, Andrea M. Harris, Thomas E. Hickey, Jacob Minang, Hang Lu, Zhidong Ma, Hanne Andersen, Nathan D. Grubaugh, Tina Guina, Mario H. Skiadopoulos, Michael J. Lacy
Summary: Research demonstrates that utilizing combinations of conserved antigens of influenza A virus, such as NP and various forms of M2e, can generate broad immune protection in mice, reducing lung viral burden and weight loss.
Article
Immunology
Krista Salo-Tuominen, Tamara Teros-Jaakkola, Laura Toivonen, Helena Ollila, Paivi Rautava, Minna Aromaa, Elina Lahti, Niina Junttila, Ville Peltola
Summary: The study investigated the association between parental socioeconomic and psychosocial factors and the uptake of the 2009 pandemic influenza vaccine in children. It found that children of younger and less educated mothers had a lower rate of vaccine uptake. However, the individual or relational psychosocial well-being of parents was not associated with children's vaccination.
Article
Virology
Shannon R. Christensen, Emily T. Martin, Joshua G. Petrie, Arnold S. Monto, Scott E. Hensley
Summary: The HA stalk domain of the pH1N1 virus has remained antigenically stable despite the presence of high levels of HA stalk antibodies within the human population. The pH1N1 HA stalk has not undergone antigenic drift in the past decade, as serum antibodies from 230 humans were unable to distinguish between the 2009 and 2019 HA stalks.
JOURNAL OF VIROLOGY
(2022)
Article
Multidisciplinary Sciences
Seungwon Kim, Margaret Carrel, Andrew Kitchen
Summary: Identifying the spatial patterns of genetic structure of influenza A viruses is important for understanding their spread. This study analyzed the genetic sequences of the A/H1N1pdm09 virus in mainland China and found that there is high genetic similarity among viruses within small geographic regions, but broad-scale genetic differentiation. Local viral circulation has a greater impact on the spatial genetic structure of the virus than countrywide viral mixing and gene flow.
Article
Virology
Nima Ghalekhani, Saied Bokaie, Sana Eybpoosh, Hesameddin Akbarein, Hamid Sharifi
Summary: Using Bayesian phylogeography analysis, this study investigates the time and path of transmission of H1N1 serotype influenza A viruses in Iran and neighboring countries. The study finds that the age of emergence of H1N1 virus in Iran is older compared to neighboring countries, and Tehran seems to have played a key role in its transmission within Iran. Continuous monitoring and screening of H1N1 virus, along with addressing gaps and shortages in virus control, are important measures to be taken.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zhihong Qian, Dylan H. H. Morris, Annika Avery, Karen A. A. Kormuth, Valerie Le Sage, Michael M. M. Myerburg, James O. O. Lloyd-Smith, Linsey C. C. Marr, Seema S. S. Lakdawala
Summary: Respiratory viruses can be transmitted through contaminated surfaces, or fomites. This study examined the stability of the H1N1 virus on different surface materials at varying humidities. The results showed that the virus was rapidly inactivated on copper, but remained stable on plastics, steel, aluminum, and glass. The stability of the virus was more influenced by the respiratory secretion of the host than the surface material.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Review
Immunology
Rory D. de Vries, Katja Hoschler, Guus F. Rimmelzwaan
Summary: In this review, the results of an assay to detect influenza virus-specific antibodies that mediate ADCC were summarized. The study found that HA-specific ADCC mediating antibodies can be detected in serum samples from individuals vaccinated or infected with influenza viruses. The presence of cross-reactive antibodies and their immunological functionalities were also investigated. The findings suggest that virus-specific antibodies induced by infection or vaccination have additional immunological functionalities that contribute to protective immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Veterinary Sciences
Michael J. Clayton, E. Jane Kelly, Marta Mainenti, Amanda Wilhelm, Mia Kim Torchetti, Mary Lea Killian, Arnaud J. Van Wettere
Summary: An outbreak of respiratory disease caused by influenza A(H1N1)2009 virus affected kits and adult mink on a farm in Utah, resulting in deaths in kits. The source of the virus was suspected to be reverse zoonosis. This case highlights the importance of monitoring interspecies transmission of influenza on mink farms and practicing safe work practices.
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION
(2022)
Article
Virology
Yan-Na Xiao, Fei-Yuan Yu, Qian Xu, Jiang Gu
Summary: This study investigated the expression of influenza virus receptors in the human placenta and found that it is susceptible to 2009 influenza A virus (H1N1/09) infection. The study highlights the importance of protecting pregnant women from infection during influenza season.
Article
Microbiology
Meiling Dai, Wenjuan Du, Carles Martinez-Romero, Tim Leenders, Tom Wennekes, Guus F. Rimmelzwaan, Frank J. M. van Kuppeveld, Ron A. M. Fouchier, Adolfo Garcia-Sastre, Erik de Vries, Cornelis A. M. de Haan
Summary: Research shows that the antigenic and enzymatic properties of the influenza A virus neuraminidase are intertwined, with several residues affecting multiple properties. This entanglement may play a crucial role in the evolution of the neuraminidase.
Article
Business, Finance
Di Gong, Tao Jiang, Liping Lu
Summary: This paper empirically analyzes the impact of pandemic on the contracting of bank loans. Using data on syndicated loans during the season of H1N1 Swine Flu, we find that more flu is associated with higher loan spreads and smaller loan size. The adverse impact of pandemic was alleviated by the approval of vaccines.
FINANCE RESEARCH LETTERS
(2021)
Article
Immunology
Chung-Guei Huang, Li-Ang Lee, Tuan-Jen Fang, Hsueh-Yu Li, Chun-Ta Liao, Chung-Jan Kang, Tzu-Chen Yen, Kuo-Chien Tsao, Tse-Ching Chen, Shin-Ru Shih
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2020)
Article
Virology
Rei-Lin Kuo, Chi-Jene Chen, Robert Y. L. Wang, Hsing-I Huang, Ya-Han Lin, Ee-Hong Tam, Wen-Jung Tu, Shang-En Wu, Shin-Ru Shih
JOURNAL OF VIROLOGY
(2019)
Article
Multidisciplinary Sciences
Mei-Ling Li, Jing-Yi Lin, Bo-Shiun Chen, Kuo-Feng Weng, Shin-Ru Shih, Jesse Davila Calderon, Blanton S. Tolbert, Gary Brewer
Article
Pediatrics
Sheng-Yuan Ho, Cheng-Hsun Chiu, Yhu-Chering Huang, Chih-Jung Chen, Reyin Lien, Shih-Ming Chu, Chung-Guei Huang, Kuo-Chien Tsao, Shin-Ru Shih, Jen-Fu Hsu
PEDIATRICS AND NEONATOLOGY
(2020)
Article
Microbiology
Peng-Nien Huang, Hsiang-Ching Wang, Hui-Chen Hung, Sung-Nien Tseng, Teng-Yuan Chang, Min-Yuan Chou, Yu-Jen Chen, Yun-Ming Wang, Shin-Ru Shih, John Tsu-An Hsu
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2020)
Article
Biochemistry & Molecular Biology
Kuo-Ming Lee, Chih-Ching Wu, Shang-En Wu, Ya-Han Lin, Li-Ting Wang, Chun-Ru Chang, Peng-Nien Huang, Shin-Ru Shih, Rei-Lin Kuo
Review
Microbiology
Bo-Shiun Chen, Hou-Chen Lee, Kuo-Ming Lee, Yu-Nong Gong, Shin-Ru Shih
FRONTIERS IN MICROBIOLOGY
(2020)
Article
Immunology
Hsing- Huang, Jhao-Yin Lin, Hsiao-Chu Chiang, Pen-Nien Huang, Qing-Dong Lin, Shin-Ru Shih
JOURNAL OF INFECTIOUS DISEASES
(2020)
Review
Biochemistry & Molecular Biology
Yen-Chin Liu, Rei-Lin Kuo, Shin-Ru Shih
BIOMEDICAL JOURNAL
(2020)
Article
Microbiology
Chung-Guei Huang, Kuo-Ming Lee, Mei-Jen Hsiao, Shu-Li Yang, Peng-Nien Huang, Yu-Nong Gong, Tzu-Hsuan Hsieh, Po-Wei Huang, Ya-Jhu Lin, Yi-Chun Liu, Kuo-Chien Tsao, Shin-Ru Shih
JOURNAL OF CLINICAL MICROBIOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Daming Zhou, Helen M. E. Duyvesteyn, Cheng-Pin Chen, Chung-Guei Huang, Ting-Hua Chen, Shin-Ru Shih, Yi-Chun Lin, Chien-Yu Cheng, Shu-Hsing Cheng, Yhu-Chering Huang, Tzou-Yien Lin, Che Ma, Jiandong Huo, Loic Carrique, Tomas Malinauskas, Reinis R. Ruza, Pranav N. M. Shah, Tiong Kit Tan, Pramila Rijal, Robert F. Donat, Kerry Godwin, Karen R. Buttigieg, Julia A. Tree, Julika Radecke, Neil G. Paterson, Piyada Supasa, Juthathip Mongkolsapaya, Gavin R. Screaton, Miles W. Carroll, Javier Gilbert-Jaramillo, Michael L. Knight, William James, Raymond J. Owens, James H. Naismith, Alain R. Townsend, Elizabeth E. Fry, Yuguang Zhao, Jingshan Ren, David Stuart, Kuan-Ying A. Huang
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2020)
Editorial Material
Medicine, General & Internal
Ville Peltola, Shin-Ru Shih, Kelvin Kai-Wang To
FRONTIERS IN MEDICINE
(2020)
Article
Cell Biology
Su-Jhen Hung, Yin-Mei Hsu, Sheng-Wen Huang, Huey-Pin Tsai, Leo Yi Yang Lee, Aeron C. Hurt, Ian G. Barr, Shin-Ru Shih, Jen-Ren Wang
JOURNAL OF BIOMEDICAL SCIENCE
(2020)
Review
Cell Biology
Jing-Yi Lin, Yu-An Kung, Shin-Ru Shih
JOURNAL OF BIOMEDICAL SCIENCE
(2019)
Article
Cell Biology
Ruey-Wen Lin, Guang-Wu Chen, Hsiang-Hsuan Sung, Ren-Jye Lin, Li-Chen Yen, Yu-Ling Tseng, Yung-Kun Chang, Shu-Pei Lien, Shin-Ru Shih, Ching-Len Liao
JOURNAL OF BIOMEDICAL SCIENCE
(2019)
