Article
Infectious Diseases
Takashi Abe, Fumihiro Yamaguchi, Shunsuke Sakakura, Yo Shiratori, Ayaka Mase, Toshitaka Funaki, Yoshito Kamio, Takashi Suzuki, Yusuke Shikama, Yasutaka Hoshino
Summary: This article reports a case of pulmonary coccidioidomycosis in a Japanese male. The patient was diagnosed with cavity-forming coccidioidomycosis during his 1-year residency in the United States and underwent partial resection of the upper lobe of his left lung after being unable to tolerate antifungal therapy. Symptoms improved after surgery.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Microbiology
Priyal J. Shah, Neil M. Ampel, Marlene E. Girardo, Janis E. Blair
Summary: Serologic rebound after antifungal treatment for primary pulmonary coccidioidomycosis is uncommon but may result in longer clinical follow-up. Continued monitoring of such patients is important to identify those who develop subsequent symptoms and extra-thoracic dissemination.
Article
Medicine, General & Internal
Nikita Ashcherkin, Simran Gupta, Daniel A. Huff, Holenarasipur R. Vikram, Neil M. Ampel, Karen M. Fischer, Janis E. Blair
Summary: The COVID-19 pandemic did not cause a significant delay in the diagnosis of primary pulmonary coccidioidomycosis (PPC). However, patients with fever were diagnosed with PPC earlier than those without fever.
Article
Cardiac & Cardiovascular Systems
R. Mark Grady, Matthew W. Canter, Fei Wan, Anton A. Shmalts, Ryan D. Coleman, Maurice Beghetti, Rolf M. F. Berger, Maria J. del Cerro Marin, Scott E. Fletcher, Russel Hirsch, Tilman H. Umpl, D. Dunbar Ivy, Edward C. Kirkpatrick, Thomas J. Kulik, Marilyne Levy, Shahin Moledina, Delphine Yung, Pirooz Eghtesady, Damien Bonnet
Summary: Pulmonary-to-systemic arterial shunt surgery provides significant clinical improvement for children with severe PH, with high survival rates after discharge, while children at high risk in-hospital are not suitable candidates for the procedure.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hongyang Pi, Lu Xia, David D. Ralph, Samuel G. Rayner, Ali Shojaie, Peter J. Leary, Sina A. Gharib
Summary: In this study, metabolic profiling was used to identify the association between plasma metabolomic profiles and right ventricular dilation, mortality, and measures of disease severity in patients with pulmonary arterial hypertension (PAH). The polyamine, histidine, and sphingomyelin metabolic pathways were found to be associated with RV dilation, mortality, and disease severity.
CIRCULATION RESEARCH
(2023)
Article
Immunology
Daniel A. Powell, Amy P. Hsu, Christine D. Butkiewicz, Hien T. Trinh, Jeffrey A. Frelinger, Steven M. Holland, John N. Galgiani, Lisa F. Shubitz
Summary: This study investigates the use of vaccination in mice with immune deficiencies to mitigate disseminated coccidioidomycosis (DCM). The results show that vaccinated mice had significantly reduced fungal burdens in the lungs and spleen, and controlled spleen dissemination. These findings suggest that the Delta cps1 vaccine could be beneficial for individuals at high risk of immune deficiencies.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Mahalakshmi Kumaran, Truong-Minh Pham, Kaiming Wang, Hussain Usman, Colleen M. Norris, Judy MacDonald, Gavin Y. Oudit, Vineet Saini, Khokan C. Sikdar
Summary: This study used decision tree modeling to identify key factors associated with severe outcomes in COVID-19 patients. Age and breathing difficulties were the most important predictors, while neurological conditions, diabetes, cardiovascular disease, hypertension, and renal disease were significant comorbidities.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
Ved A. Tanavde, Joseph Broderick, Melina J. Windon, Carole Fakhry, Charles Matthew Stewart, David W. Eisele, Francis X. Creighton
Summary: This study aimed to identify factors associated with receiving parotidectomy with temporal bone resection (TBR) and the immediate postoperative outcomes by reviewing the National Cancer Database. The results showed that having surgery at an academic facility, higher clinical stage, higher histologic grade, and adenoid cystic histology were significantly associated with receiving TBR.
Article
Respiratory System
Yu-Hsuan Chen, Tai-Ju Lee, Hsin-Jung Hsieh, Song-Chou Hsieh, Hao-Chien Wang, Yeun-Chung Chang, Chong-Jen Yu, Jung-Yien Chien
Summary: The study investigated the clinical outcomes and risk factors associated with progressive fibrosing interstitial lung disease (PF-ILD) in patients with primary Sjogren's syndrome-associated interstitial lung disease (pSjS-ILD). It was found that persistent lower albumin levels may be a risk factor for PF-ILD and the PF-ILD group had poorer 3-year survival outcomes. Early lung function tests could be helpful for the early detection of PF-ILD.
BMC PULMONARY MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Mengchi Chen, Haotian Jiang, Chunping Zhang
Summary: Primary ovarian insufficiency (POI) is a heterogeneous disease characterized by non-functional ovaries in women under 40. Genetic factors play a crucial role in POI cases, accounting for around 20% to 25%. This paper reviews various genetic causes of POI, including chromosomal abnormalities, single gene mutations, defects in mitochondrial functions, and non-coding RNA abnormalities, providing valuable insights for diagnosing and predicting POI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Meng Zhang, Huimin Qu, Feng Xu, Junfen Xia, Xiaoqing Hui, Hongyan Zhang, Cannan Shi, Junjian He, Yuan Cao, Mengcai Hu
Summary: Maternal syphilis is associated with various adverse pregnancy outcomes. Factors such as syphilis infection history, occurrence of abnormality during pregnancy, lack of standard treatment, and high titres are found to be risk factors. Using a decision tree model, six influencing factors of adverse pregnancy outcomes in syphilis-infected women were identified.
EPIDEMIOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Ka U. Lio, Oisin O'Corragain, Riyaz Bashir, Shari Brosnahan, Gary Cohen, Vladimir Lakhter, Joseph Panaro, Belinda Rivera-Lebron, Parth Rali
Summary: This study investigated the clinical features, radiographic characteristics, impact of reperfusion therapy, and outcomes of patients with pulmonary infarction in acute pulmonary embolism. The results showed that pulmonary infarction was common in patients with acute PE, but its clinical significance and prognostic relevance remain unclear. Furthermore, there was no significant difference in the rate of reperfusion therapies and outcome measures between patients with and without pulmonary infarction.
Article
Infectious Diseases
Andres F. Henao-Martinez, Michaele Francesco Corbisiero, Ixchel Salter, Daniel B. Chastain, George R. Thompson III
Summary: Invasive pulmonary aspergillosis (IPA) is a severe fungal infection primarily affecting immunocompromised patients. Analysis of a global research network revealed a 32% one-year mortality rate for IPA patients. We identified the primary risk factors, contributors, and predictors of mortality.
Editorial Material
Biochemistry & Molecular Biology
Alexandra Toporek, Noah Lechtzin
Summary: The study reports the successful treatment of a Mycobacterium abscessus lung infection with bacteriophage in an immune competent individual. This provides important information about the efficacy of phage therapy and treatment response timeline.
Article
Cardiac & Cardiovascular Systems
Qian Zhang, Fang Zhu, Guocheng Shi, Chen Hu, Weituo Zhang, Puzhen Huang, Chunfeng Zhu, Hong Gu, Dong Yang, Qiangqiang Li, Yonghua Niu, Hao Chen, Ruixiang Ma, Ziyi Pan, Huixian Miao, Xin Zhang, Genxia Li, Yabing Tang, Guyuan Qiao, Yichen Yan, Zhongqun Zhu, Hao Zhang, Fengzhen Han, Yanna Li, Jianhua Lin, Huiwen Chen
Summary: This study evaluated the pregnancy outcomes in women with congenital heart disease (CHD) with and without pulmonary hypertension (PH). The results showed that women with CHD-associated mild PH had better pregnancy outcomes compared to those with moderate-to-severe PH, with similar outcomes to women with CHD and no PH.