Journal
CLINICAL INFECTIOUS DISEASES
Volume 47, Issue 9, Pages 1222-1225Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/592304
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Funding
- Wellcome Trust [083851] Funding Source: Medline
- Department of Health Funding Source: Medline
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This study investigated pregnane X receptor polymorphisms in relation to unboosted atazanavir plasma concentrations in 2 cohorts of patients. The polymorphism 63396T -> C predicted concentrations below the minimum effective concentration (150 ng/mL) with odds ratios of 18 (P = .008) and 5.13 (P = .02). Prospective studies determining potential clinical usefulness are now warranted.
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