Article
Immunology
Leigh M. Howard, Kathryn M. Edwards, Yuwei Zhu, Carlos G. Grijalva, Wesley H. Self, Seema Jain, Krow Ampofo, Andrew T. Pavia, Sandra R. Arnold, Jonathan A. McCullers, Evan J. Anderson, Richard G. Wunderink, Derek J. Williams
Summary: Clinical features did not reliably distinguish HMPV-associated pneumonia from other pathogens. HMPV-associated pneumonia was less severe than bacterial and adult RSV pneumonia, but was otherwise as or more severe than other common pathogens.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Critical Care Medicine
Natacha Kapandji, Michael Darmon, Sandrine Valade, Maud Salmona, Jerome Legoff, Lara Zafrani, Elie Azoulay, Virginie Lemiale
Summary: This study investigates the pathogenicity of human metapneumovirus (hMPV) in adults through a retrospective cohort and systematic review. It suggests that hMPV can cause severe infection and high mortality, particularly in patients with underlying malignancies. However, more cohort studies are needed to validate these findings due to the small sample size and heterogeneity of the review.
ANNALS OF INTENSIVE CARE
(2023)
Article
Medicine, General & Internal
Zhan Wu, Rong Zhang, Dongdong Liu, Xuesong Liu, Jierong Zhang, Zhihui Zhang, Sibei Chen, Weiqun He, Yimin Li, Yonghao Xu, Xiaoqing Liu
Summary: This study found that adenovirus is an important cause of virus-related ARDS, with a higher positivity rate in lower respiratory tract secretions than in upper respiratory tract secretions. Age, lower CD3+CD4+ T cells, and higher serum creatinine may be associated with adenovirus-induced ARDS in adults requiring mechanical ventilation. Early identification and intervention to prevent disease progression are essential for reducing the mortality rate in these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Respiratory System
Eiichiro Sando, Motoi Suzuki, Masayuki Ishida, Makito Yaegashi, Masahiro Aoshima, Koya Ariyoshi, Konosuke Morimoto
Summary: The prevalence of community-acquired pneumonia due to PA was low, with clinical features and mortality rates differing between patients with definitive and indeterminate PA pneumonia. The use of antipseudomonal drugs for patients with community-acquired pneumonia was potentially unnecessary in most cases.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2021)
Article
Virology
Wen-qing Xiang, Lin Li, Bing-han Wang, Ahmed Faisal Ali, Wei Li
Summary: In this study, the predictive value of Th1/Th2 cytokines in pneumonia caused by HMPV was evaluated. The results showed significant differences in cytokine levels between children with HMPV pneumonia and healthy children, as well as between HMPV-positive patients and patients infected with other influenza viruses. IL-6 and TNF-alpha may be useful in assessing the severity and prognosis of HMPV infection.
Article
Immunology
Jung Yeon Heo, Yu Bin Seo, Won Suk Choi, Eun Jin Kim, Hye Won Jeong, Jacob Lee, Jin Gu Yoon, Ji Yun Noh, Hee Jin Cheong, Woo Joo Kim, Joon Young Song
Summary: The effectiveness of pneumococcal vaccines against pneumococcal pneumonia is low in the elderly. However, sequential PCV13/PPSV23 vaccination shows the highest effectiveness in the younger subgroup.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Pierre Bay, Cloe Loegel, Arnaud Ly, Alexandre Soulier, Melissa N'Debi, Sarah Seng, Christian Kassasseya, Christophe Rodriguez, Jean-Michel Pawlotsky, Nicolas de Prost, Slim Fourati
Summary: A study investigating the clinical phenotypes and genetic diversity of respiratory syncytial virus (RSV) found no clustering by severity. Patients infected with RSV-B at risk for severe pneumonia had higher fusion protein diversity. No substitutions conferring resistance to nirsevimab were detected.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Getasew Kassaw, Rezika Mohammed, Getahun Mengistu Tessema, Tesfaye Yesuf, Ayenew Molla Lakew, Gebrekidan Ewnetu Tarekegn
Summary: This study aimed to assess the outcomes and predictors of hospitalized severe community-acquired pneumonia patients. The study found a high rate of unfavorable outcome among these patients, with confusion, anemia, leukopenia, leukocytosis, elevated creatinine, intubation, and antibiotic revision significantly associated with unfavorable outcome.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Infectious Diseases
P. Loubet, P. Mathieu, N. Lenzi, F. Galtier, F. Lain, Z. Lesieur, P. Vanhems, X. Duval, D. Postil, S. Amour, S. Rogez, G. Lagathu, A-S L'Honneur, V Foulongne, N. Houhou, B. Lina, F. Carrat, O. Launay
Summary: This study described the prevalence, clinical features, and complications of human metapneumovirus (hMPV) infections in adults hospitalized with influenza-like illness (ILI). The results showed that hMPV infections mainly affect the elderly and patients with chronic conditions, leading to frequent cardiac and pulmonary complications similar to those of RSV infections.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Critical Care Medicine
Rishi K. Gupta, Ewen M. Harrison, Antonia Ho, Annemarie B. Docherty, Stephen R. Knight, Maarten van Smeden, Ibrahim Abubakar, Marc Lipman, Matteo Quartagno, Riinu Pius, Iain Buchan, Gail Carson, Thomas M. Drake, Jake Dunning, Cameron J. Fairfield, Carrol Gamble, Christopher A. Green, Sophie Halpin, Hayley E. Hardwick, Karl A. Holden, Peter W. Horby, Clare Jackson, Kenneth A. Mclean, Laura Merson, Jonathan S. Nguyen-Van-Tam, Lisa Norman, Piero L. Olliaro, Mark G. Pritchard, Clark D. Russell, James Scott-Brown, Catherine A. Shaw, Aziz Sheikh, Tom Solomon, Cathie Sudlow, Olivia V. Swann, Lance Turtle, Peter J. M. Openshaw, J. Kenneth Baillie, Malcolm G. Semple, Mahdad Noursadeghi
Summary: A prognostic model was developed and validated to predict the risk of clinical deterioration in acute COVID-19 cases. The model showed consistent discrimination, calibration, and clinical utility across different regions, demonstrating strong potential for informing decision making among hospitalized adults with COVID-19.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Medicine, General & Internal
Blanca Valenzuela-Mendez, Francisco Valenzuela-Sanchez, Juan Francisco Rodriguez-Gutierrez, Rafael Bohollo-de-Austria, Angel Estella, Pilar Martinez-Garcia, Maria Angela Gonzalez-Garcia, Grant Waterer, Jordi Rello
Summary: This study found that early dysregulation of host immune response in influenza pneumonia is associated with increased mortality. Immunoparalysis was identified as a major driver of death. Personalized approaches of adjunctive therapy should consider early specific host response dysregulations.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Natalie Zarabi, Martina Aldven, Sigrid Sjoelander, Hanna Fues Wahl, Goran Bencina, Kelly D. D. Johnson, Sven-Arne Silfverdal
Summary: This study investigated the burden of pneumococcal disease in Swedish adults. The results showed that the clinical and economic burden of pneumococcal disease increased with age, with hospitalizations accounting for the majority of costs. The findings can help prioritize prevention strategies for pneumococcal disease in adult and elderly populations.
Article
Infectious Diseases
Markus Fally, Simone Israelsen, Thomas Benfield, Britta Tarp, Pernille Ravn
Summary: The study found that timely administration of antibiotics within 4 hrs of admission did not significantly impact key outcomes in CAP patients. Instead, it recommended triaging and prioritizing patients based on age, comorbidities, clinical condition, and pneumonia severity.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Immunology
Jieming Qu, Jing Zhang, Yu Chen, Yi Huang, Yusang Xie, Min Zhou, Yuping Li, Dongwei Shi, Jinfu Xu, Qiuyue Wang, Bei He, Ning Shen, Bin Cao, Danyang She, Yi Shi, Xin Su, Hua Zhou, Hong Fan, Feng Ye, Qiao Zhang, Xinlun Tian, Guoxiang Lai
Summary: This prospective study in China evaluated the use of multiple pathogen detection methods in patients with severe community acquired pneumonia (SCAP) and assessed their impact on clinical outcomes. The results showed that early combined detection improved the identification rate of pathogens and may have benefited survival. Influenza virus, S pneumoniae, and Enterobacteriaceae were identified as the leading causes of SCAP in China.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Infectious Diseases
A. Balkhair, I. Al-Zakwani, M. Al Busaidi, A. Al-Khirbash, S. Al Mubaihsi, H. BaTaher, J. Al Aghbari, I. Al Busaidi, M. Al Kindi, S. Baawain, A. Al Alawi, A. Al Lawati, B. Al Rawahi, K. Al-Baimani, K. Al Zidi, N. Elfatih, B. Dawud, B. John, F. Rehman, F. Yousif, G. Al Khadouri, I. Saber, J. Lal, M. Gargouri, M. Al-Ward, N. AbuDraz, S. Al Ruqeishi, S. Kumar, W. Abdelmottaleb, Z. Al-Naamani, Z. Bin Nazar, O. Balkhair
Summary: The study evaluated the efficacy of anakinra in patients with severe COVID-19 pneumonia, showing a decreased need for mechanical ventilation, increased success in weaning off supplemental oxygen, and reduced levels of inflammatory biomarkers in patients who received anakinra.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
