Journal
CLINICAL INFECTIOUS DISEASES
Volume 46, Issue -, Pages S251-S257Publisher
OXFORD UNIV PRESS INC
DOI: 10.1086/524741
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Limited information exists regarding intermediate or long-term consequences of cardiac adverse events (CAEs) after smallpox vaccination. We conducted follow up at 5-12 months after vaccination of 203 US civilian vaccinees who reported a possible CAE. Among 31 of the 33 with confirmed CAEs, at least I health-related quality-of-life change persisted for similar to 48%; similar to 87% missed work (average, 11.5 days). Among 168 of the 170 case patients with other reported cardiovascular conditions, at least I health-related quality-of-life change persisted for similar to 40%; almost 49% missed work (average, 10.2 days). Almost all vaccinees with possible CAEs were working the same number of hours at follow-up compared with before vaccination. Although intermediate-term con-. sequences among possible postvaccination CAEs were not considered serious, lost days of work and a decline in health-related quality of life at the time of follow-up were common, resulting in personal economic and quality-of-life burden.
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