Review
Cell Biology
Kirsten Leeten, Nicolas Jacques, Patrizio Lancellotti, Cecile Oury
Summary: Infective endocarditis is a challenging disease with high mortality and morbidity rates. Antibiotic prophylaxis is recommended in high-risk patients but faces challenges of low efficacy and antibiotic resistance. Platelets play a crucial role in the disease, but there are still many unanswered questions about their antimicrobial activities in infective endocarditis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Amin Polzin, Lisa Dannenberg, Rene M'Pembele, Philipp Mourikis, David Naguib, Saif Zako, Carolin Helten, Tobias Petzold, Bodo Levkau, Thomas Hohlfeld, Mareike Barth, Tobias Zeus, Stephan Sixt, Ragnar Huhn, Payam Akhyari, Artur Lichtenberg, Malte Kelm, Till Hoffmann
Summary: In patients with infective endocarditis, platelet reactivity is increased in those with Staphylococcus aureus (SA) infection. However, the use of aspirin can reduce this increased reactivity without increasing bleeding risk. More research is needed to confirm the potential benefits of aspirin in SA-positive infective endocarditis.
SCIENTIFIC REPORTS
(2022)
Review
Medicine, General & Internal
Henning Hermanns, Tim Alberts, Benedikt Preckel, Magnus Strypet, Susanne Eberl
Summary: Infective endocarditis is a challenging condition that requires collaboration among various medical professionals. Interdisciplinary teamwork is essential for the management of the disease. This narrative review provides a summary of the current knowledge on complications and their management in the perioperative period in patients with infective endocarditis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Anesthesiology
Henning Hermanns, Susanne Eberl, Lotte E. Terwindt, Thierry C. B. Mastenbroek, Wolfgang O. Bauer, Thomas W. van der Vaart, Benedikt Preckel
Summary: The management of infective endocarditis requires multidisciplinary cooperation and a thorough understanding of specific characteristics in the perioperative period. This review summarizes the current knowledge on infective endocarditis relevant for the clinical anesthesiologist and advocates for their involvement as an important member of the endocarditis team.
Article
Medicine, General & Internal
Enrico Cecchi, Silvia Corcione, Tommaso Lupia, Ilaria De Benedetto, Nour Shbaklo, Fabio Chirillo, Antonella Moreo, Mauro Rinaldi, Pompilio Faggiano, Moreno Cecconi, Olivia Bargiacchi, Alessandro Cialfi, Stefano Del Ponte, Angelo Squeri, Oscar Gaddi, Maria Gabriella Carmina, Alessandro Lazzaro, Giovannino Ciccone, Anna Castiglione, Francesco Giuseppe De Rosa
Summary: Intravenous drug use is a predisposing condition for infective endocarditis (IE). We reported the clinical features of IE in people who inject drugs (PWIDs), based on data from the Italian Registry of IE. The study found that PWIDs with IE were predominantly male and between the ages of 41 and 50. HIV and chronic liver disease were the most common comorbidities among PWIDs with IE. This study highlights the relatively high occurrence of IE in PWIDs.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Nidaa Mikail, Fabien Hyafil
Summary: Infective endocarditis (IE) is a life-threatening disease that remains prevalent despite advancements in prophylaxis, diagnosis, and treatment. With the increasing number of patients with cardiac devices, the occurrence of IE on prosthetic valves and cardiac implanted electronic devices (CIED) is rising rapidly. The diagnosis of IE is challenging, but nuclear imaging techniques such as F-18-fluorodeoxyglucose positron emission tomography with computed tomography (F-18-FDG-PET/CT) and white blood cells single photon emission tomography with computed tomography (WBC-SPECT) have emerged as valuable tools in managing prosthetic valve and CIED IE.
Review
Pediatrics
Loay Eleyan, Ameer Ahmed Khan, Gledisa Musollari, Ashwini Suresh Chandiramani, Simran Shaikh, Ahmad Salha, Abdulla Tarmahomed, Amer Harky
Summary: Infective endocarditis in children is rare and mostly caused by underlying congenital heart defects. Diagnosis is challenging, with blood cultures and serology testing being common methods. Treatment involves antimicrobial therapy and surgical interventions such as valve repair or replacement.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Immunology
Katarzyna Holcman, Pawel Rubis, Andrzej Zabek, Krzysztof Boczar, Piotr Podolec, Magdalena Kostkiewicz
Summary: Infective endocarditis (IE) presents a significant epidemiological challenge, with diverse etiopathogenesis and clinical presentation making diagnosis difficult. Molecular imaging techniques, such as Tc-99m-HMPAO-SPECT/CT and F-18-FDG PET/CT, have shown promise in providing valuable diagnostic information. These techniques can offer insights into ongoing infection and aid in determining the optimal therapeutic strategies.
Article
Cardiac & Cardiovascular Systems
Juan M. Pericas, Jaume Llopis, Maria Jesus Jimenez-Exposito, Wissam M. Kourany, Benito Almirante, Giampiero Carosi, Emanuele Durante-Mangoni, Claudio Querido Fortes, Efthymia Giannitsioti, Stamatios Lerakis, Rodrigo Montagna-Mella, Juan Ambrosioni, Ru-San Tan, Carlos A. Mestres, Dannah Wray, Orathai Pachirat, Asuncion Moreno, Vivian H. Chu, Elisa de Lazzari, Vance G. Fowler, Jose M. Miro
Summary: In patients receiving chronic hemodialysis, infective endocarditis (IE) is a common and serious complication characterized by higher mortality and relapse rates compared to non-HD patients. Additionally, cardiac surgery is less frequently performed in HD patients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mustapha Abdeljalil Brai, Nadji Hannachi, Nabila El Gueddari, Jean-Pierre Baudoin, Abderrhamane Dahmani, Hubert Lepidi, Gilbert Habib, Laurence Camoin-Jau
Summary: The incidence of infective endocarditis (IE) has increased in the past decade, with changes in the causative bacteria. The role of bacterial interaction with human platelets in the pathogenesis of IE is crucial but not yet fully understood. This review explores the involvement of platelets in endocarditis, their role in vegetation formation depending on bacterial species, and investigates platelet therapy advancements and future research avenues to understand the mechanistic enigma of bacteria-platelet interaction for preventive and curative medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Jae Hong Lee, Jae Gun Kwak, Sungkyu Cho, Woong-Han Kim, Jeong Ryul Lee, Hye Won Kwon, Mi Kyoung Song, Sang-Yun Lee, Gi Beom Kim, Eun Jung Bae
Summary: The study compared the surgical outcomes of infective endocarditis between early surgery and non-early surgery groups in children. Results showed that the timing of surgery did not significantly impact surgical outcomes.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Francesco Nappi, Giorgia Martuscelli, Francesca Bellomo, Sanjeet Singh Avtaar Singh, Marc R. Moon
Summary: The shift from Streptococcus to Staphylococcus as the primary organism of interest in infective endocarditis has significant consequences. This poses challenges in treatment due to the virulence of Staphylococcus and antibiotic resistance, especially in high-risk groups like elderly patients with multiple comorbidities.
Article
Infectious Diseases
Laura Escola-Verge, Pau Rello, Charles Declerck, Vincent Dubee, Frederic Rouleau, Xavier Duval, Gilbert Habib, Yoan Lavie-Badie, Guillaume Martin-Blondel, Lydie Porte, Kevin Bouiller, Francois Goehringer, Christine Selton-Suty, Cristiane da Cruz Lamas, Francisco Nacinovich, Nahema Issa, Clemence Richaud, Nadjib Hammoudi, Francisco Jose Barranco, Benito Almirante, Pierre Tattevin, Nuria Fernandez-Hidalgo
Summary: This study included 25 cases of infective endocarditis in pregnant women, showing that infective endocarditis in pregnant women is not uncommon. Strict medical surveillance involving a multidisciplinary team including obstetricians and neonatologists is required to manage these cases effectively.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Immunology
Michael M. Dagher, Emily M. Eichenberger, Kateena L. Addae-Konadu, Sarah K. Dotters-Katz, Celia L. Kohler, Vance G. Fowler, Jerome J. Federspiel
Summary: Maternity-associated IE does not appear to confer additional risk for adverse outcomes over nonmaternity-associated infection. Patients who deliver with IE have worse maternal and fetal outcomes than those whose deliveries are not complicated by IE.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Ilya Polishchuk, Vered Stavi, Jenan Awesat, Yael Ben Baruch Golan, Carmi Bartal, Iftach Sagy, Alan Jotkowitz, Leonid Barski
Summary: This study found that sex may have an important role in both the microbial profile and the patient's outcome with infective endocarditis, with significant differences in etiologic factors between male and female patients. All-cause mortality was significantly higher in the female group compared to the male group.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2021)
Editorial Material
Immunology
Damon P. Eisen
CLINICAL INFECTIOUS DISEASES
(2015)
Article
Cardiac & Cardiovascular Systems
F. Delahaye, V. H. Chu, J. Altclas, B. Barsic, A. Delahaye, T. Freiberger, D. L. Gordon, M. M. Hannan, B. Hoen, S. S. Kanj, T. Lejko-Zupanc, C. A. Mestres, O. Pachirat, P. Pappas, C. Lamas, C. Selton-Suty, R. Tan, P. Tattevin, A. Wang
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2015)
Article
Respiratory System
Benjamin M. Tang, Maryam Shojaei, Grant P. Parnell, Stephen Huang, Marek Nalos, Sally Teoh, Kate O'Connor, Stephen Schibeci, Amy L. Phu, Anand Kumar, John Ho, Adrienne F. A. Meyers, Yoav Keynan, Terry Ball, Amarnath Pisipati, Aseem Kumar, Elizabeth Moore, Damon Eisen, Kevin Lai, Mark Gillett, Robert Geffers, Hao Luo, Fahad Gul, Jens Schreiber, Sandra Riedel, David Booth, Anthony McLean, Klaus Schughart
EUROPEAN RESPIRATORY JOURNAL
(2017)
Article
Medicine, General & Internal
Justin T. Denholm, Emma S. McBryde, Damon Eisen, Alan Street, Elizabeth Matchett, Caroline Chen, Thomas Shultz, Beverly Biggs, Karin Leder
INTERNAL MEDICINE JOURNAL
(2017)
Article
Clinical Neurology
Prashanth Ramachandran, Eddie Chan, Michael Poon, Hans T. H. Tu, Jennifer M. Davis, Damon Eisen, Mark Marriott
JOURNAL OF CLINICAL NEUROSCIENCE
(2017)
Article
Infectious Diseases
Vanessa Clifford, Marc Tebruegge, Christel Zufferey, Susie Germano, Ben Forbes, Lucy Cosentino, Emma McBryde, Damon Eisen, Roy Robins-Browne, Alan Street, Justin Denholm, Nigel Curtis
JOURNAL OF INFECTION
(2017)
Article
Medicine, General & Internal
Damon P. Eisen, Elizabeth M. Moore, Karin Leder, Jessica Lockery, Emma S. McBryde, John J. McNeil, David Pilcher, Rory Wolfe, Robyn L. Woods
Article
Multidisciplinary Sciences
Tan N. Doan, Damon P. Eisen, Morgan T. Rose, Andrew Slack, Grace Stearnes, Emma S. McBryde
Article
Immunology
Vanessa Clifford, Marc Tebruegge, Christel Zufferey, Susie Germano, Ben Forbes, Lucy Cosentino, Elizabeth Matchett, Emma McBryde, Damon Eisen, Roy Robins-Browne, Alan Street, Justin Denholm, Nigel Curtis
Letter
Pharmacology & Pharmacy
Damon P. Eisen, Peter McEwen, Regina Hansen, Saurabh Pandey, Steven C. Wallis, Jason A. Roberts
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2020)
Letter
Medicine, General & Internal
Damon Eisen
MEDICAL JOURNAL OF AUSTRALIA
(2020)
Review
Infectious Diseases
Narayan Pant, Damon P. Eisen
Summary: Staphylococcus aureus biofilms play a significant role in chronic infections by protecting bacteria from antimicrobials and the immune system. The complexity of biofilm biology, particularly in S. aureus, highlights the need for novel treatment approaches targeting vulnerable genetic and biochemical processes. Successful treatment strategies in animal models provide potential insights for the prevention and eradication of biofilm-related S. aureus infections.
Article
Microbiology
Narayan Pant, Catherine Rush, Jeffrey Warner, Damon P. P. Eisen
Summary: This study aimed to identify the most stably expressed reference genes in Staphylococcus aureus to study gene expression in biofilm-related infections. Four different algorithms were used to determine the optimal reference genes for savirin and ticagrelor treatment experiments. Based on consensus ranking, spa and rpoD were the most appropriate reference genes for savirin treatment, while gapdH and gyrA were most appropriate for ticagrelor treatment. It is recommended to re-validate reference genes before use.
Article
Health Care Sciences & Services
Oyelola A. Adegboye, Emma S. McBryde, Damon P. Eisen
Summary: Based on the study, male sex, Indigenous status, age and comorbidity are associated with an increased risk of mortality in patients with infectious diseases.
Article
Critical Care Medicine
James Trauer, Stephen Muhi, Emma S. McBryde, Shmeylan A. Al Harbi, Yaseen M. Arabi, Andrew J. Boyle, Rodrigo Cartin-Ceba, Wei Chen, Yung-Tai Chen, Marco Falcone, Ognjen Gajic, Jack Godsell, Michelle Ng Gong, Daryl Kor, Wolfgang Loesche, Daniel F. McAuley, Hollis R. O'Neal, Michael Osthoff, Gordon P. Otto, Maik Sossdorf, Min-Juei Tsai, Juan C. Valerio-Rojas, Tom van der Poll, Francesco Violi, Lorraine Ware, Andreas F. Widmer, Maryse A. Wiewel, Johannes Winning, Damon P. Eisen
CRITICAL CARE MEDICINE
(2017)
