Review
Medicine, Research & Experimental
Zepeng Zhang, Yaxin Gan, Yarong Guo, Xuguang Lu, Xianqi Li
Summary: The review discusses recent animal experiments and surgical protocols related to vertical bone augmentation, aiming to provide guidance for selecting experimental animal models.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Chemistry, Physical
Bruno Coelho Mendes, Rodrigo dos Santos Pereira, Carlos Fernando de Almeida Barros Mourao, Pietro Montemezzi, Anderson Maikon de Souza Santos, Jessica Monique Lopes Moreno, Roberta Okamoto, Eduardo Hochuli-Vieira
Summary: This study compared two beta-tricalcium phosphates with different particle sizes in human maxillary sinuses lifting, and evaluated osteoblast precursor cells and vascular formation using immunolabeling. The results showed that the evaluated bone substitutes had suitable outcomes for bone regeneration.
Article
Chemistry, Physical
Joao Paulo Bonardi, Rodrigo dos Santos Pereira, Carlos F. Mourao, Bruno Coelho Mendes, Adam Lowenstein, Pietro Montemezzi, Flavio Giubilato, Roberta Okamoto, Eduardo Hochuli-Vieira
Summary: The aim of this study was to compare two different forms of biphasic calcium phosphate (BCP) - granules and paste - in human maxillary sinus bone reconstruction. The results showed that both BCP granules and paste had suitable bone formation and high osteocalcin immunolabeling, indicating good bone calcification for dental implant placement.
Article
Chemistry, Multidisciplinary
Lorena Benito-Garzon, Yasmina Guadilla, Idoia Diaz-Guemes, Ivan Valdivia-Gandur, Maria-Cristina Manzanares, Arcadio Garcia de Castro, Sussette Padilla
Summary: In a study conducted in rabbit calvaria, a nanostructured multicomponent material composed of Zn-substituted monetite, amorphous calcium phosphate, hydroxyapatite, and silica gel (MSi) showed significantly higher bone regeneration and lower remaining particle count compared to anorganic bovine bone (ABB) and synthetic beta-tricalcium phosphate (beta-TCP). This suggests that MSi has great potential for vertical bone augmentation.
Article
Multidisciplinary Sciences
Koichiro Hayashi, Masaya Shimabukuro, Ryo Kishida, Akira Tsuchiya, Kunio Ishikawa
Summary: This study introduced a novel carbonate apatite honeycomb scaffold for vertical bone augmentation. By controlling the channel aperture and strut thickness, the scaffold achieved bone ingrowth and angiogenesis. The results demonstrated that the scaffold exhibited superior performance in vertical bone augmentation, with the scaffold featuring 300 μm-thick struts showing the best outcomes.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Chemistry, Physical
Bowen Zhu, Kenji Yokozeki, Md. Arafat Kabir, Masahiro Todoh, Toshiyuki Akazawa, Masaru Murata
Summary: Vertical augmentation is a challenging technique in bone engineering, with various parameters affecting vertical bone regeneration. This study chemically characterized human dentin blocks and evaluated the behavior of partially demineralized dentin matrix (PDDM) blocks in a vertical augmentation model. The results showed that PDDM facilitated bone marrow-space opening and bony bridge formation in the absence of a periosteum.
Review
Dentistry, Oral Surgery & Medicine
Istvan Urban, Eduardo Montero, Ignacio Sanz-Sanchez, David Palombo, Alberto Monje, Grazia Tommasato, Matteo Chiapasco
Summary: Vertical ridge augmentation is a challenging procedure in implant dentistry due to the advanced skills required and the difficulties associated with bone augmentation outside the bony contour. The management of flap closure often leads to complications such as swelling and hematomas. New techniques and biomaterials have been developed to reduce invasiveness and complications in vertical ridge augmentation, including diagnostic/treatment planning considerations, surgical techniques, and digital tools.
PERIODONTOLOGY 2000
(2023)
Article
Engineering, Biomedical
Mellgren Torbjorn, Trbakovic Amela, Thor Andreas, Ekman Stina, Ley Cecilia, Ohman-Magi Caroline, Hammarstrom Johansson Petra, Jensen-Waern Marianne, Hedenqvist Patricia
Summary: The study evaluated the effectiveness of calcium phosphate cement in long bone defects and found that it had good filling results, comparable to autologous bone in terms of new bone formation, but could not be distinguished from new bone histologically.
BIOMEDICAL MATERIALS
(2021)
Article
Chemistry, Physical
Masako Fujioka-Kobayashi, Elena Andrejova, Hiroki Katagiri, Benoit Schaller, Anton Sculean, Jean-Claude Imber, Niklaus P. Lang, Nikola Saulacic
Summary: The study found that cross-linked collagen matrices may be advantageous for maintaining fibrous tissue volume without disrupting bone formation in defects. The cross-linking of collagen did not significantly impact the potential for bone formation.
Article
Biochemistry & Molecular Biology
Masako Fujioka-Kobayashi, Hiroki Katagiri, Niklaus P. Lang, Jean-Claude Imber, Benoit Schaller, Nikola Saulacic
Summary: The aim of this study was to investigate the effect of synthetic bone substitutes in combination with deproteinized bovine bone mineral on bone formation. The results showed that the combination of alpha-TCP and DBBM resulted in similar levels of new bone formation compared to the negative control. Micro-CT analysis indicated resorption of the combined materials, but without any change in volume.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Carlo Mangano, Alessandra Giuliani, Ilaria De Tullio, Mario Raspanti, Adriano Piattelli, Giovanna Iezzi
Summary: The study evaluated a case of bone regeneration using a 30%HA-60%beta-TCP BCP 3D-printed scaffold, with clinical and histological results after 7 years, showing the effectiveness of BCP scaffolds for bone regeneration. Results demonstrated complete integration and preservation of correct bone tissue structure with the 3D printed scaffold.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Dentistry, Oral Surgery & Medicine
Istvan A. Urban, Eduardo Montero, Ettore Amerio, David Palombo, Alberto Monje
Summary: Vertical ridge augmentation techniques, including guided bone regeneration, bone block grafts, and distraction osteogenesis, are used for implant-supported rehabilitation. This review aims to discuss the state-of-the-art of these modalities, including indications, step-by-step approach, and effectiveness.
PERIODONTOLOGY 2000
(2023)
Article
Materials Science, Multidisciplinary
Chafik Ghayor, Indranil Bhattacharya, Franz E. Weber
Summary: The study evaluated the impact of different pore-based microarchitectures on vertical bone augmentation and osteoconduction. Results showed that increasing pore diameter was positively correlated with the extent of vertical bone augmentation, with microarchitecture having a more significant impact on osteoconduction.
MATERIALS & DESIGN
(2021)
Article
Dentistry, Oral Surgery & Medicine
Hyun-Chang Lim, Kyeong-Won Paeng, Ui-Won Jung, Goran I. Benic
Summary: This study investigated the effects of using bone-block substitute materials with or without recombinant human bone morphogenetic protein-2 (rhBMP-2) on new bone formation. The results showed that rhBMP-2 enhanced new bone formation in all experimental groups, with DBBM blocks resulting in greater new bone area compared to synthetic blocks at 2 weeks. However, there was no significant difference in new bone formation between DBBM and synthetic blocks with rhBMP-2 at 12 weeks.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2021)
Article
Materials Science, Biomaterials
Yuting Wu, Jiayi Zhang, Lina Huang, Jianjie Shi, Xin Zhao
Summary: To address the problem of insufficient bone mass in the implant area, we performed vertical bone augmentation in the posterior mandibular region with the aid of a healing abutment. Data from patients with insufficient vertical bone height were collected, and the success rate of the implant surgery was 93.3%, with a mean vertical bone gain of 2.91mm. The peri-implant soft tissue parameters showed good results with no observed complications. Rating: 7/10.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Medicine, General & Internal
Frank R. Kloss, Peer W. Kaemmerer, Anita Kloss-Brandstaetter
Summary: This study aimed to identify potential risk factors for complications related to alveolar ridge augmentation using bone blocks. The study found that complications were more frequent with autogenous bone blocks compared to allogeneic bone blocks, but these complications were minor and did not affect the success of dental rehabilitation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Lena Katharina Mueller-Heupt, Nadine Wiesmann-Imilowski, Sofia Schroeder, Jonathan Gross, Pablo Cores Ziskoven, Philipp Bani, Peer Wolfgang Kaemmerer, Eik Schiegnitz, Anja Eckelt, John Eckelt, Ulrike Ritz, Till Opatz, Bilal Al-Nawas, Christopher Synatschke, James Deschner
Summary: Periodontitis is a chronic inflammatory disease that leads to tooth loss and significantly impacts global health. A hyaluronic acid-based dispersion with controlled oxygen delivery shows potential as a treatment for periodontitis. In vitro and in vivo studies demonstrate the biocompatibility, antimicrobial activity against Porphyromonas gingivalis, and angiogenesis enhancement of the developed oxygen-releasing dispersion. This suggests the potential of oxygen-releasing biomaterials for periodontal tissue regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Polymer Science
Anja Kriegel, Eva Langendorf, Valentina Kottmann, Peer W. Kaemmerer, Franz Paul Armbruster, Nadine Wiesmann-Imilowski, Andreas Baranowski, Erol Gercek, Philipp Drees, Pol Maria Rommens, Ulrike Ritz
Summary: Bone fracture healing is a complex process involving early immune reactions, bone formation, and angiogenesis. This study focuses on the effects of bone sialoprotein (BSP) immobilized in a collagen type I gel on angiogenesis. In vitro analyses and a yolk sac membrane assay demonstrate that BSP induces angiogenesis and that collagen type I is the optimal carrier for BSP. This suggests that BSP could be a promising molecule for bone tissue regeneration.
Article
Oncology
Peer W. Kaemmerer, Silke Tribius, Lena Cohrs, Gabriel Engler, Tobias Ettl, Kolja Freier, Bernhard Frerich, Shahram Ghanaati, Martin Gosau, Dominik Haim, Stefan Hartmann, Max Heiland, Manuel Herbst, Sebastian Hoefert, Juergen Hoffmann, Frank Hoelzle, Hans-Peter Howaldt, Kilian Kreutzer, Henry Leonhardt, Rainer Lutz, Maximilian Moergel, Ali Modabber, Andreas Neff, Sebastian Pietzka, Andrea Rau, Torsten E. Reichert, Ralf Smeets, Christoph Sproll, Daniel Steller, Joerg Wiltfang, Klaus-Dietrich Wolff, Kai Kronfeld, Bilal Al-Nawas
Summary: This is the first prospective study using a multicentric approach to investigate the effectiveness of adjuvant radiotherapy in patients with early squamous cell carcinoma of the oral cavity and oropharynx. The study found that adjuvant radiotherapy does not seem to influence overall survival, but it positively affects time to progression. However, irradiated patients report a significantly decreased quality of life up to three years after therapy.
Article
Oncology
Sebastian Blatt, Peer W. Kaemmerer, Maximilian Krueger, Rambabu Surabattula, Daniel G. E. Thiem, Simon T. Dillon, Bilal Al-Nawas, Towia A. Libermann, Detlef Schuppan
Summary: Oral cancer is a life-threatening disease and specific protein biomarkers in the blood can help with early tumor detection and individualized therapy. This exploratory study used advanced technology to analyze serum proteome and identified novel biomarkers for oral cancer. The study showed significant differences in serum protein levels between oral cancer patients and controls, as well as before and after curative surgery.
Article
Biochemistry & Molecular Biology
Nadja Engel, Michael Dau, Vivien Engel, Denise Franz, Fabian Klemmstein, Christiane Thanisch, Juergen F. Kolb, Marcus Frank, Armin Springer, Ruediger Koehling, Rainer Bader, Bernhard Frerich, Nadine Wiesmann, Diana Heimes, Peer W. Kaemmerer
Summary: By combining electrical stimulation of a commercial titanium implant with real-time impedance sensing, osteogenesis progress can be monitored and electrical stimulation can be adjusted accordingly for individual fracture healing.
Review
Dentistry, Oral Surgery & Medicine
Peer W. Kaemmerer, Shengchi Fan, Carlos Aparicio, Edmond Bedrossian, Ruben Davo, Dean Morton, Gerry M. M. Raghoebar, Sepehr Zarrine, Bilal Al-Nawas
Summary: This study assessed the outcome and complications of zygomatic implant placement using the original surgical technique (OST) and an Anatomy-Guided approach (AGA) in patients with severely atrophic maxillae. Based on the systematic review, placing ZI with OST and AGA is associated with a high implant survival rate and a higher risk of surgical complications, including sinusitis and soft tissue infection around the implant, during a minimum of 6 months follow-up.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2023)
Article
Surgery
Diana Heimes, Peer W. Kaemmerer
Summary: Secondary chronic osteomyelitis (SCO) is a progressive jawbone destruction caused by bacterial infection. Antibiotics are the first-line treatment, but surgery may not provide a cure. Bisphosphonates have shown promising results in SCO patients, similar to their success in primary nonbacterial osteomyelitis.
JOURNAL OF SURGICAL CASE REPORTS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Diana Heimes, Andreas Pabst, Philipp Becker, Amely Hartmann, Frank Kloss, Jochen Tunkel, Ralf Smeets, Peer W. Kaemmerer
Summary: This study analyzed and compared morbidity-related parameters after alveolar ridge augmentation using autogenous and allogeneic bone blocks from patients' perspective. The results showed that the rate of nerve irritations was twice as high in the autologous group, and swelling was significantly higher in patients with autologous bone blocks. However, the overall satisfaction of patients in both groups was very high, with over 8/10 points.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Matthias W. Gielisch, Fabia Siegberg, Daniel G. E. Thiem, Sebastian Blatt, Diana Heimes, Peer W. Kaemmerer
Summary: This study investigated the impact of three different osteosynthesis plate systems on failure rates and complications after mandibular resections. The results suggest that RP3 should be preferred over RP1 and RP2 due to lower failure rates and complications.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2023)
Review
Medicine, General & Internal
Shengchi Fan, Gustavo Saenz-Ravello, Leonardo Diaz, Yiqun Wu, Ruben Davo, Feng Wang, Marko Magic, Bilal Al-Nawas, Peer W. Kaemmerer
Summary: The study aimed to evaluate the accuracy of different approaches for zygomatic implant (ZI) placement in patients with severe maxillary problems. The results showed that dynamic computer-aided surgery (d-CAIS) and modified static computer-aided surgery (s-CAIS) had clinically acceptable outcomes, while the conventional s-CAIS had the highest deviation values. Surgeons should be aware of potential deviations and complications regardless of the selected approach.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Daniel Stephan, Sebastian Blatt, Julian Riedel, Katja Mohnke, Robert Ruemmler, Alexander Ziebart, Bilal Al-Nawas, Peer W. Kaemmerer, Daniel G. E. Thiem
Summary: This study aimed to investigate the impact of ischemia on intra-flap metabolism and electrolyte concentrations during transplantation surgery using a novel animal model. The results showed that even a short ischemic period could induce anaerobic glycolysis and electrolyte displacement, leading to acidosis and tissue damage.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Valeriana Pantea, Vitalie Cobzac, Olga Tagadiuc, Victor Palarie, Valentin Gudumac
Summary: Cancer is a global medical problem, with a shortage of specific anticancer drugs and significant side effects. The liver plays a crucial role in drug metabolism and is a major target of anticancer compounds. Thus, it is important to evaluate the cytotoxic effects of potential anticancer substances on liver cells. This study showed that new local thiosemicarbazide coordination compounds (CCT) had a selective effect on hepatocytes in vitro and were less hepatotoxic compared to doxorubicin, indicating their potential in the development of new anticancer drugs.
Article
Medicine, General & Internal
Diana Heimes, Nicolas Alexander Mark, Robert Kuchen, Andreas Pabst, Philipp Becker, Solomiya Kyyak, Daniel G. E. Thiem, Ralf Schulze, Peer W. Kaemmerer
Summary: The study aimed to evaluate the skills of dental students in choosing the correct stage, diagnostics, and treatment option for MRONJ based on clinical and radiographic imaging. The results showed a lack of knowledge among students in staging, diagnostics, and treatment of MRONJ, although CBCT imaging positively affected decision-making. Further teaching in this disease's context and X-ray diagnostics is needed.
MEDICINA-LITHUANIA
(2023)
Article
Dentistry, Oral Surgery & Medicine
Jochen Tunkel, Frederik Hoffmann, Yannik Schmelcher, Anita Kloss-Brandstaetter, Peer W. Kaemmerer
Summary: Compared to the autogenous technique, allogeneic shell augmentation has a shorter surgical time and a similar rate of intra- and postoperative complications as autogenous bone. Together with its promising clinical results, this technique can be recommended.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2023)
