Article
Cell Biology
Linus Remling, Anke Gregus, Oliver Wirths, Thomas Meyer, Julia Staab
Summary: In this study, we have identified a previously unknown interdimeric interaction site involved in the termination of STAT1 signaling. The introduction of a glutamic acid-to-alanine mutation at position 169 in the coiled-coil domain (CCD) resulted in increased tyrosine phosphorylation, accelerated nuclear import, enhanced DNA-binding affinity, and transcriptional activity compared to the wild-type protein. Furthermore, we demonstrated that the E169 residue in the CCD mediates the release of the dimer from DNA in an autoinhibitory manner.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Biochemistry & Molecular Biology
Atif Zafar, Hang Pong Ng, Rachel Diamond-Zaluski, Gun-Dong Kim, Ernest Ricky Chan, Sally L. Dunwoodie, Jonathan D. Smith, Ganapati H. Mahabeleshwar
Summary: The transcriptionally dynamic macrophages play key roles in the development of inflammatory vascular diseases. In this study, the CITED2 was identified as a cell-intrinsic negative regulator of inflammation in macrophages. The deficiency of CITED2 elevates pro-inflammatory gene expression and contributes to the development of atherosclerotic plaques.
Review
Cell Biology
Dirk Schmidt-Arras, Stefan Rose-John
Summary: Interleukin-6 plays a key role in inflammatory processes and cancer, as well as metabolic regulation and neural activities. Its receptor complexes can signal from both the plasma membrane and endomembranes, with pathogenic GP130 variants interfering with spatial activation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Plant Sciences
Saqlain Haider, Javed Iqbal, Sana Naseer, Tabassum Yaseen, Muzaffar Shaukat, Haleema Bibi, Yumna Ahmad, Hina Daud, Nayyab Laiba Abbasi, Tariq Mahmood
Summary: Heat stress negatively impacts plant growth and metabolism, but plants have developed complex signaling networks to perceive ambient temperature changes and activate molecular changes to promote survival and reproduction. Deciphering these mechanisms could facilitate the development of heat-tolerant crop cultivars.
PLANT CELL REPORTS
(2021)
Article
Cell Biology
Atif Zafar, Hang Pong Ng, E. Ricky Chan, Sally L. Dunwoodie, Ganapati H. Mahabeleshwar
Summary: In this study, it was found that CITED2 is an essential negative regulator of pro-inflammatory macrophage activation and inflammatory disease pathogenesis. Myeloid-CITED2 deficiency significantly elevates HFD-induced expansion of adipose tissue volume, obesity, glucose intolerance, and insulin resistance. CITED2 promotes BCL6 expression by restraining STAT5 activation in macrophages, thereby limiting inflammation, preventing obesity, and insulin resistance.
Review
Plant Sciences
Masood Jan, Zhixin Liu, Jean-David Rochaix, Xuwu Sun
Summary: This article reviews the current understanding of multiple plastid retrograde signaling pathways and potential plastid signaling molecules. It also discusses how retrograde signaling regulates nuclear gene expression within a multilayered network of transcription factors.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Jiaqi Hou, Xueke Zheng, Ruifei Ren, Qipeng Shi, Huangzhuo Xiao, Zhenfei Chen, Mengxia Yue, Yequn Wu, Haoli Hou, Lijia Li
Summary: Lateral roots (LRs) are an important part of the root system in rice, which helps increase root surface area for efficient water and nutrient absorption. This study reveals that histone deacetylase 1 (OsHDAC1) plays a positive regulatory role in LR formation in rice. OsHDAC1 controls LR formation by deactivating OsGSK2 and preventing degradation of OsBZR1, which is a positive regulator of LR primordia formation. This finding provides insights into the molecular mechanism of LR formation in rice.
Article
Biochemistry & Molecular Biology
Delia Casas-Pastor, Raphael Rene Mueller, Sebastian Jaenicke, Karina Brinkrolf, Anke Becker, Mark Buttner, Carol Gross, Thorsten Mascher, Alexander Goesmann, Georg Fritz
Summary: Extracytoplasmic function sigma factors (ECFs) play a major role in bacterial signal transduction mechanisms, with our comprehensive phylogenetic analysis identifying numerous new ECF groups and expanding classification efforts. This detailed description of the phylogenetic distribution of the ECF family will serve as a powerful tool for guiding future research in the field.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Plant Sciences
Maria Graca Miguel, Carina Isabel da Silva, Luana Farah, Fernao Castro Braga, Ana Cristina Figueiredo
Summary: This study evaluated the effect of 20 essential oils on the release of CCL2 and TNF-alpha by LPS-stimulated THP-1 cells. Some essential oils showed toxicity to cells, while T. capitata and L. luisieri essential oils exhibited good inhibitory effects on TNF-alpha release.
Article
Biochemistry & Molecular Biology
Junchen Leng, Xiaotong Wei, Xinyi Jin, Longxiang Wang, Kai Fan, Ke Zou, Zichao Zheng, Georgios Saridis, Ningkang Zhao, Dan Zhou, Deqiang Duanmu, Ertao Wang, Haitao Cui, Marcel Bucher, Li Xue
Summary: A signaling pathway involving receptor-like kinases and receptor-like cytoplasmic kinases plays a crucial role in arbuscular mycorrhizal (AM) symbiosis. This pathway is conserved in legumes and cereals. The expression of certain kinases is upregulated by AM transcription factors, and several of these kinases are specifically required for AM symbiosis. The CBX1 transcription factor directly regulates the expression of KIN3, a key kinase involved in AM symbiosis, and loss of function mutations in KIN3, AMK8, or AMK24 result in reduced mycorrhizal colonization.
Article
Horticulture
Changxia Li, Xuemei Hou, Kaiping Mou, Huwei Liu, Zongxi Zhao, Weibiao Liao
Summary: This study revealed that glucose and abscisic acid play important roles in adventitious root development in cucumber. Glucose promotes adventitious rooting by enhancing abscisic acid accumulation, while abscisic acid degradation is inhibited by glucose.
SCIENTIA HORTICULTURAE
(2022)
Article
Agronomy
Yushuang Song, Simin Li, Yi Sui, Hongxiang Zheng, Guoliang Han, Xi Sun, Wenjing Yang, Hailian Wang, Kunyang Zhuang, Fanying Kong, Qingwei Meng, Na Sui
Summary: The study revealed that SbbHLH85 plays a crucial role in root development and salt tolerance in sweet sorghum, with its overexpression leading to increased root hair length and number, promoting Na+ uptake via signaling pathways, and interacting with PHF1 to modulate phosphate distribution.
THEORETICAL AND APPLIED GENETICS
(2022)
Review
Oncology
Cristina Quereda, Angels Pastor, Jose Martin-Nieto
Summary: Dystroglycan (DG) is a glycoprotein that plays a crucial role in maintaining tissue integrity, regulating cellular proliferation, and transmitting extracellular signals to the nucleus. Abnormal glycosylation levels of DG have been found in various human tumors and cancer-derived cell lines, suggesting its potential as a biomarker and therapeutic target for certain types of cancer.
CANCER CELL INTERNATIONAL
(2022)
Article
Immunology
Kogulan Yoganathan, Anqi Yan, Juliana Rocha, Ashton Trotman-Grant, Mahmood Mohtashami, Lisa Wells, Juan Carlos Zuniga-Pfluecker, Michele K. Anderson
Summary: The Alt domain in HEBAlt plays a critical role in integrating cytokine signaling and E protein activity. Phosphorylation of a unique YYY motif in the Alt domain can significantly increase HEBAlt activity, and this increase is dependent on the activity of Janus kinases. HEBAlt is sensitive to changes in cell type and signaling environment during T cell development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Priyanka Rajeev Menon, Asmma Doudin, Anke Gregus, Oliver Wirths, Julia Staab, Thomas Meyer
Summary: This study extensively characterized two STAT3 missense mutations and found that they led to increased protein phosphorylation levels, accelerated nuclear accumulation, and differential transcriptional responses. The mutants also showed higher affinity for binding to DNA on high-affinity binding sites and resistance to dephosphorylation. Additionally, one mutation hindered the transition from a parallel to an anti-parallel dimer conformation, enhancing gene-dependent transcription.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2021)
Article
Gastroenterology & Hepatology
Keely Marshall, Junfei Jin, Carl Atkinson, Ali Alawieh, Fei Qiao, Biao Lei, Kenneth D. Chavin, Songqing He, Stephen Tomlinson
Article
Cell Biology
Xin Wang, Justin Darcy, Chuan Cai, Junfei Jin, Andrzej Bartke, Deliang Cao
Article
Biochemistry & Molecular Biology
Yuekun Zhu, Chao Qu, Xuehui Hong, Yanyan Jia, Meihua Lin, Yunmei Luo, Fengqin Lin, Xiaolong Xie, Xiaoqi Xie, Juan Huang, Qin Wu, Xingfeng Qiu, Daxun Piao, Yanwei Xing, Tian Yu, Yuanfu Lu, Qiang Huang, Changyin Yu, Junfei Jin, Zhiyong Zhang
CELL DEATH AND DIFFERENTIATION
(2019)
Article
Pharmacology & Pharmacy
Qin-You Tan, Qian Hu, Sheng-Nan Zhu, Lu-Lu Jia, Juan Xiao, Hua-Zhen Su, Shao-Yuan Huang, Jing Zhang, Junfei Jin
Article
Cell Biology
Junfei Jin, Zhongyang Lu, Yanchun Li, Ji Hyun Ru, Maria F. Lopes-Virella, Yan Huang
JOURNAL OF LEUKOCYTE BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Chenfei Huang, Zhe Cao, Jun Ma, Yi Shen, Yiwen Bu, Ramina Khoshaba, Guiyuan Shi, Dan Huang, Duan-Fang Liao, Haitao Ji, Junfei Jin, Deliang Cao
MOLECULAR CARCINOGENESIS
(2018)
Article
Oncology
Aili Li, Qingqing Wang, Gaofeng He, Junfei Jin, Guojin Huang
Article
Oncology
Jun Li, Junfei Jin, Minjun Liao, Wei Dang, Xinhuang Chen, Yongfeng Wu, Weijia Liao
Article
Ophthalmology
Zhongyang Lu, Yanchun Li, Ji Hyun Ru, Maria F. Lopes-Virella, Timothy J. Lyons, Yan Huang
EXPERIMENTAL EYE RESEARCH
(2019)
Article
Multidisciplinary Sciences
Junfei Jin, Zhongyang Lu, Yanchun Li, L. Ashley Cowart, Maria F. Lopes-Virella, Yan Huang
Article
Dentistry, Oral Surgery & Medicine
Guang Li, Samantha Robles, Zhongyang Lu, Yanchun Li, Joe W. Krayer, Renata S. Leite, Yan Huang
JOURNAL OF PERIODONTAL RESEARCH
(2019)
Article
Endocrinology & Metabolism
Zhongyang Lu, Yanchun Li, Wing-Kin Syn, Zhewu Wang, Maria F. Lopes-Virella, Timothy J. Lyons, Yan Huang
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2020)
Article
Dentistry, Oral Surgery & Medicine
Yanchun Li, Zhongyang Lu, Lixia Zhang, Keith L. Kirkwood, Maria F. Lopes-Virella, Yan Huang
Article
Endocrinology & Metabolism
Zhongyang Lu, Yanchun Li, Wing-Kin Syn, Ai-Jun Li, W. Sue Ritter, Stephen A. Wank, Maria F. Lopes-Virella, Yan Huang
Summary: Deficiency of GPR40 does not alleviate high-fat diet-induced NAFLD, but instead increases metabolic abnormalities and hepatic steatosis under a low-fat diet. GPR40 deficiency leads to upregulation of hepatic fatty acid translocase (FAT)/CD36 expression, possibly inhibiting the development of nonalcoholic steatohepatitis by modulating FAT/CD36 expression.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)