Journal
CLINICAL IMMUNOLOGY
Volume 134, Issue 3, Pages 345-353Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2009.10.008
Keywords
Advanced glycation end products; Posttransplant diabetes mellitus; Mixed lymphocyte reaction
Categories
Funding
- Japan Society for the Promotion of Science [18590509, 20590539, 17659159, 19659061, 21659141, 21390071, 215905694]
- Ministry of Health, Labour and Welfare of Japan
- Takeda Science Foundation
- Grants-in-Aid for Scientific Research [18590509, 17659159, 20590539, 19659061, 21390071, 21659141] Funding Source: KAKEN
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Posttransplant diabetes mellitus (PTDM) is a frequent complication among transplant recipients. Ligation of advanced gtycation end products (AGEs) with their receptor (RAGE) on monocytes/macrophages plays roles in the diabetes complications. The enhancement of adhesion molecule expression on monocytes/macrophages activates T-cells, leading to reduced allograft survival. We investigated the effect of four distinct AGE subtypes (AGE-2/AGE-3/AGE-4/AGE-5) on the expressions of intracellular adhesion molecule (ICAM)-1, B7.1, B7.2 and CD40 on monocytes, the production of interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha and the proliferation of T-cells during human mixed lymphocyte reaction (MLR). AGE-2 and AGE-3 selectively induced the adhesion molecule expression, cytokine production and T-cell proliferation. The AGE-induced up-regulation of adhesion molecule expression was involved in the cytokine production and T-cell proliferation. AGE-2 and AGE-3 up-regulated the expression of RAGE on monocytes; therefore, the AGEs may activate monocytes, leading to the up-regulation of adhesion molecule expression, cytokine production and T-cell proliferation. (C) 2009 Elsevier Inc. All rights reserved.
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