Journal
CLINICAL IMMUNOLOGY
Volume 132, Issue 1, Pages 93-102Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2009.03.510
Keywords
Lyme disease; Bacterial infection; Borrelia burgdorferi; Antibodies; Glycolipid antigens
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Funding
- National Institutes of Health [RO1 AR-20358, P41 RR10888, S10 RR 15942, AR-007258]
- English, Bonter, Mitchell Foundation
- Eshe Fund
- Lyme/Arthritis Research Fund at Massachusetts General Hospital
- Walter J. and Lille A. Berbecker Foundation
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In this study, the membrane lipids of B. burgdorferi were separated into 16 fractions; the components in each fraction were identified, and the immunogenicity of each fraction was determined by ELISA using sera from Lyme disease patients. Only the 2 glycolipids, acylated cholesteryl galactoside (ACG, BbGL-I) and monogalactosyl diacylglycerol (MgaID, BbGL-II), were immunogenic. Early in the infection, 24 of 84 patients (29%) who were convalescent from erythema migrans and 19 of the 35 patients (54%) with neuroborreliosis had weak IgG responses to purified MgaID, and a smaller percentage of patients had early responses to synthetic ACG. However, almost all of 75 patients with Lyme arthritis, a late disease manifestation, had strong IgG reactivity with both glycolipids. Thus, almost all patients with Lyme arthritis have strong IgG antibody responses to B. burgdorferi glycolipid antigens. (C) 2009 Elsevier Inc. All rights reserved.
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