Journal
CLINICAL IMMUNOLOGY
Volume 129, Issue 2, Pages 256-267Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.clim.2008.07.016
Keywords
Autoimmunity; C57BL/6 mice; CNS inflammation; Disease staging; EAE; Infiltrate composition; MS; Neuroimmunology
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Funding
- Deutsche Forschungsgemeinschaft (DFG)
- National Institutes of Health [NS-39434, AI-47756]
- Koeln Fortune Program (University of Cologne)
- Maria-Pesch-Stiftung
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Multiple sclerosis (MS) is characterized by a dynamic inflammatory process in which CNS lesions of distinct cellular composition coexist. In particular the formation of B cell plaques has been ascribed an important role as predictor of disease progression. Here we show that the novel MBP-PLP fusion protein (MP4)-induced experimental autoimmune encephalomyelitis (EAE) of C57BL/6 mice fulfils these criteria inducing differential cellular infiltration of B cells, T cells, macrophages and granulocytes and permitting the quantification and staging of the disease. On the contrary, both key features - dynamic CNS inflammation and B cell infiltration - were absent in the classical MOG:35-55-induced EAE of C57BL/6 mice, which was characterized by a static CD4(+) T cell and macrophage-mediated CNS immunopathology throughout the disease. MP4-induced EAE may thus provide a unique opportunity for studying immune-pathomechanisms of the disease that have been previously neglected due to experimental shortcomings in murine EAE. (C) 2008 Elsevier Inc. All rights reserved.
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