The genetics of type 2 diabetes and its clinical relevance

Recent Studies of the Human Chromosome 9p21 Locus, Which Is Associated With Atherosclerosis in Human Populations

(2012) Lesca M. Holdt et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Systematic Assessment of Etiology in Adults With a Clinical Diagnosis of Young-Onset Type 2 Diabetes Is a Successful Strategy for Identifying Maturity-Onset Diabetes of the Young

(2012) G. Thanabalasingham et al.   DIABETES CARE

To the Editor

(2012) Angela Woods et al.   NATURE GENETICS

Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis

(2012) Eli A Stahl et al.   NATURE GENETICS

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

PTEN Mutations as a Cause of Constitutive Insulin Sensitivity and Obesity

(2012) Aparna Pal et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans

(2012) Nicholette D. Palmer et al.   PLoS One

The mystery of missing heritability: Genetic interactions create phantom heritability

(2012) O. Zuk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recent Explosive Human Population Growth Has Resulted in an Excess of Rare Genetic Variants

(2012) A. Keinan et al.   SCIENCE

Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases

(2012) John R. B. Perry et al.   PLoS Genetics

Clan Genomics and the Complex Architecture of Human Disease

(2011) James R. Lupski et al.   CELL

Heritability and familiality of type 2 diabetes and related quantitative traits in the Botnia Study

(2011) P. Almgren et al.   DIABETOLOGIA

Uromodulin gene variant is associated with type 2 diabetic nephropathy

(2011) Tarunveer S. Ahluwalia et al.   JOURNAL OF HYPERTENSION

An intergenic region on chromosome 13q33.3 is associated with the susceptibility to kidney disease in type 1 and 2 diabetes

(2011) Marcus G. Pezzolesi et al.   KIDNEY INTERNATIONAL

Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci

(2011) Jaspal S Kooner et al.   NATURE GENETICS

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians

(2011) Yoon Shin Cho et al.   NATURE GENETICS

Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study: Common Genetic Variants in GCK and TCF7L2 Are Associated With Fasting and Postchallenge Glucose Levels in Pregnancy and With the New Consensus Definition of Gestational Diabetes Mellitus From the International Association of Diabetes and Pregnancy Study Groups

(2010) R. M. Freathy et al.   DIABETES

Common Variants in 40 Genes Assessed for Diabetes Incidence and Response to Metformin and Lifestyle Intervention in the Diabetes Prevention Program

(2010) K. A. Jablonski et al.   DIABETES

Genetic Risk Reclassification for Type 2 Diabetes by Age Below or Above 50 Years Using 40 Type 2 Diabetes Risk Single Nucleotide Polymorphisms

(2010) J. M. de Miguel-Yanes et al.   DIABETES CARE

Assessment of High-Sensitivity C-Reactive Protein Levels as Diagnostic Discriminator of Maturity-Onset Diabetes of the Young Due to HNF1A Mutations

(2010) K. R. Owen et al.   DIABETES CARE

Cancer and diabetes: are we ready for prime time?

(2010) U. Smith et al.   DIABETOLOGIA

Genetic associations in diabetic nephropathy: a meta-analysis

(2010) A. L. Mooyaart et al.   DIABETOLOGIA

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in mice

(2010) Axel Visel et al.   NATURE

Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes

(2010) Kaixin Zhou et al.   NATURE GENETICS

Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

(2010) Rachel M Freathy et al.   NATURE GENETICS

A map of open chromatin in human pancreatic islets

(2010) Kyle J Gaulton et al.   NATURE GENETICS

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS

Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis

(2010) Benjamin F Voight et al.   NATURE GENETICS

Insights to the Genetics of Diabetic Nephropathy Through a Genome-Wide Association Study of the GoKinD Collection

(2010) Marcus G. Pezzolesi et al.   SEMINARS IN NEPHROLOGY

Association of Variants at UMOD with Chronic Kidney Disease and Kidney Stones—Role of Age and Comorbid Diseases

(2010) Daniel F. Gudbjartsson et al.   PLoS Genetics

Genome-Wide Association Study of Blood Pressure Extremes Identifies Variant near UMOD Associated with Hypertension

(2010) Sandosh Padmanabhan et al.   PLoS Genetics

Coexpression of the Type 2 Diabetes Susceptibility Gene Variants KCNJ11 E23K and ABCC8 S1369A Alter the ATP and Sulfonylurea Sensitivities of the ATP-Sensitive K+ Channel

(2009) K. S.C. Hamming et al.   DIABETES

Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth

(2009) R. M. Freathy et al.   DIABETES

Genetic Variation in the Multidrug and Toxin Extrusion 1 Transporter Protein Influences the Glucose-Lowering Effect of Metformin in Patients With Diabetes: A Preliminary Study

(2009) M. L. Becker et al.   DIABETES

Genome-Wide Association Scan for Diabetic Nephropathy Susceptibility Genes in Type 1 Diabetes

(2009) M. G. Pezzolesi et al.   DIABETES

Insulin Storage and Glucose Homeostasis in Mice Null for the Granule Zinc Transporter ZnT8 and Studies of the Type 2 Diabetes-Associated Variants

(2009) T. J. Nicolson et al.   DIABETES

The clinical application of genetic testing in type 2 diabetes: a patient and physician survey

(2009) R. W. Grant et al.   DIABETOLOGIA

Multiple loci associated with indices of renal function and chronic kidney disease

(2009) Anna Köttgen et al.   NATURE GENETICS

Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

(2009) Johan Rung et al.   NATURE GENETICS

Polymorphisms of the HNF1A Gene Encoding Hepatocyte Nuclear Factor-1α are Associated with C-Reactive Protein

(2008) Alexander P. Reiner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Immature Renal Structures Associated With a Novel UMOD Sequence Variant

(2008) Elisa Benetti et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Cancer as an endocrine problem

(2008) Jeff M.P. Holly et al.   BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM

TCF7L2 controls insulin gene expression and insulin secretion in mature pancreatic β-cells

(2008) Merewyn K. Loder et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Assessing the Combined Impact of 18 Common Genetic Variants of Modest Effect Sizes on Type 2 Diabetes Risk

(2008) H. Lango et al.   DIABETES

Adiposity-Related Heterogeneity in Patterns of Type 2 Diabetes Susceptibility Observed in Genome-Wide Association Data

(2008) N. J. Timpson et al.   DIABETES

Common Variation in the FTO Gene Alters Diabetes-Related Metabolic Traits to the Extent Expected Given Its Effect on BMI

(2008) R. M. Freathy et al.   DIABETES

Ser1369Ala Variant in Sulfonylurea Receptor Gene ABCC8 Is Associated With Antidiabetic Efficacy of Gliclazide in Chinese Type 2 Diabetic Patients

(2008) Y. Feng et al.   DIABETES CARE

Multiple loci identified in a genome-wide association study of prostate cancer

(2008) Gilles Thomas et al.   NATURE GENETICS

Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion

(2008) Valeriya Lyssenko et al.   NATURE GENETICS

Variants in MTNR1B influence fasting glucose levels

(2008) Inga Prokopenko et al.   NATURE GENETICS

Genotype Score in Addition to Common Risk Factors for Prediction of Type 2 Diabetes

(2008) James B. Meigs et al.   NEW ENGLAND JOURNAL OF MEDICINE

Clinical Risk Factors, DNA Variants, and the Development of Type 2 Diabetes

(2008) Valeriya Lyssenko et al.   NEW ENGLAND JOURNAL OF MEDICINE