Familial Breast Cancer

Genome-wide association analysis identifies three new breast cancer susceptibility loci

(2012) Maya Ghoussaini et al.   NATURE GENETICS

Common alleles at 6q25.1 and 1p11.2 are associated with breast cancer risk for BRCA1 and BRCA2 mutation carriers

(2011) Antonis C Antoniou et al.   HUMAN MOLECULAR GENETICS

RAD51C is a susceptibility gene for ovarian cancer

(2011) Liisa M. Pelttari et al.   HUMAN MOLECULAR GENETICS

Association of BRCA1 and BRCA2 Mutations With Survival, Chemotherapy Sensitivity, and Gene Mutator Phenotype in Patients With Ovarian Cancer

(2011) Da Yang et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

CHEK2*1100delC homozygosity is associated with a high breast cancer risk in women

(2011) M. A. Adank et al.   JOURNAL OF MEDICAL GENETICS

Olaparib in patients with recurrent high-grade serous or poorly differentiated ovarian carcinoma or triple-negative breast cancer: a phase 2, multicentre, open-label, non-randomised study

(2011) Karen A Gelmon et al.   LANCET ONCOLOGY

Germline mutations in RAD51D confer susceptibility to ovarian cancer

(2011) Chey Loveday et al.   NATURE GENETICS

Mutations in BRIP1 confer high risk of ovarian cancer

(2011) Thorunn Rafnar et al.   NATURE GENETICS

Iniparib plus Chemotherapy in Metastatic Triple-Negative Breast Cancer

(2011) Joyce O'Shaughnessy et al.   NEW ENGLAND JOURNAL OF MEDICINE

Exemestane for Breast-Cancer Prevention in Postmenopausal Women

(2011) Paul E. Goss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Update of the National Surgical Adjuvant Breast and Bowel Project Study of Tamoxifen and Raloxifene (STAR) P-2 Trial: Preventing Breast Cancer

(2010) V. G. Vogel et al.   Cancer Prevention Research

Common Breast Cancer Susceptibility Alleles and the Risk of Breast Cancer for BRCA1 and BRCA2 Mutation Carriers: Implications for Risk Prediction

(2010) A. C. Antoniou et al.   CANCER RESEARCH

On the origin and diffusion of BRCA1 c.5266dupC (5382insC) in European populations

(2010) Nancy Hamel et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Association of Risk-Reducing Surgery in BRCA1 or BRCA2 Mutation Carriers With Cancer Risk and Mortality

(2010) Susan M. Domchek   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Risk of breast cancer in male BRCA2 carriers

(2010) D. G. R. Evans et al.   JOURNAL OF MEDICAL GENETICS

Assessment of Clinical Validity of a Breast Cancer Risk Model Combining Genetic and Clinical Information

(2010) M. E. Mealiffe et al.   JNCI-Journal of the National Cancer Institute

Assessing Women at High Risk of Breast Cancer: A Review of Risk Assessment Models

(2010) E. Amir et al.   JNCI-Journal of the National Cancer Institute

Mammographic surveillance in women younger than 50 years who have a family history of breast cancer: tumour characteristics and projected effect on mortality in the prospective, single-arm, FH01 study

(2010)   LANCET ONCOLOGY

Genome-wide association study identifies five new breast cancer susceptibility loci

(2010) Clare Turnbull et al.   NATURE GENETICS

Germline mutations in breast and ovarian cancer pedigrees establish RAD51C as a human cancer susceptibility gene

(2010) Alfons Meindl et al.   NATURE GENETICS

Uptake of Risk-Reducing Surgery in Unaffected Women at High Risk of Breast and Ovarian Cancer Is Risk, Age, and Time Dependent

(2009) D. G. R. Evans et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Probability of BRCA1/2 mutation varies with ovarian histology: results from screening 442 ovarian cancer families

(2009) DGR Evans et al.   CLINICAL GENETICS

BRCA1 and BRCA2 mutations across race and ethnicity: distribution and clinical implications

(2009) Allison W Kurian   CURRENT OPINION IN OBSTETRICS & GYNECOLOGY

Addition of pathology and biomarker information significantly improves the performance of the Manchester scoring system for BRCA1 and BRCA2 testing

(2009) D G R Evans et al.   JOURNAL OF MEDICAL GENETICS

Risk of Estrogen Receptor–Positive and –Negative Breast Cancer and Single–Nucleotide Polymorphism 2q35-rs13387042

(2009) Roger L. Milne et al.   JNCI-Journal of the National Cancer Institute

Meta-analysis of Risk Reduction Estimates Associated With Risk-Reducing Salpingo-oophorectomy in BRCA1 or BRCA2 Mutation Carriers

(2009) T. R. Rebbeck et al.   JNCI-Journal of the National Cancer Institute

A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1)

(2009) Gilles Thomas et al.   NATURE GENETICS

Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1

(2009) Wei Zheng et al.   NATURE GENETICS

Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

(2009) Shahana Ahmed et al.   NATURE GENETICS

Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene

(2009) S. Jones et al.   SCIENCE

Common Breast Cancer-Predisposition Alleles Are Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

(2008) Antonis C. Antoniou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Penetrance estimates for BRCA1 and BRCA2based on genetic testing in a Clinical Cancer Genetics service setting: Risks of breast/ovarian cancer quoted should reflect the cancer burden in the family

(2008) D Gareth Evans et al.   BMC CANCER

International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers

(2008) Kelly A. Metcalfe et al.   INTERNATIONAL JOURNAL OF CANCER

Screening for familial ovarian cancer: poor survival of BRCA1/2 related cancers

(2008) D G Evans et al.   JOURNAL OF MEDICAL GENETICS

Risk reducing mastectomy: outcomes in 10 European centres

(2008) D G R Evans et al.   JOURNAL OF MEDICAL GENETICS

Common variants on chromosome 5p12 confer susceptibility to estrogen receptor–positive breast cancer

(2008) Simon N Stacey et al.   NATURE GENETICS

The emerging landscape of breast cancer susceptibility

(2007) Michael R Stratton et al.   NATURE GENETICS