Article
Rheumatology
Marion Delplanque, Nicolas Benech, Nathalie Rolhion, Cyriane Oeuvray, Marjolene Straube, Chloe Galbert, Loic Brot, Thomas Henry, Yvan Jamilloux, Lea Savey, Gilles Grateau, Harry Sokol, Sophie Georgin-Lavialle
Summary: This study analyzed the gut microbiota of FMF patients and found differences compared to healthy controls, with increased pro-inflammatory bacteria in severe FMF patients. The severity of FMF and resistance to colchicine correlated with specific microbiota alterations. Colchicine treatment was associated with an expansion of anti-inflammatory taxa.
Article
Rheumatology
Merve Ozkilinc Onen, Umut Onat, Serdal Ugurlu, Ahmet C. Timucin, Devrim Oz Arslan, Elif Everest, Huri Ozdogan, Eda Tahir Turanli
Summary: This study identified a rare PSTPIP1 mutation in a family with an FMF and MKD overlapping phenotype but no MEFV and MVK pathogenic variants, suggesting that this variant may cause inflammation response through enhanced PSTPIP1-pyrin interaction and pyrin inflammasome activation.
Article
Biochemistry & Molecular Biology
Mateusz Schabikowski, Pawel Kowalczyk, Agnieszka Karczmarska, Barbara Gawdzik, Aleksandra Wypych, Karol Kramkowski, Karol Wrzosek, Lukasz Laskowski
Summary: This article discusses the antimicrobial properties of pristine anodised aluminium oxide matrices, a material considered biologically inert by many. Matrices without the use of harmful compounds were fabricated and tested, showing potential as antibacterial agents. The results demonstrate stronger antibacterial properties compared to antibiotics, indicating their potential as substitutes in clinical infections.
Article
Rheumatology
Ezgi Deniz Batu, Seher Sener, Elif Arslanoglu Aydin, Emil Aliyev, Ilknur Bagrul, Seyma Turkmen, Ozlem Akgun, Zeynep Balik, Ayse Tanatar, Yagmur Bayindir, Zehra Kizildag, Ruya Torun, Aybuke Gunalp, Taner Coskuner, Rana Isguder, Tuncay Aydin, Fatih Haslak, Muserref Kasap Cuceoglu, Esra Esen, Ulas Akcay, Oezge Basaran, Aysenur Pac Kisaarslan, Fuat Akal, Deniz Yuce, Semanur Ozdel, Mehmet Bulbul, Yelda Bilginer, Nuray Aktay Ayaz, Betul Sozeri, Ozgur Kasapcopur, Erbil Unsal, Seza Ozen
Summary: The study aimed to compare the characteristics of colchicine-resistant and colchicine-responsive patients with familial Mediterranean fever (FMF) and develop a score for predicting colchicine resistance at the time of FMF diagnosis. The researchers found that colchicine-resistant patients had longer, more frequent attacks and were younger at symptom onset. By developing a score that includes age at symptom onset, attack frequency, arthritis, chest pain, and two exon 10 gene mutations, colchicine resistance can be predicted more accurately.
Article
Rheumatology
Amal El Beshlawy, Abd El Rahman Zekri, Manal S. Ramadan, Yasmeen M. M. Selim, Amina Abdel-Salam, Mohamed Tharwat Hegazy, Lamis Ragab, Carla Gaggiano, Luca Cantarini, Gaafar Ragab
Summary: This study investigates the genotype-phenotype associations of the three most common gene mutations in Egyptian FMF children. The results suggest that the genotype influences the clinical manifestations, disease severity, and response to colchicine.
CLINICAL RHEUMATOLOGY
(2022)
Article
Biochemical Research Methods
Raghvendra Mall, Mohamad Saad, Jessica Roelands, Darawan Rinchai, Khalid Kunji, Hossam Almeer, Wouter Hendrickx, Francesco M. Marincola, Michele Ceccarelli, Davide Bedognetti
Summary: An active T-helper 1/cytotoxic response in different tumors is associated with immunotherapy responsiveness and favorable prognosis. However, in some cancers, intratumoral immune activation does not prevent progression or relapse. Defining mechanisms of immune evasion is crucial for refining stratification algorithms, guiding treatment decisions, and identifying candidates for immune-targeted therapy.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Rheumatology
Irit Tirosh, Yonatan Yacobi, Asaf Vivante, Ortal Barel, Yishay Ben-Moshe, Ortal Erez Granat, Shiri Spielman, Rotem Semo Oz, Yael Shinar, Maya Gerstein
Summary: The study found that a single E148Q variant is unlikely to cause FMF in children and that the clinical presentation of E148Q/M694V is similar to that of a single M694V variant, without producing significant clinical phenotypes.
Article
Environmental Sciences
Xing Yan, Zhou Zang, Chuanfeng Zhao, Letu Husi
Summary: The study found that from 2008 to 2017, there was a significant increasing trend in global fine-mode aerosols on land, while no significant trends were observed in aerosol fine-mode fraction over the ocean and fine-mode aerosol optical depth over both land and ocean. A significant decline in fine-mode aerosol optical depth was identified in China, indicating the effectiveness of government emission controls.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Microbiology
Chih-Ming Tsai, J. R. Caldera, Irshad A. Hajam, Austin W. T. Chiang, Chih-Hsiung Tsai, Haining Li, Maria Lazaro Diez, Cesia Gonzalez, Desmond Trieu, Gislaine A. Martins, David M. Underhill, Moshe Arditi, Nathan E. Lewis, George Y. Liu
Summary: Natural exposure to Staphylococcus aureus (SA) may explain the failure of anti-SA immunization trials. Animals infected with SA do not mount protective antibody responses to vaccination, unlike naive animals.
CELL HOST & MICROBE
(2022)
Article
Rheumatology
Seher Sener, Veysel Cam, Ezgi Deniz Batu, Muserref Kasap Cuceoglu, Zeynep Balik, Emil Aliyev, Yagmur Bayindir, Ozge Basaran, Yelda Bilginer, Seza Ozen
Summary: This study aimed to establish a treatment management and discontinuation protocol for paediatric FMF patients treated with canakinumab. The protocol involved gradually reducing the frequency of canakinumab administration over time. Results showed that more than half of the patients were able to successfully discontinue canakinumab treatment within 18 months.
Article
Rheumatology
Serdal Ugurlu, Bilgesu Ergezen, Bugra Han Egeli, Oguzhan Selvi, Huri Ozdogan
Summary: Anakinra has been proven effective for colchicine-resistant patients with FMF by reducing attack frequency and subclinical inflammation. The study showed a significant decrease in attack frequency and disease severity in patients receiving anakinra treatment, with 71 patients still on treatment and 32% discontinuing due to insufficient response or side effects.
Article
Optics
Mingqing Zuo, Dawei Ge, JiaXin Liu, Yuyang Gao, Lei Shen, Xiaobo Lan, Zhangyuan Chen, Yongqi He, Juhao Li
Summary: This paper proposes an intermodal-MIMO-free MDM transmission scheme based on weakly coupled multiple-ring-core FMF, which achieves long-haul FMF transmission by reducing intermodal crosstalk. The feasibility of the scheme is verified through simulations and experiments, providing possibilities for practical applications of long-haul MDM techniques.
Article
Multidisciplinary Sciences
Emiliano Chiarot, Eleonora Naimo, Alessia Corrado, Patrizia Giannetti, Immaculada Margarit Y. Ros, Giuliano Bensi
Summary: Maternal vaccination with glycoconjugate vaccines can induce GBS-specific IgG in newborns and partially protect them against mucosal colonization and deeper infection by GBS strains.
SCIENTIFIC REPORTS
(2021)
Article
Pediatrics
Ahmet Omma, Berkan Armagan, Serdar Can Gueven, Sevinc Can Sandikci, Seda colak, Cigdem Yuecel, Orhan Kucueksahin, Abdulsamet Erden
Summary: The study found that FMF patients with colchicine resistance had significantly higher serum endocan levels, while the attack state did not affect serum endocan levels. Serum endocan may be a novel biomarker for detecting colchicine resistance and distinguishing FMF attacks.
FRONTIERS IN PEDIATRICS
(2021)
Article
Rheumatology
Soad Haj-Yahia, Ilan Ben-Zvi, Merav Lidar, Avi Livneh
Summary: This study evaluated the role of TNF in the treatment of FMF, showing that a small proportion of patients with colchicine-resistant FMF may benefit from TNF blockers, with no predictable factors for response.
Article
Genetics & Heredity
Chagai Grossman, Yonatan Kassel, Avi Livneh, Ilan Ben-Zvi
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2019)
Article
Urology & Nephrology
Olga Kukuy, Batia Kaplan, Sizilia Golderman, Alexander Volkov, Adrian Duek, Merav Leiba, Ilan Ben-Zvi, Avi Livneh
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2019)
Article
Rheumatology
Gil Bornstein, Ilan Ben-Zvi, Nadav Furie, Chagai Grossman
INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
(2019)
Review
Rheumatology
Mayan Gilboa, Gil Bornstein, Ilan Ben-Zvi, Chagai Grossman
RHEUMATOLOGY INTERNATIONAL
(2020)
Article
Infectious Diseases
M. Gilboa, E. Houri-Levi, C. Cohen, I Tal, C. Rubin, O. Feld-Simon, A. Brom, Y. Eden-Friedman, S. Segal, G. Rahav, G. Regev-Yochay
CLINICAL MICROBIOLOGY AND INFECTION
(2020)
Article
Biochemistry & Molecular Biology
Michal Kandel-Kfir, Rolando Garcia-Milan, Itai Gueta, Irit Lubitz, Ilan Ben-Zvi, Aviv Shaish, Lidar Shir, Dror Harats, Milind Mahajan, Allon Canaan, Yehuda Kamari
MOLECULAR IMMUNOLOGY
(2020)
Article
Clinical Neurology
Itay Lotan, Esther Ganelin-Cohen, Evgeny Tartakovsky, Vadim Khasminsky, Mark A. Hellmann, Israel Steiner, Ilan Ben-Zvi, Avi Livneh, Sizilia Golderman, Batia Kaplan
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2020)
Article
Rheumatology
Olga L. Kukuy, Pazit Beckerman, Dganit Dinour, Ilan Ben-Zvi, Avi Livneh
Summary: This study compared FMF amyloidosis patients who experienced an episode of amyloid storm with those who did not. It found that patients with amyloid storm were more likely to progress to ESRD or death in a shorter time period, with infections being the major triggers.
Article
Medicine, General & Internal
Ariel Israel, Gil Bornstein, Lee Gilad, Liran Shechtman, Nadav Furie, Ilan Ben-Zvi, Chagai Grossman
Summary: The study aimed to investigate the prognostic value of markedly elevated ferritin levels in hospitalized patients. It found that high ferritin levels were mainly associated with infectious and malignant diseases, but did not predict mortality rates.
POSTGRADUATE MEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Rafael Y. Brzezinski, Neta Rabin, Nir Lewis, Racheli Peled, Ariel Kerpel, Avishai M. Tsur, Omer Gendelman, Nili Naftali-Shani, Irina Gringauz, Howard Amital, Avshalom Leibowitz, Haim Mayan, Ilan Ben-Zvi, Eyal Heler, Liran Shechtman, Ori Rogovski, Shani Shenhar-Tsarfaty, Eli Konen, Edith M. Marom, Avinoah Ironi, Galia Rahav, Yair Zimmer, Ehud Grossman, Zehava Ovadia-Blechman, Jonathan Leor, Oshrit Hoffer
Summary: The newly developed non-contact thermal imaging tool showed high sensitivity and area under the curve in detecting COVID-19 infection. This technology could be used for non-invasive screening of COVID-19 in low-income regions with limited medical resources.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Soad Haj-Yahia, Ilan Ben-Zvi, Merav Lidar, Avi Livneh
Summary: This study evaluated the role of TNF in the treatment of FMF, showing that a small proportion of patients with colchicine-resistant FMF may benefit from TNF blockers, with no predictable factors for response.
Review
Biochemistry & Molecular Biology
Eitan Giat, Ilan Ben-Zvi, Merav Lidar, Avi Livneh
Summary: This article reviews the clinical manifestations of Familial Mediterranean Fever (FMF) and the utility of anakinra, a recombinant IL-1 receptor antagonist, in FMF. Anakinra, due to its short half-life, is often the preferred IL-1 blocker in certain clinical scenarios of FMF.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Karney Lahad, Elad Maor, Robert Klempfner, Chagai Grossman, Amit Druyan, Ilan Ben-Zvi
Summary: The CHA2DS2-VASC score is a predictor for the risk of cerebrovascular accident (CVA) in patients without known atrial fibrillation (AF) during the first year after hospitalization. Higher scores are associated with an increased risk of CVA/TIA.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Liran Shechtman, Karney Lahad, Ilan Ben-Zvi
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2021)
Article
Rheumatology
C. Grossman, N. Yassin, C. Avivi, G. Bornstein, I. Ben-Zvi, I. Barshack
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2019)