Review
Orthopedics
A. Bonato, M. Zenobi-Wong, G. Barreto, Z. Huang
Summary: This systematic review investigated the association between microbiota composition and osteoarthritis. The review identified certain bacteria that were upregulated in osteoarthritis subjects, as well as some bacteria associated with improved outcomes. However, the heterogeneity of methods and the lack of proper controls made it difficult to draw definitive conclusions about the causal link between microbiota and osteoarthritis.
OSTEOARTHRITIS AND CARTILAGE
(2022)
Review
Biochemistry & Molecular Biology
Laura Bozomitu, Ingrith Miron, Anca Adam Raileanu, Ancuta Lupu, Gabriela Paduraru, Florin Mihai Marcu, Ana Maria Laura Buga, Daniela Carmen Rusu, Felicia Dragan, Vasile Valeriu Lupu
Summary: This article reviews the composition and function of the human gastrointestinal microbiome in healthy individuals, as well as its role in the pathogenesis of different digestive disorders. It also highlights the potential of manipulating the gut microbiota as a therapeutic option for treating gastrointestinal diseases.
Review
Immunology
Ashton Harper, Vineetha Vijayakumar, Arthur C. Ouwehand, Jessica ter Haar, David Obis, Jordi Espadaler, Sylvie Binda, Shrilakshmi Desiraju, Richard Day
Summary: Viral infections continue to pose significant global morbidity and mortality, with factors such as climate change, increased mobility of people and goods, and disruptions in the gastrointestinal microbiome all playing a role. Understanding the complex relationship between the microbiome, viral immunity, and host physiology is crucial for developing effective prevention and treatment strategies for viral diseases.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Isabella J. McLoughlin, Eva M. Wright, John R. Tagg, Rohit Jain, John D. F. Hale
Summary: The skin, as the largest organ in the human body, plays a crucial role in our survival by supporting various functions. Dysbiosis in the microbial populations on the skin can lead to skin diseases, prompting research in medical dermatology and cosmetic industries on modulating the skin microbiome for better skin health.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Multidisciplinary Sciences
Jorge Luis Galeano Nino, Hanrui Wu, Kaitlyn D. LaCourse, Andrew G. Kempchinsky, Alexander Baryiames, Brittany Barber, Neal Futran, Jeffrey Houlton, Cassie Sather, Ewa Sicinska, Alison Taylor, Samuel S. Minot, Christopher D. Johnston, Susan Bullman
Summary: The study investigates the interactions between tumor-associated microbiota and host cells in oral squamous cell carcinoma and colorectal cancer using in situ spatial-profiling technologies and single-cell RNA sequencing. The results show that the distribution of microbiota within the tumor is highly organized in microniches with immune and epithelial cell functions, promoting cancer progression.
Editorial Material
Oncology
Karen S. Sfanos
Summary: This study investigates the impact of intratumoral bacterial signatures on the treatment response of esophageal squamous cell carcinoma (ESCC). The findings suggest that the presence of intratumoral Streptococcus, potentially translocated from the gut, predicts the efficacy of neoadjuvant chemotherapy combined with immunotherapy (NACI) in murine models and individuals with ESCC. These findings highlight the influence of intratumoral microbes and their associated metabolites on the tumor immune microenvironment and immunotherapy efficacy, as well as the potential for cross-reactivity between tumor and bacterial antigens.
Article
Oncology
Nirmala Sehrawat, Mukesh Yadav, Manoj Singh, Vikas Kumar, Var Ruchi Sharma, Anil K. Sharma
Summary: The composition of the gut microbiota is crucial for maintaining human health, with prebiotics and probiotics playing a key role in balancing the microbial population. Imbalance in the microbiota can lead to dysbiosis, which is seen in cancer patients. Utilizing probiotics can help manage cancer by maintaining a healthy microbiota and inhibiting cancer progression, highlighting the potential for personalized medicine and therapeutic targets in microbiome research.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Microbiology
Leonardo Mancabelli, Christian Milani, Federico Fontana, Gabriele Andrea Lugli, Chiara Tarracchini, Alice Viappiani, Tecla Ciociola, Andrea Ticinesi, Antonio Nouvenne, Tiziana Meschi, Francesca Turroni, Marco Ventura
Summary: The recent COVID-19 pandemic has prompted scientists to investigate the underlying causes of this disease. This study conducted a comprehensive meta-analysis of 323 fecal samples and found that the composition of the intestinal microbiota may be correlated with the severity of COVID-19 symptoms. Healthy individuals had a higher abundance of beneficial bacteria, while COVID-19 patients exhibited an increase in potentially pathogenic bacteria. Furthermore, the functional capabilities of the microbiome in COVID-19 patients were unbalanced, which may contribute to disease severity and systemic inflammation.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jilei Zhang, Yinglin Xia, Jun Sun
Summary: This article summarizes recent advances in understanding the interactions among the gut microbiome, breast microbiome, and breast diseases. It emphasizes the important roles of the microbiome in the development and progression of breast cancer and discusses the significance of breast and intestinal microbiota in maintaining healthy breasts.
Review
Biochemistry & Molecular Biology
Francesca Sciarra, Edoardo Franceschini, Federica Campolo, Mary Anna Venneri
Summary: Human blood, previously believed to be sterile, has been found to contain a thriving microbiome dominated by certain bacterial phyla. These microbes are localized in specific blood cell populations and may originate from the skin-oral-gut axis. Dysbiosis of the blood microbiome has potential prognostic value in various diseases. This review aims to summarize the latest findings and evidence in this field.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Mahmoud A. Ghannoum, Thomas S. McCormick, Mauricio Retuerto, Gurkan Bebek, Susan Cousineau, Lynn Hartman, Charles Barth, Kory Schrom
Summary: The study showed that the novel probiotic BIOHM could significantly rebalance the bacteriome and mycobiome in the gut of healthy individuals, with an increase in Ascomycota levels and a reduction in Zygomycota levels. These preliminary results suggest further trials examining the utility of BIOHM probiotic in individuals with gastrointestinal symptoms are warranted.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mattia Di Stefano, Simona Santonocito, Alessandro Polizzi, Rodolfo Mauceri, Giuseppe Troiano, Antonino Lo Giudice, Alessandra Romano, Marco Mascitti, Gaetano Isola
Summary: The human body is colonized by a diverse microbial community known as the microbiota, which plays a crucial role in influencing human health throughout life. The oral microbiota forms complex biofilms and interactions, contributing to the host's resistance to antimicrobial agents and maintaining a balanced symbiotic relationship. Understanding the functions and interactions of the microbiota is essential for developing diagnostic, therapeutic, and preventive strategies. This review focuses on the connection between the oral and gut microbiomes, and how alterations in these microbial communities can lead to oral and intestinal illnesses, as well as the potential role of probiotics in ameliorating inflammation and microbial dysbiosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Ayrton Bangolo, Chinmay Trivedi, Ishan Jani, Silvanna Pender, Hirra Khalid, Budoor Alqinai, Alina Intisar, Karamvir Randhawa, Joseph Moore, Nicoleta De Deugd, Shaji Faisal, Suchith Boodgere Suresh, Parva Gopani, Vignesh K. Nagesh, Tracy Proverbs-Singh, Simcha Weissman
Summary: The gut microbiome has a significant impact on the variation of pharmacologic response, especially in the era of precision medicine. Recent studies have focused on the influence of gut microbiome composition on the efficacy of newer cancer therapies. In the treatment of pancreatic adenocarcinoma, a synergistic effect of immunotherapy in combination with cytotoxic drugs has been observed, and commensal microbiota play a role in modulating the tumor microenvironment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Pediatrics
Maddalena Petraroli, Eleonora Castellone, Viviana Patianna, Susanna Esposito
Summary: Obesity has become a serious public health issue, with the gut microbiota playing a key role in its development. Specific probiotic strains have been shown to impact some secondary metabolic consequences of obesity without affecting weight loss. Further targeted studies are needed to fully understand the influence of microbiota on weight.
FRONTIERS IN PEDIATRICS
(2021)
Review
Biochemistry & Molecular Biology
Nayla Munawar, Khansa Ahsan, Khalid Muhammad, Aftab Ahmad, Munir A. Anwar, Iltaf Shah, Ahlam Khalifa Al Ameri, Fadwa Al Mughairbi
Summary: Schizophrenia is a chronic and heterogeneous disorder with complex symptoms and uncertain etiology. The gut microbiota regulation and microbial signaling system that correlates with the brain may play a significant role in the pathophysiology of schizophrenia. Current treatment options are limited to psychotherapy and antipsychotic drugs, but utilizing psychobiotics or targeting gut microbial diversity through novel prebiotics could be a successful alternative therapeutic approach for schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Amanda L. Blackford, Marcia Irene Canto, Alison P. Klein, Ralph H. Hruban, Michael Goggins
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2020)
Article
Gastroenterology & Hepatology
MirMilad Khoshknab Pourmousavi, Rui Wang, Tossapol Kerdsirichairat, Ayesha Kamal, Venkata S. Akshintala, Gulara Hajiyeva, Chawin Lopimpisuth, Yuri Hanada, Vivek Kumbhari, Vikesh K. Singh, Mouen A. Khashab, Olaya Gutierrez Brewer, Eun Ji Shin, Marcia I. Canto, Anne Marie Lennon, Saowanee Ngamruengphong
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2020)
Article
Gastroenterology & Hepatology
Adrianne Tsen, Samuel Han, Christopher Moreau, Venkata S. Akshintala, Cemal Yazici, Livia Archibugi, Puanani Hopson, Amir Gougol, David Jin, Pedram Paragomi, Ayesha Kamal, Francisco Valverde-Lopez, Georgios I. Papachristou, Walter G. Park, Peter J. Lee
Article
Surgery
Zhixian Lan, Kangyue Sun, Yuchen Luo, Haiyan Hu, Wei Zhu, Wen Guo, Jing Wen, Wenting Mi, Junsheng Chen, Xiang Chen, Venkata Akshintala, Ying Huang, Side Liu, Yue Li
Summary: Linear EUS was found to be more accurate in determining SMd invasion compared to radial EUS, with higher diagnostic accuracy and specificity. It can help in selecting appropriate treatment modalities for patients with non-pedunculated rectal polyp.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Gastroenterology & Hepatology
Wei Zhan, Venkata Akshintala, Phil J. Greer, Julia B. Greer, Samer Alkaade, Michelle A. Anderson, Thiruvengadam Muniraj, Georgios I. Papachristou, Bimaljit S. Sandhu, Adam Slivka, C. Mel Wilcox, Melena D. Bellin, Vikesh K. Singh, Dhiraj Yadav, Randall E. Brand, David C. Whitcomb
Article
Gastroenterology & Hepatology
Venkata S. Akshintala, Mouen A. Khashab
Summary: Artificial intelligence applications in healthcare have significantly increased, specifically in the field of pancreatobiliary disorders, improving diagnostic accuracy and precision in clinical treatment decisions. However, caution is advised in interpreting AI-based literature due to limited external validation, and a multidisciplinary approach combining various data sources is recommended for better utilization of AI technologies to enhance patient care.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Oncology
Kohei Fujikura, Zainab Alruwaii, Michael C. Haffner, Maria A. Trujillo, Nicholas J. Roberts, Seung-Mo Hong, Anne Macgregor-Das, Michael G. Goggins, Sujayita Roy, Alan K. Meeker, Ding Ding, Michael Wright, Jin He, Ralph H. Hruban, Laura D. Wood
Summary: This study revealed that 5hmC and TET1 were significantly downregulated in all types of pancreatic neoplasms and invasive pancreatic ductal adenocarcinomas, with most low-grade precancerous lesions showing downregulation. This suggests that downregulation of 5hmC and TET1 is an early event in pancreatic tumorigenesis.
JOURNAL OF PATHOLOGY
(2021)
Article
Gastroenterology & Hepatology
Makoto Kawamoto, Takeichi Yoshida, Koji Tamura, Mohamad Dbouk, Marcia Irene Canto, Richard Burkhart, Jin He, Nicholas J. Roberts, Alison P. Klein, Michael Goggins
Summary: This study finds that ER stress-inducing CEL variants are not associated with an increased likelihood of having pancreatic cancer.
Letter
Oncology
Mohamad Dbouk, Bryson W. Katona, Randall E. Brand, Amitabh Chak, Sapna Syngal, James J. Farrell, Fay Kastrinos, Elena M. Stoffel, Marcia Irene Canto, Michael Goggins
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Respiratory System
Mitchell L. Ramsey, Susan S. Li, Luis F. Lara, Yevgeniya Gokun, Venkata S. Akshintala, Darwin L. Conwell, John Heintz, Stephen E. Kirkby, Karen S. McCoy, Georgios I. Papachristou, Alpa Patel, Vikesh K. Singh, Phil A. Hart
Summary: The study aimed to investigate the effects of CFTR modulators on pancreatic function in patients with cystic fibrosis (CF). The systematic search revealed that CFTR modulators significantly reduced the occurrence of acute pancreatitis and improved indirect measures of pancreatic function. Future research is needed to further explore the mechanisms and impact of CFTR modulators on acute pancreatitis and pancreatic insufficiency caused by CFTR dysfunction.
JOURNAL OF CYSTIC FIBROSIS
(2023)
Article
Oncology
Nancy Porter, Daniel Laheru, Bryan Lau, Jin He, Lei Zheng, Amol Narang, Nicholas J. Roberts, Marcia Canto, Anne Marie Lennon, Michael G. Goggins, Ralph H. Hruban, Alison P. Klein
Summary: Individuals with a family history of pancreatic cancer, especially with multiple first-degree relatives affected, have a significantly increased risk of developing pancreatic cancer. The risk is also higher among individuals with a family history of young-onset pancreatic cancer.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Multidisciplinary Sciences
Arijit Ghosh, Ling Li, Liyi Xu, Ranjeet P. Dash, Neha Gupta, Jenny Lam, Qianru Jin, Venkata Akshintala, Gayatri Pahapale, Wangqu Liu, Anjishnu Sarkar, Rana Rais, David H. Gracias, Florin M. Selaru
Meeting Abstract
Gastroenterology & Hepatology
Ayesha Kamal, Venkata S. Akshintala, Serhii Chuklin, Victor Jimenez-Beltran, Rita Martins, Daniel Abad-Baroja, Jose P. Pinto, Cezar I. Ciubotaru, Vanesa Bernal, Carlos Marra-Lopez, Anita Gasiorowska, Laszlo Czako, Ainhoa Abando-Zurimendi, Young Koog Cheon, Enrique de-Madaria, Vikesh Singh
Meeting Abstract
Gastroenterology & Hepatology
Kavin Kanthasamy, Merve Gurakar, Christopher Fan, Furqan A. Bhullar, Ayesha Kamal, Anthony N. Kalloo, Vivek Kumbhari, Saowanee Ngamruengphong, Olaya I. Brewer Gutierrez, Mahya Faghih, Mouen A. Khashab, Elham Afghani, Vikesh Singh, Venkata S. Akshintala
Meeting Abstract
Gastroenterology & Hepatology
Vivek Kumbhari, John Hauschild, Courtney Flynn, Jianying Zhang, Venkata S. Akshintala
