Article
Gastroenterology & Hepatology
Tonya Kaltenbach, Andrew Gawron, Craig S. Meyer, Samir Gupta, Amandeep Shergill, Jason A. Dominitz, Roy M. Soetikno, Tiffany Nguyen-Vu, Mary A. Whooley, Charles J. Kahi
Summary: The study showed that assessing adenoma detection rate (ADR) for colonoscopies irrespective of indication may be as effective as conventional ADR based on screening colonoscopies. This could facilitate quality monitoring and implementation of quality measurement and reporting. Future studies should further evaluate the validity of using overall ADR for quality reporting before adopting this method in clinical practice.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Environmental Sciences
Donele Wilkins, Amy J. Schulz
Summary: Communities affected by environmental exposures and health disparities recognize the role of racism in shaping these risks. More researchers are focusing on racism as a fundamental driver of racial inequities in environmental health. Research and funding institutions are committed to addressing structural racism. This article discusses strategies for taking explicitly antiracist approaches to community engagement in environmental health research.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2023)
Article
Pharmacology & Pharmacy
Klaudia Englezos, Lingxin Wang, Edwin C. K. Tan, Lifeng Kang
Summary: The healthcare dynamic has shifted to patient-centred care, requiring more individualised therapies. However, the pharmaceutical industry has not fully adapted to this shift, preventing pharmacists from providing completely personalised medicine to patients. This article reviews the limitations of current pharmaceutical manufacturing methods, discusses the benefits of 3D printing for personalised medicine, and explores the implications for pharmacy practice and policy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Review
Public, Environmental & Occupational Health
Liyin Zhang, Lin Yang, Zhiguang Zhou
Summary: Hypoglycemia is a major barrier to optimal glycemic control in people with diabetes, causing various adverse outcomes. The use of big data analysis and machine learning approaches has increased the importance of hypoglycemia prediction in diabetes management. This study aimed to summarize existing prediction algorithms and models to guide clinical practice.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Pharmacology & Pharmacy
Andrei Lucian Groza, Bogdan Silviu Ungureanu, Cristian Tefas, Bogdan Miutescu, Marcel Tantau
Summary: Colorectal cancer is a significant global public health burden, and colonoscopy is the primary diagnostic and preventive method. Many countries have implemented screening programs. In Romania, despite the highest incidence of CRC, there is no national screening program and the quality of colonoscopy is not regularly assessed. A study conducted in a region of Romania found that the quality level of colonoscopy is above the minimum recommended by international societies. The adenoma detection rate (ADR) correlates well with other quality indicators, and ADR is higher in colonoscopies performed without sedation.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Karin L. Andersson, Jasmine B. Ha, Diane R. Abraczinskas, Emily J. Campbell, James M. Richter
Summary: This study found that colonoscopy takes longer in female patients compared to males, female endoscopists perform a higher proportion of female exams, and female patients have a lower adenoma detection rate. These gender differences could result in a 9.6% revenue loss per session for female gastroenterologists compared to their male counterparts.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Editorial Material
Gastroenterology & Hepatology
Anastasios Koulaouzidis, Gunnar Baatrup
Summary: Colon capsule endoscopy (CCE) is currently used for specific indications. The increasing demand for outpatient treatment along with advancements in technology and clinical quality may allow for broader use of CCE. Artificial intelligence-based analysis and quality assessment could enhance the quality and affordability of CCE.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Rajesh N. Keswani, Seth D. Crockett, Audrey H. Calderwood
Summary: The purpose of this study was to provide best practice advice on improving the quality of screening and surveillance colonoscopy, but no formal rating of evidence quality or strength of recommendation was conducted.
Article
Gastroenterology & Hepatology
Anne F. Peery, Aasma Shaukat, Lisa L. Strate
Summary: Management of colonic diverticulitis should involve personalized diagnosis and treatment based on the patient's condition, including the use of imaging and lower endoscopy to exclude alternative diagnoses, selective antibiotic use, and lifestyle modifications to reduce the risk of recurrence. Patients should understand the importance of diet and healthy behaviors in preventing future episodes of diverticulitis.
Review
Public, Environmental & Occupational Health
Wanying Mao, Vincent I. O. Agyapong
Summary: This literature review examines the impacts of social determinants on mental health and resilience following natural and man-made disasters. Factors such as gender, age, ethnicity, social support, and socioeconomic status are explored, along with other potential factors like previous trauma and family psychiatric history. The implications for public health policy and practice are discussed in relation to the findings.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Food Science & Technology
Melvin A. Pascall, Kris DeAngelo, Julie Richards, Mary Beth Arensberg
Summary: This article discusses specialized products that meet the nutrition needs of vulnerable populations and the important role of packaging in these products. However, there is limited research literature on the functional and sustainable packaging for specialized products. The article also highlights that waste reduction strategies and legislative/regulatory policies in the United States and Canada may not sufficiently address the packaging requirements for specialized products. The article concludes by offering perspectives on emerging innovations and policy development for sustainability.
Article
Environmental Studies
Ehsan Elahi, Hongxia Zhang, Xing Lirong, Zainab Khalid, Haiyun Xu
Summary: The study reveals that farmers' attitudes play a key role in their intention to use improved grassland, while social pressure and perceived difficulty also influence behavior. Understanding farmers' behavior belief, normative belief, and perceived behavior control can better promote their use of improved grassland.
Article
Public, Environmental & Occupational Health
Pia Kvillemo, Anna K. Strandberg, Johanna Gripenberg
Summary: Young adults' attitudes toward cannabis use and public prevention information were explored in a qualitative interview study. The study found that risk awareness among young adults regarding cannabis use is insufficient. Both cannabis users and abstainers recognized the risks associated with cannabis, but for users, the positive effects seemed to outweigh the expected harm. The existing public prevention information was perceived as less credible due to its excessive focus on harm. The participants expressed a desire for neutral and fact-based information delivered by credible senders who young people can identify with or look up to.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Geriatrics & Gerontology
Sue Anne Bell, Lydia Krienke, Allyson Brown, Jen Inloes, Zoe Rettell, Tamar Wyte-Lake
Summary: This study investigated the experiences of home-based care providers in providing care to older adults during the COVID-19 pandemic. The results showed that home-based care faced various challenges during the pandemic, including limited resources, restrictions in administrative needs, and unclear messaging from public health officials. The study emphasized the importance of home-based care in disaster situations and recommended the need for innovative solutions and policy support.
Article
Green & Sustainable Science & Technology
Barbara Hedeler, Hans Hellsmark, Patrik Soderholm
Summary: This paper investigates the role of policy mixes and policy feedback in the emergence of domestic green industries, using the empirical case of biofuels in Sweden. The findings show that policy feedback dynamics created difficulties in aligning national policy with technology and industrial developments, hindering the scaling up of domestic production capacity. However, R&D and import of biofuels experienced strong growth. Based on this empirical case, a process model is developed to explain the role of policy feedback in domestic industry development, demonstrating how policy effects and feedback processes drive industry growth.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Article
Gastroenterology & Hepatology
Fasiha Kanwal, Saira Khaderi, Amit G. Singal, Jorge A. Marrero, Nicole Loo, Sumeet K. Asrani, Christopher Amos, Aaron P. Thrift, Xiangjun Gu, Michelle Luster, Abeer Al-Sarraj, Jing Ning, Hashem B. El-Serag
Summary: This study investigated the risk of developing HCC in patients with cirrhosis and found that the incidence rate of HCC was lower than previously reported. The risk of HCC varied depending on the etiology, with higher risk in patients with cured HCV and lower risk in those with NAFLD. Current smoking and overweight/obesity were also associated with increased HCC risk.
Article
Gastroenterology & Hepatology
Nikita Sandeep Wagle, Sulki Park, David Washburn, Robert L. Ohsfeldt, Nicole E. Rich, Amit G. Singal, Hye-Chung Kum
Summary: This study found that treatment delays are prevalent in patients with hepatocellular carcinoma (HCC) and are associated with worse survival. Treatment delays varied across different treatment modalities and were more likely to occur in Black patients and those living in high poverty neighborhoods. The results highlight the importance of interventions to improve time-to-treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Sandi L. Pruitt, Anna Tavakkoli, Hong Zhu, Daniel F. Heitjan, David E. Gerber, Amit G. Singal, Ethan A. Halm, Muhammad Shaalan Beg, Bhumika Maddineni, Ankit J. Kansagra, Caitlin C. Murphy
Summary: Pancreas cancer patients who have previously had another cancer have similar survival rates to those without previous cancer, suggesting that cancer survivors should be considered for inclusion in pancreas cancer clinical trials.
Article
Oncology
Andrew M. Brown, Ihab Kassab, Marco Massani, Whitney Townsend, Amit G. Singal, Cigdem Soydal, Laura Moreno-Luna, Lewis R. Roberts, Vincent L. Chen, Neehar D. Parikh
Summary: This study conducted an overall and individual patient data (IPD) meta-analysis of transarterial radioembolization (TARE) and transarterial chemoembolization (TACE) for the treatment of hepatocellular carcinoma (HCC). The results showed that TARE had a significantly longer time to progression (TTP) compared to TACE, but there was no significant difference in overall survival (OS) between the two modalities. The limitations of the current data include inconsistent length of follow-up and response criteria. Therefore, prospective studies comparing these treatments are needed.
Editorial Material
Gastroenterology & Hepatology
Amit G. Singal, Neehar D. Parikh, Yujin Hoshida
DIGESTIVE DISEASES AND SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Neehar D. Parikh, Nabihah Tayob, Amit G. Singal
Summary: Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths globally due to inadequate early detection strategies. Current screening recommendations have several deficiencies, including suboptimal sensitivity and poor adherence. Blood-based biomarkers show promise but require validation and logistical solutions before clinical implementation. Maturing validation cohorts, such as the Hepatocellular Carcinoma Early Detection Study and the Texas Hepatocellular Carcinoma Consortium, are expected to provide robust validation for candidate biomarkers.
JOURNAL OF HEPATOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Caitlin C. Murphy, Piera M. Cirillo, Nickilou Y. Krigbaum, Amit G. Singal, Dean P. Jones, Timothy Zaki, Barbara A. Cohn
Summary: This study examined the association between in-utero exposure to antibiotics and the risk of colorectal cancer (CRC) in adult offspring. The findings suggest that in-utero exposure to long-acting sulfonamides is associated with an increased risk of CRC in adulthood.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Fay Kastrinos, Sonia S. Kupfer, Samir Gupta
Summary: Current colorectal cancer (CRC) screening recommendations are based on age, but precision screening using additional factors could improve outcomes and resource utilization. Prediction models can identify high-risk groups for more intensive screening and low-risk groups for less invasive screening. Developing reliable and accurate prediction models and studying their feasibility and cost-effectiveness are critical for future implementation of precision CRC screening.
Article
Multidisciplinary Sciences
Aaron P. Thrift, Fasiha Kanwal, Yanhong Liu, Saira Khaderi, Amit G. Singal, Jorge A. Marrero, Nicole Loo, Sumeet K. Asrani, Michelle Luster, Abeer Al-Sarraj, Jing Ning, Spiridon Tsavachidis, Xiangjun Gu, Christopher I. Amos, Hashem B. El-Serag
Summary: This study found that polygenic risk scores can be used to predict the risk of hepatocellular cancer in contemporary U.S. cirrhosis patients and can improve the predictive ability of traditional risk factor models.
Article
Chemistry, Multidisciplinary
Yifei Tan, Jianhui Zhu, Cristian D. Gutierrez Reyes, Yu Lin, Zhijing Tan, Zuowei Wu, Jie Zhang, Alva Cano, Sara Verschleisser, Yehia Mechref, Amit G. Singal, Neehar D. Parikh, David M. Lubman
Summary: Aberrant changes in site-specific core fucosylation (CF) of serum proteins can serve as potential diagnostic markers of tumors. A study employed an optimized data-dependent acquisition (DDA) workflow to identify CF of serum proteins in patients with nonalcoholic steatohepatitis-related cirrhosis and hepatocellular carcinoma. The study found significant changes in CF peptides between cirrhosis and HCC, with one peptide showing the best diagnostic performance in discriminating HCC from cirrhosis.
Article
Gastroenterology & Hepatology
Amit G. Singal, T. Tara Ghaziani, Neil Mehta, Kali Zhou, Lauren T. Grinspan, Jihane N. Benhammou, Andrew M. Moon, Ju Dong Yang, Reena Salgia, Anjana Pillai, Elizabeth Zheng, Nicole E. Rich, Purva Gopal, Prasun Jalal, Elizabeth Verna, Sruthi Yekkaluri, Samuel Phen, Jonathan Melendez-Torres, Omar Alshuwaykh, Hailey Choi, Kevin Junus, John Grady, Michael Song, Emily A. Leven, Jung Yum, Vrushab Gowda, Manaf Alsudaney, Perla Hernandez, Nirmal Desai, Neehar D. Parikh
Summary: There is a wide variation in recall patterns for patients with subcentimeter liver lesions on ultrasound. The low risk of primary liver cancer (PLC) in these patients supports short-interval ultrasound follow-up in 3-6 months, but high-risk subgroups may require diagnostic CT/MRI.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Oncology
Caitlin C. Murphy, Piera M. Cirillo, Nickilou Y. Krigbaum, Amit G. Singal, Barbara A. Cohn
Summary: This study found that offspring exposed to Bendectin in utero had a higher risk of colorectal cancer (CRC) compared to unexposed offspring. The increased risk may be due to the presence of dicyclomine in Bendectin. Further experimental studies are needed to confirm these findings and identify the mechanisms of risk.
JNCI CANCER SPECTRUM
(2023)
Article
Gastroenterology & Hepatology
Amit G. Singal, Masatoshi Kudo, Jordi Bruix
Summary: Breakthroughs in HCC therapy, including surgical and local ablative therapies, have expanded the number of eligible patients for curative-intent procedures. Transarterial chemoembolization (TACE) remains the treatment of choice for liver-localized disease, but there is increasing recognition of patients who may benefit from systemic therapy. Systemic therapy, especially immune checkpoint inhibitor combinations, has shown promising results with objective responses in approximately 30% of patients and improved survival. Multidisciplinary care is critical for complex decision-making and improved clinical outcomes in HCC treatment. Further research is needed to explore combination therapies and identify remaining areas of need.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Multidisciplinary Sciences
Noa Kopplin, Angie Garcia, Annika Reczek, Kate Wilkinson, Sruthi Yekkaluri, Caitlin C. Murphy, Jasmin Tiro, Alagar R. Muthukumar, Andrew Masica, Amit G. Singal
Summary: This study investigated the natural history and sequelae symptoms of mild COVID-19 infection. More than one in five patients reported persistent symptoms during follow-up. Levels of anti-nucleocapsid and anti-spike antibodies decreased within six months following infection and vaccination.
Article
Gastroenterology & Hepatology
Andrew M. Moon, Sarah Cook, Rachel M. Swier, Hanna K. Sanoff, Michael D. Kappelman, Lynne I. Wagner, A. Sidney Barritt, Amit G. Singal, Neil D. Shah, David M. Mauro, Ted K. Yanagihara, David A. Gerber, Michael W. Fried, Cristal Brown, Myra Waheed, Randall Teal, Donna M. Evon
Summary: This study found that posttreatment symptoms after locoregional therapies in HCC patients are common and often severe. These findings can help prioritize patient-reported outcomes (PRO) domains and suggest that patients are interested in electronic PRO symptom monitoring. Further investigation of electronic PRO monitoring in HCC patients is warranted.
HEPATOLOGY COMMUNICATIONS
(2023)