Article
Nutrition & Dietetics
Tingting Huang, Alexander Ploner, Ellen T. Chang, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qihong Huang, Shanghang Xie, Sumei Cao, Weihua Jia, Yuming Zheng, Jian Liao, Yufeng Chen, Longde Lin, Ingemar Ernberg, Guangwu Huang, Yi Zeng, Yixin Zeng, Hans-Olov Adami, Weimin Ye
Summary: Plant-based and animal-based dietary factors are significantly associated with the risk of nasopharyngeal carcinoma (NPC), while high intakes of preserved foods are linked to an increased risk of NPC. The study suggests that dietary factors in adulthood may be more stable and robust predictors of NPC risk compared to those in adolescence.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2021)
Article
Immunology
Seong Mi Moon, Hayoung Choi, Sang Hyuk Kim, Hyung Koo Kang, Dong Won Park, Jin Hyung Jung, Kyungdo Han, Dong Wook Shin, Hyun Lee
Summary: This study comprehensively evaluated the risk of lung cancer in tuberculosis survivors, considering smoking and chronic obstructive pulmonary disease (COPD). The results showed that tuberculosis survivors had a 1.72-fold higher risk of lung cancer compared to the control group. Current smokers with >= 20 pack-years and tuberculosis survivors with COPD had the highest risks. Risk factors for lung cancer in tuberculosis survivors included pulmonary tuberculosis, age >60 years, smoking, and the presence of COPD or asthma.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Yi-Chiao Bai, Cheng-You Wang, Cheng-Li Lin, Jung-Nien Lai, James Cheng-Chung Wei
Summary: This study conducted a retrospective cohort study using the Taiwan Longitudinal Health Insurance Database and the Taiwan Air Quality Monitoring Database, revealing a significant association between air pollution and the risk of uveitis, especially at high THC and CH4 levels. The risk of uveitis seemed to increase with increasing levels of NOx and THC.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Weiming Chen, Yang Ao, Xiaochun Lan, Wenzhou Tong, Xiaohui Liu, Xia Zhang, Qiang Ye, Yin Li, Linfen Liu, Hao Ye, Pan Zhuang, Yu Zhang, Weifang Zheng, Jingjing Jiao
Summary: This study aimed to explore the associations between different types of unsaturated fatty acids (FAs) and overweight/obesity risk in the Chinese population. The results showed that higher intake of monounsaturated FAs (MUFAs) was associated with a lower risk of overweight/obesity. However, intake of n-3 polyunsaturated FAs (PUFAs) and alpha-linolenic acid (ALA) was positively linked to overweight/obesity risk.
FRONTIERS IN NUTRITION
(2023)
Article
Clinical Neurology
Rune A. Aa Hoglund, Haakon E. Meyer, Hein Stigum, Oivind Torkildsen, Nina Grytten, Trygve Holmoy, Ola Nakken
Summary: This study found that high BMI in individuals aged 14 to 24 was associated with an increased risk of developing multiple sclerosis (MS) later in life, with the risk no longer present for those over 30 years old.
Article
Immunology
Jacob Bodilsen, Jannik Helweg Larsen, Jens Otto Jarlov, Morten Ziebell, Svend Ellermand-Eriksen, Ulrik S. Justesen, Niels Frimodt-Moller, Niels Obel, Lars Haukali Omland
Summary: This study examined the association between dental status, invasive dental procedures, and the risk of brain abscess caused by oral cavity bacteria. The results showed that recent invasive dental procedures and number of dentist's visits were not significant risk factors for brain abscess caused by oral cavity bacteria.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Mahmood Bakhtiyari, Elham Kazemian, Kourosh Kabir, Farzad Hadaegh, Sepehr Aghajanian, Parham Mardi, Nooshin Taherzadeh Ghahfarokhi, Ali Ghanbari, Mohammad Ali Mansournia, Freidoun Azizi
Summary: This study found that in men, systolic blood pressure plays a crucial mediating role in general and central obesity, accounting for more than 60% of the risk. However, in women, controlling metabolic risk factors does not efficiently contribute to decreasing cardiovascular diseases as effectively as in men.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Yanyan Dai, Yujuan Li, Shu Yang, Weiwei Xu, Hong Jia, Chao Yang
Summary: Weight change is associated with the risk of metabolic abnormalities. Long-term excessive weight gain is positively associated with an increased risk of metabolic abnormalities in non-overweight/obese individuals, while long-term weight loss is a protective factor for metabolic health in overweight/obese individuals.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Oncology
Fanxiu Xiong, Jingxuan Wang, Jovia L. Nierenberg, Erin L. Van Blarigan, Stacey A. Kenfield, June M. Chan, Gabriela Schmajuk, Chiung-Yu Huang, Rebecca E. Graff
Summary: The objective of this study was to evaluate the associations between overall diabetes, type 1 diabetes (T1D), type 2 diabetes (T2D), and breast cancer risk. The study found no overall association between diabetes and breast cancer risk, but revealed that women with T1D had a higher risk of breast cancer compared to women without diabetes. T2D was not associated with breast cancer risk overall, but there was a significantly increased risk in the short time window after T2D diagnosis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Cardiac & Cardiovascular Systems
Luwei Li, Sishuai Cheng, Guoquan Xu
Summary: This study identified the independent risk factors for hypertension in overweight and obese people and analyzed the interaction between these risk factors. The results showed that NAFLD, FPG, age, TG, LDL-c, UA, and Cr were independent risk factors for hypertension in overweight and obese people. Among them, age + UA exhibited synergistic interaction, providing a reference for the prevention and control of hypertension in this population.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Fei Wu, Lei Mao, Yu Zhang, Xiaoqian Chen, Pan Zhuang, Wenqiao Wang, Jun Wang, Jingjing Jiao
Summary: This study found that the intake of medium chain saturated fatty acids (MCSFA) was associated with an increased risk of overweight/obesity, especially decanoic acid (10:0). On the other hand, hexanoic acid (6:0) intake was linked to a lower risk of overweight/obesity.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Murui Zheng, Xueru Duan, Huanning Zhou, Weidi Sun, Guoqiang Sun, Jianying Chen, Xiuyi Wu, Sijing Rong, Jun Huang, Wengjing Zhao, Hai Deng, Xudong Liu
Summary: This study investigates the associations between glycolipid biomarkers and the risk of obstructive sleep apnea (OSA). The results show that serum HDL-CH is inversely associated with OSA risk, while elevated levels of triglyceride and FBG increase the risk of OSA. Therefore, attention should be paid to healthy glycolipid metabolism in OSA prevention.
FRONTIERS IN NUTRITION
(2023)
Article
Medicine, General & Internal
Tsung-Po Chen, Hui-Chieh Yu, Tai-Hsin Lin, Yu-Hsun Wang, Yu-Chao Chang
Summary: This population-based cohort study in Taiwan found an association between obesity and the development of chronic periodontitis (CP), with obese patients having a 1.12-fold increased risk of CP compared to non-obese patients. The risk was higher in patients aged 65 or older. Differences in CP risk between obesity and non-obesity groups were not observed by sex.
Article
Public, Environmental & Occupational Health
Martin Chi-Sang Wong, Junjie Huang, Yuet-Yan Wong, Grace Lai-Hung Wong, Terry Cheuk-Fung Yip, Rachel Ngan-Yin Chan, Steven Wai-Ho Chau, Siew-Chien Ng, Yun-Kwok Wing, Francis Ka-Leung Chan
Summary: This study investigated the prevalence and risk factors of long COVID symptoms among patients with COVID-19 in 4 major Chinese cities. The most common severe long COVID symptoms were fatigue, cough, sore throat, difficulty in concentrating, feeling of anxiety, myalgia, and arthralgia. Female gender, living with domestic workers, smoking, poor self-perceived health status, having >= 3 chronic diseases, chronic medication use, and critical severity of COVID-19 were associated with severe long COVID. Prior vaccination with >= 2 doses of COVID-19 vaccines was a protective factor.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Oncology
Huimin Zhang, Mengmeng Zhang, Xuanfu Chen, Mingyue Guo, Runing Zhou, Hong Lv, Yue Li, Bei Tan, Ji Li, Hui Xu, Weiyang Zheng, Hong Yang, Jiaming Qian
Summary: The increased risks of multiple cancers are particularly prominent in Chinese IBD patients, especially digestive cancers, thyroid cancer, and hematological malignancies, emphasizing the need for more targeted guidance for cancer monitoring.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Clinical Neurology
Tingting Wang, Kevin Huynh, Corey Giles, Natalie A. Mellett, Thy Duong, Anh Nguyen, Wei Ling Florence Lim, Alex A. T. Smith, Gavriel Olshansky, Gemma Cadby, Joseph Hung, Jennie Hui, John Beilby, Gerald F. Watts, Pratishtha Chatterjee, Ian Martins, Simon M. Laws, Ashley Bush, Christopher C. Rowe, Victor L. Villemagne, David Ames, Colin L. Masters, Kevin Taddei, Vincent Dore, Juergen Fripp, Matthias Arnold, Gabi Kastenmueller, Kwangsik Nho, Andrew J. Saykin, Rebecca Baillie, Xianlin Han, Ralph N. Martins, Eric K. Moses, Rima Kaddurah-Daouk, Peter J. Meikle
Summary: The APOE genotype is strongly associated with late-onset Alzheimer's disease, with specific lipid species mediating up to 30% and 10% of the treatment effect of APOE epsilon 2 and epsilon 4, respectively. Plasma lipid species represent a potential therapeutic target for Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2022)
Article
Medicine, General & Internal
Reece Jefferies, Harish Puttagunta, Anoushka Krishnan, Ashley Irish, Ramyasuda Swaminathan, John K. Olynyk
Summary: This study investigated the role of mTOR inhibitors in hemopoiesis regulation in stable renal transplant recipients. The results showed that EPO levels were significantly higher in the group receiving mTOR therapy, indicating that EPO resistance rather than impaired iron metabolism may contribute to the impaired hemopoiesis in RTR on mTOR therapy.
FRONTIERS IN MEDICINE
(2022)
Article
Obstetrics & Gynecology
L. A. Wijs, D. A. Doherty, J. A. Keelan, P. Burton, J. L. Yovich, L. Beilin, T. A. Mori, R. C. Huang, L. A. Adams, J. K. Olynyk, O. T. Ayonrinde, B. Penova-Veselinovic, R. J. Hart
Summary: A study comparing cardiometabolic health parameters between adolescents conceived through ART and those conceived without ART found that the majority of health indicators were similar or more favorable in the ART group.
HUMAN REPRODUCTION
(2022)
Article
Gastroenterology & Hepatology
Phillip E. E. Melton, M. A. Burton, K. A. Lillycrop, K. M. Godfrey, S. Rauschert, D. Anderson, G. C. Burdge, T. A. Mori, L. J. Beilin, O. T. Ayonrinde, J. M. Craig, J. K. Olynyk, J. D. Holbrook, C. E. Pennell, W. H. Oddy, E. K. Moses, L. A. Adams, R. C. Huang
Summary: Through DNA methylation epigenome-wide association study, we identified novel DNA methylation loci associated with NAFLD and serum liver biochemistry markers during adolescence, implicating putative dmCpG/gene regulatory pathways and providing insights for future mechanistic studies.
HEPATOLOGY INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Ross J. Marriott, Kevin Murray, Charley A. Budgeon, Veryan Codd, Jennie Hui, Gillian M. Arscott, John P. Beilby, Graeme J. Hankey, Gary A. Wittert, Frederick C. W. Wu, Bu B. Yeap
Summary: Lower testosterone concentrations in middle-aged and older men are associated with shorter telomeres, suggesting that testosterone may contribute to biological aging in men.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Darrell H. G. Crawford, Grant A. Ramm, Kim R. Bridle, Amanda J. Nicoll, Martin B. Delatycki, John K. Olynyk
HEPATOLOGY INTERNATIONAL
(2023)
Article
Genetics & Heredity
Nick Shrine, Abril G. Izquierdo, Jing Chen, Richard Packer, Robert J. Hall, Anna L. Guyatt, Chiara Batini, Rebecca J. Thompson, Chandan Pavuluri, Vidhi Malik, Brian D. Hobbs, Matthew Moll, Wonji Kim, Ruth Tal-Singer, Per Bakke, Katherine A. Fawcett, Catherine John, Kayesha Coley, Noemi Nicole Piga, Alfred Pozarickij, Kuang Lin, Iona Y. Millwood, Zhengming Chen, Liming Li, Sara R. A. Wijnant, Lies Lahousse, Guy Brusselle, Andre G. Uitterlinden, Ani Manichaikul, Elizabeth C. Oelsner, Stephen S. Rich, R. Graham Barr, Shona M. Kerr, Veronique Vitart, Michael R. Brown, Matthias Wielscher, Medea Imboden, Ayoung Jeong, Traci M. Bartz, Sina A. Gharib, Claudia Flexeder, Stefan Karrasch, Christian Gieger, Annette Peters, Beate Stubbe, Xiaowei Hu, Victor E. Ortega, Deborah A. Meyers, Eugene R. Bleecker, Stacey B. Gabriel, Namrata Gupta, Albert Vernon Smith, Jian'an Luan, Jing-Hua Zhao, Ailin F. Hansen, Arnulf Langhammer, Cristen Willer, Laxmi Bhatta, David Porteous, Blair H. Smith, Archie Campbell, Tamar Sofer, Jiwon Lee, Martha L. Daviglus, Bing Yu, Elise Lim, Hanfei Xu, George T. O'Connor, Gaurav Thareja, Omar M. E. Albagha, Said I. Ismail, Wadha Al-Muftah, Radja Badji, Hamdi Mbarek, Dima Darwish, Tasnim Fadl, Heba Yasin, Maryem Ennaifar, Rania Abdellatif, Fatima Alkuwari, Muhammad Alvi, Yasser Al-Sarraj, Chadi Saad, Asmaa Althani, Eleni Fethnou, Fatima Qafoud, Eiman Alkhayat, Nahla Afifi, Sara Tomei, Wei Liu, Stephan Lorenz, Najeeb Syed, Hakeem Almabrazi, Fazulur Rehaman Vempalli, Ramzi Temanni, Tariq Abu Saqri, Mohammedhusen Khatib, Mehshad Hamza, Tariq Abu Zaid, Ahmed El Khouly, Tushar Pathare, Shafeeq Poolat, Rashid Al-Ali, Souhaila Al-Khodor, Mashael Alshafai, Ramin Badii, Lotfi Chouchane, Xavier Estivill, Khalid Fakhro, Younes Mokrab, Jithesh Puthen, Zohreh Tatari, Karsten Suhre, Raquel Granell, Tariq O. Faquih, Pieter S. Hiemstra, Annelies M. Slats, Benjamin H. Mullin, Jennie Hui, Alan James, John Beilby, Karina Patasova, Pirro Hysi, Jukka T. Koskela, Annah B. Wyss, Jianping Jin, Sinjini Sikdar, Mikyeong Lee, Sebastian May-Wilson, Nicola Pirastu, Katherine A. Kentistou, Peter K. Joshi, Paul R. H. J. Timmers, Alexander T. Williams, Robert C. Free, Xueyang Wang, John L. Morrison, Frank D. Gilliland, Zhanghua Chen, Carol A. Wang, Rachel E. Foong, Sarah E. Harris, Adele Taylor, Paul Redmond, James P. Cook, Anubha Mahajan, Lars Lind, Teemu Palviainen, Terho Lehtimaki, Olli T. Raitakari, Jaakko Kaprio, Taina Rantanen, Kirsi H. Pietilainen, Simon R. Cox, Craig E. Pennell, Graham L. Hall, W. James Gauderman, Chris Brightling, James F. Wilson, Tuula Vasankari, Tarja Laitinen, Veikko Salomaa, Dennis O. Mook-Kanamori, Nicholas J. Timpson, Eleftheria Zeggini, Josee Dupuis, Caroline Hayward, Ben Brumpton, Claudia Langenberg, Stefan Weiss, Georg Homuth, Carsten Oliver Schmidt, Nicole Probst-Hensch, Marjo-Riitta Jarvelin, Alanna C. Morrison, Ozren Polasek, Igor Rudan, Joo-Hyeon Lee, Ian Sayers, Emma L. Rawlins, Frank Dudbridge, Edwin K. Silverman, David P. Strachan, Robin G. Walters, Andrew P. Morris, Stephanie J. London, Michael H. Cho, Louise Wain, Ian P. Hall, Martin Tobin
Summary: Through a large-scale multi-ancestry genome-wide association meta-analysis, 1020 independent association signals implicating 559 genes related to COPD were identified. These genes were enriched in 29 pathways. Variants showed heterogeneity across ancestries, age and smoking groups, and the genetic risk score was strongly associated with COPD across ancestry groups. New potential causal variants, genes, proteins and pathways were highlighted, including those targeted by existing drugs. These findings contribute to a better understanding of lung function and COPD mechanisms and have implications for functional genomics experiments and future COPD therapies.
Article
Hematology
Surendra Karki, Katy J. L. Bell, Andrew Hayen, Bette Liu, Anne E. E. Cust, John K. K. Olynyk, David O. O. Irving
Summary: Through a study on blood donors and adjusting for potential confounders, it was found that regular and high-frequency blood donation does not significantly reduce the risk of cardiovascular diseases.
Article
Multidisciplinary Sciences
John K. Olynyk, Richard Grainger, Helen Currie, Louise E. Ramm, Grant A. Ramm
Summary: HLA-A3 and HLA-B7 alleles are not associated with the risk of advanced hepatic fibrosis or cirrhosis in C282Y hemochromatosis, according to a study involving 133 individuals with HFEC282Y homozygous. HLA typing and liver biopsies were conducted to determine the severity of fibrosis.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
N. Dianah B. Abu Bakar, Rodrigo Carlessi, Jully Gogoi-Tiwari, Julia Kohn-Gaone, Vincent Williams, Marco Falasca, John K. Olynyk, Grant A. Ramm, Janina E. E. Tirnitz-Parker
Summary: The TWEAK/Fn14 signalling pathway plays a crucial role in tissue injury and regeneration, and its involvement in pancreatic injury and cancer is not well understood. This study demonstrates that TWEAK/Fn14 signalling is important in the establishment and progression of chronic pancreatitis, increasing the risk of pancreatic cancer. The findings suggest the TWEAK/Fn14 pathway as a potential therapeutic target.
Article
Hematology
Lucy Z. Kornblith, Bindhya Sadhanandhan, Sreepriya Arun, Rebecca Long, Alicia J. Johnson, Jamie Noll, C. N. Ramchand, John K. Olynyk, David H. Farrell
Summary: COVID-19 is associated with a strong inflammatory response leading to organ failure, thrombosis, and death. A study investigated a novel inflammatory biomarker, GPF, in 103 hospitalized patients with COVID-19 and 19 healthy controls. The findings showed that GPF levels were significantly associated with the severity of COVID-19, and it may be a useful marker for evaluating the respiratory disease severity.
BLOOD CELLS MOLECULES AND DISEASES
(2023)
Article
Endocrinology & Metabolism
Jennifer L. Ng, Ee Mun Lim, Rui Zhang, John P. Beilby, Gerald F. Watts, Suzanne J. Brown, Bronwyn G. A. Stuckey
Summary: Liquid chromatography and tandem mass spectrometry (LC-MS/MS) can accurately differentiate nonclassic congenital adrenal hyperplasia (NCCAH) and polycystic ovary syndrome (PCOS) using measured 17-hydroxyprogesterone (17OHP) and 21-deoxycortisol (21DF). The LC-MS/MS-specific 17OHP thresholds are lower than those based on immunoassay and are suitable for NCCAH diagnosis. 21DF shows high sensitivity and specificity for the diagnosis of NCCAH and heterozygosity (HTZ).
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Cell Biology
Rodrigo Carlessi, Elena Denisenko, Ebru Boslem, Julia Kohn-Gaone, Nathan Main, N. Dianah B. Abu Bakar, Gayatri D. Shirolkar, Matthew Jones, Aaron B. Beasley, Daniel Poppe, Benjamin J. Dwyer, Connie Jackaman, M. Christian Tijam, Ryan Lister, Michael Karin, Jonathan A. Fallowfield, Timothy J. Kendall, Stuart J. Forbes, Elin S. Gray, John K. Olynyk, George Yeoh, Alistair R. R. Forrest, Grant A. Ramm, Mark A. Febbraio, Janina E. E. Tirnitz-Parker
Summary: By using single-nucleus RNA sequencing, researchers identified a disease-associated hepatocyte transcriptional state that is increasingly prevalent in chronic liver disease and associated with structural variants. Integrated analysis of human data confirmed this finding and revealed a correlation between high levels of this hepatocyte transcriptional state and an increased risk of hepatocellular carcinoma development.
Article
Gastroenterology & Hepatology
Ashika D. Maharaj, John Lubel, Eileen Lam, Paul J. Clark, Oliver Duncan, Jacob George, Gary P. Jeffrey, Lara Lipton, Howard Liu, Geoffrey McCaughan, Eu-Ling Neo, Jennifer Philip, Simone Strasser, Katherine Stuart, Alexander Thompson, Jonathan Tibballs, Thomas Tu, Michael C. Wallace, Alan Wigg, Marnie Wood, Amany Zekry, Elysia Greenhill, Liane J. Ioannou, Golo Ahlenstiel, Kaye Bowers, Stephen J. Clarke, Anouk Dev, Michael Fink, Mark Goodwin, Christos S. Karapetis, Miriam T. Levy, Kate Muller, James O'Beirne, David Pryor, James Seow, Nicholas Shackel, Caroline Tallis, Nick Butler, John K. Olynyk, Kate Reed-Cox, John R. Zalcberg, Stuart K. Roberts
Summary: This study aimed to develop a core set of quality indicators for the management of hepatocellular carcinoma (HCC). Through a Delphi consensus study, 23 specific indicators were identified, covering aspects such as diagnosis, staging, and treatment of HCC. Adherence to these indicators can improve the quality of care and patient outcomes, including survival.
HEPATOLOGY COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Malik Janjua, Matthew Knuiman, Mark Divitini, Brendan McQuillan, John K. Olynyk, Gary P. Jeffrey, Leon A. Adams
Summary: The study found that low to moderate alcohol consumption is associated with a reduced risk of cardiovascular disease hospitalizations but not cardiovascular disease death in patients with nonalcoholic fatty liver disease (NAFLD).
HEPATOLOGY COMMUNICATIONS
(2022)