Article
Gastroenterology & Hepatology
Marc Monachese, Gautam Mankaney, Faris El-Khider, Carol Rouphael, Rocio Lopez, Carol A. Burke
Summary: Patients with small proximal and distal HPs are at increased risk of metachronous SSLs, underscoring the importance of considering these findings in surveillance recommendations and future studies with larger cohorts.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Oncology
Chaotao Tang, Jun Li, Zhenzhen Yang, Youxiang Chen, Chunyan Zeng
Summary: The lipid metabolism profiles of serrated lesions in the development of colorectal cancer were investigated. The study found that compared to benign colorectal polyps, malignant serrated lesions had lower levels of high-density lipoprotein (HDL) and higher levels of triglycerides (TG), and these factors may be associated with metabolic genomic markers.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Anatomy & Morphology
Klorin Geula, Hayat Noa, Linder Revital, Amit Amnon, Reiss Ari, Sabo Edmond
Summary: This study used automated computerized texture analysis to differentiate between hyperplastic polyps (HP) and sessile serrated adenomas (SSA). The results showed that Fourier-based texture image analysis is helpful in distinguishing between HP and SSA.
MICROSCOPY RESEARCH AND TECHNIQUE
(2023)
Review
Medicine, Research & Experimental
David E. F. W. M. van Toledo, Joep E. G. IJspeert, Evelien Dekker
Summary: Recent studies have shown that serrated polyps (SPs) also have the potential to develop into colorectal cancer, leading to a paradigm shift in CRC prevention, diagnosis, and treatment. While understanding of SPs and associated CRC has improved, there is still much work to be done in the clinical management of SPs and serrated polyposis syndrome (SPS).
ANNUAL REVIEW OF MEDICINE
(2022)
Article
Cell Biology
Yasmijn J. van Herwaarden, Lieke M. Koggel, Femke Simmer, Elisa M. Vink-Borger, Polat Dura, Gerrit A. Meijer, Fokko M. Nagengast, Nicoline Hoogerbrugge, Tanya M. Bisseling, Iris D. Nagtegaal
Summary: Truncating germline RNF43 mutations are uncommon in SPS patients. Somatic mutations in RNF43 were found in sporadic TSA and SSL, as well as serrated polyps and adenomas from Lynch syndrome patients, suggesting that they do not develop early in the pathway to CRC and are not specific for serrated polyp subtypes.
Article
Pathology
Phoenix D. Bell, Joseph C. Anderson, Amitabh Srivastava
Summary: The serrated pathway of carcinogenesis is still not fully understood, and limitations in endoscopic detection and pathologic interpretation of serrated polyps have implications on risk prediction and surveillance recommendations.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2022)
Article
Oncology
Giada Munari, Gianluca Businello, Paola Mattiolo, Gianmaria Pennelli, Marta Sbaraglia, Chiara Borga, Salvatore Pucciarelli, Gaya Spolverato, Claudia Mescoli, Francesca Galuppini, Antonio Sommariva, Elena Bellan, Sara Lonardi, Fotios Loupakis, Claudio Luchini, Angelo Paolo Dei Tos, Matteo Fassan
Summary: A comprehensive molecular characterization of non-neuroendocrine neoplasms of the appendix was conducted, revealing KRAS as the most frequently mutated gene, and highlighting the lack of a genetic similarity between appendiceal mucinous lesions and serrated colon lesions.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Dan Li, Amanda R. Doherty, Menaka Raju, Liyan Liu, Nan Ye Lei, Laura B. Amsden, Jeffrey K. Lee, Theodore R. Levin, Douglas A. Corley, Lisa J. Herrinton
Summary: This community-based, case-control study found a close association between serrated polyps (SPs) and the risk of colorectal cancer (CRC), especially large proximal serrated lesions or those with dysplasia. Close endoscopic surveillance of serrated polyps can help reduce the risk of CRC. Proximal unspecified SPs are also associated with an increased risk of CRC and should be managed as serrated lesions.
Article
Biotechnology & Applied Microbiology
Julio Avelar-Barragan, Lauren DeDecker, Zachary Lu, Bretton Coppedge, William E. Karnes, Katrine L. Whiteson
Summary: This study categorized the developmental pathways of colorectal cancer and investigated the differences in microbiome composition between these pathways. The researchers found significant differences between the microbiomes of colon mucosa and fecal samples and were able to accurately predict the polyp types using microbiome composition.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Multidisciplinary Sciences
Masafumi Nishio, Reiko Kunisaki, Wataru Shibata, Yoichi Ajioka, Kingo Hirasawa, Akiko Takase, Sawako Chiba, Yoshiaki Inayama, Wataru Ueda, Kiyotaka Okawa, Haruka Otake, Tsuyoshi Ogashiwa, Hiroto Kinoshita, Yusuke Saigusa, Hideaki Kimura, Jun Kato, Shin Maeda
Summary: This study retrospectively examined the prevalence and characteristics of serrated polyps in patients with ulcerative colitis (UC) in Japan. Among 2035 UC patients, 36 serrated polyps were identified, with a prevalence of 1.8%. Serrated polyps were more common in colitis-affected segments and in male patients. The findings suggest a potential association between chronic inflammation and the development of serrated polyps in UC patients.
Article
Pathology
Hisanori Matoba, Mai Iwaya, Yoshiko Sato, Noriyasu Kobayashi, Haruka Takemura, Yusuke Kouno, Ayumi Karasawa, Jun Nakayama
Summary: In this study, the binding of GS-II lectin and expression of various markers were examined in SSLs, MVHPs, and TAs. SSLs and MVHPs showed high expression of MUC5AC and MUC6, while TAs had lower expression. GS-II staining was mainly seen in the Golgi region and showed goblet cell distribution in SSLs and MVHPs. SATB2 expression was decreased in SSLs and MVHPs. Overall, increased terminal beta GlcNAc and decreased SATB2 expression are characteristic features of SSLs and MVHPs.
PATHOLOGY INTERNATIONAL
(2023)
Article
Oncology
Seth D. Crockett, Elizabeth L. Barry, Leila A. Mott, Dale C. Snover, Kristin Wallace, John A. Baron
Summary: This study found that risk factors for serrated polyps differed by race, alcohol and smoking status, and prior history of polyps. These findings allow for better risk stratification of patients undergoing colorectal cancer screening.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Engineering, Biomedical
Lino Polese, Carlotta La Raja, Silvano Fasolato, Anna Chiara Frigo, Paolo Angeli, Stefano Merigliano
Summary: Diode laser therapy was found to be a safe and effective treatment for hyperplastic polyps in cirrhotic patients. Multiple laser sessions resulted in better clinical outcomes, but had no significant impact on anemia and transfusion requirements in these patients.
LASERS IN MEDICAL SCIENCE
(2021)
Review
Gastroenterology & Hepatology
Lucile Heroin, Antonio Saviano, Tanguy Fenouil, Leonardo Sosa-Valencia, Thomas F. Baumert, Francois Habersetzer, Pierre Mayer
Summary: Portal hypertension is a serious complication of chronic liver diseases, often leading to conditions such as esophageal varices, portal hypertensive gastropathy, and hyperplastic polyps. Recent studies have identified a new entity called portal hypertensive polyps (PHPs) in PH patients, which differ from classical hyperplastic polyps. PHPs may cause symptoms such as pyloric obstruction, iron deficiency, and anemia, and may require resection if symptomatic or >10 mm in size.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Nutrition & Dietetics
Zhixin Zhu, Xifei Guan, Nawen Liu, Xiaoxia Zhu, Sheng Dai, Dehai Xiong, Xiuyang Li
Summary: This study conducted a systematic review and meta-analysis and found that high dietary fiber intake can effectively prevent the occurrence of colorectal serrated polyps, while red meat intake increases the risk of colorectal serrated polyps.
FRONTIERS IN NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Martin Menendez Rodriguez, Natalia Garcia-Morales, Teresa Seoane Pillado, Jorge Garau Ramirez, Alba Traver Salvador, Yesica Hervas Jimenezf, Noel Pin Vieito, Luis Menendez Rodriguez, Joaquin Cubiella
Summary: Colorectal cancer is the second leading cause of cancer-related death worldwide, and the tumor stage at diagnosis is the main prognostic factor for survival. However, the participation rate in colorectal cancer screening programs is only around 50%. This study aimed to identify the perceived benefits and barriers of the population when participating in a colorectal cancer screening program using the faecal occult blood test. Through a case-control study with 408 participants, epidemiological and social variables associated with lifestyle and behavioral factors were analyzed based on the Health Belief Model. Descriptive analysis was conducted, and variables associated with adherence were identified through logistic regression.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Review
Gastroenterology & Hepatology
Maria Moreno-Sanchez, Joaquin Cubiella, Gloria Fernandez Esparrach, Jose Carlos Marin-Gabriel
Summary: This article discusses the challenge that diagnosis of early gastric cancer and its precancerous lesions poses for most Western endoscopists. The subtle changes in mucosal pattern make them difficult to identify. The article reviews the usefulness of conventional and virtual chromoendoscopy and magnification endoscopy in the recognition and classification of these lesions.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Article
Gastroenterology & Hepatology
Frederik Emil Juul, Kjetil Garborg, Eugen Nesbakken, Magnus Loberg, Paulina Wieszczy, Joaquin Cubiella, Mette Kalager, Michael F. Kaminski, Rune Erichsen, Hans-Olov Adami, Monika Ferlitsch, Siv K. B. Furholm, Ann G. Zauber, Enrique Quintero, Marek Bugajski, Oyvind Holme, Evelien Dekker, Rodrigo Jover, Michael Bretthauer
Summary: There is significant practice variation in the number of colonoscopies performed to achieve complete polyp removal, indicating the need for targeted quality improvement to reduce patient burden.
Article
Genetics & Heredity
Yasmin Soares de Lima, Coral Arnau-Collell, Jenifer Munoz, Cristina Herrera-Pariente, Leticia Moreira, Teresa Ocana, Marcos Diaz-Gay, Sebastia Franch-Exposito, Miriam Cuatrecasas, Sabela Carballal, Anael Lopez-Novo, Lorena Moreno, Guerau Fernandez, Aranzazu Diaz de Bustamante, Sophia Peters, Anna K. Sommer, Isabel Spier, Iris B. A. W. te Paske, Yasmijn J. van Herwaarden, Antoni Castells, Luis Bujanda, Gabriel Capella, Verena Steinke-Lange, Khalid Mahmood, JiHoon Eric Joo, Julie Arnold, Susan Parry, Finlay A. Macrae, Ingrid M. Winship, Christophe Rosty, Joaquin Cubiella, Daniel Rodriguez-Alcalde, Elke Holinski-Feder, Richarda de Voer, Daniel D. Buchanan, Stefan Aretz, Clara Ruiz-Ponte, Laura Valle, Francesc Balaguer, Laia Bonjoch, Sergi Castellvi-Bel
Summary: Rare germline variants in the WNK2 gene were identified through functional evaluation of a candidate gene and replication in additional SPS cohorts. These variants may affect protein function in the MAPK pathway, thereby increasing the risk for SPS.
JOURNAL OF MEDICAL GENETICS
(2023)
Letter
Biochemistry & Molecular Biology
Keisuke Okuno, Raju Kandimalla, Marta Mendiola, Francesc Balaguer, Luis Bujanda, Carlos Fernandez-Martos, Jorge Aparicio, Jaime Feliu, Masanori Tokunaga, Yusuke Kinugasa, Joan Maurel, Ajay Goel
Article
Gastroenterology & Hepatology
Francisco J. Caballero-Camino, Pedro M. Rodrigues, Fredrik Wangsell, Alona Agirre-Lizaso, Paula Olaizola, Laura Izquierdo-Sanchez, Maria J. Perugorria, Luis Bujanda, Bo Angelin, Sara Straniero, Anna Walleback, Ingemar Starke, Per-Goran Gillberg, Ellen Strangberg, Britta Bonn, Jan P. Mattsson, Martin R. Madsen, Henrik H. Hansen, Erik Lindstrom, Peter Akerblad, Jesus M. Banales
Summary: The ASBT inhibitor A3907 improves cholestatic liver diseases by clearing circulating bile acids and protecting liver function. A3907 targets ASBT in the intestine, liver, and kidney, leading to improved bilirubin and liver injury markers. A3907 is well tolerated in healthy individuals, supporting further clinical development.
Article
Biochemistry & Molecular Biology
Miriam Gene, Miriam Cuatrecasas, Irene Amat, Jesus Alberto Veiga, Maria Jesus Fernandez Acenero, Victoria Fuste Chimisana, Jordi Tarragona, Ismael Jurado, Rebeca Fernandez-Victoria, Carolina Martinez Ciarpaglini, Cristina Alenda Gonzalez, Carlos Zac, Pilar Ortega de la Obra, Maria Teresa Fernandez-Figueras, Manel Esteller, Eva Musulen
Summary: Colitis-associated colorectal carcinoma (CAC) in inflammatory bowel disease (IBD) is caused by p53 alterations and follows a chronic inflammation-dysplasia-cancer carcinogenesis pathway. Gastric metaplasia (GM) is described as the initial event of serrated colorectal cancer (CRC) in the colon mucosa under chronic stress. This study analyzed p53 alterations and microsatellite instability (MSI) to characterize CAC and investigate its relationship with GM. Results showed that p53 mutation pattern was present in more than half of the CAC cases, with stable (MSS) tumors being the most common and MUC5AC negative. Only six unstable (MSI-H) tumors had wild-type p53 pattern (p=0.010) and were MUC5AC positive (p=0.005). MUC5AC staining was more frequently observed in intestinal mucosa with inflammation or chronic changes than in CAC, particularly in those with wild-type p53 pattern and MSS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Joel Flores-Arriaga, Maria C. Aso, Arantzazu Izagirre, Ami D. Sperber, Olafur S. Palsson, Shrikant I. Bangdiwala, Angel Lanas, Luis Bujanda, Beatriz Lobo, Carmen Alonso-Cotoner, Alex Sanchez-Pla, Javier Santos
Summary: The study used data from the Rome Foundation Global Epidemiology Study to assess the prevalence and burden of gut-brain disorders in Spain. The survey, completed by 2072 participants, revealed that 43.6% of respondents met diagnostic criteria for at least one disorder, with functional constipation being the most prevalent. The study highlights the need for specialized training and future research in this area.
NEUROGASTROENTEROLOGY AND MOTILITY
(2023)
Article
Medicine, General & Internal
Carolina Mangas-Sanjuan, Luisa de-Castro, Joaquin Cubiella, Pilar Diez-Redondo, Adolfo Suarez, Maria Pellise, Nereida Fernandez, Sara Zarraquinos, Henar Nunez-Rodriguez, Veronica Alvarez-Garcia, Oswaldo Ortiz, Noelia Sala-Miquel, Pedro Zapater, Rodrigo Jover, CADILLAC Study Investigators
Summary: Computer-aided detection did not improve the identification of advanced colorectal neoplasias during colonoscopy.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Annalisa Schiepatti, Stiliano Maimaris, Suneil A. Raju, Olivia L. Green, Giulia Mantica, Amelie Therrien, David Flores-Marin, Justin Linden, Fernando Fernandez-Banares, Maria Esteve, Daniel Leffler, Federico Biagi, David S. Sanders
Summary: Objective Persistent villous atrophy (pVA), a condition where the intestinal lining remains damaged despite a gluten-free diet, has unclear significance in coeliac disease (CD). This study aimed to investigate the relationship between pVA and long-term outcomes and develop a scoring system to identify patients at risk of pVA. The results showed that patients with pVA had increased risk of complications and mortality. A 5-point score was developed to classify patients into low, intermediate, and high risk categories. Age at diagnosis, classic pattern of CD, lack of clinical response to GFD, and poor GFD adherence were identified as predictors for pVA.
Article
Oncology
Joan Llach, Inmaculada Salces, Ana Guerra, Beatriz Penas, Daniel Rodriguez-Alcalde, Pilar Diez Redondo, Joaquin Cubiella, Oscar Murcia, Maite Escalante, Jordi Gratacos-Gines, Anna Pocurull, Maria Daca-Alvarez, Irina Luzko, Ariadna Sanchez, Cristina Herrera-Pariente, Teresa Ocana, Sabela Carballal, Ignasi Elizalde, Sergi Castellvi-Bel, Gloria Fernandez-Esparrach, Antoni Castells, Francesc Balaguer, Leticia Moreira
Summary: While clinical practice guidelines exist for hereditary diffuse gastric cancer, there is no consensus on how to approach familial intestinal gastric cancer. A multicenter observational study was conducted in nine Spanish hospitals to investigate the yield of gastric cancer surveillance, as well as identify risk factors for development of gastric cancer and precursor lesions in these families. The study found that Helicobacter pylori infection was independently associated with an increased risk of developing precursor lesions or gastric cancer.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Natalia Gonzalez-Lopez, Enrique Quintero, Antonio Z. Gimeno-Garcia, Luis Bujanda, Jesus Banales, Joaquin Cubiella, Maria Salve-Bouzo, Jesus Miguel Herrero-Rivas, Estela Cid-Delgado, Victoria Alvarez-Sanchez, Alejandro Ledo-Rodriguez, Maria Luisa de-Castro-Parga, Romina Fernandez-Poceiro, Luciano Sanroman-Alvarez, Jose Santiago-Garcia, Alberto Herreros-de-Tejada, Teresa Ocana-Bombardo, Francesc Balaguer, Maria Rodriguez-Soler, Rodrigo Jover, Marta Ponce, Cristina Alvarez-Urturi, Xavier Bessa, Maria-Pilar Roncales, Federico Sopena, Angel Lanas, David Nicolas-Perez, Zaida Adrian-de-Ganzo, Marta Carrillo-Palau, Enrique Gonzalez-Davila
Summary: In this study, the uptake of FIT screening was compared to colonoscopy screening in high-risk individuals for CRC. The results showed that FIT screening did not improve the screening uptake and detected fewer advanced colorectal neoplasia compared to colonoscopy. Further studies are needed to improve the screening uptake in this high-risk group, including inclusion in population-based screening programs.
Article
Oncology
Joaquin Cubiella, Beatriz Calderon-Cruz, Raquel Almazan, Angel Gomez-Amorin
Summary: The interruption of population-based organized colorectal cancer screening programs due to the COVID pandemic increased delays but did not reduce participation, adherence to colonoscopy, or the diagnostic yield of colonoscopy.
Article
Oncology
Ana Beatriz Sanchez-Heras, Teresa Ramon y Cajal, Marta Pineda, Elena Aguirre, Begona Grana, Isabel Chirivella, Judit Balmana, Joan Brunet
Summary: Li-Fraumeni syndrome is caused by TP53 gene heterozygous germline pathogenic variants. It is associated with a high risk of various malignant tumors in childhood and adulthood, including premenopausal breast cancer, soft tissue sarcomas and osteosarcomas, central nervous system tumors, and adrenocortical carcinomas. The concept of SLF has expanded to hereditable TP53-related cancer syndrome (hTP53rc) due to the variability of clinical manifestations, which don't always meet the classic criteria of Li-Fraumeni syndrome. Prospective studies are needed to assess genotype-phenotype characteristics and risk-adjusted recommendations.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)