Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Nan Yi, Hailiang Zhao, Juan He, Xike Xie, Liexin Liang, Guowen Zuo, Mingyue Xiong, Yunxiao Liang, Tingzhuang Yi
Summary: Almost 50% of esophageal adenocarcinoma (EAC) patients are progressed from Barrett's esophagus (BE). However, effective stratification and therapy methods for BE and EAC are still lacking. Differentially expressed genes (DEGs) between BE and EAC were identified through the analysis of two public datasets (GSE26886 and GSE37200), followed by bioinformatics analyses to explore potential biomarkers associated with BE-EAC. The results revealed a number of up- and down-regulated genes, which were highly involved in tumorigenesis according to the GO and KEGG enrichment analysis. In addition, the study identified several potential diagnostic and prognostic biomarkers in BE-EAC.
SCIENTIFIC REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Sho Fukuda, Kenta Watanabe, Tatsuki Yoshida, So Takahashi, Shusei Fujimori, Yohei Horikawa, Taiga Komatsu, Kenji Shirane, Yosuke Shimodaira, Tamotsu Matsuhashi, Katsunori Iijima
Summary: Although the prevalence of USSBE is quite high (36.4%), the incidence of EAC in USSBE is very low (0.0068%/year). Accordingly, USSBE can be excluded from targets for endoscopic surveillance in Japan.
DIGESTIVE ENDOSCOPY
(2022)
Review
Oncology
Franz Ludwig Dumoulin, Fabian Dario Rodriguez-Monaco, Alanna Ebigbo, Ingo Steinbruck
Summary: Esophageal adenocarcinoma is the most common subtype of esophageal cancer in Western societies and its incidence is increasing. The development and validation of artificial intelligence systems in the field of gastroenterology may help address unresolved issues in the prevention and surveillance of this cancer.
Review
Gastroenterology & Hepatology
Motasem Alkhayyat, Prabhat Kumar, Krishna O. Sanaka, Prashanthi N. Thota
Summary: The incidence of Barrett's esophagus and esophageal adenocarcinoma has been increasing, leading to a search for chemoprevention strategies. Proton-pump inhibitors and Aspirin have shown effectiveness in reducing cancer incidence in Barrett's patients. Other agents lack sufficient evidence for chemoprevention in these patients.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Chunyang Bao, Richard W. Tourdot, Gregory J. Brunette, Chip Stewart, Lili Sun, Hideo Baba, Masayuki Watanabe, Agoston T. Agoston, Kunal Jajoo, Jon M. Davison, Katie S. Nason, Gad Getz, Kenneth K. Wang, Yu Imamura, Robert Odze, Adam J. Bass, Matthew D. Stachler, Cheng-Zhong Zhang
Summary: By analyzing chromosomal copy-number evolution in early cancers and precancerous lesions of the esophagus, the authors reveal signatures of ongoing chromosomal instability and its role in promoting tumor progression.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Lei Chen, Farah Ballout, Heng Lu, Tianling Hu, Shoumin Zhu, Zheng Chen, Dunfa Peng
Summary: In this study, the gene expression of NEK family members in esophageal adenocarcinoma and its precancerous condition was analyzed. The findings suggest that upregulation of certain NEKs may be important in the development of esophageal adenocarcinoma.
Article
Oncology
Anshuman Panda, Gyan Bhanot, Shridar Ganesan, Manisha Bajpai
Summary: Stable cell lines derived from primary tissues and tumors are commonly used in medical research. This study evaluated gene expression profiles of esophageal tissues and cell lines, finding discrepancies in the gene expression profiles of Barrett's esophagus (BE) cell lines compared to primary BE tissues and esophageal adenocarcinoma (EAC) tumors. Exposure to an acidic bile environment did not alter the squamous-like gene expression pattern of a BE cell line. The findings underscore the importance of carefully selecting appropriate in vitro tools for studying esophageal adenocarcinoma.
Article
Oncology
Shruti G. Dighe, Jianhong Chen, Li Yan, Qianchuan He, Puya Gharahkhani, Lynn Onstad, David M. Levine, Claire Palles, Weimin Ye, Marilie D. Gammon, Prasad G. Iyer, Lesley A. Anderson, Geoffrey Liu, Anna H. Wu, James Y. Dai, Wong-Ho Chow, Harvey A. Risch, Jesper Lagergren, Nicholas J. Shaheen, Leslie Bernstein, Douglas A. Corley, Hans Prenen, John DeCaestecker, David MacDonald, Paul Moayyedi, Hugh Barr, Sharon B. Love, Laura Chegwidden, Stephen Attwood, Peter Watson, Rebecca Harrison, Katja Ott, Susanne Moebus, Marino Venerito, Hauke Lang, Rupert Mayershofer, Michael Knapp, Lothar Veits, Christian Gerges, Josef Weismueller, Ines Gockel, Yogesh Vashist, Markus M. Noethen, Jakob R. Izbicki, Hendrik Manner, Horst Neuhaus, Thomas Roesch, Anne C. Boehmer, Arnulf H. Hoelscher, Mario Anders, Oliver Pech, Brigitte Schumacher, Claudia Schmidt, Thomas Schmidt, Tania Noder, Dietmar Lorenz, Michael Vieth, Andrea May, Timo Hess, Nicole Kreuser, Jessica Becker, Christian Ell, Christine B. Ambrosone, Kirsten B. Moysich, Stuart MacGregor, Ian Tomlinson, David C. Whiteman, Janusz Jankowski, Johannes Schumacher, Thomas L. Vaughan, Margaret M. Madeleine, Laura J. Hardie, Matthew F. Buas
Summary: Genome-wide association studies of esophageal adenocarcinoma and Barrett's esophagus have revealed significant genetic components of risk, with central obesity being a key risk factor linked to systemic inflammation and hormonal signaling dysfunction. Assessing IGF-related genetic variation identified GHR and IGF1R gene-level associations with BE risk, highlighting the importance of cell-surface receptors in influencing disease susceptibility.
Review
Medicine, General & Internal
Kazumi Inokuchi, Takahiro Ochiya, Juntaro Matsuzaki
Summary: Esophageal adenocarcinoma (EAC) is the major histologic type of esophageal cancer in Western countries with a poor prognosis primarily due to late stage diagnosis. Barrett's esophagus (BE) is a precursor lesion of EAC. Extracellular microRNAs (miRNAs) may serve as non-invasive markers for the management of EAC in the future, with potential utility for diagnosis and treatment responses. Multiple studies have reported dysregulation of certain miRNAs in both EAC and BE, suggesting their potential as valuable biomarkers.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Takuya Shijimaya, Tomomitsu Tahara, Jumpei Yamazaki, Yasushi Matsumoto, Naohiro Nakamura, Yu Takahashi, Takashi Tomiyama, Toshiro Fukui, Tomoyuki Shibata, Makoto Naganuma
Summary: The molecular mechanisms of Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC) in Japanese patients are still unclear. A study conducted on Japanese patients, mostly with short-segment BE (SSBE), found that methylation levels of the N33, DPYS, and SLC16A12 genes were higher in the ADJ and T groups compared to the N group.
MOLECULAR CARCINOGENESIS
(2023)
Article
Immunology
Cathryn M. Kolka, Julie Webster, Ailin Lepletier, Clay Winterford, Ian Brown, Renee S. Richards, Wioleta M. Zelek, Yilang Cao, Ramlah Khamis, Karthik B. Shanmugasundaram, Alain Wuethrich, Matt Trau, Sandra Brosda, Andrew Barbour, Alok K. Shah, Guy D. Eslick, Nicholas J. Clemons, B. Paul Morgan, Michelle M. Hill
Summary: This study confirms the increased formation of C5b-9 in esophageal adenocarcinoma (EAC) and demonstrates the capability and heterogeneity in C5b-9 formation and shedding in Barrett's Esophagus (BE) and EAC cell lines following sublytic C9 exposure.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Jitka Vaculova, Radek Kroupa, Zdenek Kala, Jiri Dolina, Tomas Grolich, Jakub Vlazny, David Said, Lydie Izakovicova Holla, Petra Borilova Linhartova, Vladimir Prochazka, Marek Joukal, Petr Jabandziev, Ondrej Slaby, Lumir Kunovsky
Summary: Confocal laser endomicroscopy (CLE) is a real-time microscopic imaging technique used mainly in gastroenterology, particularly in the diagnosis of Barrett's esophagus and esophageal adenocarcinoma. Although many studies have shown that CLE increases diagnostic accuracy in detecting neoplastic transformation of BE, it is still not widely used as a standard diagnostic tool in BE surveillance due to a lack of scientific evidence.
Article
Ecology
Li Jiao, Themistoklis Kourkoumpetis, Diane Hutchinson, Nadim J. Ajami, Kristi Hoffman, Donna L. White, David Y. Graham, Clark Hair, Rajesh Shah, Fasiha Kanwal, Maria Jarbrink-Sehgal, Nisreen Husain, Ruben Hernaez, Jason Hou, Rhonda Cole, Maria Velez, Gyanprakash Ketwaroo, Jennifer Kramer, Hashem B. El-Serag, Joseph F. Petrosino
Summary: Limited data exists on the spatial distribution of colonic bacteria in humans. This study investigated the bacterial composition in different segments of the colon in healthy adults, finding unique bacterial communities in each individual with no significant differences across colon segments except for distinct differences between rectal and fecal bacteria.
Article
Gastroenterology & Hepatology
Ji Young Lee, Audrey H. Calderwood, William Karnes, James Requa, Brian C. Jacobson, Michael B. Wallace
Summary: This study demonstrates the objective assessment of bowel preparation adequacy using an AI/CNN algorithm developed from colonoscopy videos, showing good performance and agreement with experts.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Kasper A. Overbeek, Nikki van Leeuwen, Matteo Tacelli, Muhammad S. Anwar, Muhammad N. Yousaf, Ankit Chhoda, Paolo Giorgio Arcidiacono, Tamas A. Gonda, Michael B. Wallace, Gabriele Capurso, James J. Farrell, Djuna L. Cahen, Marco J. Bruno
Summary: The study validated the performance of DART-1 in predicting the development of WFs or HRS in BD-IPMN, with risk estimations most accurate for patients in the middle risk quintile and slightly underestimated in the lowest quintiles.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Neurosciences
Sarah T. Ahmed, Lea Steele, Peter Richardson, Shree Nadkarni, Sandhya Bandi, Mazhgan Rowneki, Kellie J. Sims, Jacqueline Vahey, Elizabeth J. Gifford, Stephen H. Boyle, Theresa H. Nguyen, Alice Nono Djotsa, Donna L. White, Elizabeth R. Hauser, Helena Chandler, Jose-Miguel Yamal, Drew A. Helmer
Summary: This study provides insights into the chronic symptoms and exposures experienced by Gulf War veterans referred to a specialized evaluation center. The findings highlight the high burden of chronic symptoms and the association between these symptoms and reported neurotoxicant exposures during the war.
Article
Oncology
Angela L. Mazul, Christine M. Hartman, Yvonne M. Mowery, Jennifer R. Kramer, Donna L. White, Kathryn E. Royse, Suchismita Raychaudhury, Vlad C. Sandulache, Sarah T. Ahmed, Jose P. Zevallos, Peter A. Richardson, Andrew G. Sikora, Elizabeth Y. Chiao
Summary: The study indicates that persons living with HIV/AIDS have a higher risk of developing oropharyngeal and nonoropharyngeal head and neck squamous cell carcinoma compared to HIV-negative individuals. Additionally, HIV may play a role in both virally mediated and nonvirally mediated HNSCC.
Article
Infectious Diseases
Jose M. Garcia, Yongquan Dong, Peter Richardson, Jennifer R. Kramer, Christine M. Hartman, Kathryn Royse, Donna L. White, Elizabeth Y. Chiao
Summary: HIV-infected individuals gain more weight than HIV-negative individuals in the first two years after starting antiretroviral therapy. Additionally, HIV-infected individuals have lower rates of obesity compared to HIV-negative individuals.
Review
Gastroenterology & Hepatology
Pujan Kandel, Murtaza Hussain, Deepesh Yadav, Santosh K. Dhungana, Bhaumik Brahmbhatt, Massimo Raimondo, Frank J. Lukens, Ghassan Bachuwa, Michael B. Wallace
Summary: The application of snare tip soft coagulation (STSC) at the margins of mucosal defects can significantly reduce adenoma recurrence at the first surveillance colonoscopy and decrease the risk of bleeding complications, according to the findings of a systematic review and meta-analysis.
ENDOSCOPY INTERNATIONAL OPEN
(2022)
Editorial Material
Gastroenterology & Hepatology
Michael B. Wallace, Stephanie Kinnan
Editorial Material
Oncology
Eva H. Clark, Sarah T. Ahmed, Elaine Chang, Elizabeth Y. Chiao, Donna L. White
Summary: Studies suggest that statins may have a protective effect in patients with hepatitis B and hepatitis C, reducing the risk of hepatocellular carcinoma. However, there is limited research on the impact of statins on populations with other oncogenic viral infections.
INFECTIOUS AGENTS AND CANCER
(2022)
Review
Oncology
Raefa Abou Khouzam, Jean-Marie Lehn, Hemma Mayr, Pierre-Alain Clavien, Michael Bradley Wallace, Michel Ducreux, Perparim Limani, Salem Chouaib
Summary: Hypoxia is a crucial characteristic of the tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC) and plays a significant role in its pathogenesis. This review focuses on the impact of hypoxia on genomic instability and the tumor immune microenvironment in PDAC. Strategies for alleviating hypoxia and their potential applications for diagnosis and therapy in PDAC patients will also be discussed.
Meeting Abstract
Gastroenterology & Hepatology
Megan M. Engels, Sanne Hoogenboom, Ugur Demir, Tara Pattilachan, Jeanin E. Van Hooft, Yan Bi, Candice W. Bolan, Michael B. Wallace, Ulas Bagci
Article
Gastroenterology & Hepatology
Karthik Ravi, William Ross, Ara Sahakian, Brian Weston, Prasad G. Iyer, Amit Rastogi, Michael B. Wallace
GASTROINTESTINAL ENDOSCOPY
(2022)
Review
Gastroenterology & Hepatology
Babu P. Mohan, Antonio Facciorusso, Shahab R. Khan, Deepak Madhu, Lena L. Kassab, Suresh Ponnada, Saurabh Chandan, Stefano F. Crino, Gursimran S. Kochhar, Douglas G. Adler, Michael B. Wallace
Summary: Based on rigorous systematic review and meta-analysis, this study found that artificial intelligence performs well in the analysis of EUS-images of pancreatic lesions, with good accuracy, sensitivity, and specificity.
ENDOSCOPIC ULTRASOUND
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Marco Spadaccini, Ludovico Alfarone, Leonardo Da Rio, Roberta Maselli, Silvia Carrara, Piera Alessia Galtieri, Gaia Pellegatta, Alessandro Fugazza, Glenn Koleth, James Emmanuel, Andrea A. Anderloni, Yuichi Mori, Michael B. Wallace, Prateek Sharma, Alessandro Repici, Cesare Hassan
GASTROINTESTINAL ENDOSCOPY
(2022)
Meeting Abstract
Gastroenterology & Hepatology
Michael B. Wallace, Prateek Sharma, Pradeep Bhandari, James E. East, Giulio Antonelli, Roberto Lorenzetti, Michael Vieth, Ilaria Speranza, Marco Spadaccini, Madhav Desai, Frank Lukens, Genci Babameto, Daisy D. Batista, William C. Palmer, Tisha Lunsford, Kevin C. Ruff, Elizabeth L. Bird-Liebermann, Victor Ciofoaia, Sophie Arndtz, David Cangemi, Kristy Puddick, Gregory Derfus, Amitpal S. Johal, Mohammed Barawi, Luigi Longo, Alessandro Repici, Cesare Hassan
GASTROINTESTINAL ENDOSCOPY
(2022)