Review
Nutrition & Dietetics
Bara Aljada, Ahmed Zohni, Wael El-Matary
Summary: The gluten-free diet is popular for treating immune-mediated disorders caused by gluten, but it has disadvantages like high costs, nutritional deficiencies, and social and psychological barriers. Close follow-up with patients following the diet is recommended, and more data is needed to assess its effectiveness in managing mental and cognitive disorders.
Review
Nutrition & Dietetics
Edurne Simon, Marta Molero-Luis, Ricardo Fueyo-Diaz, Cristian Costas-Batlle, Paula Crespo-Escobar, Miguel A. Montoro-Huguet
Summary: The gluten-free diet (GFD) is complex and requires a multidisciplinary team for effective management of celiac disease (CeD) patients. Involvement of experts from various fields including medicine, nutrition, and psychology can improve clinical practice and reduce nutritional risks.
Article
Health Care Sciences & Services
Aurelio Seidita, Pasquale Mansueto, Stella Compagnoni, Daniele Castellucci, Maurizio Soresi, Giorgio Chiarello, Giorgia Cavallo, Gabriele De Carlo, Alessia Nigro, Marta Chiavetta, Francesca Mandreucci, Alessandra Giuliano, Rosaria Disclafani, Antonio Carroccio
Summary: This study assessed the frequency, severity, morphologic features, and pathogenic factors of anemia in patients with Celiac Disease (CD) and found that iron deficiency anemia (IDA) is common, especially in women. The study also showed that some women with CD continue to have IDA despite following a strict gluten-free diet, and low body mass index and menstrual abnormalities might contribute to the persistence of anemia.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Nutrition & Dietetics
Aner Cardo, Itziar Churruca, Arrate Lasa, Virginia Navarro, Maialen Vazquez-Polo, Gesala Perez-Junkera, Idoia Larretxi
Summary: Celiac disease (CD) is an autoimmune disorder of the small intestine that requires a gluten-free diet (GFD) for effective treatment. Nutritional imbalances may occur in adults with CD following GFD, but deficiencies can improve as intestinal mucosa recovers over time. Monitoring nutrient intake, especially plant proteins and essential nutrients, is important to prevent nutritional deficiencies in the long term.
Article
Nutrition & Dietetics
Alberto Raiteri, Alessandro Granito, Chiara Faggiano, Alice Giamperoli, Teresa Catenaro, Giulia Negrini, Francesco Tovoli
Summary: The dietary habits of celiac disease (CD) patients adhering to a gluten-free diet (GFD) are correlated with the risk of nonalcoholic fatty liver disease (NAFLD). A questionnaire-based study found that specific patterns of packaged gluten-free food consumption are significantly associated with NAFLD. The information obtained through this study can be used in clinical practice for personalized treatment and further research.
Article
Nutrition & Dietetics
Vincenza Lombardo, Alice Scricciolo, Andrea Costantino, Luca Elli, Giorgia Legnani, Angel Cebolla, Luisa Doneda, Federica Mascaretti, Maurizio Vecchi, Leda Roncoroni
Summary: The aim of this study was to evaluate the clinical efficacy of urinary gluten immunogenic peptides (uGIP) in the follow-up of celiac disease (CD). The results showed that uGIP test can accurately assess the adherence to gluten-free diet and correlated significantly with duodenal biopsy results.
Review
Nutrition & Dietetics
Rafael Martin-Masot, Maria Jimenez-Munoz, Marta Herrador-Lopez, Victor Manuel Navas-Lopez, Elia Obis, Mariona Jove, Reinald Pamplona, Teresa Nestares
Summary: Celiac disease is a complex disease caused by the interaction of genetic and environmental factors, and currently there are no effective biomarkers for early diagnosis. The cellular effects of a gluten-free diet, the only treatment available, are not well understood. Metabolomics studies are significant in unraveling the complexities of multifactorial and multisystemic disorders, and can provide insights into disease occurrence and treatment impact.
Article
Nutrition & Dietetics
Rafael Martin-Masot, Maria Jimenez-Munoz, Marta Herrador-Lopez, Marta Flor-Alemany, Victor Manuel Navas-Lopez, Teresa Nestares
Summary: This study aims to assess the importance of early follow-up for celiac patients, identify the role of stool gluten immunogenic peptides (GIPs) in assessing diet adherence, and analyze nutritional imbalances or deficiencies in the gluten-free diet (GFD). The results highlight the importance of early follow-up for celiac patients and the potential use of stool GIPs in monitoring adherence to the GFD.
Article
Gastroenterology & Hepatology
Valeriia Dotsenko, Mikko Oittinen, Juha Taavela, Alina Popp, Markku Peraaho, Synnove Staff, Jani Sarin, Francisco Leon, Jorma Isola, Markku Maki, Keijo Viiri
Summary: Gluten challenge studies showed that even on a strict gluten-free diet, celiac disease patients exhibit patterns of ongoing disease, with changes in gene expression and mucosal morphology. A regression model using four gene transcripts described the extent of gluten-induced duodenal mucosal injury with high accuracy.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Nutrition & Dietetics
Roxana Nemteanu, Andreea Clim, Corina Elena Hincu, Liliana Gheorghe, Irina Ciortescu, Anca Trifan, Alina Plesa
Summary: Potential celiac disease (PCD) is a condition where there is positive celiac serology and HLA DQ2 or DQ8 heterodimers, but no villous atrophy on duodenal biopsies. PCD accounts for one fifth of all celiac disease diagnoses. Adult patients with PCD generally have lower rates of nutrient deficiencies and extraintestinal symptoms compared to celiac disease patients. Recommending a gluten-free diet (GFD) to symptomatic PCD patients provides significant clinical improvement, but the implementation of GFD for asymptomatic PCD is still debated. Further research is needed to determine the potential progression of PCD to overt celiac disease and the benefits of early GFD implementation.
Article
Nutrition & Dietetics
Zsofia Vereczkei, Timea Dergez, Zsuzsanna Fodor, Zsolt Szakacs, Judit Bajor
Summary: This retrospective cohort study aimed to investigate factors associated with baseline and follow-up BMI in celiac disease (CD) patients. The study found that males had higher mean BMI compared to females at diagnosis and during follow-up, and non-classical CD patients had higher mean BMI at diagnosis and long-term follow-up than classical patients.
Article
Nutrition & Dietetics
Katarzyna Gladys, Jolanta Dardzinska, Marek Guzek, Krystian Adrych, Zdzislaw Kochan, Sylwia Malgorzewicz
Summary: The study found that plant protein intake was lower, and fat and calories were higher in celiac disease (CD) patients, who also did not consume enough calcium, iron, vitamin D, folic acid or fiber. While standard dietary education improved adherence to a gluten-free diet, it did not significantly improve its nutritional value.
Article
Nutrition & Dietetics
Teresa Nestares, Rafael Martin-Masot, Carlos de Teresa, Rocio Bonillo, Jose Maldonado, Marta Flor-Alemany, Virginia A. Aparicio
Summary: The study found that adherence to the Mediterranean Diet has a positive impact on bone health in young patients with celiac disease, while physical activity is associated with lean mass and bone density. Therefore, correctly monitoring dietary habits and physical activity levels in children with CD is crucial for improving their lean mass and bone quality.
Review
Nutrition & Dietetics
Dimitri Poddighe, Kuanysh Dossybayeva, Diyora Abdukhakimova, Lyudmila Akhmaltdinova, Aigul Ibrayeva
Summary: This review analyzes the pathophysiological aspects and clinical evidence of gallbladder dysfunction in CD patients, highlighting the potential medical complications and research gaps. CD patients may develop gallbladder dysmotility, leading to impaired emptying during digestion. Although CD patients do not seem to be more susceptible to gallbladder complications, further clinical studies are needed to fully understand the clinical implications of gallbladder alterations in CD patients.
Article
Nutrition & Dietetics
Maria Roca, Ester Donat, Etna Masip, Paula Crespo-Escobar, Antonio Jose Canada-Martinez, Begona Polo, Carmen Ribes-Koninckx
Summary: The study aimed to evaluate the efficacy of detecting gluten immunogenic peptides (GIP) in feces as a tool to monitor dietary compliance to the gluten-free diet (GFD) in pediatric patients with celiac disease (CD). The results indicated that GIP detection is more effective in identifying inadvertent gluten consumption compared to food records, and there is a positive correlation between the concentration of GIP in feces and the amount of gluten intake. Further research on gastrointestinal factors influencing GIP recovery is needed to better understand interindividual variations.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Article
Gastroenterology & Hepatology
S. J. Simpkins, M. I. Pinto-Sanchez, P. Moayyedi, P. Bercik, D. G. Morgan, C. Bolino, A. C. Ford
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2017)
Article
Gastroenterology & Hepatology
Maria I. Pinto-Sanchez, Edgardo C. Smecuol, Maria P. Temprano, Emilia Sugai, Andrea Gonzalez, Maria L. Moreno, Xianxi Huang, Premysl Bercik, Ana Cabanne, Horacio Vazquez, Sonia Niveloni, Roberto Mazure, Eduardo Maurino, Elena F. Verdu, Julio C. Bai
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2017)
Article
Gastroenterology & Hepatology
Andrew J. Irvine, Maria Ines Pinto-Sanchez, Premysl Bercik, Paul Moayyedi, Alexander C. Ford
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY
(2017)
Review
Gastroenterology & Hepatology
Maria I. Pinto-Sanchez, Elena F. Verdu
NEUROGASTROENTEROLOGY AND MOTILITY
(2018)
Article
Gastroenterology & Hepatology
Neeraj Narula, Maria Ines Pinto-Sanchez, Natalia Causada Calo, Alexander C. Ford, Premsyl Bercik, Walter Reinisch, Paul Moayyedi
INFLAMMATORY BOWEL DISEASES
(2019)
Letter
Gastroenterology & Hepatology
Neeraj Narula, Maria Ines Pinto-Sanchez, Natalia Causada Calo, Alexander C. Ford, Premsyl Bercik, Walter Reinisch, Paul Moayyedi
INFLAMMATORY BOWEL DISEASES
(2019)
Review
Gastroenterology & Hepatology
Betty Zhang, Zainab Najarali, Leyo Ruo, Abdullah Alhusaini, Natalie Solis, Marlie Valencia, Maria Ines Pinto Sanchez, Pablo E. Serrano
JOURNAL OF GASTROINTESTINAL SURGERY
(2019)
Article
Endocrinology & Metabolism
Mai Yamamoto, Maria Ines Pinto-Sanchez, Premysl Bercik, Philip Britz-McKibbin
Review
Gastroenterology & Hepatology
Laura Kivela, Alberto Caminero, Daniel A. Leffler, Maria Ines Pinto-Sanchez, Jason A. Tye-Din, Katri Lindfors
Summary: A gluten-free diet is currently the only effective treatment for coeliac disease, but some patients face challenges such as high cost, strict restrictions, and perceived reduced quality of life. As a result, there is a need for alternative treatment forms to better control the disease.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
M. Ines Pinto-Sanchez, Jocelyn A. Silvester, Benjamin Lebwohl, Daniel A. Leffler, Robert P. Anderson, Amelie Therrien, Ciaran P. Kelly, Elena F. Verdu
Summary: Coeliac disease is a serious condition with significant research progress, but there are still many gaps in diagnosis and treatment, as the gluten-free diet is not universally effective, and new treatment options are currently being investigated.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Review
Nutrition & Dietetics
Lindsey A. Russell, Maria Teresa Balart, Pablo Serrano, David Armstrong, Maria Ines Pinto-Sanchez
Summary: Patients with IBD are predisposed to malnutrition, which can lead to worse prognosis, higher complication rates, decreased quality of life, and increased mortality risk. Screening and timely treatment are crucial to optimize nutrition and improve outcomes.
Article
Nutrition & Dietetics
Aseera Jivraj, Joy M. Hutchinson, Emily Ching, Avantika Marwaha, Elena F. Verdu, David Armstrong, Ines Pinto-Sanchez
Summary: This study compared nutritional deficiencies in patients with celiac disease (CD) to those of non-celiac populations on a gluten-free diet (GFD). The results showed that CD patients generally have micronutrient deficiencies, but there were no significant differences compared to non-celiac individuals. Additionally, there were no significant differences in deficiencies between long-term and strict GFD adherence, as well as between patients with persistent symptoms and asymptomatic patients.
Review
Nutrition & Dietetics
Fardowsa Abdi, Saania Zuberi, Jedid-Jah Blom, David Armstrong, Maria Ines Pinto-Sanchez
Summary: A gluten-free diet is essential for treating celiac disease and may improve symptoms in non-celiac gluten/wheat sensitivity. However, adopting a gluten-free diet or a gluten-restricted diet may increase the risk of malnutrition and nutrient deficiencies. Therefore, patients with these conditions should undergo nutritional assessment and monitoring, and receive multidisciplinary care for long-term nutrition management.
Article
Gastroenterology & Hepatology
Brigida Barberio, Maria Ines Pinto-Sanchez, Premysl Bercik, Ruchit Sood, Edoardo Savarino, Paul Moayyedi, Christopher J. Black, Alexander C. Ford
Summary: Latent class analysis identified four distinct subgroups of functional dyspepsia patients characterized by varying degrees of gastrointestinal symptoms, extraintestinal symptoms, and psychological co-morbidity. These findings may help guide the development of personalized treatment approaches.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2021)
Review
Primary Health Care
Donald Duerksen, Maria Ines Pinto-Sanchez, Alexandra Anca, Joyce Schnetzler, Shelley Case, Jenni Zelin, Adrianna Smallwood, Justine Turner, Elena Verdu, J. Decker Butzner, Mohsin Rashid
CANADIAN FAMILY PHYSICIAN
(2018)