Review
Biochemistry & Molecular Biology
Ksenia Maslenkina, Liudmila Mikhaleva, Maxim Naumenko, Rositsa Vandysheva, Michail Gushchin, Dmitri Atiakshin, Igor Buchwalow, Markus Tiemann
Summary: Barrett's esophagus (BE) is a premalignant lesion that can develop into esophageal adenocarcinoma (EAC). The development of BE is caused by biliary reflux and involves various stem cell origins. The concept of healing has been replaced by the cytokine storm and inflammatory microenvironment, leading to intestinal metaplasia. This review discusses the roles of molecular pathways in the pathogenesis of BE and EAC, including NOTCH, hedgehog, NF-?B, and IL6/STAT3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Alisha Fernandes, Chao Li, Daniel French, James Ellsmere
Summary: This retrospective study compared the long-term outcomes of EMR and esophagectomy for the treatment of intramucosal adenocarcinoma (IMC) in the esophagus. The study found that both procedures had comparable recurrence rates and disease-free survival at 10 years. However, EMR was associated with significantly lower procedure-related morbidity.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Surgery
Alisha Fernandes, Chao Li, Daniel French, James Ellsmere
Summary: This retrospective study compared the outcomes of endoscopic mucosal resection (EMR) and esophagectomy for the treatment of esophageal intramucosal adenocarcinoma (IMC) in 10-year follow-up. The results showed that EMR and esophagectomy had similar recurrence rates and disease-free survival, but EMR had lower incidence of procedure-related morbidity.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Biochemistry & Molecular Biology
Pelin Ergun, Sezgi Kipcak, Serhat Bor
Summary: Barrett's esophagus (BE) is a condition resulting from chronic gastroesophageal reflux disease, which may progress to esophageal adenocarcinoma (EAC). The histological dysplasia grade is commonly used as a biomarker, but its effectiveness is limited due to cost and lack of progression in many BE patients. Clinicians require multiple or more quantitative biomarkers for early diagnosis of EAC, which has high mortality. Epigenetic factors in the early stages of neoplastic transformation show promise as predictive biomarkers. This review summarizes current research on DNA methylations, histone modifications, and noncoding RNAs (miRNAs) during the progression from BE dysplasia to EAC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Surgery
Kesha Oza, Tejasvi Peesay, Benjamin Greenspun, John E. Carroll, Shervin Shafa, Jay C. Zeck, Nadim G. Haddad, Marc Margolis, Puja Gaur Khaitan
Summary: The study reviewed the experience of endoscopic mucosal resections in 80 patients with early-stage esophageal cancer, finding that endoscopic resections are a safe and effective treatment. Patients who require repeat resection or surgery should undergo esophagectomy.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Tarek Sawas, Saam Dilmaghani, Lovekirat Dhaliwal, Kenneth K. Wang, Prasad G. Iyer, David A. Katzka
Summary: The study found that compared to BE patients, EAC patients had significantly lower rates of heartburn, diabetes, hyperlipidemia, hypertension, nonalcoholic steatohepatitis, and metabolic syndrome. Therefore, optimal strategies for screening for prevalent EAC may need to be adjusted.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Nan Yi, Hailiang Zhao, Juan He, Xike Xie, Liexin Liang, Guowen Zuo, Mingyue Xiong, Yunxiao Liang, Tingzhuang Yi
Summary: Almost 50% of esophageal adenocarcinoma (EAC) patients are progressed from Barrett's esophagus (BE). However, effective stratification and therapy methods for BE and EAC are still lacking. Differentially expressed genes (DEGs) between BE and EAC were identified through the analysis of two public datasets (GSE26886 and GSE37200), followed by bioinformatics analyses to explore potential biomarkers associated with BE-EAC. The results revealed a number of up- and down-regulated genes, which were highly involved in tumorigenesis according to the GO and KEGG enrichment analysis. In addition, the study identified several potential diagnostic and prognostic biomarkers in BE-EAC.
SCIENTIFIC REPORTS
(2023)
Article
Gastroenterology & Hepatology
Paul Doumbe-Mandengue, Anna Pellat, Arthur Belle, Einas Abou Ali, Rachel Hallit, Frederic Beuvon, Benoit Terris, Stanislas Chaussade, Romain Coriat, Maximilien Barret
Summary: This study compared the efficacy of endoscopic mucosal resection (EMR) and endoscopic submucosal dissection (ESD) in the treatment of early esophageal adenocarcinoma. The results showed that ESD was superior to EMR in terms of surgical characteristics and treatment outcomes. ESD should be more widely adopted for the resection of esophageal lesions suspected of harboring early esophageal adenocarcinoma.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Esther A. Nieuwenhuis, Sanne N. van Munster, Sybren L. Meijer, Lodewijk A. A. Brosens, Marnix Jansen, Bas L. A. M. Weusten, Lorenza Alvarez Herrero, Alaa Alkhalaf, Ed Schenk, Erik J. Schoon, Wouter L. Curvers, Arjun D. Koch, Steffi E. M. van de Ven, Eva P. D. Verheij, Wouter B. Nagengast, Jessie Westerhof, Martin H. M. G. Houben, Thjon Tang, Jacques J. G. H. M. Bergman, Roos E. Pouw
Summary: This study evaluated the outcomes of endoscopic follow-up after ER for high-risk esophageal adenocarcinoma. It found that the annual metastasis rate for high-risk submucosal EAC was somewhat lower than expected, but the rate for high-risk intramucosal EAC was concerning.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Multidisciplinary Sciences
Chengjiao Yao, Yilin Li, Lihong Luo, Qin Xiong, Xiaowu Zhong, Fengjiao Xie, Peimin Feng
Summary: The study identified differentially expressed miRNAs (DEMs) and genes (DEGs) between EAC and BE tissue samples, performed pathway and functional enrichment analysis, and identified enriched functions and pathways. Some hub genes, such as GART and TNFSF11, as well as highly connected miRNAs like hsa-miR-143 and hsa-miR-133b were determined. This research provides insights into the development mechanism of BE and EAC.
Article
Multidisciplinary Sciences
Mamoru Tokunaga, Kenichiro Okimoto, Naoki Akizue, Kentaro Ishikawa, Yosuke Hirotsu, Kenji Amemiya, Masayuki Ota, Keisuke Matsusaka, Motoi Nishimura, Kazuyuki Matsushita, Tsubasa Ishikawa, Ariki Nagashima, Wataru Shiratori, Tatsuya Kaneko, Hirotaka Oura, Kengo Kanayama, Yuki Ohta, Takashi Taida, Keiko Saito, Tomoaki Matsumura, Tetsuhiro Chiba, Hitoshi Mochizuki, Makoto Arai, Jun Kato, Jun-ichiro Ikeda, Masao Omata, Naoya Kato
Summary: This study investigated the genetic characteristics of nondysplastic Barrett's esophagus (NDBE) to early esophageal adenocarcinoma (EAC) in the Japanese population. The results showed that the genetic variants of TP53 in Japanese early EAC were similar to those in western countries, and TP53 putative drivers were even detected in Japanese patients with nondysplastic short-segment Barrett's esophagus, indicating a potential higher risk of progression. Proper follow-ups may be necessary for patients with short-segment Barrett's esophagus to monitor the risk of progression to high-grade dysplasia or EAC.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Franz Ludwig Dumoulin, Fabian Dario Rodriguez-Monaco, Alanna Ebigbo, Ingo Steinbruck
Summary: Esophageal adenocarcinoma is the most common subtype of esophageal cancer in Western societies and its incidence is increasing. The development and validation of artificial intelligence systems in the field of gastroenterology may help address unresolved issues in the prevention and surveillance of this cancer.
Article
Oncology
Yue Chen, Chenyu Sun, Yile Wu, Xin Chen, Sujatha Kailas, Zeid Karadsheh, Guangyuan Li, Zhichun Guo, Hongru Yang, Lei Hu, Qin Zhou
Summary: The use of PPI is negatively associated with the risk of progression to HGD/EAC in BE patients, and the risk of HGD/EAC can be reduced with the prolonged use of PPI. Sensitivity analysis showed the stable results of this meta-analysis, and no publication bias was detected.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Mate Knabe, Torsten Beyna, Thomas Roesch, Jacques Bergman, Hendrik Manner, Andrea May, Guido Schachschal, Horst Neuhaus, Jennis Kandler, Bas Weusten, Oliver Pech, Siegbert Faiss, Mario Anders, Michael Vieth, Susanne Sehner, Raf Bisschops, Pradeep Bhandari, Christian Ell, Hanno Ehlken
Summary: This study evaluated a potential alternative treatment for neoplastic Barrett's esophagus, called hybrid argon plasma ablation. The results showed that this technique achieved the expected eradication and recurrence rates of Barrett's intestinal metaplasia and neoplasia within 2 years. However, a randomized comparative trial is needed to provide final evidence compared to radiofrequency ablation.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Motasem Alkhayyat, Prabhat Kumar, Krishna O. Sanaka, Prashanthi N. Thota
Summary: The incidence of Barrett's esophagus and esophageal adenocarcinoma has been increasing, leading to a search for chemoprevention strategies. Proton-pump inhibitors and Aspirin have shown effectiveness in reducing cancer incidence in Barrett's patients. Other agents lack sufficient evidence for chemoprevention in these patients.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2021)
Letter
Gastroenterology & Hepatology
Gregory A. Cote, Haley Nitchie, B. Joseph Elmunzer, Richard S. Kwon, Field F. Willingham, Sachin Wani, Daniel Mullady, Amitabh Chak, Vikesh Singh, Adam Slivka, Shyam Varadarajulu, Martin Freeman, Srinivas Gaddam, Priya Jamidar, Paul Tarnasky, Lydia Foster, Peter B. Cotton
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Tamas A. Gonda, James Farrell, Michael Wallace, Lauren Khanna, Eileen Janec, Richard Kwon, Michael Saunders, Uzma D. Siddiqui, Randall Brand, Diane M. Simeone
Summary: The adoption of a standardized EUS reporting template will improve consistency in clinical decision-making for individuals at risk of pancreatic cancer and provide complete and accurate reporting of pancreatic abnormalities. Standardization will also facilitate research and clinical trial design, allowing for comparison of results across different centers.
GASTROINTESTINAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Jaeil Chung, Kelly Wang, Alexander Podboy, Srinivas Gaddam, Simon K. Lo
Summary: This study aimed to demonstrate the feasibility, safety, and effectiveness of endoscopic suturing (ES) for the closure of mucosal defects after endoscopic mucosal resection (EMR) of duodenal adenomas. ES was found to be technically successful in all cases and no complications such as bleeding or duodenal stricture were encountered. ES should be considered as an option for preventing or treating perforations associated with EMR of large duodenal adenomas.
CLINICAL ENDOSCOPY
(2022)
Article
Gastroenterology & Hepatology
Kelly K. Wang, Katherine Kim, Liliana Bancila, Daniel Lew, Brent K. Larson, Sungjin Kim, Jong Y. Lee, Srinivas Gaddam, Simon K. Lo
Summary: This study found that the incidence of dysplasia and gastric cancer in FAP patients was higher than previously reported, and the EPS technique can aid in early detection. Upper endoscopic guidelines should include a more rigorous sampling method, such as EPS, for the diagnosis of FGPs.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Touseef Ahmad Qureshi, Srinivas Gaddam, Ashley Max Wachsman, Lixia Wang, Linda Azab, Vahid Asadpour, Wansu Chen, Yibin Xie, Bechien Wu, Stephen Jacob Pandol, Debiao Li
Summary: Radiomic analysis of pre-diagnostic abdominal CT scans can aid in stratifying high risk individuals for PDAC.
Review
Gastroenterology & Hepatology
Alexander Podboy, Srinivas Gaddam, Kenneth Park, Kapil Gupta, Quin Liu, Simon K. Lo
Summary: This article explores the characteristics of difficult common bile duct stones and provides an algorithmic approach for their treatment. It also describes additional clinical circumstances and management strategies to aid in the extraction of biliary stones.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Fabian Emura, Viveksandeep Thoguluva Chandrasekar, Cesare Hassan, David Armstrong, Helmut Messmann, Vitor Arantes, Raul Araya, Oscar Barrera-Leon, Jacques J. G. H. M. Bergman, Pradeep Bandhari, Michael J. Bourke, Cecilio Cerisoli, Philip Wai-Yan Chiu, Madhav Desai, Mario Dinis-Ribeiro, Gary W. Falk, Mitsuhiro Fujishiro, Srinivas Gaddam, Kenichi Goda, Seth Gross, Rehan Haidry, Lawrence Ho, Prasad G. Iyer, Sergey Kashin, Shivangi Kothari, Yeong Yeh Lee, Koji Matsuda, Horst Neuhaus, Tsuneo Oyama, Krish Ragunath, Alessandro Repici, Nicholas Shaheen, Rajvinder Singh, Sergio Sobrino-Cossio, Kenneth K. Wang, Irving Waxman, Prateek Sharma
Summary: This study developed evidence-based, consensus-driven statements on endoscopic landmarks, definitions, and classifications of Barrett's esophagus (BE). These recommendations may facilitate global uniform reporting in BE.
Letter
Medicine, General & Internal
Srinivas Gaddam, Simon K. Lo
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Gastroenterology & Hepatology
Dhruvil Radadiya, Kalpit Devani, Ashraf Ashhab, Polina Gaisinskaya, Paris Charilaou, Chakradhar Reddy, Srinivas Gaddam
Summary: We assessed the post-ERCP 30-day readmission rates, their etiologies, and impact on the health care system in the United States using national data. A total of 130,145 patients underwent ERCP, with a 12.5% readmission rate within 30 days, costing $268 million. The majority of readmissions occurred within 7 days and were related to gastrointestinal issues. Male gender, comorbidities, cirrhosis, Medicare insurance, and pancreatitis or pancreatitis-related indications were risk factors for readmission. Performing cholecystectomy during the index hospitalization reduced the odds of readmission by 50%.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Article
Oncology
Jamil S. Samaan, Yazan Abboud, Janice Oh, Yi Jiang, Rabindra Watson, Kenneth Park, Quin Liu, Katelyn Atkins, Andrew Hendifar, Jun Gong, Arsen Osipov, Debiao Li, Nicholas N. Nissen, Stephen J. Pandol, Simon K. Lo, Srinivas Gaddam
Summary: The incidence of pancreatic cancer is increasing at a greater rate in young women compared to young men. A study using the SEER 21 database found that young Hispanic women had the highest increase in incidence, followed by young Black women. This highlights the disproportionate burden of disease on young women of color.
Article
Oncology
Janice Oh, Yazan Abboud, Miguel Burch, Jun Gong, Kevin Waters, Jenan Ghaith, Yi Jiang, Kenneth Park, Quin Liu, Rabindra Watson, Simon K. Lo, Srinivas Gaddam
Summary: Although the global incidence of non-cardia gastric cancer (NCGC) is decreasing, there are limited data on sex-specific incidence in the U.S. Our study found that NCGC incidence has been increasing at a greater rate in younger women compared to counterpart men, and this rise may be explained by a disproportionate increase in young non-Hispanic White women. These findings highlight the need for dedicated research to determine the etiologies of these alarming trends.
Letter
Gastroenterology & Hepatology
Yazan Abboud, Gerardo Perrotta, Srinivas Gaddam
Meeting Abstract
Gastroenterology & Hepatology
Kenneth H. Park, Ulysses S. Rosas, Quin Liu, Srinivas Gaddam, Kapil Gupta, Laith H. Jamil, Christopher C. Thompson, Simon K. Lo
GASTROINTESTINAL ENDOSCOPY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Ulysses S. Rosas, Shirley Paski, Srinivas Gaddam, Quin Liu, Kapil Gupta, Simon K. Lo, Kenneth H. Park
GASTROINTESTINAL ENDOSCOPY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Daniel Lew, Suellen M. Picha, Ellis C. Lai, Yazan Abboud, Kenneth H. Park, Quin Liu, Kapil Gupta, Stephen J. Pandol, Christopher V. Almario, Simon K. Lo, Srinivas Gaddam
