Review
Biochemistry & Molecular Biology
Xavier J. Reid, Jason K. K. Low, Joel P. Mackay
Summary: The nucleosome-remodeling and deacetylase (NuRD) complex is a crucial transcriptional regulator in complex animals. The complex consists of multiple paralogs of its seven core subunits, which raises the possibility of utilizing paralog switching for cell type-specific functions. Analysis of quantitative proteomic data in different tissues and a large-scale CRISPR knockout screen in human cancer cell lines provides strong evidence that different permutations of the NuRD complex regulate tissue-specific gene expression programs.
TRENDS IN BIOCHEMICAL SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Yoshitaka Hata, Eikichi Ihara, Masafumi Wada, Hirotaka Tsuru, Kazumasa Muta, Yosuke Minoda, Xiaopeng Bai, Mitsuru Esaki, Yoshimasa Tanaka, Takatoshi Chinen, Haruei Ogino, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: This study evaluated the utility of barium esophagography (BE) screening using two novel findings to diagnose esophageal motility disorders (EMDs). The results showed that BE screening using these two additional novel findings, along with conventional findings, had higher sensitivity and specificity in diagnosing EMDs, and could be useful in general clinical practice.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Jennifer Vonk, Jordyn Truax, Molly C. McGuire
Summary: This study assessed the food preferences of three adult male zoo-housed gorillas over a 20-month period. The use of touchscreen images was validated as an effective method to assess preferences. However, preferences may vary relative to other contextual factors.
Review
Agriculture, Multidisciplinary
Charlotte F. Nellist, Kazusato Ohshima, Fernando Ponz, John A. Walsh
Summary: Turnip mosaic virus (TuMV) is an economically important virus with a broad host range, making it valuable for scientific research and biotechnological applications.
ANNALS OF APPLIED BIOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Lolita Piersimoni, Panagiotis L. Kastritis, Christian Arlt, Andrea Sinz
Summary: Mass spectrometry (MS) is a key technology in structural biology, and chemical cross-linking combined with mass spectrometry (XL-MS) plays an important role in studying protein structures and protein-protein interactions. This review outlines the contributions of XL-MS, including cross-linking reagents, software tools, workflows, and significant examples, in characterizing proteins and their interactions in vitro and in vivo. Computational modeling and integration with other structural biology techniques have greatly enhanced the capabilities of XL-MS.
Article
Chemistry, Physical
Francesca Mancuso, Daniele Crisafulli, Marco Milone, Anna Irto, Rosalia Maria Cigala, Gabriele Lando, Ilenia Pisagatti, Anna Notti, Giuseppe Gattuso
Summary: Tetraamino-dihydroxy-oxacalix[4]arenes with different protonation states were synthesized and characterized. The conformational preferences of the macrocycles in different protonation states were investigated using NMR titrations and DFT calculations. The stability constants of the host-guest complexes formed between the macrocycles and paraquat were determined, and 1 · H^- was identified as the most efficient receptor for paraquat.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Behavioral Sciences
Gisele A. Oda, Veronica S. Valentinuzzi
Summary: This study reviews the integrated laboratory, field, and modeling work conducted on subterranean rodents to uncover the mechanisms of circadian clock entrainment and photoperiodic time measurement. The importance of integrating theory with practice to fully understand the clock in the wild is emphasized.
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Francis J. P. Ebling, John Fletcher, David G. Hazlerigg, Andrew S. I. Loudon
Summary: Gerald Anthony Lincoln, a distinguished scientist and naturalist, made significant contributions in the field of biological timing, particularly in understanding seasonality, photoperiodism, and circannual rhythmicity. Through his research, we have gained a deeper understanding of the roles of neuroendocrine mechanisms in seasonal rhythmicity.
JOURNAL OF NEUROENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Christiane Ader, Jakyu Chun, Han-Ill Yoo, Manfred Martin
Summary: The kinetic unmixing and decomposition of multinary oxides ABO(3) were investigated by treating it as a truly ternary system with defects in all three sublattices and electronic defects. The complete set of transport equations was derived and a numerical solution was obtained to investigate the time-dependence of kinetic unmixing. The results provide predictions for the lifetime of the oxide and the voltage threshold for kinetic decomposition.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Zoology
Jasmien Ellen Maria Jozef Orije, Annemie Van der Linden
Summary: Research on seasonal neuroplasticity in songbirds has revealed the role of sex steroids in males, and using in vivo magnetic resonance imaging (MRI), advancements have been made in analyzing the entire brain, monitoring birds longitudinally, and determining the neuronal correlates of seasonal variations in hormone levels and singing behavior. This research has provided insights into the structural and functional changes in the song control system (SCS) and other sensory systems during different seasons, highlighting the potential for heightened neuroplasticity during specific periods.
JOURNAL OF EXPERIMENTAL ZOOLOGY PART A-ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chrysan J. Mohammed, Sabitri Lamichhane, Jacob A. Connolly, Sophia M. Soehnlen, Fatimah K. Khalaf, Deepak Malhotra, Steven T. Haller, Dragan Isailovic, David J. Kennedy
Summary: Paraoxonases (PONs) are a family of hydrolytic enzymes that play an important role in various diseases, especially cardiovascular diseases. Among them, PON3 is the least studied member, but it has potential implications in diseases such as HIV and cancer. Identifying the specific substrates and activities of PONs is crucial for understanding their biological roles and biomedical applications.
Article
Environmental Sciences
Bingjun Han, Fengxia Yang, Xueli Tian, Meirui Mu, Keqiang Zhang
Summary: The study found that various common ARGs and high-risk ARGs are present in swine waste and farmland soil, with different levels of change from season to season. Tetracycline resistance genes (tet-ARGs) were the predominant genes in all four seasons in different sources, while levels of most ARGs decreased to varying degrees after natural composting of solid waste, and were poorly reduced after wastewater treatment, especially in winter.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Physical
Leonid Skripnikov, Dmitry Chubukov, Vera M. Shakhova
Summary: Studying transition energies of heavy-atom alkaline earth monofluoride molecules can simplify the preparation and interpretation of experiments by incorporating quantum electrodynamics (QED) effects. The deviation of calculated values from experimental ones is significantly small, and the importance of QED effects on transition energies is comparable to high-order correlation effects.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Environmental Sciences
Qinhui Lu, Zhidong Xu, Xiaohang Xu, Lin Liu, Longchao Liang, Zhuo Chen, Xian Dong, Chan Li, Guangle Qiu
Summary: In an active barite mining district, residents were found to be at high risk of cadmium exposure rather than barium exposure. Vegetables were the main route of barium exposure for residents, while rice consumption was the major pathway of cadmium exposure.
Article
Public Administration
Asbjorn Roiseland
Summary: 'Co-creation' is a popular concept in contemporary governance, with many public sector organizations adopting it as an overall strategy. However, the operational meaning of co-creation often remains unclear. This article explores co-creation within three different policy contexts: authority, service delivery, and regulation. Examples from Norwegian policy sectors are used to illustrate the arguments.
PUBLIC MONEY & MANAGEMENT
(2023)
