Article
Pediatrics
Ali Kamran, Charles J. Smithers, Shawn N. Izadi, Steven J. Staffa, David Zurakowski, Farokh R. Demehri, Somala Mohammed, Hester F. Shieh, Peter D. Ngo, Jessica Yasuda, Michael A. Manfredi, Thomas E. Hamilton, Russell W. Jennings, Benjamin Zendejas
Summary: Anastomotic strictures (AS) after esophageal atresia (EA) repair are common complications. While most can be controlled with endoscopic therapy, some require surgical intervention. This study retrospectively reviewed data from two institutions and found that surgery for refractory AS is associated with low morbidity and high rates of esophageal preservation.
JOURNAL OF PEDIATRIC SURGERY
(2023)
Article
Pediatrics
Roghayeh Faraji Akhijahani, Fatemeh Farahmand, Parisa Rahmani, Farzaneh Motamed, Kambiz Eftekhari, Elma Izzeda da Silva Magalhaes, Mohammad Hassan Sohouli
Summary: Ingestion of caustic agents by children can have long-term effects on their health. Limited studies have shown that sucralfate may reduce the development of esophageal stricture in children who ingested caustic agents.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Surgery
Robert Cubas, Robert Andres, Shravan Chintalapani, Estefania Roldan, Andrea Marcadis, Valerie Wu Chao Ying, Robert Bowles, Jose Martinez
Summary: The study reviewed one surgeon's experience with esophageal dilations after transhiatal esophagectomy, showing that early aggressive endoscopic management of esophageal anastomotic strictures after THE can be safely performed.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Editorial Material
Medicine, General & Internal
Francesca Ambrogio, Alexandre Raphael Meduri, Giovanni Infante, Melita Anna Poli, Paolo Romita, Domenico Bonamonte, Raffaele Filotico, Giuseppe Ingravallo, Gerardo Cazzato, Carmelo Laface, Aurora De Marco, Caterina Foti
Summary: Healing viral warts in immunocompromised patients is difficult, but immunocompetent patients can be treated with various methods like topical ointments, cryotherapy, laser therapy, imiquimod, and photodynamic therapy (PDT). PDT has been found to be a valid option for immunocompromised patients, who are at a higher risk of relapse.
Article
Oncology
Ming Zhang, Shuai Xu, Zhenhua Sun, Ruifeng Qi, Jing Xu, Haiping Shen, Jing Zhao
Summary: Esophageal carcinoma (EC) is a highly aggressive gastrointestinal cancer. Dysphagia is the main symptom of advanced EC, which leads to reduced quality of life and difficulty in tolerating systemic treatments. This report presents a case of a 76-year-old female patient with severe obstructive esophageal squamous cell carcinoma (ESCC) and bilateral interstitial pneumonia. Due to her age and comorbidities, the patient was unable to undergo surgery and radical chemoradiotherapy. After multidisciplinary team discussion, photodynamic therapy (PDT) was administered, resulting in significant improvement of the obstruction within 1 week and resumption of a normal diet after 2 weeks. Four weeks later, concurrent dose-reduction chemoradiotherapy was given for esophageal lesions and abdominal metastatic lymph nodes. To date, there has been no recurrence or progression in the esophagus and abdominal lymph nodes, and biopsy of the primary esophageal lesion showed pathologic complete response. The patient is currently under regular follow-up.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
(2023)
Article
Pediatrics
Yi-Hsuan Lu, Ting-An Yen, Chien-Yi Chen, Po-Nien Tsao, Wen-Hsi Lin, Wen-Ming Hsu, Hung-Chieh Chou
Summary: Esophageal atresia with/without tracheoesophageal fistula repair is associated with a high incidence of postoperative digestive morbidities, with GERD and esophageal stricture being common. Long-gap EA/TEF and postoperative GERD are independent risk factors for postoperative esophageal stricture.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Review
Medicine, General & Internal
Tomonori Yano, Tatsunori Minamide, Kenji Takashima, Keiichiro Nakajo, Tomohiro Kadota, Yusuke Yoda
Summary: Photodynamic therapy using a conventional photosensitizer was replaced by second-generation photosensitizer talaporfin sodium to reduce adverse reactions in treating esophageal cancer. Endoscopic PDT using talaporfin sodium was approved as a salvage treatment for patients with local failure after chemoradiotherapy for esophageal cancer, based on favorable clinical trial results. Further evaluation is needed to determine the importance of PDT in the treatment of esophageal cancer.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Zi-Han Geng, Yan Zhu, Quan-Lin Li, Pei-Yao Fu, An-Yi Xiang, Hai-Ting Pan, Mei-Dong Xu, Shi-Yao Chen, Yun-Shi Zhong, Yi-Qun Zhang, Li-Li Ma, Jian-Wei Hu, Ming-Yan Cai, Wen-Zheng Qin, Wei-Feng Chen, Ping-Hong Zhou
Summary: This study aimed to classify the degrees of muscular injury and investigate their association with postoperative esophageal stenosis. The findings revealed that muscular injury was an independent risk factor for esophageal stenosis, and the scoring system showed good performance in predicting muscular injury.
GASTROINTESTINAL ENDOSCOPY
(2023)
Article
Gastroenterology & Hepatology
Dustin A. Carlson, Ikuo Hirano, Nirmala Gonsalves, Peter J. Kahrilas, Isis K. Araujo, Mira Yang, Marie-Pier Tetreault, John E. Pandolfino
Summary: Classifying the physiological and mechanical esophageal function in EoE based on FLIP panometry features may help define the severity of the disease and guide its management.
Article
Gastroenterology & Hepatology
Bo Zhou, Zhe Zhao, Xing-Wei Wang, Ling Fan, Jian-Ru Zhu, Ying-Ying Yang, Pei-Ying Zou, Dong-Feng Chen, Xiao-Chun Shen, Chun-Hui Lan
Summary: The study identified tumor location and circumferential resection range as reliable risk factors for predicting the occurrence of esophageal strictures. A predictive flow chart was developed based on these factors to assess the risk of postoperative stricture.
JOURNAL OF GASTROINTESTINAL SURGERY
(2022)
Article
Gastroenterology & Hepatology
Osama Baghdadi, Jessica Yasuda, Steven Staffa, Peter Ngo, Benjamin Zendejas, Thomas Hamilton, Russell Jennings, Michael Manfredi
Summary: Esophageal stenting can be successful in preventing anastomotic strictures following surgical repair in pediatric patients with esophageal atresia. The change in luminal diameter after stenting is the most significant predictor of stent success.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Review
Medicine, General & Internal
Senol Tonyali, Mehmet Yilmaz, Lazaros Tzelves, Esteban Emiliani, Vincent De Coninck, Etienne Xavier Keller, Arkadiusz Miernik
Summary: The rate of ureteral stricture formation following ureteroscopy ranges from 0.5% to 5% and it can be as high as 24% in patients with impacted ureteral stones. The main risk factor for ureteral stricture formation is ureteral perforation and/or mucosal damage during retrograde ureteroscopy for impacted ureteral stones.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Onyisi Christiana Didamson, Heidi Abrahamse
Summary: Esophageal cancer is often diagnosed late, making early diagnosis crucial. Photodynamic diagnosis and therapy using photosensitizers, along with functionalized nanomedicine, are emerging strategies to improve diagnosis and treatment outcomes.
Article
Surgery
Jian Tang, Fanyang Kong, Jun Li, Feng Liu, Xiangyu Kong, Zhaoshen Li
Summary: This study investigated the risk factors for refractory postoperative stricture after extensive esophageal ESD, finding that longitudinal resection length, depth of tumor infiltration, and muscular injury are independent risk factors for esophageal refractory stricture.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Biophysics
Yunlei Wei, Jian Tang, Jun Li, Xiaojia Hou, Lei Li, Di Zhang, Duo Chai, Min Zhao, Feng Liu
Summary: Endoscopic submucosal dissection (ESD) is an effective treatment for early esophageal cancer and precancerous lesions, but it often leads to postoperative esophageal stricture. This study developed a tetra-armed poly(ethylene glycol) (Tetra-PEG) hydrogel and demonstrated its efficacy in preventing ESD-induced stricture in a porcine model. The Tetra-PEG hydrogel exhibited great biocompatibility, moisture retention, tissue adhesion, and mechanical strength. Compared to the control group, the Tetra-PEG hydrogel promoted early esophageal ulcer healing by enhancing epithelium regeneration, reducing inflammation, and fibrosis through the TGF-β/Smad2 signaling pathway.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Correction
Gastroenterology & Hepatology
J. Yang, Y. Chen, S. Friedland, Ian Holmes, Christopher Paiji, Ryan Law, Amy Hosmer, Tyler Stevens, Franco Matheus, Rishi Pawa, Nihar Mathur, Divyesh Sejpal, Sumant Inamdar, Tyler M. Berzin, Christopher J. DiMaio, Sanchit Gupta, Patrick S. Yachimski, Andrea Anderloni, Alessandro Repici, Theodore James, Laith H. Jamil, Mel Ona, Simon K. Lo, Srinivas Gaddam, Markus Dollhopf, Nuha Alammar, Eugenie Shieh, Majidah Bukhari, Vivek Kumbhari, Vikesh Singh, Olaya Brewer, Omid Sanaei, Lea Fayad, Saowanee Ngamruengphong, Eun Ji Shin, Todd H. Baron, Mouen A. Khashab
Article
Gastroenterology & Hepatology
Sachin Wani, Samuel Han, Violette Simon, Matthew Hall, Dayna Early, Eva Aagaard, Wasif M. Abidi, Subhas Banerjee, Todd H. Baron, Michael Bartel, Erik Bowman, Brian C. Brauer, Jonathan M. Buscaglia, Linda Carlin, Amitabh Chak, Hemant Chatrath, Abhishek Choudhary, Bradley Confer, Gregory A. Cote, Koushik K. Das, Christopher J. DiMaio, Andrew M. Dries, Steven A. Edmundowicz, Abdul Hamid El Chafic, Ihab El Hajj, Swan Ellert, Jason Ferreira, Anthony Gamboa, Ian S. Gan, Lisa Gangarosa, Bhargava Gannavarapu, Stuart R. Gordon, Nalini M. Guda, Hazem T. Hammad, Cynthia Harris, Sujai Jalaj, Paul Jowell, Sana Kenshil, Jason Klapman, Michael L. Kochman, Sri Komanduri, Gabriel Lang, Linda S. Lee, David E. Loren, Frank J. Lukens, Daniel Mullady, Raman V. Muthusamy, Andrew S. Nett, Mojtaba S. Olyaee, Kavous Pakseresht, Pranith Perera, Patrick Pfau, Cyrus Piraka, John M. Poneros, Amit Rastogi, Anthony Razzak, Brian Riff, Shreyas Saligram, James M. Scheiman, Isaiah Schuster, Raj J. Shah, Rishi Sharma, Joshua P. Spaete, Ajaypal Singh, Muhammad Sohail, Jayaprakash Sreenarasimhaiah, Tyler Stevens, James H. Tabibian, Demetrios Tzimas, Dushant S. Uppal, Shiro Urayama, Domenico Vitterbo, Andrew Y. Wang, Wahid Wassef, Patrick Yachimski, Sergio Zepeda-Gomez, Tobias Zuchelli, Rajesh N. Keswani
GASTROINTESTINAL ENDOSCOPY
(2019)
Article
Gastroenterology & Hepatology
Jordan Orr, Robert Lockwood, Anthony Gamboa, James C. Slaughter, Keith L. Obstein, Patrick Yachimski
Summary: Enteral stents provide durable symptom palliation for the majority of patients with malignant gastric outlet obstruction due to pancreatic adenocarcinoma, with lower rates of reintervention compared to other malignant etiologies. Further studies are needed to determine the optimal palliative intervention for patients with different malignant etiologies.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Letter
Gastroenterology & Hepatology
B. Joseph Elmunzer, Zachary L. Smith, Paul Tarnasky, Andrew Y. Wang, Patrick Yachimski, Filip Banovac, Jonathan M. Buscaglia, James Buxbaum, Amitabh Chak, Bradford Chong, Gregory A. Cote, Peter V. Draganov, Kulwinder Dua, Valerie Durkalski, Brian S. Geller, Laith H. Jamil, Rajesh N. Keswani, Mouen A. Khashab, Ryan Law, Simon K. Lo, Sean McCarthy, J. Bayne Selby, Vikesh K. Singh, Jason R. Taylor, Field F. Willingham, Rebecca L. Spitzer, Lydia D. Foster
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Editorial Material
Gastroenterology & Hepatology
Vincent Quoc-Huy Trinh, Patrick Stephen Yachimski
Article
Gastroenterology & Hepatology
Patrick Yachimski, Claire A. Landewee, Federico Campisano, Pietro Valdastri, Keith L. Obstein
GASTROINTESTINAL ENDOSCOPY
(2020)
Article
Gastroenterology & Hepatology
B. Joseph Elmunzer, Catharine M. Walsh, Gretchen Guiton, Jose Serrano, Amitabh Chak, Steven Edmundowicz, Richard S. Kwon, Daniel Mullady, Georgios Papachristou, Grace Elta, Todd H. Baron, Patrick Yachimski, Evan L. Fogel, Peter Draganov, Jason R. Taylor, James Scheiman, Vikesh K. Singh, Shyam Varadarajulu, Field F. Willingham, Gregory A. Cote, Peter B. Cotton, Violette Simon, Rebecca Spitzer, Rajesh Keswani, Sachin Wani
Summary: The study developed and validated a video-based ERCP skill assessment tool, showing favorable validity evidence. The tool includes 6 technical elements and 11 subelements, reliably differentiating between endoscopists' skill levels and providing important guidance for future clinical practice.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
B. Joseph Elmunzer, Rebecca L. Spitzer, Lydia D. Foster, Ambreen A. Merchant, Eric F. Howard, Vaishali A. Patel, Mary K. West, Emad Qayed, Rosemary Nustas, Ali Zakaria, Marc S. Piper, Jason R. Taylor, Lujain Jaza, Nauzer Forbes, Millie Chau, Luis F. Lara, Georgios I. Papachristou, Michael L. Volk, Liam G. Hilson, Selena Zhou, Vladimir M. Kushnir, Alexandria M. Lenyo, Caroline G. McLeod, Sunil Amin, Gabriela N. Kuftinec, Dhiraj Yadav, Charlie Fox, Jennifer M. Kolb, Swati Pawa, Rishi Pawa, Andrew Canakis, Christopher Huang, Laith H. Jamil, Andrew M. Aneese, Benita K. Glamour, Zachary L. Smith, Katherine A. Hanley, Jordan Wood, Harsh K. Patel, Janak N. Shah, Emil Agarunov, Amrita Sethi, Evan L. Fogel, Gail McNulty, Abdul Haseeb, Judy A. Trieu, Rebekah E. Dixon, Jeong Yun Yang, Robin B. Mendelsohn, Delia Calo, Olga C. Aroniadis, Joseph F. LaComb, James M. Scheiman, Bryan G. Sauer, Duyen T. Dang, Cyrus R. Piraka, Eric D. Shah, Heiko Pohl, William M. Tierney, Stephanie Mitchell, Ashwinee Condon, Adrienne Lenhart, Kulwinder S. Dua, Vikram S. Kanagala, Ayesha Kamal, Vikesh K. Singh, Maria Ines Pinto-Sanchez, Joy M. Hutchinson, Richard S. Kwon, Sheryl J. Korsnes, Harminder Singh, Zahra Solati, Field F. Willingham, Patrick S. Yachimski, Darwin L. Conwell, Evan Mosier, Mohamed Azab, Anish Patel, James Buxbaum, Sachin Wani, Amitabh Chak, Amy E. Hosmer, Rajesh N. Keswani, Christopher J. DiMaio, Michael S. Bronze, Raman Muthusamy, Marcia I. Canto, V. Mihajlo Gjeorgjievski, Zaid Imam, Fadi Odish, Ahmed I. Edhi, Molly Orosey, Abhinav Tiwari, Soumil Patwardhan, Nicholas G. Brown, Anish A. Patel, Collins O. Ordiah, Ian P. Sloan, Lilian Cruz, Casey L. Koza, Uchechi Okafor, Thomas Hollander, Nancy Furey, Olga Reykhart, Natalia H. Zbib, John A. Damianos, James Esteban, Nick Hajidiacos, Melissa Saul, Melanie Mays, Gulsum Anderson, Kelley Wood, Laura Mathews, Galina Diakova, Molly Caisse, Lauren Wakefield, Haley Nitchie, Akbar K. Waljee, Weijing Tang, Yueyang Zhang, Ji Zhu, Amar R. Deshpande, Don C. Rockey, Teldon B. Alford, Valerie Durkalski
Summary: This study aimed to assess the prevalence and significance of digestive manifestations in patients with COVID-19. The research found that gastrointestinal symptoms were common in hospitalized COVID-19 patients, but were mostly mild and not independently associated with a more severe clinical course. Abnormal liver test results were also common, but not significantly linked to mechanical ventilation or death among these patients.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Ji Young Bang, Thomas Roesch, Hyungjin Myra Kim, Shyam Thakkar, Ernesto Robalino Gonzaga, Benjamin Tharian, Sumant Inamdar, Linda S. Lee, Patrick Yachimski, Priya Jamidar, Thiruvengadam Muniraj, Christopher DiMaio, Nikhil Kumta, Amrita Sethi, Peter Draganov, Dennis Yang, Talal Seoud, Abhilash Perisetti, Gayatri Bondi, Sachin Kirtane, Robert Hawes, C. Mel Wilcox, Richard Kozarek, D. Nageshwar Reddy, Shyam Varadarajulu
Summary: The newly developed assessment tool for evaluating the technical performance of reusable duodenoscopes was found to be reliable and valid based on its assessment of maneuverability, mechanical/imaging characteristics, and ability to perform requisite interventions. The study evaluated 1080 ERCP procedures, with indications being biliary in 92.8% and pancreatic in 7.2%. The overall Cronbach's coefficient alpha for maneuverability, mechanical/imaging characteristics, and ability to perform requisite interventions were 0.81, 0.92, and 0.87 respectively. Multiple linear regression analysis showed that prolonged procedure duration, older patient age, and pancreatic interventions were positively associated with higher (worse) scores.
DIGESTIVE ENDOSCOPY
(2021)
Editorial Material
Gastroenterology & Hepatology
B. Joseph Elmunzer, Bethany J. Wolf, James M. Scheiman, William M. Tierney, Jason R. Taylor
Article
Surgery
Jason G. Bill, Marvin Ryou, Kelly E. Hathorn, Pedro Cortes, John T. Maple, Abdullah Al-Shahrani, Gabriel Lang, Daniel K. Mullady, Koushik Das, Natalie Cosgrove, Habeeb Salameh, Nikhil A. Kumta, Christopher J. DiMaio, Hassaan Zia, Jordan Orr, Patrick Yachimski, Vladimir M. Kushnir
Summary: EUS-BD is a viable therapeutic option for patients with benign biliary disease and normal foregut anatomy, with a success rate of 77.8%. Adverse events were more common with EUS-BD compared to repeat ERCP, highlighting the importance of expert centers and considering urgency of biliary decompression before attempting EUS-BD.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Gabriela Kuftinec, B. Joseph Elmunzer, Sunil Amin
Summary: In a large and diverse cohort of COVID-19 hospitalized patients in North America, few patients underwent endoscopic procedures despite common gastrointestinal manifestations. The findings and interventions from endoscopy were largely related to critical illness rather than direct viral injury. This systematic assessment of endoscopic necessity and outcomes may aid in resource allocation for ongoing and future surges.
BMC GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Patrick Yachimski, Aimee Lucas, Stacie B. Dusetzina
Summary: In a SEER-Medicare population between 2001 and 2015, both the proportion of patients with unresectable pancreas cancer who underwent ERCP and the mean number of ERCPs per patient decreased over time. Survival improved over time despite decreased use of ERCP.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Gastroenterology & Hepatology
Olga C. Aroniadis, Xianling Wang, Tang Gong, Nauzer Forbes, Jeong Yun Yang, Andrew Canakis, Badih Joseph Elmunzer, Dhiraj Yadav
Summary: Older age, irritable bowel syndrome, and immunosuppressive therapy were associated with higher rates of gastrointestinal symptoms in patients with Covid-19, while patients with pulmonary disease alone had lower rates. Knowledge of these characteristics may help in understanding the pathophysiology and providing targeted care to reduce morbidity related to Covid-19.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Oncology
Yuhan Hao, Ulas Karaoz, Liying Yang, Patrick S. Yachimski, Wenzhi Tseng, Carlos W. Nossa, Weimin Ye, Mengkao Tseng, Michael Poles, Fritz Francois, Morris Traube, Stuart M. Brown, Yu Chen, Manolito Torralba, Richard M. Peek, Eoin L. Brodie, Zhiheng Pei
Summary: The incidence of esophageal adenocarcinoma (EA) in the United States has increased significantly since the 1970s, and the reasons for this are still unclear. This study suggests that the widespread use of antibiotics may have increased the procarcinogenic potential of the orodigestive microbiota, leading to the development of gastroesophageal reflux (GR), Barrett's esophagus (BE), and EA. By analyzing the microbiota in the mouth, esophagus, stomach, and rectum, the researchers discovered significant differences in the abundance of microbial taxa between normal controls (NC) and the three disease phenotypes. They also found that the oral and esophageal microbiota became more diverse along the sequence of GR -> BE -> EA, with certain genera progressively depleted or enriched. In addition, gene functional content analysis revealed an enrichment of genes related to antibiotic resistance, immune response, nitrate-nitrite-nitric oxide pathway, and acetaldehyde metabolism throughout the stages of EA development. These findings suggest that the orodigestive microbiota undergoes dysbiosis and microbial gene changes during the development of EA, and further research is needed to understand their roles in EA pathogenesis.
INTERNATIONAL JOURNAL OF CANCER
(2022)