Article
Endocrinology & Metabolism
Adina F. Turcu, Richard Auchus
Summary: Recent studies have shown that primary aldosteronism (PA) has a higher prevalence among hypertensive patients than previously assumed, with the most common subtypes being aldosterone-producing adenomas (APAs) and bilateral hyperaldosteronism (BHA). Screening and distinguishing between different subtypes can be costly, and it is important to assess the likelihood of benefit from imaging and adrenal vein sampling before embarking on these studies.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Gregory A. Kline, Alexander Ah-Chi Leung, Davis Sam, Alex Chin, Benny So
Summary: Repeat adrenal vein sampling (AVS) shows moderate correlation in biochemical results and diagnostic lateralization between the first and second procedures, indicating high repeatability and success rate in patients with primary aldosteronism.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Minggang Huang, Di Yang, Yan Zhang, Yuqing Zhang, Yue Mu
Summary: This study investigates the feasibility of dual-energy CT energy imaging parameters as a novel biomarker in identifying bilateral adrenal dominant lesions in patients with primary aldosteronism (PA). The results show that the dual-energy CT energy spectrum imaging parameters have high sensitivity and specificity in distinguishing bilateral adrenal lesions, and can serve as a complementary method to adrenal venous sampling (AVS) in the diagnosis of PA.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Keith B. Quencer, Abhilasha Singh, Anu Sharma
Summary: Primary hyperaldosteronism (PA) is the most common secondary form of hypertension in middle-aged adults. Treatment options depend on the extent of aldosterone secretion, with unilateral cases treated surgically and bilateral cases treated medically. Adrenal vein sampling (AVS) is crucial in determining the appropriate treatment approach, but there is variability in AVS techniques and guidelines regarding its use in young patients with unilateral adrenal findings on imaging.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2023)
Article
Endocrinology & Metabolism
Yingxing Wu, Zuxiang Wu, Huan Hu, Jingan Rao, Chenkai Hu, Qiang Peng, Ping Li
Summary: This study evaluated the diagnostic utility of adrenal CT combined with PST in the classification diagnosis of primary aldosteronism (PA). The results showed that the concordance rate between adrenal CT and PST was 51.0%, and the combination of adrenal CT and PST had good sensitivity and specificity for determining the laterality of PA.
BMC ENDOCRINE DISORDERS
(2023)
Article
Endocrinology & Metabolism
Fabrizio Buffolo, Jacopo Pieroni, Federico Ponzetto, Vittorio Forestiero, Denis Rossato, Paolo Fonio, Antonello Nonnato, Fabio Settanni, Paolo Mulatero, Giulio Mengozzi, Silvia Monticone
Summary: This study assessed the impact of asymmetrical cortisol secretion on the lateralization index during adrenal venous sampling, and the effectiveness of metanephrines as a normalization factor for aldosterone levels. The results showed that 18% of patients with primary aldosteronism had asymmetrical cortisol secretion, and the use of metanephrines as a normalization factor improved the accuracy of diagnosis compared to aldosterone to cortisol lateralization index.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Masatoshi Ogata, Hironobu Umakoshi, Tazuru Fukumoto, Yayoi Matsuda, Maki Yokomoto-Umakoshi, Hiromi Nagata, Norio Wada, Takashi Miyazawa, Ryuichi Sakamoto, Yoshihiro Ogawa
Summary: The study suggests that a significant left adrenal vein absolute aldosterone gradient may indicate unilateral excess aldosterone, especially in patients with spontaneous hypokalemia or left unilateral disease on computed tomography. This finding can be a useful tool in diagnosing the left unilateral subtype of primary aldosteronism during adrenal vein sampling.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Giulio Ceolotto, Giorgia Antonelli, Brasilina Caroccia, Michele Battistel, Giulio Barbiero, Mario Plebani, Gian Paolo Rossi
Summary: This study compared the selectivity index of androstenedione, metanephrine, and normetanephrine with cortisol in patients with primary aldosteronism, finding that androstenedione and metanephrine outperformed cortisol in verifying the success of adrenal vein sampling.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Pathology
Nicola Sawyer, Paul Glendenning, Samuel D. Vasikaran, Michael M. Page, Sze Ling Wong, Jun Yang, Markus P. Schlaich, Greg Van Schie, Damon A. Bell
Summary: The objective of this study was to determine the clinical and biochemical success rates of adrenalectomy in patients with unilateral primary aldosteronism (PA), subtyped by adrenal vein sampling (AVS), using the Primary Aldosteronism Surgical Outcome (PASO) criteria. Clinical and biochemical outcomes were evaluated retrospectively in patients who underwent adrenalectomy according to AVS between September 2017 and September 2020. Follow-up data were collected through questionnaires, clinic letter reviews, and examination of pathology and radiological reports. The results showed high clinical and biochemical success rates in patients who underwent adrenalectomy for unilateral PA in Western Australia, but further standardization of post-operative follow-up care is needed.
Article
Cardiac & Cardiovascular Systems
Gian Paolo Rossi, Giacomo Rossitto, Laurence Amar, Michel Azizi, Anna Riester, Martin Reincke, Christoph Degenhart, Jiri Widimsky, Mitsuhide Naruse, Jaap Deinum, Leo Schultze Kool, Tomaz Kocjan, Aurelio Negro, Ermanno Rossi, Gregory Kline, Akiyo Tanabe, Fumitoshi Satoh, Lars Christian Rump, Oliver Vonend, Holger S. Willenberg, Peter J. Fuller, Jun Yang, Nicholas Yong Nian Chee, Steven B. Margill, Zulfiya Shafigullina, Marcus Quinkler, Anna Oliveras, Bo-Ching Lee, Vin Cent Wu, Zuzana Kratka, Teresa M. Seccia, Livia Lenzini
Summary: This study aimed to determine the rate of drug-resistant arterial hypertension in patients with primary aldosteronism (PA) and investigate the diagnostic performance of adrenal vein sampling (AVS). The results showed that resistant hypertension was common in PA patients, and AVS-guided adrenalectomy effectively resolved treatment-resistant hypertension.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Endocrinology & Metabolism
Carmina Teresa Fuss, Katharina Brohm, Martin Fassnacht, Matthias Kroiss, Stefanie Hahner
Summary: Postural stimulation testing (PST) is a simple and noninvasive method for differentiating between unilateral and bilateral primary aldosteronism (PA). A study showed that when the aldosterone plasma concentration decreased by at least 28% after 4 hours in the upright position, PST had a specificity of 100% for identifying unilateral disease.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Sophie Dream, Sandra Park, Tina W. Yen, William Rilling, Lisa Rein, Kara Doffek, James W. Findling, Steven B. Magill, Srividya Kidambi, Douglas B. Evans, Tracy S. Wang
Summary: This study investigates the utility of AV epinephrine levels in assessing successful AV cannulation for patients with primary aldosteronism. The results show that measuring epinephrine levels can help determine the success of AV catheter placement during AVS, thereby preventing unnecessary repeat AVS.
ENDOCRINE PRACTICE
(2022)
Article
Endocrinology & Metabolism
S. Arjani, T. J. Bostonian, V Prasath, P. L. Quinn, R. J. Chokshi
Summary: The study compared the cost-effectiveness of adrenal vein sampling (AVS) and computed tomography (CT) in adrenalectomy. The findings showed that AVS-guided care is more cost-effective based on biochemical outcomes and was consistent in sensitivity analyses.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Endocrinology & Metabolism
Fen Xu, Zhangwei Gao, Guoqiang Wang, Yang Gao, Yang Guo, Yutong Guo, Zhou Zhou
Summary: This study revealed a high prevalence of PA among hypertensive patients in China, with some discordance in PA classification and favorable outcomes of surgery and medication for unilateral PA.
ENDOCRINE PRACTICE
(2021)
Article
Endocrinology & Metabolism
Davis Sam, Gregory A. Kline, Benny So, Janice L. Pasieka, Adrian Harvey, Alex Chin, Stefan J. Przybojewski, Alexander A. Leung
Summary: The study found that patients with unilateral PA and normal adrenal imaging had favorable outcomes following adrenalectomy, with a majority of patients showing complete or partial response in both biochemical and clinical outcomes. Therefore, patients with lateralizing disease should be considered for surgery even if their adrenal imaging appears normal.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Editorial Material
Cell Biology
Liang Cheng, Daniel M. Berney
Review
Cell Biology
Dan M. Berney, Eva Comperat, Darren R. Feldman, Robert J. Hamilton, Muhammad T. Idrees, Hemamali Samaratunga, Satish K. Tickoo, Asli Yilmaz, John R. Srigley
Editorial Material
Cell Biology
Daniel M. Berney
Article
Cell Biology
Daniel M. Berney, Luis Beltran, Holly Sandu, Geraldine Soosay, Henrik Moller, Peter Scardino, Jacqueline Murphy, Amar Ahmad, Jack Cuzick
Article
Pathology
Thomas Wagner, Glenda Scandura, Amy Roe, Luis Beltran, Jonathan Shamash, Costantine Alfrangis, Gedske Daugaard, Marianne Grantham, Daniel Berney
Review
Cell Biology
Daniel M. Berney, Sara Stoneham, Rupali Arora, Jonathan Shamash, Michelle Lockley
Editorial Material
Cell Biology
Murali Varma, Brett Delahunt, W. Glenn McCluggage, Varsha I. Shah, Daniel M. Berney
Article
Pathology
Glenda Scandura, Thomas Wagner, Luis Beltran, Constantine Alifrangis, Jonathan Shamash, Daniel M. Berney
Summary: Pathological predictors such as lymphovascular invasion, tumor size, percentage of embryonal carcinoma, and stromal rete testis invasion are strong indicators of metastatic disease at presentation in patients with testicular non-seminomatous germ cell tumors. These factors should be considered in future revisions of the TNM classification for testicular cancers. Additionally, changes in the AJCC TNM eighth edition, including invasion of the epididymis and hilar soft tissue, were found to be significant predictors of metastatic disease.
Review
Cell Biology
Daniel M. Berney, Ian Cree, Vishal Rao, Holger Moch, John R. Srigley, Toyonori Tsuzuki, Mahul B. Amin, Eva M. Comperat, Arndt Hartmann, Santosh Menon, George J. Netto, Mark A. Rubin, Samra Turajlic, Maria R. Raspollini, Satish K. Tickoo
Summary: The 5th edition of the WHO Blue Book provides a comprehensive update on testicular tumours, while retaining the structure and nomenclature of the previous edition. The classification paradigm remains rooted in morphology, but important changes have been made in terms of terminology and the inclusion of new entities. The update highlights the importance of both molecular understanding and morphology in the study of testicular cancer.
Review
Cell Biology
Joao Lobo, Riuko Ohashi, Mahul B. Amin, Daniel M. Berney, Eva M. Comperat, Ian A. Cree, Anthony J. Gill, Arndt Hartmann, Santosh Menon, George J. Netto, Maria R. Raspollini, Mark A. Rubin, Puay Hoon Tan, Satish K. Tickoo, Toyonori Tsuzuki, Samra Turajlic, Ming Zhou, John R. Srigley, Holger Moch
Summary: The 5th edition of the WHO Classification of Tumours of the Urinary and Male Genital Systems introduces molecularly defined renal tumour subtypes, eliminates the subcategorization of papillary renal cell carcinoma (pRCC), includes emerging entities within the pRCC spectrum, introduces a category of 'other oncocytic tumours', accepts eosinophilic solid and cystic RCC as a new entity, and highlights the need for a reproducible grading system for chromophobe renal cell carcinoma (chRCC).
Review
Cell Biology
Eva Comperat, Mahul B. Amin, Dan M. Berney, Ian Cree, Santosh Menon, Holger Moch, George J. Netto, Vishal Rao, Maria Rosaria Raspollini, Mark A. Rubin, John R. Srigley, Puay Hoon Tan, Satish Kumar Tickoo, Samra Turajlic, Toyonori Tsuzuki
Summary: The fifth edition of the WHO Blue Book on urological tumours provides refinement and updates in the classification of bladder tumours, with special attention given to burning questions in bladder pathology.
Article
Cell Biology
S. Menon, H. Moch, D. M. Berney, I. A. Cree, J. R. Srigley, T. Tsuzuki, E. Comperat, A. Hartmann, G. Netto, M. A. Rubin, A. J. Gill, S. Turajlic, P. H. Tan, M. R. Raspollini, S. K. Tickoo, M. B. Amin
Summary: Squamous cell carcinoma (SCC) is the most common malignant tumor of the penis. The 2022 WHO classification reinforces the 2016 classification and subclassifies precursor lesions and tumors into human papillomavirus (HPV)-associated and HPV-independent types. The use of p16 immunohistochemistry is practical for differentiating HPV-associated from HPV-independent penile SCC. The classification and reporting of scrotal tumors is provided for the first time in the fifth edition of the WHO Blue book, following the schema of penile cancer classification.
Letter
Cell Biology
Andres M. Acosta, Maurizio Colecchia, Daniel M. Berney
Article
Cell Biology
Daniel M. Berney, Kier Finnegan, Kim Chu, Samson W. Fine, Murali Varma, Jack Cuzick, Luis Beltran
Summary: This study aimed to determine the optimal method of measuring cancer extent in prostate cancer biopsies. The results showed that only the percentage of positive cores (%+cores) was a significant predictor of patient outcome in multivariate models. Thus, we propose using %+cores as a simple method of assessment, which is preferred over more complicated methods.
Article
Urology & Nephrology
Glenda Scandura, Clare Verrill, Andrew Protheroe, Johnson Joseph, Wendy Ansell, Anju Sahdev, Jonathan Shamash, Daniel M. Berney
