Article
Nutrition & Dietetics
Tingting Sha, Ning Wang, Jie Wei, Hongyi He, Yilun Wang, Chao Zeng, Guanghua Lei
Summary: This study used Mendelian randomization analysis to explore the association between serum metabolites and sarcopenia. It identified two metabolites that were associated with sarcopenia and its related traits.
Article
Multidisciplinary Sciences
Satoshi Kurose, Katsuko Onishi, Nana Takao, Takumi Miyauchi, Kazuhisa Takahashi, Yutaka Kimura
Summary: The study found that levels of adiponectin and myostatin in the body are associated with body composition and metabolic parameters in obese patients. Adiponectin levels are related to decreased muscle strength, while myostatin levels may be regulated by the percentage of body weight from appendicular lean mass.
Article
Pharmacology & Pharmacy
Taijing Xu, Mengjun Liu, Xinhui Zhao, Shenglei Zhang, Shuchen Ma, Jun Wang, Yi Wang, Yide Guo, He Wang, Xuan Hong, Feng Liu
Summary: This study found that carboxyl terminus of Hsp70-interacting protein (CHIP) is closely related to cardiovascular disease (CVD) in maintenance hemodialysis (MHD) patients. The data showed that serum CHIP concentration in MHD patients was lower than in healthy controls. Additionally, CHIP was negatively correlated with multiple risk factors of CVD and low serum CHIP concentration predicted the occurrence of CVD risk and death.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Urology & Nephrology
Andrew Davenport
Summary: The study aims to assess the mortality risk of patients with muscle weakness using the Clinical Frailty Score (CFS). Analysis and comparison of 2089 patients revealed that frail patients were associated with factors such as age, gender, comorbidity, and various body indicators. Frail patients are at increased risk of mortality, thus requiring simple and reliable screening tools to rapidly detect at-risk patients.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Multidisciplinary Sciences
Rayne de Almeida Marques, Vanusa Felicio de Souza, Thaina Cezini do Rosario, Maria Rita Pereira da Silva Garcia, Taisa Sabrina Silva Pereira, Jose Luiz Marques-Rocha, Valdete Regina Guandalini
Summary: This study analyzed the agreement between maximum and mean handgrip strength (HGS) measurements in identifying probable sarcopenia in cancer patients. The results showed a satisfactory agreement between maximum and mean HGS values, but individuals with probable sarcopenia were better identified through mean values.
Article
Nutrition & Dietetics
Andreja Ocepek, Robert Ekart, Petra Povalej Brzan, Sebastjan Bevc
Summary: Protein-energy wasting is a common and serious co-morbidity in haemodialysis patients. This study examines the effect of oral nutritional supplements on the nutritional status of HD patients after 12 months.
FRONTIERS IN NUTRITION
(2023)
Article
Endocrinology & Metabolism
Hee-Won Jung, Jin Hoon Park, Da Ae Kim, Il-Young Jang, So Jeong Park, Jin Young Lee, Seungjoo Lee, Jeoung Hee Kim, Hyon-Seung Yi, Eunju Lee, Beom-Jun Kim
Summary: The study found that higher serum FGF21 levels were positively correlated with an increased risk of sarcopenia, lower muscle mass, and weaker grip strength in older adults, while also showing a negative correlation with these muscle-related indicators. This suggests a potential catabolic role of FGF21 in human muscle health.
Article
Medicine, General & Internal
Fatma Cansu Aktas Arslan, Arzu Demirguc, Naime Ulug
Summary: Continuous hemodialysis treatment has adverse effects on hand grip strength, range of motion, upper extremity functions, physical activity, and physical function levels of patients.
Article
Nutrition & Dietetics
Yongjae Kim, Sungjae Shin, Namki Hong, Yumie Rhee
Summary: This study found that lower serum vitamin E levels were associated with decreased hand grip strength in older men living in the community, but not in women. Individuals with the lowest vitamin E levels had higher odds of low hand grip strength, independent of various other factors. Further validation of these findings is needed.
Article
Transplantation
Emilie Bres, Cecile Pagan, Anais Bouchara, Myriam Pastural, Samuel Granjon, Maurice Laville, Denis Fouque, Christophe O. Soulage, Laetitia Koppe
Summary: This study found that serum 3-MH levels were associated with clinical outcomes in MHD patients, with high levels indicating better lean tissue mass and nutritional status, while low levels were a predictor of cardiovascular events in this population.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Nutrition & Dietetics
Eric Bartholomae, Jessica Knurick, Carol S. Johnston
Summary: A growing number of Americans are adopting vegetarian or vegan diets, raising concerns about sufficient protein intake. This study found that vegetarian participants had lower protein intake, lean body mass, serum creatinine, and handgrip strength compared to omnivorous participants. However, regardless of diet, serum creatinine concentrations correlated with lean body mass and strength in healthy adults.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Chun-Hua Jin, Jun-Wei Wang, Jiang-Feng Ke, Jing-Bo Li, Mei-Fang Li, Lian-Xi Li
Summary: This study aimed to investigate the association between serum UCB levels within normal limits and carotid atherosclerosis in T2DM patients. The results showed that high serum UCB levels within the normal range were inversely associated with the risk of carotid plaque and stenosis, but not with CIMT. Furthermore, high-normal UCB levels may protect against carotid atherosclerosis through its anti-inflammatory effect.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Pei-Yun Chen, Yi-Hsuan Lee, Chien-Hsieh Chiang, Hao-Hsiang Chang, Chia-Wen Lu, Kuo-Chin Huang
Summary: This study aimed to investigate the association between serum osteocalcin levels and handgrip strength in middle-aged and older diabetic individuals. The results showed that higher serum osteocalcin levels were associated with worse handgrip strength, especially in postmenopausal women.
Article
Biochemistry & Molecular Biology
Angela Oranger, Giuseppina Storlino, Manuela Dicarlo, Roberta Zerlotin, Patrizia Pignataro, Lorenzo Sanesi, Marco Narici, Rado Pisot, Bostjan Simunic, Graziana Colaianni, Maria Grano, Silvia Colucci
Summary: Bed rest (BR) is used as a model to simulate microgravity and study skeletal-muscle alterations. This study investigated the role of the myokine irisin and bone-muscle turnover markers during and after 10 days of BR. The results showed that irisin may protect against muscle atrophy and delay the expression of atrophy and senescence cellular markers.
Article
Rheumatology
Cintia M. de Sordi, Edgard T. dos Reis-Neto, Gerson D. Keppeke, Samuel K. Shinjo, Emilia Inoue Sato
Summary: This study found that serum levels of myostatin and follistatin did not differ between patients with idiopathic inflammatory myopathy and control subjects, suggesting that these levels may not be helpful in clinical practice.
JCR-JOURNAL OF CLINICAL RHEUMATOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yu-Hui Hung, Tai-Shuan Lai, Mohamed Belmouaz, Ya-Chun Tu, Chun-Fu Lai, Shuei-Liong Lin, Yung-Ming Chen
Summary: Studies have shown that MCO membranes are superior to standard high flux membranes in clearing middle molecular weight uremic toxins in hemodialysis. Meta-analysis results indicate significantly higher reduction ratio of serum β2M, κFLC, and λFLC in the MCO group. However, the use of MCO membranes may result in albumin loss, which should be monitored.
Article
Endocrinology & Metabolism
Wan-Chen Wu, Kang-Yung Peng, Jin-Ying Lu, Chieh-Kai Chan, Chih-Yuan Wang, Fen-Yu Tseng, Wei-Shiung Yang, Yen-Hung Lin, Po-Chih Lin, Ting-Chu Chen, Kuo-How Huang, Jeff S. Chueh, Vin-Cent Wu
Summary: The study found that CPA-related mutations were detected in 36.7% of uPA/ACS adenomas. The presence of these mutations was associated with higher post-DST cortisol levels, larger adenoma sizes, and a high percentage of non-classical uPA. However, these mutations did not significantly affect the clinical and biochemical outcomes after adrenalectomy of uPA/ACS patients but they showed a better trend.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Heng-Chih Pan, Chiao-Yin Sun, Thomas Tao-Min Huang, Chun-Te Huang, Chun-Hao Tsao, Chien-Heng Lai, Yung-Ming Chen, Vin-Cent Wu
Summary: This study identified specific phenotypes of critically ill patients with acute kidney injury who may be successfully weaned off renal replacement therapy. Urinary NGAL/Cr and distinct clustering phenotypes could predict 90-day mortality or re-dialysis.
Article
Immunology
Mao-Jan Lin, Yu-Chun Lin, Nae-Chyun Chen, Allen Chilun Luo, Sheng-Kai Lai, Chia-Lang Hsu, Jacob Shujui Hsu, Chien-Yu Chen, Wei-Shiung Yang, Pei-Lung Chen
Summary: The study of adaptive immune receptor repertoire (AIRR) is crucial for understanding adaptive immune responses. The authors developed the gAIRR Suite, which includes three modules: gAIRR-seq, gAIRR-call, and gAIRR-annotate. Using this suite, they were able to accurately profile and annotate the germline genes encoding AIRR, leading to the discovery of new alleles and comparison of gene differences across genomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Hung-Ju Lin, Jui Wang, Po-Yuan Tseng, Li-Chen Fu, Yi-Chia Lee, Ming-Shiang Wu, Wei-Shiung Yang, Han-Mo Chiu
Summary: Lower glycemic levels than currently accepted could lead to optimal risk reduction of incident diabetes among individuals with prediabetes, highlighting the importance of stringent glycemic management for diabetes prevention.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2023)
Article
Geriatrics & Gerontology
Ching-Ming Chiu, Kuen-Cheh Yang, Hao-Hsiang Chang, Chia-Wen Lu, Chien-Hsieh Chiang, Kuo-Chin Huang
Summary: This study investigates the correlation between vertebral fragility fracture and the severity of sarcopenia in older adults at increased risk for fractures. The results show that individuals with abnormal bone mineral density are more likely to have sarcopenia, poor muscle mass, and hand grip strength. Sarcopenia is also found to be associated with a higher prevalence of moderate-to-severe thoracic vertebral fragility fracture, with a dose-dependent relationship.
Article
Medicine, General & Internal
Chun-Fu Lai, Jung-Hua Liu, Li-Jung Tseng, Chun-Hao Tsao, Nai-Kuan Chou, Shuei-Liong Lin, Yung-Ming Chen, Vin-Cent Wu
Summary: This study used unsupervised consensus clustering to investigate the heterogeneity in dialysis-requiring sepsis-associated acute kidney injury (SA-AKI) patients. Three sub-phenotypes were identified based on 23 clinical variables, which exhibited distinct clinical manifestations at the initiation of renal replacement therapy. Among them, sub-phenotype 1, characterized by younger age, lower Charlson Comorbidity Index, higher baseline estimated glomerular filtration rate but higher severity of acute illness, had a higher risk of death and a lower probability of being free of dialysis compared to sub-phenotype 3.
ANNALS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Chia-Wen Lu, Kuen-Cheh Yang, Yu-Chiao Chi, Tsan-Yu Wu, Chien-Hsieh Chiang, Hao-Hsiang Chang, Kuo-Chin Huang, Wei-Shiung Yang
Summary: Lean non-alcoholic fatty liver disease (NAFLD) is similar to overweight NAFLD and should be detected early. The adiponectin-leptin ratio (AL ratio) may serve as a reliable marker for early detection of lean NAFLD independent of insulin resistance.
ANNALS OF MEDICINE
(2023)
Article
Clinical Neurology
Der-Sheng Han, Cheng-Han Lee, Yih-Dar Shieh, Ke-Vin Chang, Shing-Hong Lin, Ya-Cherng Chu, Jaw-Lin Wang, Chih-Cheng Chen
Summary: Therapeutic ultrasound has analgesic effects against chronic muscle pain by activating ASIC3-containing channels and releasing substance P in muscle afferents.
Article
Medicine, General & Internal
Yu-Chieh Tsai, Yung-Ming Chen, Chiung-Jung Wen, Meng-Chen Wu, Yi-Chun Chou, Jen-Hau Chen, Kun-Pei Lin, Ding-Cheng Chan, Feng-Ping Lu
Summary: The 30-day hospital readmission rate is significantly related to advanced age, and the predictive ability of existing models for readmission risk in the oldest population is uncertain. In addition to multimorbidity, a history of falls and frailty are associated with higher readmission risk in older adults.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Zhi-Ye Yu, Tai-Shuan Lai, Shao-Yu Yang, Shih- Chen, Mei-Jun Lai, Chun-Min Kang, Yu-Tsung Huang, Yi-Ting Chen, Po-Ren Hsueh, Yung-Ming Chen, Shuei-Liong Lin
Summary: Patients on peritoneal dialysis (PD) had fewer adverse events after COVID-19 vaccination compared to volunteers. PD patients had lower antibody concentrations compared to volunteers, but the levels increased after the second dose of vaccination. The mRNA-1273 vaccine induced a higher antibody and T cell response than the ChAdOx1-S vaccine in PD patients.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Vin- Cent Wu, Chieh-Kai Chan, Jeff S. Chueh, Yung-Ming Chen, Yen- Hung Lin, Chin-Chen Chang, Po-Chih Lin, Shiu-Dong Chung, TAIPAI grp
Summary: A study found that targeted treatment with MRAs or adrenalectomy in patients with PA leads to a decline in estimated glomerular filtration rate. However, the changes in biomarkers of kidney tubule health are still unclear.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Pharmacology & Pharmacy
Yi-Chih Lin, Hsiao-Mei Tsao, Tai-Shuan Lai, Yi-Ting Chen, Yu-Hsiang Chou, Shuei-Liong Lin, Yung-Ming Chen, Kuan-Yu Hung, Yu-Kang Tu
Summary: The use of lipid-lowering drugs in patients with advanced chronic kidney disease and dyslipidemia can reduce the risk of end-stage kidney disease and major adverse cardiovascular events.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Geriatrics & Gerontology
Pei-Yun Chen, Yi-Hsuan Lee, Chien-Hsieh Chiang, Hao-Hsiang Chang, Chia-Wen Lu, Kuo-Chin Huang
Summary: This study aimed to investigate the association between serum osteocalcin levels and handgrip strength in middle-aged and older diabetic individuals. The results showed that higher serum osteocalcin levels were associated with worse handgrip strength, especially in postmenopausal women.
Article
Urology & Nephrology
Yu-Hsiang Chou, Tai-Shuan Lai, Yi-Chih Lin, Wen-Chih Chiang, Tzong-Shinn Chu, Shuei-Liong Lin, Yung-Ming Chen
Summary: Older adults with chronic kidney disease (CKD) may experience accelerated progression of the disease due to acute kidney injury (AKI), despite old age being considered a positive modifier of CKD. This study aimed to investigate this paradoxical interaction and identify age-specific predictors for end-stage kidney disease (ESKD). The results showed that older adults with CKD had a slower decline rate of estimated glomerular filtration rate (eGFR) but were more likely to develop ESKD following AKI episodes. Therefore, preventing AKI to prevent accelerated initiation of renal replacement therapy in elderly patients with pre-existing CKD is necessary.