Article
Endocrinology & Metabolism
Renee M. G. Verdiesen, N. Charlotte Onland-Moret, Carla H. van Gils, Rebecca K. Stellato, Annemieke M. W. Spijkerman, H. Susan J. Picavet, Frank J. M. Broekmans, W. M. Monique Verschuren, Yvonne T. van der Schouw
Summary: Lower age-specific AMH levels were associated with a higher risk of type 2 diabetes in women. Longitudinal analyses did not show clear evidence of differing AMH trajectories between women who developed type 2 diabetes compared with women who did not. More research is needed to explore the biological mechanism underlying the association between reproductive ageing and type 2 diabetes.
Article
Endocrinology & Metabolism
Solene Rerat, Jessica Amsellem-Jager, Marie Clemence L'hour, Natacha Bouhours-Nouet, Aurelie Donzeau, Stephanie Rouleau, Lucie Levaillant, Fabienne Emeriau, Valerie Moal, Florence Boux de Casson, Najiba Lahlou, Regis Coutant
Summary: This study described alterations in circulating Sertoli and Leydig cell hormone levels in overweight-obese boys throughout childhood and adolescence. The findings showed significantly lower levels of inhibin B and testosterone in overweight-obese boys during puberty compared to healthy boys, with some hormone values below the normal range.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Endocrinology & Metabolism
Casper P. P. Hagen, Margit Bistrup Fischer, Gylli Mola, Theis Bech Mikkelsen, Line Hartvig Cleemann, Claus Hojbjerg Gravholt, Mette H. H. Viuff, Anders Juul, Anette Tonnes Pedersen, Katharina Maria Main
Summary: Turner syndrome (TS) is a chromosomal disorder characterized by the absence of the second X chromosome, affecting about 1 in 2500 female births. TS is associated with primary ovarian insufficiency (POI), with only a small percentage of women achieving pregnancy without egg donation. This review evaluates the clinical use of ovarian function markers in TS patients and reports on the transition from pediatric to gynecological and adult endocrinological care in a Danish center.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Renee M. G. Verdiesen, Carla H. van Gils, Rebecca K. Stellato, W. M. Monique Verschuren, Frank J. M. Broekmans, Annelien C. de Kat, Yvonne T. van der Schouw, N. Charlotte Onland-Moret
Summary: The study found that baseline age-specific AMH levels were not associated with overall cancer risk, but there may be an increased risk of breast cancer in women under 40. Analysis of age-related AMH trajectories suggested that women diagnosed with cancer had higher AMH levels at a younger age and declined faster compared to those who were not diagnosed with cancer, although there was no actual evidence for differences in trajectories.
Article
Geriatrics & Gerontology
Nydjie P. Grimes, Brian W. Whitcomb, Katherine W. Reeves, Lynnette L. Sievert, Alexandra Purdue-Smithe, JoAnn E. Manson, Susan E. Hankinson, Bernard A. Rosner, Elizabeth R. Bertone-Johnson
Summary: The study evaluated the association between parity, breastfeeding, and AMH levels over time, with a focus on age at menopause. Results showed that breastfeeding was associated with higher AMH levels and later onset of menopause, suggesting that observed relations of parity with AMH levels and menopause timing may be largely attributable to breastfeeding.
Article
Medicine, General & Internal
Li-Te Lin, Kuan-Hao Tsui
Summary: The study revealed a weak positive association between serum DHEA-S and AMH levels in infertile women. Women in the highest DHEA-S quartile category (Q4) had significantly higher AMH levels, suggesting a positive correlation between these two hormones.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Casper P. Hagen, Margit Bistrup Fischer, Christine Wohlfahrt-Veje, Maria Assens, Alexander S. Busch, Anette Tonnes Pedersen, Anders Juul, Katharina M. Main
Summary: This study indicates that ovarian activity in healthy girls remains remarkably stable from small growing follicles, suggesting that AMH concentrations in early life can serve as a useful clinical tool to predict future ovarian activity.
Article
Obstetrics & Gynecology
Renee M. G. Verdiesen, Yvonne T. van der Schouw, Carla H. van Gils, W. M. Monique Verschuren, Frank J. M. Broekmans, Maria C. Borges, Ana L. Goncalves Soares, Deborah A. Lawlor, A. Heather Eliassen, Peter Kraft, Dale P. Sandler, Sioban D. Harlow, Jennifer A. Smith, Nanette Santoro, Minouk J. Schoemaker, Anthony J. Swerdlow, Anna Murray, Katherine S. Ruth, N. Charlotte Onland-Moret
Summary: This study identified four loci associated with circulating anti-Müllerian hormone levels in premenopausal women through a large-scale genome-wide association study meta-analysis. The findings contribute to the understanding of the biology of anti-Müllerian hormone and its role in ovarian aging.
HUMAN REPRODUCTION
(2022)
Review
Endocrinology & Metabolism
Chenxi Lin, Miaomiao Jing, Wenjun Zhu, Xiaoyu Tu, Qi Chen, Xiufang Wang, Youbing Zheng, Runju Zhang
Summary: The study aimed to determine whether serum anti-Mullerian hormone (AMH) level is a predictor of clinical pregnancy in women trying to achieve a natural conception. The results showed that serum AMH levels have poor predictive value for natural pregnancy, regardless of age groups. These findings suggest that low serum AMH levels are not associated with reduced fertility in women.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Benjamin S. Harris, Anne Z. Steiner, Anne Marie Jukic
Summary: This study investigated the association between biomarkers of ovarian reserve and menstrual cycle length, indicating that higher AMH levels are associated with longer menstrual cycles, independent of age.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Benjamin S. Harris, Anne Z. Steiner, Anne Marie Jukic
Summary: This study analyzed data from 632 women aged 30-44 without infertility history who were attempting to conceive for less than 3 months, and found that increasing AMH levels were associated with longer menstrual cycle lengths.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Tess Clendenen, Wenzhen Ge, Karen L. Koenig, Yelena Afanasyeva, Claudia Agnoli, Elizabeth Bertone-Johnson, Louise A. Brinton, Farbod Darvishian, Joanne F. Dorgan, A. Heather Eliassen, Roni T. Falk, Goran Hallmans, Susan E. Hankinson, Judith Hoffman-Bolton, Timothy J. Key, Vittorio Krogh, Hazel B. Nichols, Dale P. Sandler, Minouk J. Schoemaker, Patrick M. Sluss, Malin Sund, Anthony J. Swerdlow, Kala Visvanathan, Mengling Liu, Anne Zeleniuch-Jacquotte
Summary: This study found positive associations between AMH and age at menarche and parity, and negative associations with hysterectomy/partial oophorectomy. Women who were obese, currently used oral contraceptives, or were current/former smokers had lower AMH concentrations. Interestingly, higher AMH concentrations were observed in women who had a benign breast biopsy, especially in women over 40 years old.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Yong Han, Huiyu Xu, Guoshuang Feng, Haiyan Wang, Kannan Alpadi, Lixue Chen, Mengqian Zhang, Rong Li
Summary: This study established a model for predicting ovarian reserve using AMH level and age, and demonstrated its effectiveness in predicting poor ovarian response based on external validation data.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Reproductive Biology
Mei Jiang, Ying Gao, Tiange Qu, Yuechen Ji, Yiwen Niu, Jiaxin Zhang, Ling Huang
Summary: This study aimed to investigate the relationship between serum levels of inhibin B (INHB), anti-mullerian hormone (AMH) and precocious puberty in girls. Through a meta-analysis of 11 studies, it was found that the INHB level was significantly increased in girls with precocious puberty, while there was no significant association with serum AMH levels. This suggests that INHB levels may serve as a marker for the auxiliary diagnosis of precocious puberty, especially central precocious puberty and premature thelarche.
JOURNAL OF OVARIAN RESEARCH
(2023)
Review
Obstetrics & Gynecology
Maeliss Peigne, Valerie Bernard, Laura Dijols, Helene Creux, Geoffroy Robin, Claude Hocke, Michael Grynberg, Didier Dewailly, Charlotte Sonigo
Summary: This study conducted a systematic review and meta-analysis to evaluate whether serum anti-Mullerian hormone (AMH) level can predict the cumulative live birth (CLB) rate after assisted reproductive technology (ART) or in women trying to conceive naturally. The results showed a positive relation between serum AMH level and CLB after IVF/ICSI, but there is a lack of data for IUI or natural conception without ART.
HUMAN REPRODUCTION
(2023)
Review
Endocrinology & Metabolism
Rodolfo A. Rey
Summary: Puberty is characterized by major changes in the anatomy and function of reproductive organs, with androgen playing a crucial role in this process.
Review
Developmental Biology
Franco G. Brunello, Rodolfo A. Rey
Summary: Anti-mullerian hormone (AMH) is crucial for male fetal genital development, with its deficiency potentially leading to abnormalities. Defects in the AMH pathway, resulting in Persistent Mullerian Duct Syndrome, cause a rare condition where patients have male external genitalia but also internal female reproductive organs.
SEXUAL DEVELOPMENT
(2022)
Editorial Material
Endocrinology & Metabolism
Rodolfo A. Rey
BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lloyd J. W. Tack, Saskia van der Straaten, Stefan Riedl, Alexander Springer, Paul-Martin Holterhus, Nadine C. Hornig, Zofia Kolesinska, Marek Niedziela, Federico Baronio, Antonio Balsamo, Sabine E. Hannema, Anna Nordenstrom, Sukran Poyrazoglu, Fatma F. Darendeliler, Romina Grinspon, Rodolfo Rey, Fahad Aljuraibah, Jillian Bryce, Faisal Ahmed, Rieko Tadokoro-Cuccaro, Ieuan Hughes, Guilherme Guaragna-Filho, Andrea T. Maciel-Guerra, Gil Guerra-Junior, Martine Cools
Summary: The study found that almost one out of three SGA boys experience insufficient catch-up growth by the age of 2. Additionally, SGA boys had higher LH levels during minipuberty and lower testosterone levels in stimulation tests.
CLINICAL ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Romina P. Grinspon, Sebastian Castro, Rodolfo A. Rey
Summary: In this review, we present a practical and updated approach to clinical and hormonal laboratory workup for newborns, children, and adolescents with suspected DSD. We emphasize the importance of tailoring the diagnostic approach based on age and presentation.
HORMONE RESEARCH IN PAEDIATRICS
(2023)
Review
Endocrinology & Metabolism
Gabriela P. Finkielstain, Ana Vieites, Ignacio Bergada, Rodolfo A. Rey
Summary: Disorders of Sex Development (DSD) refer to anomalies in fetal sexual differentiation resulting in discordance between chromosomal sex and gonadal or genitalia sex. DSD can be associated with adrenal disorders in both 46,XX and 46,XY individuals, with different pathogenic mechanisms. The pathophysiology, clinical presentation, and management of these disorders are reviewed, focusing on biomarkers and therapeutic development.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Rodolfo A. Rey
Summary: Clinical manifestations and treatment needs of hypogonadism in males vary according to age. Early onset hypogonadism may result in disorders of sex development, while hypogonadism established later in fetal life presents with micropenis, cryptorchidism, and/or micro-orchidism. Diagnosis of hypogonadism becomes challenging after neonatal activation of the gonadal axis diminishes. Treatment usually focuses on micropenis and/or cryptorchidism in infancy and childhood, and on lack of pubertal development and relative short stature in teenagers.
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM
(2022)
Editorial Material
Endocrinology & Metabolism
Rodolfo A. Rey
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Pediatrics
Sebastian Castro, Franco G. Brunello, Gabriela Sanso, Paula Scaglia, Maria Esnaola Azcoiti, Agustin Izquierdo, Florencia Villegas, Ignacio Bergada, Maria Gabriela Ropelato, Marcelo A. Marti, Rodolfo A. Rey, Romina P. Grinspon
Summary: Pubertal delay in males can be caused by constitutional delay of growth and puberty or pathologic hypogonadism. Central (or hypogonadotropic) hypogonadism, resulting from a defective function of the GnRH/gonadotropin axis, is the main differential diagnosis after ruling out general illnesses and primary testicular failure. Ciliopathies arising from defects in non-motile cilia can cause developmental disorders affecting the sense organs and reproductive system.
FRONTIERS IN PEDIATRICS
(2022)
Review
Endocrinology & Metabolism
Nadia Y. Edelsztein, Clara Valeri, Maria M. Lovaisa, Helena F. Schteingart, Rodolfo A. Rey
Summary: Anti-Mullerian hormone (AMH) is a biomarker of immature Sertoli cells, which is regulated by specific transcription factors and plays a role in the regression of Mullerian ducts in males. AMH is highly expressed before puberty and then downregulated. FSH increases AMH output, while intratesticular levels of androgens and estrogens also regulate AMH secretion.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Rodolfo A. Rey
Summary: This review discusses the etiologies and specific pharmacological therapies for delayed puberty in males. There is limited high-quality evidence available for the best pharmacological therapy approach, with most current practice based on small case series or unpublished experience. Medical treatment is likely beneficial for male teenagers seeking attention for pubertal delay to prevent psychosocial distress. While watchful waiting is appropriate for boys aged 12-14 with suspected constitutional delay of growth and puberty, hormone replacement should not be delayed beyond the age of 14. Hormone replacement should be proposed by the age of 12 when hypogonadism is diagnosed. Testosterone replacement is the standard treatment, but aromatase inhibitors have emerged as an interesting alternative. Gonadotrophin therapy appears more physiological for patients with central hypogonadism, but its efficacy and timing still need further research.
EXPERT OPINION ON PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Nathalie di Clemente, Chrystele Racine, Rodolfo A. Rey
Summary: This article reviews the main findings on anti-Mullerian hormone (AMH) and its involvement in the pathogenesis of polycystic ovary syndrome (PCOS) and its male equivalent. AMH has important roles in ovarian reserve, follicular development, and the differentiation of the genital tract. It is also used to assess Sertoli cell function in children and has potential implications for male fertility.
Editorial Material
Endocrinology & Metabolism
Lourdes Correa Brito, Rodolfo A. Rey
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Health Care Sciences & Services
Lourdes Correa Brito, Romina P. Grinspon, Jimena Lopez Dacal, Paula Scaglia, Maria Esnaola Azcoiti, Agustin Izquierdo, Maria Gabriela Ropelato, Rodolfo A. Rey
Summary: This study reported a case of a patient with 46,XY disorders of sex development (DSDs) in whom a novel variant in MYRF gene was identified, leading to the detection of a clinically inapparent congenital heart defect.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Meeting Abstract
Endocrinology & Metabolism
Luciana Brenzoni, Silvina Prada, Maria Arozarena de Gamboa, Maria Gabriela Ropelato, Maria Gabriela Ballerini, Maria Eugenia Rodriguez, Marcela E. Gutierrez, Patricia Bedecarras, Luis Aversa, Rodolfo A. Rey, Romina P. Grinspon, Romina Paula Grinspon
HORMONE RESEARCH IN PAEDIATRICS
(2021)