Article
Endocrinology & Metabolism
Lena Jafri, Hafsa Majid, Sibtain Ahmed, Ghazala Naureen, Aysha Habib Khan
Summary: This study investigated the relationships between anthropometry, dietary and caloric intake, body composition measurements, physical activity, and vitamin D status with bone parameters among medical students. The results showed a high prevalence of vitamin D deficiency, with females exhibiting significantly lower dietary intakes and poorer bone parameters compared to males. Overall body fat and visceral fat were identified as negatively associated determinants of bone strength.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Popi Kasvis, Tamara R. Cohen, Sarah-Eve Loiselle, Tom J. Hazell, Catherine A. Vanstone, Hope A. Weiler
Summary: This study aimed to examine the association between body composition and vitamin D status. The results showed that vitamin D deficiency was not present in children aged 6-12 with obesity. The study also found that reductions in adiposity did not alter the vitamin D status.
Review
Nutrition & Dietetics
Vincent Brandenburg, Markus Ketteler
Summary: This review examines the developments of vitamin D therapies in CKD patients and discusses the association between vitamin D deficiency and sHPT as well as its impact on important clinical outcomes in CKD patients. However, vitamin D therapy also comes with the risk of side effects, so it is necessary to address core issues regarding PTH target levels, optimal vitamin D levels, and the effectiveness of sHPT treatment in CKD patients.
Article
Endocrinology & Metabolism
Hope A. Weiler, Wen Hsuan Fu, Maryam Razaghi, Nathalie Gharibeh, Catherine A. Vanstone
Summary: This study found an association between vitamin D deficiency and elevated parathyroid hormone levels in newborn infants. The global consensus recommendation on vitamin D deficiency (<25 nmol/L) aligns better with the threshold at which parathyroid hormone is elevated compared to the definition set by the National Academy of Medicine (<30 nmol/L).
Article
Nutrition & Dietetics
Ola Hysaj, Patricia Marques-Gallego, Aline Richard, Magdeldin Elgizouli, Alexandra Nieters, Katharina C. Quack Lotscher, Sabine Rohrmann
Summary: This study assessed parathyroid hormone concentrations in pregnant women during early and late pregnancy, finding an inverse correlation between serum 25(OH)D and PTH levels. Statistically significant determinants of PTH concentrations included 25(OH)D levels, season, parity, and partner's education in early pregnancy, while late pregnancy was affected by 25(OH)D levels and country of origin. These factors seem to primarily impact PTH through 25(OH)D, but may also have other mechanisms of influence.
Article
Pediatrics
Chayatat Ruangkit, Sukrit Suwannachat, Pornchanok Wantanakorn, Napapailin Sethaphanich, Surapat Assawawiroonhakarn, Oraporn Dumrongwongsiri
Summary: Most exclusively breastfed Thai infants at 6 months old have serum vitamin D levels below sufficiency level. However, supplementing with vitamin D (400 IU/day) improves their vitamin D status and prevents deficiency.
Article
Nutrition & Dietetics
Jacklyn N. Hellwege, Xiangzhu Zhu, Xiang Huang, Martha J. Shrubsole, Lei Fan, Bingshan Li, Reid Ness, Douglas L. Seidner, Edward L. Giovannucci, Todd L. Edwards, Qi Dai
Summary: Optimal 25(OH)D levels are associated with a significantly reduced risk of colorectal cancer, particularly among women. Individuals with BPRVID are at higher risks of incident adenoma and colorectal cancer compared to those with HPRVID, especially among women. Treatment strategies should be tailored based on individuals' different response types.
CLINICAL NUTRITION
(2021)
Article
Endocrinology & Metabolism
Sharon H. Chou, Elle M. Murata, Cindy Yu, Jacqueline Danik, Gregory Kotler, Nancy R. Cook, Vadim Bubes, Samia Mora, Paulette D. Chandler, Deirdre K. Tobias, Trisha Copeland, Julie E. Buring, JoAnn E. Manson, Meryl S. LeBoff
Summary: This study aimed to investigate the effects of vitamin D-3 supplementation on weight and body composition, and the results showed that there were no significant effects on weight, BMI, or measures of adiposity and lean tissue. However, it did slightly improve body fat percentage in participants with normal BMI at baseline, indicating a potential benefit for individuals with normal weight.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Endocrinology & Metabolism
Audrey Bobillier, Philippe Wagner, Danielle E. Whittier, Rene Ecochard, Steven K. Boyd, Roland Chapurlat, Pawel Szulc
Summary: The study found that poor vitamin D status and high parathyroid hormone levels are associated with the deterioration of bone microarchitecture and reduced bone strength in older men.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Hirotaka Komaba, Junhui Zhao, Angelo Karaboyas, Suguru Yamamoto, Indranil Dasgupta, Mohamed Hassan, Li Zuo, Anders Christensson, Christian Combe, Bruce M. Robinson, Masafumi Fukagawa
Summary: This study analyzed the association between the prescription of active vitamin D and fracture incidence in hemodialysis patients. The results suggested that active vitamin D does not have a PTH-independent benefit in fracture prevention, supporting the current guideline of using active vitamin D only in patients with elevated or rising PTH.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Physiology
Xiaomin Sun, Wenjuan Xiao, Zhongying Li, Sirui Zhou, Mengyue Dong, Cong Huang, Yan Ma, Bo Gou
Summary: This study aimed to assess the effects of a 12-week vitamin D and endurance exercise intervention on bone health, body composition, and physical performance among patients with type 2 diabetes. The results showed that vitamin D supplementation had significant effects on maintaining bone health, while exercise had a main effect on reducing body fat percentage.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Urology & Nephrology
Mario Cozzolino, Paola Minghetti, Pierluigi Navarra
Summary: A high percentage of chronic kidney disease patients have low vitamin D levels, which can lead to secondary hyperparathyroidism. Early intervention to restore vitamin D levels is recommended to prevent/delay secondary hyperparathyroidism. Controlling parathyroid hormone levels becomes a major focus of therapy for patients with intermediate-stage chronic kidney disease.
JOURNAL OF NEPHROLOGY
(2022)
Article
Endocrinology & Metabolism
John P. Bilezikian, Anna Maria Formenti, Robert A. Adler, Neil Binkley, Roger Bouillon, Marise Lazaretti-Castro, Claudio Marcocci, Nicola Napoli, Rene Rizzoli, Andrea Giustina
Summary: The conference discussed the important role of vitamin D in skeletal and extra-skeletal systems, recommending personalized management based on the specific mechanisms underlying vitamin D deficiency in different diseases. Furthermore, the supplementation of vitamin D in COVID-19 and the optimal route of administration for vitamin D in different clinical conditions were also discussed.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Nutrition & Dietetics
Souzana E. Xyda, Kalliopi Kotsa, Argyrios Doumas, Emmanouil Papanastasiou, Alexandros A. Garyfallos, George Samoutis
Summary: The prevalence of vitamin D deficiency is paradoxically high in both Mediterranean countries, Greece and Cyprus, despite ample sunlight in the region. Only the month and gender were significantly associated with vitamin D levels.
Article
Veterinary Sciences
Dennis E. Jewell, Kiran S. Panickar
Summary: The optimum concentration of vitamin D for dogs is still debated, but a minimum concentration of 100 ng/mL (250 nM) of circulating vitamin D has been suggested for optimal health. The relationship between dietary intake of vitamin D-3 and circulating 25(OH) D in adult dogs has not been well studied. The safe upper limit of vitamin D in dog foods for adult maintenance is 3,200 IU/kg on a dry matter basis, but this guideline was not based on studies of adult maintenance requirements. Understanding the relationship between dietary vitamin D and circulating vitamin D is important for promoting health in dogs.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Endocrinology & Metabolism
Jens Bollerslev, Evelina Sjostedt, Lars Rejnmark
Summary: PTH plays a crucial role in regulating calcium and phosphate balance in adults, with various clinical manifestations and cardiovascular risks associated with parathyroid disorders. While most PHPT patients are asymptomatic, they still face cardiovascular risks; Ps-HypoPT patients show resistance to PTH with unclear CV risks; HypoPT patients often develop hormonal deficiency syndrome post-surgery, leading to increased CV risk.
ANNALES D ENDOCRINOLOGIE
(2021)
Article
Endocrinology & Metabolism
Etki A. R. Hartogsohn, Aliya A. Khan, Line Underbjerg Kjaersulf, Tanja Sikjaer, Sharjil Hussain, Lars Rejnmark
CLINICAL ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Neil J. Gittoes, Sherwin Criseno, Natasha M. Appelman-Dijkstra, Jens Bollerslev, Ernesto Canalis, Lars Rejnmark, Zaki Hassan-Smith
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2020)
Article
Nutrition & Dietetics
Lise Sofie Bislev, Ulrik Kraemer Sundekilde, Ece Kilic, Trine Kastrup Dalsgaard, Lars Rejnmark, Hanne Christine Bertram
Review
Endocrinology & Metabolism
Lars Rejnmark, Henriette Ejlsmark-Svensson
CURRENT OSTEOPOROSIS REPORTS
(2020)
Article
Endocrinology & Metabolism
Giovanna Mantovani, Murat Bastepe, David Monk, Luisa De Sanctis, Susanne Thiele, S. Faisal Ahmed, Roberto Bufo, Timothee Choplin, Gianpaolo De Filippo, Guillemette Devernois, Thomas Eggermann, Francesca M. Elli, Aurora Garcia Ramirez, Emily L. Germain-Lee, Lionel Groussin, Neveen A. T. Hamdy, Patrick Hanna, Olaf Hiort, Harald Jueppner, Peter Kamenicky, Nina Knight, Elvire Le Norcy, Beatriz Lecumberri, Michael A. Levine, Outi Maekitie, Regina Martin, Gabriel Angel Martos-Moreno, Manasori Minagawa, Philip Murray, Arrate Pereda, Robert Pignolo, Lars Rejnmark, Rebeca Rodado, Anya Rothenbuhler, Vrinda Saraff, Ashley H. Shoemaker, Eileen M. Shore, Caroline Silve, Serap Turan, Philip Woods, M. Carola Zillikens, Guiomar Perez de Nanclares, Agnes Linglart
HORMONE RESEARCH IN PAEDIATRICS
(2020)
Article
Multidisciplinary Sciences
Tilman A. Grunewald, Marianne Liebi, Nina K. Wittig, Andreas Johannes, Tanja Sikjaer, Lars Rejnmark, Zirui Gao, Martin Rosenthal, Manuel Guizar-Sicairos, Henrik Birkedal, Manfred Burghammer
Article
Multidisciplinary Sciences
Christine Rohr Thomsen, Ioanna Milidou, Lone Hvidman, Mohammed Rohi Khalil, Lars Rejnmark, Niels Uldbjerg
Article
Multidisciplinary Sciences
Aline Clabaut, Celine Grare, Gaelle Rolland-Valognes, Jean-Guillaume Letarouilly, Chantal Bourrier, Thomas L. Andersen, Tanja Sikjaer, Lars Rejnmark, Charlotte Ejersted, Philippe Pastoureau, Pierre Hardouin, Massimo Sabatini, Odile Broux
Summary: Preliminary findings suggest that bone marrow adipocyte secretions may contribute to bone loss by inducing transdifferentiation of osteoblasts into adipocytes. This phenomenon was confirmed in elderly subjects, indicating a potential mechanism for decreased bone mass with aging.
Review
Endocrinology & Metabolism
Elvira O. Gosmanova, Pascal Houillier, Lars Rejnmark, Claudio Marelli, John P. Bilezikian
Summary: Patients with chronic hypoparathyroidism managed with conventional therapy, including oral calcium and active vitamin D, may have a higher risk of renal complications such as nephrolithiasis and nephrocalcinosis compared to the general population. Studies show an increased risk of chronic kidney disease in these patients, with rates varying depending on the duration of disease and treatment.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2021)
Article
Endocrinology & Metabolism
Rasmus Espersen, Lars Rejnmark
Summary: This study aimed to investigate the immediate effects of milk intake on cardiovascular function. The results showed that milk intake significantly increased ionized calcium levels, but did not have acute effects on cardiovascular health indices.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Lise Sofie Bislev, Louise Wamberg, Lars Rolighed, Diana Grove-Laugesen, Lars Rejnmark
Summary: Supplementation of vitamin D did not have a significant impact on muscle health or quality of life overall. However, there was a potential beneficial effect on muscle strength in severely obese individuals and on quality of life in vitamin D deficient individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
Lars Rejnmark, Olulade Ayodele, Angela Lax, Fan Mu, Elyse Swallow, Elvira O. Gosmanova
Summary: This study found that adult patients with chronic hypoparathyroidism treated with rhPTH(1-84) had a significantly lower risk of developing chronic kidney disease (CKD) compared to patients not treated with rhPTH(1-84).
CLINICAL ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Aliya A. Khan, John P. Bilezikian, Maria Luisa Brandi, Bart L. Clarke, Neil J. Gittoes, Janice L. Pasieka, Lars Rejnmark, Dolores M. Shoback, John T. Potts, Gordon H. Guyatt, Michael Mannstadt
Summary: This clinical practice guideline provides evidence-based recommendations for the prevention, diagnosis, and management of hypoparathyroidism. Evaluating serum PTH within 12 to 24 hours post total thyroidectomy can predict the development of permanent postsurgical hypoparathyroidism. Genetic testing may be helpful for individuals with nonsurgical hypoparathyroidism.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Elvira O. Gosmanova, Olulade Ayodele, Kristina Chen, Erin E. Cook, Fan Mu, Joshua A. Young, Lars Rejnmark
Summary: This study found an association between elevated serum calcium levels and the development of CKD in patients with chronic hypoparathyroidism.
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
(2022)