Article
Rheumatology
Matthew J. Koster, Cynthia S. Crowson, Rachel E. Giblon, Jane M. Jaquith, Ali Duarte-Garcia, Eric L. Matteson, Cornelia M. Weyand, Kenneth J. Warrington
Summary: This study investigated the use of baricitinib in patients with relapsing giant cell arteritis (GCA) and found it was well tolerated, allowing for discontinued use of glucocorticoids in most patients. Larger randomized clinical trials are necessary to further evaluate the efficacy of JAK inhibition in GCA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Psychiatry
Haishan Wu, Xijin Wang, Xuejun Liu, Hong Sang, Qijing Bo, Xiaodong Yang, Zhiyuan Xun, Keqing Li, Ruiling Zhang, Meijuan Sun, Duanfang Cai, Huaili Deng, Guijun Zhao, Juhong Li, Xianglai Liu, Guilai Zhan, Jindong Chen
Summary: This study evaluated the safety and effectiveness of blonanserin in Chinese patients with schizophrenia. The results demonstrated the drug to be safe and effective.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Masaomi Iyo, Jun Ishigooka, Masatoshi Nakamura, Reiko Sakaguchi, Keisuke Okamoto, Yongcai Mao, Joyce Tsai, Alison Fitzgerald, Kentaro Takai, Teruhiko Higuchi
Summary: In this 12-week open-label extension study, lurasidone at 40 or 80 mg/day continued to be well tolerated and effective in patients with schizophrenia. Treatment-emergent adverse events were low, with akathisia being the most common. Lurasidone had minimal effects on metabolic parameters, body weight, and ECG parameters, with patients demonstrating further improvement in symptoms over the study period.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Medicine, General & Internal
Katharina Schmidt, Julian Kleine-Borgmann, Dagny Holle-Lee, Charly Gaul, Ulrike Bingel
Summary: This study aims to systematically investigate the impact of open-label placebo treatment on headache days in patients with migraine, analyzing various indicators such as pain intensity, quality of life, and brain connectivity to identify potential predictors of placebo responses.
Article
Allergy
Flavia C. L. Hoyte, Giselle S. Mosnaim, Linda Rogers, Guilherme Safioti, Randall Brown, Thomas Li, Michael DePietro, Michael Reich, Tanisha D. Hill, Michael E. Wechsler
Summary: This study aimed to compare the effectiveness of the Reliever Digihaler System (RDS) and standard of care in improving asthma control. The results showed that participants using RDS had a higher probability of clinically meaningful improvements in asthma control. Further investigation of the potential of RDS in improving asthma management is warranted.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Clinical Neurology
Itaru Miura, Kei Watabe, Reiko Sakaguchi, Keisuke Okamoto, Hidenori Maruyama
Summary: In a 12-week extension study, lurasidone at a dose of 80 mg/day was found to be more effective in improving symptoms in patients with acute schizophrenia compared to a dose of 40 mg/day, with good tolerability.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Immunology
Robert Ndege, Omary Ngome, Fiona Vanobberghen, Farida Bani, Yvan Temba, Herieth Wilson, Jerry Hella, Winfrid Gingo, Mohamed Sasamalo, Dorcas Mnzava, Namvua Kimera, Hellen Hiza, John Wigayi, Herry Mapesi, Irene B. Kato, Francis Mhimbira, Klaus Reither, Manuel Battegay, Daniel H. Paris, Maja Weisser, Martin Rohacek
Summary: In this randomized two-center trial, a diagnostic algorithm including Extended Focused Assessment with Sonography for Human Immunodeficiency Virus and Tuberculosis did not increase the proportion of correctly managed patients with suspected extrapulmonary tuberculosis versus control, but increased definite tuberculosis.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Pharmacology & Pharmacy
Dejan B. Budimirovic, Kelli C. Dominick, Lidia Gabis, Maxwell Adams, Mathews Adera, Linda Huang, Pamela Ventola, Nicole R. Tartaglia, Elizabeth Berry-Kravis
Summary: This study aimed to evaluate the safety, tolerability, efficacy, and optimal daily dose of the GABA(A) receptor agonist OV101 in patients with FXS. Results showed that OV101 was well tolerated across different treatment regimens and demonstrated potential efficacy in improving symptoms of FXS.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Respiratory System
Aditi S. Shah, Alyson W. Wong, Cameron J. Hague, Darra T. Murphy, James C. Johnston, Christopher J. Ryerson, Christopher Carlsten
Summary: The long-term respiratory morbidity of COVID-19 remains unclear. A study found that a significant percentage of previously hospitalized patients had persisting abnormalities in clinical, radiological, and pulmonary function, highlighting the importance of developing treatment strategies and long-term respiratory follow-up.
Article
Clinical Neurology
Niaz Ahmed, Kennedy R. Lees, Rudiger von Kummer, Staffan Holmin, Irene Escudero-Martinez, Matteo Bottai, Olav Jansen, Nils Wahlgren
Summary: The SITS Open trial demonstrated that thrombectomy is superior to standard care for patients with large artery occlusion stroke in clinical practice. Results showed a significant shift in modified Rankin Scale at 3 months favoring the thrombectomy group.
Article
Gastroenterology & Hepatology
Christopher L. Bowlus, Michael R. Galambos, Richard J. Aspinall, Gideon M. Hirschfield, David E. J. Jones, Yvonne Doerffel, Stuart C. Gordon, Stephen A. Harrison, Andreas E. Kremer, Marlyn J. Mayo, Paul J. Thuluvath, Cynthia Levy, Mark G. Swain, Guy W. Neff, David A. Sheridan, Carmen M. Stanca, Christoph P. Berg, Aparna Goel, Mitchell L. Shiffman, John M. Vierling, Pol Boudes, Alexandra Steinberg, Yun-Jung Choi, Charles A. McWherter
Summary: This study examined the efficacy and safety of seladelpar in patients with primary biliary cholangitis (PBC). The results showed that seladelpar significantly improved biochemical markers of cholestasis and inflammation, and the improvements were maintained or improved after dose escalation at 52 weeks. The treatment was safe and not associated with worsening pruritus.
JOURNAL OF HEPATOLOGY
(2022)
Article
Critical Care Medicine
Axel Bauer, Michael Schreinlechner, Nikolay Sappler, Theresa Dolejsi, Herbert Tilg, Benedikt A. Aulinger, Guenter Weiss, Rosa Bellmann-Weiler, Christian Adolf, Dominik Wolf, Markus Pirklbauer, Ivo Graziadei, Hannes Gaenzer, Christian von Bary, Andreas E. May, Ewald Woell, Wolfgang von Scheidt, Tienush Rassaf, Daniel Duerschmied, Christoph Brenner, Stefan Kaeaeb, Bernhard Metzler, Michael Joannidis, Hans-Ulrich Kain, Norbert Kaiser, Robert Schwinger, Bernhard Witzenbichler, Hannes Alber, Florian Straube, Niels Hartmann, Stephan Achenbach, Michael von Bergwelt-Baildon, Lukas von Stuelpnagel, Sebastian Schoenherr, Lukas Forer, Sabine Embacher-Aichhorn, Ulrich Mansmann, Konstantinos D. Rizzast, Steffen Massberg
Summary: Stopping ACEI or ARB treatment did not significantly affect the maximum severity of COVID-19, but may result in a faster and better recovery. The decision to continue or discontinue should be made on an individual basis, considering the risk profile, indication for RAS inhibition, and availability of alternative therapies and outpatient monitoring options.
LANCET RESPIRATORY MEDICINE
(2021)
Article
Oncology
Golo Petzold, Sebastian C. B. Bremer, Felix C. Heuschert, Hannes Treiber, Volker Ellenrieder, Steffen Kunsch, Albrecht Neesse
Summary: Recurrent abdominal fluid collection, or ascites, is a common issue in patients with advanced malignancy, causing discomfort and other symptoms. Tunnelled peritoneal PleurX catheters have been shown to effectively reduce ascites-related symptoms and hospitalization rates, and are a safe and routine option for patients with recurrent malignant ascites.
Article
Clinical Neurology
Jun Ishigooka, Tadafumi Kato, Mari Miyajima, Kei Watabe, Takahiro Masuda, Katsuhiko Hagi, Teruhiko Higuchi
Summary: This study evaluated the long-term safety and effectiveness of open-label lurasidone treatment in patients with bipolar depression. The results showed that long-term treatment with lurasidone was well-tolerated and associated with continued improvement in depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Immunology
Jae-Min Kim, Hee-Ju Kang, Ju-Wan Kim, Min Jhon, Wonsuk Choi, Ju-Yeon Lee, Sung-Wan Kim, Il-Seon Shin, Min-Gon Kim, Robert Stewart
Summary: This study investigated the association between serum biomarkers and treatment outcomes in depression. The findings suggest that certain serum biomarkers are prospectively associated with remission at 12-week and 12-month periods. Inflammatory markers, in particular, show good predictability for remission, but the association weakens with increasing treatment steps.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Psychiatry
Seung-Hoon Lee, Cheolmin Shin, Hyounwook Kim, Sang Won Jeon, Ho-Kyoung Yoon, Young-Hoon Ko, Chi-Un Pae, Changsu Han
Summary: This study examined the validity and reliability of the Korean version of the GAD-7 scale. Results showed that the GAD-7 had high internal consistency, good test-retest reliability, and convergent validity. However, the GAD-7 had poor sensitivity and specificity for detecting anxiety disorders in a psychiatric setting.
ASIA-PACIFIC PSYCHIATRY
(2022)
Article
Clinical Neurology
Eunsoo Choi, Kwan Woo Choi, Hyun-Ghang Jeong, Moon-Soo Lee, Young-Hoon Ko, Changsu Han, Byung-Joo Ham, Jisoon Chang, Kyu-Man Han
Summary: This study found that working long hours may lead to depressive symptoms, especially having a greater impact on female workers, standard wage workers, and those with low income levels. Long working hours may have significant partial mediation pathways through perceived stress levels and self-rated health on depressive symptoms.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Engineering, Electrical & Electronic
Cheolmin Shin, Jongha Lee, Ho-Kyoung Yoon, Kun-Woo Park, Changsu Han, Young-Hoon Ko
Summary: This study investigated the differences in brain processing of sensory information while watching 2DTV and 3DTV. The findings showed that watching different types of television can lead to changes in brain wave activity, with watching 3DTV increasing slow-wave activity. Prolonged viewing of 3DTV may lead to an increase in symptoms of simulation sickness.
SIGNAL PROCESSING-IMAGE COMMUNICATION
(2021)
Article
Clinical Neurology
Song Heui Cho, Ji-Eun Lim, Jiseung Lee, Jee Soo Lee, Hyun-Ghang Jeong, Moon-Soo Lee, Young-Hoon Ko, Changsu Han, Byung-Joo Ham, Kyu-Man Han
Summary: This study found a significant association between high hsCRP levels and depressive symptoms, with a more prominent relationship observed in the non-geriatric population, males, obese adults, and those without aerobic physical activity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Boram Chae, June Kang, Cheolmin Shin, Young-Hoon Ko, Ho-Kyoung Yoon
Summary: The study found that female emotional laborers who complain of sleep difficulty may have decreased function of the parasympathetic nervous system. Therefore, good sleep quality is essential for maintaining and promoting the mental and physical health of women engaged in emotional labor.
PSYCHIATRY INVESTIGATION
(2021)
Article
Neurosciences
Sehee Jin, Cheolmin Shin, Changsu Han, Yong-Ku Kim, Jongha Lee, Sang Won Jeon, Seung-Hoon Lee, Young-Hoon Ko
Summary: This study found that changes in brain structure, particularly in the amygdala, medial prefrontal cortex, hippocampus, and insula, are associated with post-traumatic stress symptoms (PTSS). Participants with worsened PTSS showed increased delta slow wave changes in specific brain regions compared to those with improved symptoms.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2021)
Article
Geosciences, Multidisciplinary
Jongha Lee, Seung-Hoon Lee, Cheolmin Shin, Ho-Kyoung Yoon, Ha Eun Park, Eun Bee Cho, Hae Sun Jung, Young-Hoon Ko
Summary: This study evaluated the factors affecting the severity of indirect trauma in human-made disasters, finding that gender, presence of children, and higher income levels can impact the severity. The severity of indirect trauma was higher in the control community, and risk and protective factors are determined by the characteristics of the disaster and the victim.
INTERNATIONAL JOURNAL OF DISASTER RISK REDUCTION
(2021)
Article
Clinical Neurology
Jong-ha Lee, SuHyuk Chi, Minsoo Ko, Minjae Song, Byung-Joo Ham, Young-Hoon Ko, Sang-il Suh, Moon-Soo Lee
Summary: The study found that compared to healthy controls, patients with MDD had significantly increased FA values, but these values decreased after 3 months of treatment. This suggests that early pharmacological treatment may help restore brain integrity.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Pediatrics
Jongha Lee, Changsu Han, Young-Hoon Ko, Moon-Soo Lee, Ho-Kyoung Yoon
Summary: The study identified factors influencing the experience of depressive symptoms in adolescents, with perceived stress increasing with age among Korean adolescents. High school seniors and girls were more likely to report depressive symptoms. Perceived health status, academic performance, time spent studying, physical activity, duration of internet use, and effort to control weight were associated with individual experiences of depressive symptoms.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2021)
Article
Clinical Neurology
Suyeon Kim, Eunsoo Won, Hyun-Ghang Jeong, Moon-Soo Lee, Young-Hoon Ko, Jong-Woo Paik, Changsu Han, Byung-Joo Ham, Eunsoo Choi, Kyu-Man Han
Summary: This study found a significant association between workplace gender discrimination and the prevalence of depressive symptoms among female employees.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Developmental
Jongha Lee, Young-Hoon Ko, Suhyuk Chi, Moon-Soo Lee, Ho-Kyoung Yoon
Summary: This study compared lifestyle factors and mental health status of Korean adolescents before and during the COVID-19 pandemic. The results showed that during the pandemic, perceived stress levels, self-reported depressive mood, and suicidal thoughts and attempts were lower among adolescents compared to before the outbreak. However, caution is needed when interpreting these results, and further research is needed to understand the long-term effects of a pandemic on the mental health and lifestyle factors of adolescents.
JOURNAL OF ADOLESCENT HEALTH
(2022)
Article
Psychiatry
Jiseung Lee, Ji-Eun Lim, Song Heui Cho, Eunsoo Won, Hyun-Ghang Jeong, Moon-Soo Lee, Young-Hoon Ko, Changsu Han, Byung-Joo Ham, Kyu-Man Han
Summary: This study investigated the association between work-family conflict, depressive symptoms, and potential moderators among adult female workers. The results showed that female workers with high levels of work-family conflict were more likely to have depressive symptoms than those with low levels. Furthermore, the association was moderated by factors such as age, education and income levels, marital status, family size, number of children, and job conditions.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Jongha Lee, Young-Hoon Ko, Cheolmin Shin, Rayoung Han, Nayoung Chae, Ho-Kyoung Yoon
Summary: This study aimed to investigate the severity of depression and suicidality in Korean community populations and examine their awareness of suicide and suicide prevention during the pandemic. The results showed that the severity of depression and suicidality in the community population decreased in 2021 compared to 2020. Awareness of the importance of suicide prevention increased in 2021, but the percentage reporting that it is possible decreased slightly. The group with higher depressive symptoms reported a lower possibility of suicide prevention.
PSYCHIATRY INVESTIGATION
(2022)
Article
Neurosciences
Jihoon Oh, Sekye Jeon, Tae Hyon Ha, Woojae Myung, Seung-Hwan Lee, Young-Hoon Ko, Do Hoon Kim, Hwa-Young Lee, Jeong-Ho Chae
Summary: This study found that self-administered transcranial direct current stimulation (tDCS) treatment for depressive patients at home is comparable to clinic-based treatment. The results also suggest that self-administered tDCS treatment can effectively improve depressive symptoms in patients with mild to moderate major depressive disorder.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)
Article
Neurosciences
Seung-Hoon Lee, Cheolmin Shin, Young-Hoon Ko, Moon -Soo Lee, Moon Ho Park, Chi-Un Pae, Ho-Kyoung Yoon, Changsu Han
Summary: This study examined the blood adipokine levels in geriatric depression, taking into account the effects of metabolic syndrome. The results showed that metabolic syndrome significantly affected the blood adipokine levels and only PAI-1 was associated with the diagnosis of depression.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2023)